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The map label for this gene is paaJ [C]

Identifier: 154245331

GI number: 154245331

Start: 1588725

End: 1589912

Strand: Direct

Name: paaJ [C]

Synonym: Xaut_1384

Alternate gene names: 154245331

Gene position: 1588725-1589912 (Clockwise)

Preceding gene: 154245330

Following gene: 154245334

Centisome position: 29.93

GC content: 66.58

Gene sequence:

>1188_bases
ATGCCTGCAGGAGATCTGGAGAACAAGGCCGCCATCGTGGGCTGGGCCCATTCGCCGTTCGGCAAGCTCGAGGATGCCGA
CACCGAAGCGCTGATGGGCCGCGTGGCCGGCGCCGCTATCGAGCATGCGGGCCTTGCCCCCTCGGATGTGGATTCCATCC
ATGTGGGCGTGTTCAACGCCGGCTTCCAGAAGCAGGATTTCCAGGGCGCCATGCCAGCCCTGAGCGTGCCGGAACTCGCC
CACACCCCGGCGGTGCGGGTGGAGAATGCCTGCGCCACCGGATCGGCCGCCATCCATTCGGCGCTCAACTATATCGCCAG
CGGTCAGGGCCGCATCGCCCTCGTGGTGGGGGCCGAGAAGATGACCGCCAAGCCCACCGCCGAGGTGGGTGACATCCTCC
TCAACGCCTCCTACCGTAAGGAAGAAGCCGACATCGACGGCGGTTTTGCCGGCGTGTTCGGCCGCATCGCGCAGCATTAT
TTCCAGCGCTACGGCGATCGCTCCGAGGAACTTGCGCGCATCGCCGCCAAGAACCACAAGAACGGCGTTTCCAATCCCTA
CGCCCAGATGCGCAAGGATTTCGGCTTCGAGTTCTGCAACACCATTTCCGAGAAGAACCCCTATGTGGCCGGCCCCCTGC
GCCGCACCGACTGCTCGCTGGTGTCGGACGGCGCCGCGGCCCTCGTGATCGCCTCGCCCGACGTGGCGCAGACGCTGCAG
CGCGCCGTCGCCTTCCGCGCCCGTGCCCATGCCAACGACATCCTGCCGTTGTCGCGGCGCGATCCCATCGCCTTCGAGGG
CGCCCGCCGCGCCTGGGTGAAGGCGCTGGAGCAGGGCGGCATCAGCCTCGACGACCTCGACCTGGTGGAGACCCACGACT
GTTTCACCATCGCCGAACTGCTTGAATACGAGGCCATGGGCCTCGCCAAGCCCGGCGAGGGTTACAAGGTGGTGCGCGAG
GGCATCACCGAGAAGACCGGCAAGCTGCCGGTGAACGCCTCGGGCGGGCTGAAGTCCAAGGGCCATCCCATCGGCGCCAC
CGGCGTGTCCATGCATGTGCTCTGCGCCATGCAGCTCATGGGCGAGGCCGGCGACATGCAGATCGCCGACGCCAAGATGG
CCGGCATCTTCAACATGGGCGGTGCCGCCGTGGCCAATTACGTCTCCGTGCTCGAACGGGTGAAGTGA

Upstream 100 bases:

>100_bases
GATGCCGGATGGCTTTATCGCGGGCCTGTCATAAAGACGGCCGCGTCCCTATCTCAACCAAGACCAACACAACGCGGCGT
CACGCCGCCGGGAGAACGAC

Downstream 100 bases:

>100_bases
GGGCAGGGGGGCCCCAGGCCCCCTTTCCCCCTCTTGGCCCCCTTTCCCGCTGGGGACGGCTTCGGCCGTTTCAAGCACCG
GCCGTCGCGAGACTTATTCG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MPAGDLENKAAIVGWAHSPFGKLEDADTEALMGRVAGAAIEHAGLAPSDVDSIHVGVFNAGFQKQDFQGAMPALSVPELA
HTPAVRVENACATGSAAIHSALNYIASGQGRIALVVGAEKMTAKPTAEVGDILLNASYRKEEADIDGGFAGVFGRIAQHY
FQRYGDRSEELARIAAKNHKNGVSNPYAQMRKDFGFEFCNTISEKNPYVAGPLRRTDCSLVSDGAAALVIASPDVAQTLQ
RAVAFRARAHANDILPLSRRDPIAFEGARRAWVKALEQGGISLDDLDLVETHDCFTIAELLEYEAMGLAKPGEGYKVVRE
GITEKTGKLPVNASGGLKSKGHPIGATGVSMHVLCAMQLMGEAGDMQIADAKMAGIFNMGGAAVANYVSVLERVK

Sequences:

>Translated_395_residues
MPAGDLENKAAIVGWAHSPFGKLEDADTEALMGRVAGAAIEHAGLAPSDVDSIHVGVFNAGFQKQDFQGAMPALSVPELA
HTPAVRVENACATGSAAIHSALNYIASGQGRIALVVGAEKMTAKPTAEVGDILLNASYRKEEADIDGGFAGVFGRIAQHY
FQRYGDRSEELARIAAKNHKNGVSNPYAQMRKDFGFEFCNTISEKNPYVAGPLRRTDCSLVSDGAAALVIASPDVAQTLQ
RAVAFRARAHANDILPLSRRDPIAFEGARRAWVKALEQGGISLDDLDLVETHDCFTIAELLEYEAMGLAKPGEGYKVVRE
GITEKTGKLPVNASGGLKSKGHPIGATGVSMHVLCAMQLMGEAGDMQIADAKMAGIFNMGGAAVANYVSVLERVK
>Mature_394_residues
PAGDLENKAAIVGWAHSPFGKLEDADTEALMGRVAGAAIEHAGLAPSDVDSIHVGVFNAGFQKQDFQGAMPALSVPELAH
TPAVRVENACATGSAAIHSALNYIASGQGRIALVVGAEKMTAKPTAEVGDILLNASYRKEEADIDGGFAGVFGRIAQHYF
QRYGDRSEELARIAAKNHKNGVSNPYAQMRKDFGFEFCNTISEKNPYVAGPLRRTDCSLVSDGAAALVIASPDVAQTLQR
AVAFRARAHANDILPLSRRDPIAFEGARRAWVKALEQGGISLDDLDLVETHDCFTIAELLEYEAMGLAKPGEGYKVVREG
ITEKTGKLPVNASGGLKSKGHPIGATGVSMHVLCAMQLMGEAGDMQIADAKMAGIFNMGGAAVANYVSVLERVK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI302344767, Length=322, Percent_Identity=36.0248447204969, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI302344760, Length=322, Percent_Identity=36.0248447204969, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI19923233, Length=322, Percent_Identity=36.0248447204969, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI302344762, Length=351, Percent_Identity=33.6182336182336, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI55956775, Length=314, Percent_Identity=32.1656050955414, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17537653, Length=394, Percent_Identity=30.2030456852792, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI19921506, Length=317, Percent_Identity=32.807570977918, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24585051, Length=317, Percent_Identity=32.807570977918, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 41748; Mature: 41617

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAGDLENKAAIVGWAHSPFGKLEDADTEALMGRVAGAAIEHAGLAPSDVDSIHVGVFNA
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEC
GFQKQDFQGAMPALSVPELAHTPAVRVENACATGSAAIHSALNYIASGQGRIALVVGAEK
CCCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHH
MTAKPTAEVGDILLNASYRKEEADIDGGFAGVFGRIAQHYFQRYGDRSEELARIAAKNHK
HCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
NGVSNPYAQMRKDFGFEFCNTISEKNPYVAGPLRRTDCSLVSDGAAALVIASPDVAQTLQ
CCCCCHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCCCHHCCCCCEEEEEECCHHHHHHH
RAVAFRARAHANDILPLSRRDPIAFEGARRAWVKALEQGGISLDDLDLVETHDCFTIAEL
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHH
LEYEAMGLAKPGEGYKVVREGITEKTGKLPVNASGGLKSKGHPIGATGVSMHVLCAMQLM
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GEAGDMQIADAKMAGIFNMGGAAVANYVSVLERVK
CCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAGDLENKAAIVGWAHSPFGKLEDADTEALMGRVAGAAIEHAGLAPSDVDSIHVGVFNA
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEC
GFQKQDFQGAMPALSVPELAHTPAVRVENACATGSAAIHSALNYIASGQGRIALVVGAEK
CCCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHH
MTAKPTAEVGDILLNASYRKEEADIDGGFAGVFGRIAQHYFQRYGDRSEELARIAAKNHK
HCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
NGVSNPYAQMRKDFGFEFCNTISEKNPYVAGPLRRTDCSLVSDGAAALVIASPDVAQTLQ
CCCCCHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCCCHHCCCCCEEEEEECCHHHHHHH
RAVAFRARAHANDILPLSRRDPIAFEGARRAWVKALEQGGISLDDLDLVETHDCFTIAEL
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHH
LEYEAMGLAKPGEGYKVVREGITEKTGKLPVNASGGLKSKGHPIGATGVSMHVLCAMQLM
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GEAGDMQIADAKMAGIFNMGGAAVANYVSVLERVK
CCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]