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The map label for this gene is ycgM [C]

Identifier: 154244449

GI number: 154244449

Start: 546347

End: 547120

Strand: Direct

Name: ycgM [C]

Synonym: Xaut_0492

Alternate gene names: 154244449

Gene position: 546347-547120 (Clockwise)

Preceding gene: 154244448

Following gene: 154244453

Centisome position: 10.29

GC content: 66.67

Gene sequence:

>774_bases
ATGACCACCTGGCTGCGCTTCAGCGCCAACGGCACCGCTGGCTTCGGCACCCTTGAAGGCGAAACCATCCTTGTCCACGA
GGGCTGCCTGTTCTCCGGCGCCAGCCCCACGGGCGCGCGCATTCCACTCGCCGAGGTGACGCTGGAAGCGCCCTGCGCTC
CCACCAAGATCGTCGCCCTGTGGAACAACTTCCACCAGCTGGCCGCCAAGCTGAACGTGGCCGAGCCGGCCGAGCCGCTC
TATCTGCTGAAGGCGGTGACCTCGGTGGCGGCTCCCGGCGCCACCGTGCGGCGCCCGGCGGCCTATAGCGGCAAGACGGT
CTATGAAGGCGAGCTGGGCATCGTCATCGGCAAGCCCACCACCAATGTGTCCGAACAAGAGGCCGCCGCCCATATCTTCG
GCTACACGGTGGTCAACGACATCACCGCCGCCGACATTCTCAACCGCGACCCCACCTTTCCCCAGTGGGCGCGGGCCAAG
GGCATCGACGGCTACGGCCCGTTCGGCCCGTGGATCGTCACCGATTTCGATCCGGCGACGGCCCATGTGCGCACCATCCT
GAACGGGGCGGAACGGCAGAATTATCCGCTGGCCGACATGATCTTCCCGCCGGCGCGCCTCGTCTCGCTGCTGTCGCAGG
ACATGACGCTGAACCCCGGCGACCTGATCGCCTGCGGCACCTCCATCGGGGTGGGCGTCATGAAGGAGCCGTCTAACGAC
ATCGCCATCGAGATCGAGGGCATCGGCACGCTGCGCAACACCTTCGTGCAGTGA

Upstream 100 bases:

>100_bases
AAGGTGGCCGACGCCGGAACCGTCCGGCTACGGCGCGGGAGAGGGCTCTACCGGTCCGCGGGATTTGCATCCGCCAAACA
ATTCCAACGAGGAAACACCC

Downstream 100 bases:

>100_bases
AAGGGCGCGTGCAGTGAGCGGGTGGGCGTCGGTTCGCCTGCCCGCTCCTGCCGAGCCGTCCTGCCAGGCCTTGAGGCTGC
GCCTATGTCCGGATCGCCCG

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTTWLRFSANGTAGFGTLEGETILVHEGCLFSGASPTGARIPLAEVTLEAPCAPTKIVALWNNFHQLAAKLNVAEPAEPL
YLLKAVTSVAAPGATVRRPAAYSGKTVYEGELGIVIGKPTTNVSEQEAAAHIFGYTVVNDITAADILNRDPTFPQWARAK
GIDGYGPFGPWIVTDFDPATAHVRTILNGAERQNYPLADMIFPPARLVSLLSQDMTLNPGDLIACGTSIGVGVMKEPSND
IAIEIEGIGTLRNTFVQ

Sequences:

>Translated_257_residues
MTTWLRFSANGTAGFGTLEGETILVHEGCLFSGASPTGARIPLAEVTLEAPCAPTKIVALWNNFHQLAAKLNVAEPAEPL
YLLKAVTSVAAPGATVRRPAAYSGKTVYEGELGIVIGKPTTNVSEQEAAAHIFGYTVVNDITAADILNRDPTFPQWARAK
GIDGYGPFGPWIVTDFDPATAHVRTILNGAERQNYPLADMIFPPARLVSLLSQDMTLNPGDLIACGTSIGVGVMKEPSND
IAIEIEGIGTLRNTFVQ
>Mature_256_residues
TTWLRFSANGTAGFGTLEGETILVHEGCLFSGASPTGARIPLAEVTLEAPCAPTKIVALWNNFHQLAAKLNVAEPAEPLY
LLKAVTSVAAPGATVRRPAAYSGKTVYEGELGIVIGKPTTNVSEQEAAAHIFGYTVVNDITAADILNRDPTFPQWARAKG
IDGYGPFGPWIVTDFDPATAHVRTILNGAERQNYPLADMIFPPARLVSLLSQDMTLNPGDLIACGTSIGVGVMKEPSNDI
AIEIEGIGTLRNTFVQ

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=226, Percent_Identity=33.6283185840708, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI156231349, Length=226, Percent_Identity=33.1858407079646, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI66348062, Length=202, Percent_Identity=33.1683168316832, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI13654274, Length=199, Percent_Identity=30.6532663316583, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI215422413, Length=196, Percent_Identity=31.1224489795918, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1787428, Length=200, Percent_Identity=28, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17557057, Length=180, Percent_Identity=32.7777777777778, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324161, Length=228, Percent_Identity=25, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28572127, Length=222, Percent_Identity=33.7837837837838, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663695, Length=214, Percent_Identity=33.6448598130841, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571789, Length=184, Percent_Identity=35.8695652173913, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 27277; Mature: 27146

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTWLRFSANGTAGFGTLEGETILVHEGCLFSGASPTGARIPLAEVTLEAPCAPTKIVAL
CCEEEEEECCCCCCEEECCCCEEEEECCEEECCCCCCCCCCCHHHEEEECCCCCEEEEEH
WNNFHQLAAKLNVAEPAEPLYLLKAVTSVAAPGATVRRPAAYSGKTVYEGELGIVIGKPT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEEEECCCC
TNVSEQEAAAHIFGYTVVNDITAADILNRDPTFPQWARAKGIDGYGPFGPWIVTDFDPAT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCHH
AHVRTILNGAERQNYPLADMIFPPARLVSLLSQDMTLNPGDLIACGTSIGVGVMKEPSND
HHHHHHHCCHHCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCC
IAIEIEGIGTLRNTFVQ
EEEEEECCCHHHHHHCC
>Mature Secondary Structure 
TTWLRFSANGTAGFGTLEGETILVHEGCLFSGASPTGARIPLAEVTLEAPCAPTKIVAL
CEEEEEECCCCCCEEECCCCEEEEECCEEECCCCCCCCCCCHHHEEEECCCCCEEEEEH
WNNFHQLAAKLNVAEPAEPLYLLKAVTSVAAPGATVRRPAAYSGKTVYEGELGIVIGKPT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEEEECCCC
TNVSEQEAAAHIFGYTVVNDITAADILNRDPTFPQWARAKGIDGYGPFGPWIVTDFDPAT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCHH
AHVRTILNGAERQNYPLADMIFPPARLVSLLSQDMTLNPGDLIACGTSIGVGVMKEPSND
HHHHHHHCCHHCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCC
IAIEIEGIGTLRNTFVQ
EEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]