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The map label for this gene is pgsA2 [H]

Identifier: 154247059

GI number: 154247059

Start: 3472115

End: 3472645

Strand: Reverse

Name: pgsA2 [H]

Synonym: Xaut_3130

Alternate gene names: 154247059

Gene position: 3472645-3472115 (Counterclockwise)

Preceding gene: 154247060

Following gene: 154247058

Centisome position: 65.41

GC content: 65.91

Gene sequence:

>531_bases
GTGAGCCTGCCGAACATCATCACCCTCATGCGCATCCTGCTGGTGCCGGCGGTGGTCTGGTCGATCGCCTCCAGCGAATA
TGCGCTGGCGTTCTGGCTGTTCCTCGCGGCCGGCATCTCCGATGCGCTCGACGGCTTCATCGCCAAGCGGTTCGATATGC
AGACGGAGCTCGGCTCCTATCTCGATCCGGTGGCCGACAAGGCCCTGCTCATCTCCATCTACGTGGCGCTGGCGGTCTGC
GGCCTGATCCCGCGCTGGGTGGCCATCGCCGTGGTGTCGCGCGACGTGATGATCATCGGGGCGGTGGTGCTGTCCCTGGT
CATGGCCAAGCCCGTGGCCATCAGCCCGCTGCTGGTCTCCAAGGTGAACACGGCGGTGCAGATCGTGTTCGCAGCCTTCG
TGCTGGCCGCGTCCGGGTTCGGTCTGGACCTGCCGGGGCTGTTCCAGGTGGGGCTGGTGATGGTCGGGCTCTTGACGGGA
CTTTCGGCCGCTGCCTATCTCGCCGCATGGACGCGCCACGTTGCGAATTGA

Upstream 100 bases:

>100_bases
CCGGGGCGTGGACAGCGCCTAACATCAAGACAGGGAACGCGATATCCGGCCGGCTTGCGATCGAGGCGGCCGGCATCCTC
CCGGCGGCGCGGAGGACGAG

Downstream 100 bases:

>100_bases
CGCACAGTCAGTTGAAACTGGCGAACCGACGAATGGCGCACTCACGAACGGCAAGCTGATGGATCGTGAGTTGATCGGCG
AACGCGACCCCCGCAACTCC

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MSLPNIITLMRILLVPAVVWSIASSEYALAFWLFLAAGISDALDGFIAKRFDMQTELGSYLDPVADKALLISIYVALAVC
GLIPRWVAIAVVSRDVMIIGAVVLSLVMAKPVAISPLLVSKVNTAVQIVFAAFVLAASGFGLDLPGLFQVGLVMVGLLTG
LSAAAYLAAWTRHVAN

Sequences:

>Translated_176_residues
MSLPNIITLMRILLVPAVVWSIASSEYALAFWLFLAAGISDALDGFIAKRFDMQTELGSYLDPVADKALLISIYVALAVC
GLIPRWVAIAVVSRDVMIIGAVVLSLVMAKPVAISPLLVSKVNTAVQIVFAAFVLAASGFGLDLPGLFQVGLVMVGLLTG
LSAAAYLAAWTRHVAN
>Mature_175_residues
SLPNIITLMRILLVPAVVWSIASSEYALAFWLFLAAGISDALDGFIAKRFDMQTELGSYLDPVADKALLISIYVALAVCG
LIPRWVAIAVVSRDVMIIGAVVLSLVMAKPVAISPLLVSKVNTAVQIVFAAFVLAASGFGLDLPGLFQVGLVMVGLLTGL
SAAAYLAAWTRHVAN

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=181, Percent_Identity=34.2541436464088, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI10092647, Length=181, Percent_Identity=34.2541436464088, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788220, Length=174, Percent_Identity=30.4597701149425, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71984838, Length=182, Percent_Identity=32.967032967033, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71984834, Length=182, Percent_Identity=32.967032967033, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320059, Length=101, Percent_Identity=36.6336633663366, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650130, Length=191, Percent_Identity=35.6020942408377, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24650126, Length=191, Percent_Identity=35.6020942408377, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24650128, Length=191, Percent_Identity=35.6020942408377, Blast_Score=93, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 18560; Mature: 18428

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPNIITLMRILLVPAVVWSIASSEYALAFWLFLAAGISDALDGFIAKRFDMQTELGSY
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPVADKALLISIYVALAVCGLIPRWVAIAVVSRDVMIIGAVVLSLVMAKPVAISPLLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KVNTAVQIVFAAFVLAASGFGLDLPGLFQVGLVMVGLLTGLSAAAYLAAWTRHVAN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLPNIITLMRILLVPAVVWSIASSEYALAFWLFLAAGISDALDGFIAKRFDMQTELGSY
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPVADKALLISIYVALAVCGLIPRWVAIAVVSRDVMIIGAVVLSLVMAKPVAISPLLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KVNTAVQIVFAAFVLAASGFGLDLPGLFQVGLVMVGLLTGLSAAAYLAAWTRHVAN
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]