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The map label for this gene is fhs1 [H]

Identifier: 154245330

GI number: 154245330

Start: 1586961

End: 1588658

Strand: Direct

Name: fhs1 [H]

Synonym: Xaut_1383

Alternate gene names: 154245330

Gene position: 1586961-1588658 (Clockwise)

Preceding gene: 154245329

Following gene: 154245331

Centisome position: 29.89

GC content: 69.38

Gene sequence:

>1698_bases
ATGCACGAGAGAACTGCCCGCCCGCTCGATCCCTCCTCGGACGCCGCCATCGCCGCCAGCGTGACACCCCGGCCCATCGC
CGAGGTGGCGGACGCCCTGGGGATCCCGGCGGATGCGCTCTACCGCTATGGCCCGTACAAGGCCAAGGTGGCGCTGGATT
TCATCACCGAGATCGAGACCCGGCCGCGCGGGCACCTGGTGCTGGTCACCGCCATCAACCCGACCCCGGCGGGGGAGGGC
AAGACCACCACCACCATCGGCCTTGGCGATGCCCTGGCCCGCCTCGGCACCAGGGCCGCCGTGTGCCTGCGCGAACCCTC
CCTCGGCCCGGTGTTCGGCGCCAAGGGCGGCGCCACCGGCGGTGGGCGGGCGCAAATCATCCCCATGCAGGACATCAACC
TGCATTTCACCGGCGACCTCCACGCCATCACCGCCGCGCATAACCTCTTGTCGGCGCTCATCGACAATCACATCCACTGG
GGCAACGGCCTCGACCTCGACGCCAGGCGCATCAGCTGGCGGCGGGTGATGGATCTCAACGACCGCGTGCTGCGCCATGT
CACCGTGGGCCTCGGCGGGCCGGGCAACGGCTTCCCCCGCGAGGACGGCTTCGACATCACGGTCGCCAGCGAGGTCATGG
CTATCCTGTGCCTCGCCACCGATCTGGCGGACCTGGAGGAGCGCCTGTCGCGCATGGTCATCGGCCAGACCCGCGGCCGC
CGGCTGGTGACCGCCGAGGAACTGGGCGGCGTCGGCGCCATGGTGGCGCTGCTGCGCGATGCCTTCCAGCCGAACCTGGT
GCAGACCATGGAGGGCACCCCCGCCTTCGTCCATGGCGGCCCGTTCGCCAACATCGCCCATGGATGTAATTCGGTGATGG
CCACGAAGGCCGCCCTCGGCCTTGCCGACGTGGTGGTGACCGAGGCCGGCTTCGGCGCCGATCTCGGGGCCGAGAAGTTT
CTCGATATCAAGTGCCGGCAGGCCGGCCTTGCCCCCTCCGCCGCCGTGGTGGTGGCCACCGTCCGGGCGTTGAAAATGCA
TGGCGGCGTCTCGCTCAAGGAGCTGGGCACGCCGGACCCCCATGCGGTCACGCGCGGCTGCGCCAACCTGAAGCGACATG
TGGAGAACCTGGAGAAGTTCGGCTTGCCGGTGGTGGTGGCCCTGAACCACTTCACCTCCGACACGCCGGAGGAGACGCAG
GCGGTGCGCGCCACCCTGGCGCCGCTCGGGGTGGGCGTCCACGTCTGCGGCCATTGGGCCAAAGGTGGCGCGGGCGCTGA
AGATCTGGCCCGCGCGGTGCTGGAACTGGTGGCCCGTCCCTCCACCTTCCACACCCTCTATCCCGACCAGATGCCCCTCA
CCGCCAAGATCGAGACCATCGCCCGGCAGATCTACCGCGCCGCCCGGGTCGACATCACCCCCGCCGCCGCACGCAAGCTC
CATGAGTATGAGATCGCCGGCTTCGGCGACCTGCCGGTGTGCATGGCGAAGACGCAATATTCCTTCTCCGCCGATCCGGC
GGCGCGCAACGCGCCGGAAGGCCATGTGCTGCCGGTGCGGGAGGTGCGCCTGTCCGCCGGTGCCGGTTTCGTGGTGGCGC
TGGCAGGCGACATCATGACCATGCCGGGCCTGCCATCGGCCCCTGCCGCAGAACAGATTTTCGTGATGCCGGATGGCTTT
ATCGCGGGCCTGTCATAA

Upstream 100 bases:

>100_bases
AGGCGCGGTGCCCCCTCACTGGGGCACAGCATTTTTGCCGCGCCCATGCTTCCCTCGCGTGGTGCGACCCGGTAGGGTCG
CGCCGCCTGGGGACTGATGC

Downstream 100 bases:

>100_bases
AGACGGCCGCGTCCCTATCTCAACCAAGACCAACACAACGCGGCGTCACGCCGCCGGGAGAACGACATGCCTGCAGGAGA
TCTGGAGAACAAGGCCGCCA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MHERTARPLDPSSDAAIAASVTPRPIAEVADALGIPADALYRYGPYKAKVALDFITEIETRPRGHLVLVTAINPTPAGEG
KTTTTIGLGDALARLGTRAAVCLREPSLGPVFGAKGGATGGGRAQIIPMQDINLHFTGDLHAITAAHNLLSALIDNHIHW
GNGLDLDARRISWRRVMDLNDRVLRHVTVGLGGPGNGFPREDGFDITVASEVMAILCLATDLADLEERLSRMVIGQTRGR
RLVTAEELGGVGAMVALLRDAFQPNLVQTMEGTPAFVHGGPFANIAHGCNSVMATKAALGLADVVVTEAGFGADLGAEKF
LDIKCRQAGLAPSAAVVVATVRALKMHGGVSLKELGTPDPHAVTRGCANLKRHVENLEKFGLPVVVALNHFTSDTPEETQ
AVRATLAPLGVGVHVCGHWAKGGAGAEDLARAVLELVARPSTFHTLYPDQMPLTAKIETIARQIYRAARVDITPAAARKL
HEYEIAGFGDLPVCMAKTQYSFSADPAARNAPEGHVLPVREVRLSAGAGFVVALAGDIMTMPGLPSAPAAEQIFVMPDGF
IAGLS

Sequences:

>Translated_565_residues
MHERTARPLDPSSDAAIAASVTPRPIAEVADALGIPADALYRYGPYKAKVALDFITEIETRPRGHLVLVTAINPTPAGEG
KTTTTIGLGDALARLGTRAAVCLREPSLGPVFGAKGGATGGGRAQIIPMQDINLHFTGDLHAITAAHNLLSALIDNHIHW
GNGLDLDARRISWRRVMDLNDRVLRHVTVGLGGPGNGFPREDGFDITVASEVMAILCLATDLADLEERLSRMVIGQTRGR
RLVTAEELGGVGAMVALLRDAFQPNLVQTMEGTPAFVHGGPFANIAHGCNSVMATKAALGLADVVVTEAGFGADLGAEKF
LDIKCRQAGLAPSAAVVVATVRALKMHGGVSLKELGTPDPHAVTRGCANLKRHVENLEKFGLPVVVALNHFTSDTPEETQ
AVRATLAPLGVGVHVCGHWAKGGAGAEDLARAVLELVARPSTFHTLYPDQMPLTAKIETIARQIYRAARVDITPAAARKL
HEYEIAGFGDLPVCMAKTQYSFSADPAARNAPEGHVLPVREVRLSAGAGFVVALAGDIMTMPGLPSAPAAEQIFVMPDGF
IAGLS
>Mature_565_residues
MHERTARPLDPSSDAAIAASVTPRPIAEVADALGIPADALYRYGPYKAKVALDFITEIETRPRGHLVLVTAINPTPAGEG
KTTTTIGLGDALARLGTRAAVCLREPSLGPVFGAKGGATGGGRAQIIPMQDINLHFTGDLHAITAAHNLLSALIDNHIHW
GNGLDLDARRISWRRVMDLNDRVLRHVTVGLGGPGNGFPREDGFDITVASEVMAILCLATDLADLEERLSRMVIGQTRGR
RLVTAEELGGVGAMVALLRDAFQPNLVQTMEGTPAFVHGGPFANIAHGCNSVMATKAALGLADVVVTEAGFGADLGAEKF
LDIKCRQAGLAPSAAVVVATVRALKMHGGVSLKELGTPDPHAVTRGCANLKRHVENLEKFGLPVVVALNHFTSDTPEETQ
AVRATLAPLGVGVHVCGHWAKGGAGAEDLARAVLELVARPSTFHTLYPDQMPLTAKIETIARQIYRAARVDITPAAARKL
HEYEIAGFGDLPVCMAKTQYSFSADPAARNAPEGHVLPVREVRLSAGAGFVVALAGDIMTMPGLPSAPAAEQIFVMPDGF
IAGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=610, Percent_Identity=44.5901639344262, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=45.1456310679612, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=43.0232558139535, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=613, Percent_Identity=45.1876019575856, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17568739, Length=613, Percent_Identity=45.1876019575856, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321643, Length=624, Percent_Identity=44.0705128205128, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=42.1303656597774, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24645718, Length=626, Percent_Identity=42.8115015974441, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=626, Percent_Identity=42.8115015974441, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI62472483, Length=626, Percent_Identity=42.8115015974441, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=626, Percent_Identity=42.8115015974441, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59390; Mature: 59390

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHERTARPLDPSSDAAIAASVTPRPIAEVADALGIPADALYRYGPYKAKVALDFITEIET
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEHHHHHHHHCC
RPRGHLVLVTAINPTPAGEGKTTTTIGLGDALARLGTRAAVCLREPSLGPVFGAKGGATG
CCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCC
GGRAQIIPMQDINLHFTGDLHAITAAHNLLSALIDNHIHWGNGLDLDARRISWRRVMDLN
CCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHH
DRVLRHVTVGLGGPGNGFPREDGFDITVASEVMAILCLATDLADLEERLSRMVIGQTRGR
HHEEHHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RLVTAEELGGVGAMVALLRDAFQPNLVQTMEGTPAFVHGGPFANIAHGCNSVMATKAALG
EEEEHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LADVVVTEAGFGADLGAEKFLDIKCRQAGLAPSAAVVVATVRALKMHGGVSLKELGTPDP
HHHHHHCCCCCCCCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCH
HAVTRGCANLKRHVENLEKFGLPVVVALNHFTSDTPEETQAVRATLAPLGVGVHVCGHWA
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCC
KGGAGAEDLARAVLELVARPSTFHTLYPDQMPLTAKIETIARQIYRAARVDITPAAARKL
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
HEYEIAGFGDLPVCMAKTQYSFSADPAARNAPEGHVLPVREVRLSAGAGFVVALAGDIMT
HHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECHHHHHCCCCCCEEEEEECCHHC
MPGLPSAPAAEQIFVMPDGFIAGLS
CCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MHERTARPLDPSSDAAIAASVTPRPIAEVADALGIPADALYRYGPYKAKVALDFITEIET
CCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEHHHHHHHHCC
RPRGHLVLVTAINPTPAGEGKTTTTIGLGDALARLGTRAAVCLREPSLGPVFGAKGGATG
CCCCCEEEEEEECCCCCCCCCCEEEEEHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCC
GGRAQIIPMQDINLHFTGDLHAITAAHNLLSALIDNHIHWGNGLDLDARRISWRRVMDLN
CCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHH
DRVLRHVTVGLGGPGNGFPREDGFDITVASEVMAILCLATDLADLEERLSRMVIGQTRGR
HHEEHHEEEECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RLVTAEELGGVGAMVALLRDAFQPNLVQTMEGTPAFVHGGPFANIAHGCNSVMATKAALG
EEEEHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LADVVVTEAGFGADLGAEKFLDIKCRQAGLAPSAAVVVATVRALKMHGGVSLKELGTPDP
HHHHHHCCCCCCCCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCH
HAVTRGCANLKRHVENLEKFGLPVVVALNHFTSDTPEETQAVRATLAPLGVGVHVCGHWA
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCC
KGGAGAEDLARAVLELVARPSTFHTLYPDQMPLTAKIETIARQIYRAARVDITPAAARKL
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
HEYEIAGFGDLPVCMAKTQYSFSADPAARNAPEGHVLPVREVRLSAGAGFVVALAGDIMT
HHHEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCEECHHHHHCCCCCCEEEEEECCHHC
MPGLPSAPAAEQIFVMPDGFIAGLS
CCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA