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The map label for this gene is ahcY [H]

Identifier: 154244144

GI number: 154244144

Start: 186746

End: 188143

Strand: Reverse

Name: ahcY [H]

Synonym: Xaut_0186

Alternate gene names: 154244144

Gene position: 188143-186746 (Counterclockwise)

Preceding gene: 154244147

Following gene: 154244143

Centisome position: 3.54

GC content: 65.81

Gene sequence:

>1398_bases
ATGAGCAACGATTACGTGGTGAAGGACATCAACCTTGCGGACTGGGGTCGCAAGGAGCTGGACATCGCCGAAATCGAAAT
GCCCGGCCTCATGGCCACCCGCGCCGAATACGGCCCGTCCCAGCCGCTGAAGGGCGCCCGCATCGCCGGCTCCCTGCACA
TGACCATCCAGACCGGCGTGCTCATCGAGACGCTGAAGGCGCTGGGCGCCGACGTGCGCTGGGCCTCCTGCAACATCTAC
TCCACCCAGGACCATGCCGCGGCCGCCATCGCTGCCGCCGGCGTCCCCGTCTTCGCCGTGAAGGGCGAGACGCTGGAGGA
ATACTGGGAATACACCCACCGCATCTTCGAGTGGGCCGACGGCGGCGCGCCGAACATGATCCTGGACGACGGCGGCGACG
CCACCCTGCTGGTCCACCTCGGCCTGCGCGCGGAGAACGGCGACACCGCCTTCCTCGACGGCGCCACCAACGAGGAGGAG
GAAGTCCTCTTCGCCGCCATCAAGCGCCGCCTGAAGCACAAGCCCGGCTGGTACACCCTGCTCGCCAAGTCCATCCGCGG
CGTGACCGAAGAGACCACCACGGGCGTGCACCGTCTCTACGAGATGCAGAAGAAGGGCACGCTGCTGTGGCCCGCCATCA
ACGTCAACGACAGCGTCACCAAGTCCAAGTTCGACAACCTCTACGGCTGCCGTGAGTCGCTGGTGGACGGCATCCGCCGC
GGCACCGACGTGATGATGGCCGGCAAGGTGGCCATGGTCGCGGGCTTCGGCGACGTGGGCAAGGGCTCCGCCGCCTCCCT
GCGCAATGCCGGCTGCCGGGTGATGGTGTCGGAGGTCGATCCCATCTGCGCCCTCCAGGCCGCCATGGAAGGCTATGAGG
TCACCACCATGGAGGACGCCGCCAAGCGCGCCGACATCTTCGTGACCGCCACCGGTAACCTGGACGTGATCACGGTGGAT
CACATGCGGGCCATGAAGGACCGCGCCATCGTCTGCAACATCGGCCACTTCGACAGCGAGATCCAGGTGGCCGGCCTCAA
GAACCTGAAGTGGCACAATGTGAAGCCGCAGGTGGACGAGGTGGAGTTCGCCGACGGCAAGCGCATCATCCTGCTGTCGG
AAGGCCGCCTGGTGAACCTCGGCAACGCCACCGGCCACCCGAGCTTCGTGATGAGCGCGTCGTTCACCAACCAGACGCTG
GCGCAGATCGAGCTGTTCACCAAGCCCGGCCAGTACGCCAAGGAAGTCTACACCCTGCCCAAGCACCTCGACGAGAAGGT
GGCCTCGCTCCACCTCGAGAAGATCGGGGTGAAGCTCACCAAGCTCACCGACCAGCAGTCGGCCTATATCGGCGTGCCCC
AGCAGGGCCCGTTCAAGAGCGAGCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CATTTCTTTATATCCTTATTGCCCCAAGGGAGGCGCCGTGCTACAGGCCTCCATCCCGACCTGCGCCCGTGCGGCGCGGC
GCATTCCAGCGGAGCAATCC

Downstream 100 bases:

>100_bases
ACAGTATCCGGCGGCGCCTCCGCGCCCCACCCCTGATCCAGCGGAACGCCGGCCCTCGGGCCGGCGTTCTTCGTTTTTGA
GGGCGATCTGGACCTGTTTC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSNDYVVKDINLADWGRKELDIAEIEMPGLMATRAEYGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADVRWASCNIY
STQDHAAAAIAAAGVPVFAVKGETLEEYWEYTHRIFEWADGGAPNMILDDGGDATLLVHLGLRAENGDTAFLDGATNEEE
EVLFAAIKRRLKHKPGWYTLLAKSIRGVTEETTTGVHRLYEMQKKGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRR
GTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVMVSEVDPICALQAAMEGYEVTTMEDAAKRADIFVTATGNLDVITVD
HMRAMKDRAIVCNIGHFDSEIQVAGLKNLKWHNVKPQVDEVEFADGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTL
AQIELFTKPGQYAKEVYTLPKHLDEKVASLHLEKIGVKLTKLTDQQSAYIGVPQQGPFKSEHYRY

Sequences:

>Translated_465_residues
MSNDYVVKDINLADWGRKELDIAEIEMPGLMATRAEYGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADVRWASCNIY
STQDHAAAAIAAAGVPVFAVKGETLEEYWEYTHRIFEWADGGAPNMILDDGGDATLLVHLGLRAENGDTAFLDGATNEEE
EVLFAAIKRRLKHKPGWYTLLAKSIRGVTEETTTGVHRLYEMQKKGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRR
GTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVMVSEVDPICALQAAMEGYEVTTMEDAAKRADIFVTATGNLDVITVD
HMRAMKDRAIVCNIGHFDSEIQVAGLKNLKWHNVKPQVDEVEFADGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTL
AQIELFTKPGQYAKEVYTLPKHLDEKVASLHLEKIGVKLTKLTDQQSAYIGVPQQGPFKSEHYRY
>Mature_464_residues
SNDYVVKDINLADWGRKELDIAEIEMPGLMATRAEYGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADVRWASCNIYS
TQDHAAAAIAAAGVPVFAVKGETLEEYWEYTHRIFEWADGGAPNMILDDGGDATLLVHLGLRAENGDTAFLDGATNEEEE
VLFAAIKRRLKHKPGWYTLLAKSIRGVTEETTTGVHRLYEMQKKGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRRG
TDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVMVSEVDPICALQAAMEGYEVTTMEDAAKRADIFVTATGNLDVITVDH
MRAMKDRAIVCNIGHFDSEIQVAGLKNLKWHNVKPQVDEVEFADGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLA
QIELFTKPGQYAKEVYTLPKHLDEKVASLHLEKIGVKLTKLTDQQSAYIGVPQQGPFKSEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=463, Percent_Identity=59.8272138228942, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI239937451, Length=441, Percent_Identity=59.1836734693878, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=467, Percent_Identity=48.3940042826552, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=467, Percent_Identity=48.3940042826552, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=467, Percent_Identity=48.3940042826552, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=467, Percent_Identity=48.3940042826552, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=467, Percent_Identity=47.7516059957173, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=466, Percent_Identity=60.7296137339056, Blast_Score=543, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320882, Length=481, Percent_Identity=58.4199584199584, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24642172, Length=463, Percent_Identity=63.2829373650108, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=50.6465517241379, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24656245, Length=468, Percent_Identity=48.0769230769231, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=50.5399568034557, Blast_Score=440, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50936; Mature: 50805

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDYVVKDINLADWGRKELDIAEIEMPGLMATRAEYGPSQPLKGARIAGSLHMTIQTGV
CCCCEEEEECCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCEEECEEEEEEECCH
LIETLKALGADVRWASCNIYSTQDHAAAAIAAAGVPVFAVKGETLEEYWEYTHRIFEWAD
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCC
GGAPNMILDDGGDATLLVHLGLRAENGDTAFLDGATNEEEEVLFAAIKRRLKHKPGWYTL
CCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHH
LAKSIRGVTEETTTGVHRLYEMQKKGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRR
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVMVSEVDPICALQAAMEGYEVTTMEDA
CCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEEHHHH
AKRADIFVTATGNLDVITVDHMRAMKDRAIVCNIGHFDSEIQVAGLKNLKWHNVKPQVDE
HCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEECCCCCCEEEEECCCCCEECCCCCCCCC
VEFADGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELFTKPGQYAKEVYTLP
EEECCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHH
KHLDEKVASLHLEKIGVKLTKLTDQQSAYIGVPQQGPFKSEHYRY
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SNDYVVKDINLADWGRKELDIAEIEMPGLMATRAEYGPSQPLKGARIAGSLHMTIQTGV
CCCEEEEECCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCEEECEEEEEEECCH
LIETLKALGADVRWASCNIYSTQDHAAAAIAAAGVPVFAVKGETLEEYWEYTHRIFEWAD
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCC
GGAPNMILDDGGDATLLVHLGLRAENGDTAFLDGATNEEEEVLFAAIKRRLKHKPGWYTL
CCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHH
LAKSIRGVTEETTTGVHRLYEMQKKGTLLWPAINVNDSVTKSKFDNLYGCRESLVDGIRR
HHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVMVSEVDPICALQAAMEGYEVTTMEDA
CCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEEHHHH
AKRADIFVTATGNLDVITVDHMRAMKDRAIVCNIGHFDSEIQVAGLKNLKWHNVKPQVDE
HCCCCEEEEECCCEEEEEHHHHHHHCCCEEEEECCCCCCEEEEECCCCCEECCCCCCCCC
VEFADGKRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELFTKPGQYAKEVYTLP
EEECCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHH
KHLDEKVASLHLEKIGVKLTKLTDQQSAYIGVPQQGPFKSEHYRY
HHHHHHHHHHHHHHHCEEEEEECCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA