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The map label for this gene is gppA [H]

Identifier: 154244786

GI number: 154244786

Start: 934040

End: 935365

Strand: Direct

Name: gppA [H]

Synonym: Xaut_0836

Alternate gene names: 154244786

Gene position: 934040-935365 (Clockwise)

Preceding gene: 154244785

Following gene: 154244787

Centisome position: 17.59

GC content: 73.0

Gene sequence:

>1326_bases
ATGAGGGACGAGACGCACGGACCCGGTGCGGGTCCGGGGCAGTCTTGCCGCGAGCGTGCCGTAACGGAAGCCGTAACGGA
TGCACGCTGCGGGGCAAAAGGGCTCGCGGGTTCGGCCACGGTGACCGTGGACGGGGTCGCGCCTCTGGACCCGCCTTCGT
GTTCCGACAAGATCGCGTCCCCCGGCAAGATCGTGTCCCCCGACCCTGCGCAACCCTGCGCCAGCCCGCCCCGCACCCCT
CCGGACCATCCGGTTTCAGCGCCTCCCGCGTCGGCCAGCGGGCATCCCGCGCCGTCCTATCCGTCCGGCAATGCCAGCGC
GGTCTATGCCGCCATTGACCTCGGCACCAACAATTGCCGCCTCTTGGTGGCGCGGCCCACGGCGCGCAGCTTCCGGGTGG
TGGATGCGTTTTCGCGCATCGTCCGCCTCGGCGAGGGGCTGACCGCCTCCGGCCGCCTGTGCGACGAGGCCATGGCGCGG
GCAGTGGCTGCCCTTGAGGTCTGCGCCGCCAAGATGGACCTGCGCGGCGTGACCCGCGCCCGCATCGTCGCCACCGAGGC
CTGCCGCGCCGCCGACAACGGCGCCGAATTCTGCGCCCGGGTGGAAGAGCGCACCGGGCTCCAGCTGGAGGTGGTTGACC
GCCGCACCGAGGCGGGGCTCGCGGCCACCGGCTGCGCGCCGCTGGTGGACCCCACCTGCGACGGTGCCGTGCTGTTCGAT
ATCGGCGGCGGCTCCACCGAGGTGGTGTGGCTGGGCCGGCGCTCGGCGGGGGATGACGGGCCGCCGCGCGCCCGCATCCG
CTCCTGGGTGTCGCTGCCGGTGGGCGTGGTCTCCCTGTCCGAGCGGCATGGGGGGGTGCGCGTCTCGCCCGATGTCTTCC
ACGCCATGGTGGACGAGGTGTGCGGCATGCTGGACGGCGTGCGCCAGAGTTGGGGCGTGCGCGCTCCCGGCCGACTGCAC
CTGCTCGGCACCTCCGGCACCGTCACCACCGTGGCCGGCATCCATCTCGGCCTCGACCGCTACGACCGCACCCGGGTGGA
CGGCGCGTGGCTCGGCGCCAGCCACATCGAGGAGGTGGTGGAGCGCCTCATGTGCATGTCCTTCGAGGAGCGGGTGGCCA
ATCCCTGCATCGGGGCCCAGCGGGCGGATTTGGTGCTGGCCGGCTGCGCCATCATGGAGGCGGTGCGCCGGGTTTTCCCC
ACGGACCGCCTGCGGGTGGCGGACCGGGGCTTGCGCGAGGGCATGCTGGTGCAGTTGATGCGGGCTGATGGCGCCTGGCG
GCGCAATCGCCCCGCCGGCACCCCTTCCGGAGACGCACACGCGTGA

Upstream 100 bases:

>100_bases
CACATCGCGCGCGCTGTTACACTGGCCGCAAGGCGCAGCCGGTCGCTGACCCAGCGGCAGGCCTGAGCGCATGTTTCCGC
CTTGCGGCGAGGGGATGGAC

Downstream 100 bases:

>100_bases
CCACCCCACCCCGCGGGCCGGACGGCCGGCCCCTGAAAGTGCGCGTGAAAAAATCGCGCGGCCGCACCACGTCCTCCCAG
AAATGGCTGCAGCGCCAGCT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRDETHGPGAGPGQSCRERAVTEAVTDARCGAKGLAGSATVTVDGVAPLDPPSCSDKIASPGKIVSPDPAQPCASPPRTP
PDHPVSAPPASASGHPAPSYPSGNASAVYAAIDLGTNNCRLLVARPTARSFRVVDAFSRIVRLGEGLTASGRLCDEAMAR
AVAALEVCAAKMDLRGVTRARIVATEACRAADNGAEFCARVEERTGLQLEVVDRRTEAGLAATGCAPLVDPTCDGAVLFD
IGGGSTEVVWLGRRSAGDDGPPRARIRSWVSLPVGVVSLSERHGGVRVSPDVFHAMVDEVCGMLDGVRQSWGVRAPGRLH
LLGTSGTVTTVAGIHLGLDRYDRTRVDGAWLGASHIEEVVERLMCMSFEERVANPCIGAQRADLVLAGCAIMEAVRRVFP
TDRLRVADRGLREGMLVQLMRADGAWRRNRPAGTPSGDAHA

Sequences:

>Translated_441_residues
MRDETHGPGAGPGQSCRERAVTEAVTDARCGAKGLAGSATVTVDGVAPLDPPSCSDKIASPGKIVSPDPAQPCASPPRTP
PDHPVSAPPASASGHPAPSYPSGNASAVYAAIDLGTNNCRLLVARPTARSFRVVDAFSRIVRLGEGLTASGRLCDEAMAR
AVAALEVCAAKMDLRGVTRARIVATEACRAADNGAEFCARVEERTGLQLEVVDRRTEAGLAATGCAPLVDPTCDGAVLFD
IGGGSTEVVWLGRRSAGDDGPPRARIRSWVSLPVGVVSLSERHGGVRVSPDVFHAMVDEVCGMLDGVRQSWGVRAPGRLH
LLGTSGTVTTVAGIHLGLDRYDRTRVDGAWLGASHIEEVVERLMCMSFEERVANPCIGAQRADLVLAGCAIMEAVRRVFP
TDRLRVADRGLREGMLVQLMRADGAWRRNRPAGTPSGDAHA
>Mature_441_residues
MRDETHGPGAGPGQSCRERAVTEAVTDARCGAKGLAGSATVTVDGVAPLDPPSCSDKIASPGKIVSPDPAQPCASPPRTP
PDHPVSAPPASASGHPAPSYPSGNASAVYAAIDLGTNNCRLLVARPTARSFRVVDAFSRIVRLGEGLTASGRLCDEAMAR
AVAALEVCAAKMDLRGVTRARIVATEACRAADNGAEFCARVEERTGLQLEVVDRRTEAGLAATGCAPLVDPTCDGAVLFD
IGGGSTEVVWLGRRSAGDDGPPRARIRSWVSLPVGVVSLSERHGGVRVSPDVFHAMVDEVCGMLDGVRQSWGVRAPGRLH
LLGTSGTVTTVAGIHLGLDRYDRTRVDGAWLGASHIEEVVERLMCMSFEERVANPCIGAQRADLVLAGCAIMEAVRRVFP
TDRLRVADRGLREGMLVQLMRADGAWRRNRPAGTPSGDAHA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=320, Percent_Identity=28.4375, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788848, Length=340, Percent_Identity=25.5882352941176, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 46166; Mature: 46166

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDETHGPGAGPGQSCRERAVTEAVTDARCGAKGLAGSATVTVDGVAPLDPPSCSDKIAS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCC
PGKIVSPDPAQPCASPPRTPPDHPVSAPPASASGHPAPSYPSGNASAVYAAIDLGTNNCR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEE
LLVARPTARSFRVVDAFSRIVRLGEGLTASGRLCDEAMARAVAALEVCAAKMDLRGVTRA
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RIVATEACRAADNGAEFCARVEERTGLQLEVVDRRTEAGLAATGCAPLVDPTCDGAVLFD
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHCCCEECCCCCCCCCCCCCEEEEE
IGGGSTEVVWLGRRSAGDDGPPRARIRSWVSLPVGVVSLSERHGGVRVSPDVFHAMVDEV
ECCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHEEEEHHCCCCEEECHHHHHHHHHHH
CGMLDGVRQSWGVRAPGRLHLLGTSGTVTTVAGIHLGLDRYDRTRVDGAWLGASHIEEVV
HHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHHHHCCCHHHHCCCCCCCCCHHHHHHHH
ERLMCMSFEERVANPCIGAQRADLVLAGCAIMEAVRRVFPTDRLRVADRGLREGMLVQLM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RADGAWRRNRPAGTPSGDAHA
HHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDETHGPGAGPGQSCRERAVTEAVTDARCGAKGLAGSATVTVDGVAPLDPPSCSDKIAS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCC
PGKIVSPDPAQPCASPPRTPPDHPVSAPPASASGHPAPSYPSGNASAVYAAIDLGTNNCR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEE
LLVARPTARSFRVVDAFSRIVRLGEGLTASGRLCDEAMARAVAALEVCAAKMDLRGVTRA
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RIVATEACRAADNGAEFCARVEERTGLQLEVVDRRTEAGLAATGCAPLVDPTCDGAVLFD
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHCCCEECCCCCCCCCCCCCEEEEE
IGGGSTEVVWLGRRSAGDDGPPRARIRSWVSLPVGVVSLSERHGGVRVSPDVFHAMVDEV
ECCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHEEEEHHCCCCEEECHHHHHHHHHHH
CGMLDGVRQSWGVRAPGRLHLLGTSGTVTTVAGIHLGLDRYDRTRVDGAWLGASHIEEVV
HHHHHHHHHHCCCCCCCEEEEEECCCCEEEHHHHHHCCCHHHHCCCCCCCCCHHHHHHHH
ERLMCMSFEERVANPCIGAQRADLVLAGCAIMEAVRRVFPTDRLRVADRGLREGMLVQLM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RADGAWRRNRPAGTPSGDAHA
HHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA