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The map label for this gene is moaA [H]

Identifier: 154245334

GI number: 154245334

Start: 1591439

End: 1592494

Strand: Direct

Name: moaA [H]

Synonym: Xaut_1387

Alternate gene names: 154245334

Gene position: 1591439-1592494 (Clockwise)

Preceding gene: 154245331

Following gene: 154245335

Centisome position: 29.98

GC content: 66.76

Gene sequence:

>1056_bases
GTGAGTGATGTGCCGAGGGATCTGATCGACAGGCCAAGCGTGGCAGCGGCGGCTCAGGCCGGACCGCTGGTGGATACGTT
CGGCCGCGCCGTCACCTATCTGCGCGTCTCCGTGACCGACCGCTGCGATTTCCGCTGTGTCTATTGCATGGCCGAGCACA
TGACCTTCCTGCCCAAGCAGGACCTGCTCAGCCTGGAAGAACTGGACCGCCTGTGCAGCGCCTTCGTGCTGCGCGGGGTG
CGAAAGCTCCGCCTCACCGGCGGCGAGCCCCTGGTGCGCCGGGATGTGATGACCCTGTTCCGCAGCCTGTCCCGCCACAT
GGAGACCGGGCAGCTCGAGGAACTCACCCTCACCACCAACGGCTCCCAGCTGTCCCGCCACGCGGCTGACCTCGCGGCCT
GCGGGGTGAAGCGCATCAATGTGTCCATCGATACGCTGGACGTGGCCAAGTTCCGCGCCATCACCCGTTGGGGTGAATTG
TCCAAGGTGCTGGAGGGGGTGAAGGCCGCCAGCGCGGCCGGGCTCAAGGTGAAGATCAACGCGGTGGCGCTCAAGGACGT
GAACGAGCACGAGATCGCCTCCATGATGGAATGGGCCCATGGCGAGGGGCACGACCTCTCCCTCATCGAGGTGATGCCGC
TGGGCGAGGTGGGCGAGGAACGGGTGGACCAGTATCTGCCGCTGTCCGACGTGCGCGCACGGCTGGAAGAGCGCTTCACC
CTCACCGACATCGACTATCGCACCGGCGGGCCGGCCCGCTATGCGGCAGTGAAGGAGACTGGCGGGCGGATCGGCTTCAT
CACGCCTATGACCCACAATTTCTGCGAGGGCTGCAACCGGGTGCGGGTCACCTGCACCGGTACCCTCTATATGTGCCTCG
GCCAGGAGGACGCTGCAGACCTGCGCGCGCCGCTGCGGGCCGCGAAGGACGATGCCCTGCTGCAGAAGGCCATCGACGAG
GCCATCTTCCGCAAGCCCAAGGGCCACGACTTCGTCATCGACCGCCGCACCCGCCAGCCGGCGGTGAGCCGCCATATGAG
CATGACGGGCGGCTGA

Upstream 100 bases:

>100_bases
CGCAGTCCCTCCGGAAATGGGGCGGCGGGCGGCAGCGGGCCTTCGAGACCGGCAGAAGCCGGCGGGAGAGGCGGCGCAGG
GTGGATGTGGGAGTGGTCTC

Downstream 100 bases:

>100_bases
AGCACGCCTGCTGCCACCACAATAGCCTTCACTCAGAGCCGGGAGGTTTCCCGCTAACGTCCGGTCCCCGCGCGAAGGGG
GAAATGCGGCGGTGAGGTGG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSDVPRDLIDRPSVAAAAQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMAEHMTFLPKQDLLSLEELDRLCSAFVLRGV
RKLRLTGGEPLVRRDVMTLFRSLSRHMETGQLEELTLTTNGSQLSRHAADLAACGVKRINVSIDTLDVAKFRAITRWGEL
SKVLEGVKAASAAGLKVKINAVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSDVRARLEERFT
LTDIDYRTGGPARYAAVKETGGRIGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQEDAADLRAPLRAAKDDALLQKAIDE
AIFRKPKGHDFVIDRRTRQPAVSRHMSMTGG

Sequences:

>Translated_351_residues
MSDVPRDLIDRPSVAAAAQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMAEHMTFLPKQDLLSLEELDRLCSAFVLRGV
RKLRLTGGEPLVRRDVMTLFRSLSRHMETGQLEELTLTTNGSQLSRHAADLAACGVKRINVSIDTLDVAKFRAITRWGEL
SKVLEGVKAASAAGLKVKINAVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSDVRARLEERFT
LTDIDYRTGGPARYAAVKETGGRIGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQEDAADLRAPLRAAKDDALLQKAIDE
AIFRKPKGHDFVIDRRTRQPAVSRHMSMTGG
>Mature_350_residues
SDVPRDLIDRPSVAAAAQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMAEHMTFLPKQDLLSLEELDRLCSAFVLRGVR
KLRLTGGEPLVRRDVMTLFRSLSRHMETGQLEELTLTTNGSQLSRHAADLAACGVKRINVSIDTLDVAKFRAITRWGELS
KVLEGVKAASAAGLKVKINAVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSDVRARLEERFTL
TDIDYRTGGPARYAAVKETGGRIGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQEDAADLRAPLRAAKDDALLQKAIDEA
IFRKPKGHDFVIDRRTRQPAVSRHMSMTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=334, Percent_Identity=36.2275449101796, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI22027536, Length=334, Percent_Identity=36.2275449101796, Blast_Score=188, Evalue=8e-48,
Organism=Escherichia coli, GI1786999, Length=335, Percent_Identity=34.0298507462687, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=332, Percent_Identity=35.5421686746988, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=314, Percent_Identity=36.3057324840764, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32566329, Length=311, Percent_Identity=36.0128617363344, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574488, Length=345, Percent_Identity=35.3623188405797, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI28574490, Length=323, Percent_Identity=36.8421052631579, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38876; Mature: 38745

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVPRDLIDRPSVAAAAQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMAEHMTFLPKQ
CCCCCHHHHCCCCHHHHHHCCCHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCHH
DLLSLEELDRLCSAFVLRGVRKLRLTGGEPLVRRDVMTLFRSLSRHMETGQLEELTLTTN
HHCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GSQLSRHAADLAACGVKRINVSIDTLDVAKFRAITRWGELSKVLEGVKAASAAGLKVKIN
CHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSDVRARLEERFT
EEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCE
LTDIDYRTGGPARYAAVKETGGRIGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQEDAAD
EEECCCCCCCCHHEEEHHHCCCEEEEECCCHHHHHCCCCEEEEEEEEEEEEEECCCCHHH
LRAPLRAAKDDALLQKAIDEAIFRKPKGHDFVIDRRTRQPAVSRHMSMTGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SDVPRDLIDRPSVAAAAQAGPLVDTFGRAVTYLRVSVTDRCDFRCVYCMAEHMTFLPKQ
CCCCHHHHCCCCHHHHHHCCCHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCHH
DLLSLEELDRLCSAFVLRGVRKLRLTGGEPLVRRDVMTLFRSLSRHMETGQLEELTLTTN
HHCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GSQLSRHAADLAACGVKRINVSIDTLDVAKFRAITRWGELSKVLEGVKAASAAGLKVKIN
CHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AVALKDVNEHEIASMMEWAHGEGHDLSLIEVMPLGEVGEERVDQYLPLSDVRARLEERFT
EEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHCCE
LTDIDYRTGGPARYAAVKETGGRIGFITPMTHNFCEGCNRVRVTCTGTLYMCLGQEDAAD
EEECCCCCCCCHHEEEHHHCCCEEEEECCCHHHHHCCCCEEEEEEEEEEEEEECCCCHHH
LRAPLRAAKDDALLQKAIDEAIFRKPKGHDFVIDRRTRQPAVSRHMSMTGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]