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The map label for this gene is sucD [H]

Identifier: 154244448

GI number: 154244448

Start: 545190

End: 546074

Strand: Direct

Name: sucD [H]

Synonym: Xaut_0491

Alternate gene names: 154244448

Gene position: 545190-546074 (Clockwise)

Preceding gene: 154244447

Following gene: 154244449

Centisome position: 10.27

GC content: 68.36

Gene sequence:

>885_bases
ATGTCCGTGCTTATCGACGCCAATACCCGTGTCATCACCCAGGGCTTCACCGGCAAGAACGGCACCTTCCACGCCCAGCA
GGCCATTGCCTACGGCACCAAGATGGTCGGCGGCACCTCGCCGGGCAAGGGTGGCACCACCCACCTGAACCTGCCGGTGT
TCGACACCGTGATCGAGGCGAAGGAAGCCACCGGCGCCGACGCCTCGGTGATCTACGTGCCGCCGCCCGGCGCCGCCGAC
GCGATCCTGGAGGCCATCGACGCCGAGATCCCGCTCATCGTCTGCATCACCGAGGGTATCCCGGTACTGGACATGGTGAA
GGTGAAGCGGGCGCTGTCGGGCTCCAAGTCGCGCCTGGTGGGCCCCAACTGCCCCGGCATCGTGACCGCCGGCCAGTCGA
AGATCGGCATCATGCCGGCCAACATCTTCAAGACCGGCTCGGTGGGCGTGGTGTCGCGCTCCGGCACGCTGACCTATGAG
GCGGTGTTCCAGACCTCGCAGGAGGGCCTGGGCCAGACCTCGGCGGTGGGCATCGGCGGCGACCCGGTGAAGGGCACCGA
GTTCATCGACGTGCTTGAGATGTTCCTGGCTGACCCCAAGACCGAGTCGATCATCATGATCGGCGAGATCGGCGGCTCGG
CGGAGGAAGAGGCGGCGCAGTTCATCGCCGACGAGGCGAAGAAGGGCCGCAAGAAGCCGATGGTTGGCTTCATCGCCGGC
CGCACGGCGCCTCCCGGCCGCCGCATGGGCCATGCGGGCGCCATCATCTCCGGCGGCAAGGGCGGCGCCGAGGACAAGAT
CGCGGCCATGGAGGCGGCGGGCATCCGCGTGTCGCCGTCCCCGGCCCGCCTCGGCAAGACCCTCGTCGAGGTGCTCAAGG
GCTGA

Upstream 100 bases:

>100_bases
AGAAGATCATCCGGGAATCGGGTCTGAACGTGATCCCGGCGGATGACCTCGATGACGCGGCGCAGAAGATTGTCGCGGCC
GTGAAGAAGGAAGCTGCGTG

Downstream 100 bases:

>100_bases
GCGACCTCGGGTTGAGTAGCTGAGACGGTGCGCCGGCAAACTCCCTCGCCCGCGTGTGGGGGAGGGGGGAGAGGATAAAC
GCTCTCCGCATTTCAGGCGC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSVLIDANTRVITQGFTGKNGTFHAQQAIAYGTKMVGGTSPGKGGTTHLNLPVFDTVIEAKEATGADASVIYVPPPGAAD
AILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLVGPNCPGIVTAGQSKIGIMPANIFKTGSVGVVSRSGTLTYE
AVFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLEMFLADPKTESIIMIGEIGGSAEEEAAQFIADEAKKGRKKPMVGFIAG
RTAPPGRRMGHAGAIISGGKGGAEDKIAAMEAAGIRVSPSPARLGKTLVEVLKG

Sequences:

>Translated_294_residues
MSVLIDANTRVITQGFTGKNGTFHAQQAIAYGTKMVGGTSPGKGGTTHLNLPVFDTVIEAKEATGADASVIYVPPPGAAD
AILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLVGPNCPGIVTAGQSKIGIMPANIFKTGSVGVVSRSGTLTYE
AVFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLEMFLADPKTESIIMIGEIGGSAEEEAAQFIADEAKKGRKKPMVGFIAG
RTAPPGRRMGHAGAIISGGKGGAEDKIAAMEAAGIRVSPSPARLGKTLVEVLKG
>Mature_293_residues
SVLIDANTRVITQGFTGKNGTFHAQQAIAYGTKMVGGTSPGKGGTTHLNLPVFDTVIEAKEATGADASVIYVPPPGAADA
ILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLVGPNCPGIVTAGQSKIGIMPANIFKTGSVGVVSRSGTLTYEA
VFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLEMFLADPKTESIIMIGEIGGSAEEEAAQFIADEAKKGRKKPMVGFIAGR
TAPPGRRMGHAGAIISGGKGGAEDKIAAMEAAGIRVSPSPARLGKTLVEVLKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=67.1280276816609, Blast_Score=330, Evalue=6e-91,
Organism=Homo sapiens, GI38569423, Length=263, Percent_Identity=29.277566539924, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI38569421, Length=263, Percent_Identity=29.277566539924, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=65.8703071672355, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17550194, Length=294, Percent_Identity=63.265306122449, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17553126, Length=294, Percent_Identity=62.2448979591837, Blast_Score=345, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17551266, Length=258, Percent_Identity=28.6821705426357, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17557344, Length=267, Percent_Identity=27.7153558052434, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=54.5762711864407, Blast_Score=292, Evalue=4e-80,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=60, Blast_Score=354, Evalue=3e-98,
Organism=Drosophila melanogaster, GI28574296, Length=293, Percent_Identity=67.2354948805461, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI281363475, Length=263, Percent_Identity=28.5171102661597, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363473, Length=263, Percent_Identity=28.5171102661597, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363477, Length=263, Percent_Identity=28.5171102661597, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30013; Mature: 29882

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIDANTRVITQGFTGKNGTFHAQQAIAYGTKMVGGTSPGKGGTTHLNLPVFDTVIEA
CEEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHH
KEATGADASVIYVPPPGAADAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLV
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCC
GPNCPGIVTAGQSKIGIMPANIFKTGSVGVVSRSGTLTYEAVFQTSQEGLGQTSAVGIGG
CCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEECCCC
DPVKGTEFIDVLEMFLADPKTESIIMIGEIGGSAEEEAAQFIADEAKKGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
RTAPPGRRMGHAGAIISGGKGGAEDKIAAMEAAGIRVSPSPARLGKTLVEVLKG
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLIDANTRVITQGFTGKNGTFHAQQAIAYGTKMVGGTSPGKGGTTHLNLPVFDTVIEA
EEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHH
KEATGADASVIYVPPPGAADAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLV
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCC
GPNCPGIVTAGQSKIGIMPANIFKTGSVGVVSRSGTLTYEAVFQTSQEGLGQTSAVGIGG
CCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEECCCC
DPVKGTEFIDVLEMFLADPKTESIIMIGEIGGSAEEEAAQFIADEAKKGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
RTAPPGRRMGHAGAIISGGKGGAEDKIAAMEAAGIRVSPSPARLGKTLVEVLKG
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]