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The map label for this gene is nuoE [H]

Identifier: 154247409

GI number: 154247409

Start: 3876707

End: 3877237

Strand: Reverse

Name: nuoE [H]

Synonym: Xaut_3481

Alternate gene names: 154247409

Gene position: 3877237-3876707 (Counterclockwise)

Preceding gene: 154247410

Following gene: 154247408

Centisome position: 73.03

GC content: 66.67

Gene sequence:

>531_bases
ATGCGCCCTCACGGCTTTTGGGAAAGCGAGACGTCCATGGCGGTCTATGAGGATTGGAGCACCGAGCGCGCAGCGCAGGT
GATCTCGGAGAACCGGCATCTCGAAGGGGCCACCATGCCCATCCTGCATGCCCTGCAGGAGACGTTCGGCTTCGTGCCGG
ACCCGGCGGTGCCCATGATCGCCGAAAGCCTCAACCTCTCGCGCGCCGAGGTCTATGGCGTCCTCACCTTCTATCACGAC
TTCCGGCGTGAGGCGCCCGGTCGCCATGTGGTGAAGCTGTGCGCCGCTGAGGCCTGCCAGTCCGTGGGCGGCAAGGCGCT
CGCCCAGTATGTCGAGGAAAAGCTCGGCGTGGACATGGGTTCGACCTCCCCCGACGGGCGGGTGACCCTGGAGCCCATCT
ATTGCCTGGGCCTGTGCGCCTGCGCTCCGTCCGCTCTGGTGGACGGCCAGCTGGTGGGCCGCCTCGACCGCGATGCCATC
GACGAGATCGCCGACTGCTTCGCCAACGGCAAGAGCTTCGGAGACGCCTGA

Upstream 100 bases:

>100_bases
CCGTATTTAATAGAGATGTTCTATTGCAACATCCCACAGCTGGCTTGATCCGAGAGCCGGGTGTGACACACTTTCCCATA
AGCAAGACGAAGCGGCGGTA

Downstream 100 bases:

>100_bases
TGAAATCCCCCCGCATCTTCGTCCCGAACGACGCCACTGCCGTCGCCTGCGGCGCCGACCGCGTCGCGCGCAAGCTGGAA
GCCGGGCTGCTGGCCCGCGG

Product: NADH dehydrogenase (ubiquinone) 24 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MRPHGFWESETSMAVYEDWSTERAAQVISENRHLEGATMPILHALQETFGFVPDPAVPMIAESLNLSRAEVYGVLTFYHD
FRREAPGRHVVKLCAAEACQSVGGKALAQYVEEKLGVDMGSTSPDGRVTLEPIYCLGLCACAPSALVDGQLVGRLDRDAI
DEIADCFANGKSFGDA

Sequences:

>Translated_176_residues
MRPHGFWESETSMAVYEDWSTERAAQVISENRHLEGATMPILHALQETFGFVPDPAVPMIAESLNLSRAEVYGVLTFYHD
FRREAPGRHVVKLCAAEACQSVGGKALAQYVEEKLGVDMGSTSPDGRVTLEPIYCLGLCACAPSALVDGQLVGRLDRDAI
DEIADCFANGKSFGDA
>Mature_176_residues
MRPHGFWESETSMAVYEDWSTERAAQVISENRHLEGATMPILHALQETFGFVPDPAVPMIAESLNLSRAEVYGVLTFYHD
FRREAPGRHVVKLCAAEACQSVGGKALAQYVEEKLGVDMGSTSPDGRVTLEPIYCLGLCACAPSALVDGQLVGRLDRDAI
DEIADCFANGKSFGDA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=139, Percent_Identity=30.9352517985612, Blast_Score=84, Evalue=8e-17,
Organism=Escherichia coli, GI1788621, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561328, Length=169, Percent_Identity=28.9940828402367, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859877, Length=141, Percent_Identity=30.4964539007092, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355353, Length=137, Percent_Identity=29.1970802919708, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19110; Mature: 19110

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPHGFWESETSMAVYEDWSTERAAQVISENRHLEGATMPILHALQETFGFVPDPAVPMI
CCCCCCCCCCCCEEEHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AESLNLSRAEVYGVLTFYHDFRREAPGRHVVKLCAAEACQSVGGKALAQYVEEKLGVDMG
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
STSPDGRVTLEPIYCLGLCACAPSALVDGQLVGRLDRDAIDEIADCFANGKSFGDA
CCCCCCCEEEHHHHHHHHHHHCCHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRPHGFWESETSMAVYEDWSTERAAQVISENRHLEGATMPILHALQETFGFVPDPAVPMI
CCCCCCCCCCCCEEEHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
AESLNLSRAEVYGVLTFYHDFRREAPGRHVVKLCAAEACQSVGGKALAQYVEEKLGVDMG
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
STSPDGRVTLEPIYCLGLCACAPSALVDGQLVGRLDRDAIDEIADCFANGKSFGDA
CCCCCCCEEEHHHHHHHHHHHCCHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]