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The map label for this gene is rnd [H]

Identifier: 154247067

GI number: 154247067

Start: 3483210

End: 3484358

Strand: Reverse

Name: rnd [H]

Synonym: Xaut_3138

Alternate gene names: 154247067

Gene position: 3484358-3483210 (Counterclockwise)

Preceding gene: 154247068

Following gene: 154247060

Centisome position: 65.63

GC content: 69.02

Gene sequence:

>1149_bases
ATGGATCCGATCTCCTCGACCGAGGCGCTGGCAGCGGCCTGCGAACGCCTCGCCCGCCACCCTTTCGTCACCGTCGACAC
GGAATTCCTAAGGGAAACCACGTTCTGGCCGAAGCTCTGCGTCGTGCAGGTCGCCTCGCCGGAAGAAGCCGTGCTCATCG
ACGCGCTGGCGGACGGGCTCGATCTCGCCCCCTTCTACCGGCTCATGGCCAATGAGCGGGTGATGAAGGTGTTCCACGCC
GGCCGGCAGGACATCGAGATCATCTGGCACCAGGCCCGACTCATCCCGCATCCGGTGTTCGACACCCAGGTGGCGGCGAT
GGTGCTCGGCTATGGCGACAGCATCTCTTATGACCAGCTGGTTCAGCGCGTCACGGGCCACGCCCTCGACAAGTCGTCGC
GCTTCACCGACTGGTCGCGCCGGCCGCTGAGCCAGGCGCAGATCGTCTATGCCGTGGCCGACGTCACCCATCTGCGCGAC
ATCTACATCAAGCTGACAACGGACCTGGAGACGCGGGGCCGCGCGGAGTGGGTGGGCGAGGAAATGCACGTCCTCACCTC
CCCCGCCACCTACGAGCAGCACCCGGACAGCGCCTGGGAGCGGCTGAAGTCCCGCGTGCGCAAGCCGCGCGAGCTGGCCG
TGCTGGTGGAGGTGGCCGCCTGGCGCGAGCGCGAGGCCCAGACCCGCGACCTGCCGCGCGGCCGCGTGATCAAGGACGAG
GTGATCGGCGAGATCGCGGTGCAGCAGCCGCAGACGCCGGAGAAGCTGGCCGAGCTGCGCTCCCTGCCCAAGGGCTTCGA
ACGCTCGCGCTACGGCGAGGCGGTGCTGGAGGCGGTGCGTCGGGGCGTCGCCCGAGACCCCAAGACCCTGCCGCGCATCG
AGCGCGACAAGCCCTTGCCCAACGGTGCCAGCGCCACGGTGGAACTGCTGAAGGTGCTGCTGCGCATGACGGCGGAGCAG
AATGCGGTGGCCGCCAAGGTGATCGCCACCACCGAGGACCTGGAGCGTATCGCGGTCAGCGACGAAGCCGACGTGCAGGC
GCTGAAGGGCTGGCGCCGCGAGCTGTTCGGCGAGCGCGCCCTGGCCCTGAAGGCCGGCCGCCTGGCGCTGGCGGTGAACC
ACGGCCGCGTCATTGCGGTGGAGAAATAA

Upstream 100 bases:

>100_bases
ACCGCCGAGGCCGCCCTCGCCATGGCCCGTTCCGCCGCAGCCTGACAAAATCGCGCCACATTCCCTTTTCGGGACGGCCT
GGCATGGGTATGGTCTGCGG

Downstream 100 bases:

>100_bases
GCGAACGGCCGGCGCGAAGCTCGCACCGGCCGCTGGAAAGACCTGCTCGAATATCTGAAGCGTGCGGGGATCTCCCCCGC
ACTTCACCCCGGCCGGGAGA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDPISSTEALAAACERLARHPFVTVDTEFLRETTFWPKLCVVQVASPEEAVLIDALADGLDLAPFYRLMANERVMKVFHA
GRQDIEIIWHQARLIPHPVFDTQVAAMVLGYGDSISYDQLVQRVTGHALDKSSRFTDWSRRPLSQAQIVYAVADVTHLRD
IYIKLTTDLETRGRAEWVGEEMHVLTSPATYEQHPDSAWERLKSRVRKPRELAVLVEVAAWREREAQTRDLPRGRVIKDE
VIGEIAVQQPQTPEKLAELRSLPKGFERSRYGEAVLEAVRRGVARDPKTLPRIERDKPLPNGASATVELLKVLLRMTAEQ
NAVAAKVIATTEDLERIAVSDEADVQALKGWRRELFGERALALKAGRLALAVNHGRVIAVEK

Sequences:

>Translated_382_residues
MDPISSTEALAAACERLARHPFVTVDTEFLRETTFWPKLCVVQVASPEEAVLIDALADGLDLAPFYRLMANERVMKVFHA
GRQDIEIIWHQARLIPHPVFDTQVAAMVLGYGDSISYDQLVQRVTGHALDKSSRFTDWSRRPLSQAQIVYAVADVTHLRD
IYIKLTTDLETRGRAEWVGEEMHVLTSPATYEQHPDSAWERLKSRVRKPRELAVLVEVAAWREREAQTRDLPRGRVIKDE
VIGEIAVQQPQTPEKLAELRSLPKGFERSRYGEAVLEAVRRGVARDPKTLPRIERDKPLPNGASATVELLKVLLRMTAEQ
NAVAAKVIATTEDLERIAVSDEADVQALKGWRRELFGERALALKAGRLALAVNHGRVIAVEK
>Mature_382_residues
MDPISSTEALAAACERLARHPFVTVDTEFLRETTFWPKLCVVQVASPEEAVLIDALADGLDLAPFYRLMANERVMKVFHA
GRQDIEIIWHQARLIPHPVFDTQVAAMVLGYGDSISYDQLVQRVTGHALDKSSRFTDWSRRPLSQAQIVYAVADVTHLRD
IYIKLTTDLETRGRAEWVGEEMHVLTSPATYEQHPDSAWERLKSRVRKPRELAVLVEVAAWREREAQTRDLPRGRVIKDE
VIGEIAVQQPQTPEKLAELRSLPKGFERSRYGEAVLEAVRRGVARDPKTLPRIERDKPLPNGASATVELLKVLLRMTAEQ
NAVAAKVIATTEDLERIAVSDEADVQALKGWRRELFGERALALKAGRLALAVNHGRVIAVEK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=262, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=24.7148288973384, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788105, Length=368, Percent_Identity=29.3478260869565, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531757, Length=162, Percent_Identity=32.7160493827161, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=320, Percent_Identity=26.5625, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078302, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42980; Mature: 42980

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPISSTEALAAACERLARHPFVTVDTEFLRETTFWPKLCVVQVASPEEAVLIDALADGL
CCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCC
DLAPFYRLMANERVMKVFHAGRQDIEIIWHQARLIPHPVFDTQVAAMVLGYGDSISYDQL
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
VQRVTGHALDKSSRFTDWSRRPLSQAQIVYAVADVTHLRDIYIKLTTDLETRGRAEWVGE
HHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHCCC
EMHVLTSPATYEQHPDSAWERLKSRVRKPRELAVLVEVAAWREREAQTRDLPRGRVIKDE
HHHEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
VIGEIAVQQPQTPEKLAELRSLPKGFERSRYGEAVLEAVRRGVARDPKTLPRIERDKPLP
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NGASATVELLKVLLRMTAEQNAVAAKVIATTEDLERIAVSDEADVQALKGWRRELFGERA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH
LALKAGRLALAVNHGRVIAVEK
HHEECCCEEEEEECCEEEEEEC
>Mature Secondary Structure
MDPISSTEALAAACERLARHPFVTVDTEFLRETTFWPKLCVVQVASPEEAVLIDALADGL
CCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCC
DLAPFYRLMANERVMKVFHAGRQDIEIIWHQARLIPHPVFDTQVAAMVLGYGDSISYDQL
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
VQRVTGHALDKSSRFTDWSRRPLSQAQIVYAVADVTHLRDIYIKLTTDLETRGRAEWVGE
HHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHCCC
EMHVLTSPATYEQHPDSAWERLKSRVRKPRELAVLVEVAAWREREAQTRDLPRGRVIKDE
HHHEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
VIGEIAVQQPQTPEKLAELRSLPKGFERSRYGEAVLEAVRRGVARDPKTLPRIERDKPLP
HHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NGASATVELLKVLLRMTAEQNAVAAKVIATTEDLERIAVSDEADVQALKGWRRELFGERA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH
LALKAGRLALAVNHGRVIAVEK
HHEECCCEEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]