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The map label for this gene is ywrD [H]

Identifier: 154244147

GI number: 154244147

Start: 189946

End: 191556

Strand: Reverse

Name: ywrD [H]

Synonym: Xaut_0189

Alternate gene names: 154244147

Gene position: 191556-189946 (Counterclockwise)

Preceding gene: 154244149

Following gene: 154244144

Centisome position: 3.61

GC content: 72.13

Gene sequence:

>1611_bases
ATGCTGCCGGCCGAAGCCCACGAGAGCCTTCACGCCATGGGGGGCATGGTCGCCGCCCCGCACCAGCTGGCGGCGGAGGC
GGGACGCGAGGTGCTGGCCGAGGGCGGCAACGCCATCGAGGCCATGGTGGCGGCAGCCGCCGCCATCGCCGTGGTCTATC
CGCACATGAACCATGTGGGCGGCGACGGCTTCTGGCTCATCCGCGAGCCCTCCGGACGGGTGCGCTACATCGAGGCCTGC
GGCTTCGCCGGAGCCCGCGCCACCATTCCCTTCTACCATGAGGTCGGCCTCGGGGCGGTGCCCACCCGGGGGCCGCTGGC
CGCCGTCACCGTGCCCGGCGCGGTGGATGGCTGGCGCCTCGCCCTTGAGGCCGCCGCGGTCCATGGCGGCCGCATGACAC
TCAAGAGGCTTCTGGAGCCCGCCGTCCGTCATGCCCGCGAGGGCGTGGCCGTCTCGCGCTCGCAGGCCGCCCTCACGGCG
CAGAAGAAGGCCGAACTGGAAGACGCGCCCGGCTTCGCCGCCGCCTTCCTCACCGCGGACCGGGCGGTGCCGCAGGCGGG
AACGCTCCAGCGCCAGCAGCGCCTCGCCGATACGCTGGACCATCTCGCTCGCGCCGGCCTCGCCGATTTCTATCGCGGCG
ACGTGGGCCGCGAGATCGGGACCGACCTCGAGCGCATCGGCAGCCCGGTCACCCGGGAGGATCTCAAGCGCTATGCGGCG
GTGGAGCGCCCGCCGCTGTCCGTGGACATCGGCGTCGGCCGGCTGTTCAACGCCCCGCCGCCCACCCAGGGGCTGGCCTC
CCTGCTCATCCTCGCGCTGTTCGACCGGCTGAAGGTAAAGCGCGGCGACAGCTTCGAGCACGTGCACGGCCTCATCGAGG
CCACCAAACGCGCCTTCATGGTGCGCGACAAGGTGGTGTGCGACTATGATCACCTCACCCACGACCTTGCCGCCCTGCTC
ACCCCCGAGGCCATCGCCAAACGGGCTGACGGCATCGAGATGGGCCGCGCCCTCCCCTGGCCGCAGGCCAAGGCCGGCGG
CGACACGGTGTGGCTCGGCGCGACGGACAAGTCCGGGCTGGTGGTGTCCTACATCCAGTCCATCTTCTTCGAGTTCGGCT
CGGGCTGCGTGCTGCCTTCCACCGGTGTGCTGATGCAGAATCGCGGCGCCAGCTTCTCGCTGGAGCCGGGCGCGCTCAAT
CCGCTGAAGCCCGGCCGGCGGCCGTTCCATACCCTGAACCCGGCGCTGGCGGTGCTCGCCGACGGGCGGGTGATGGCTTA
TGGCACCATGGGCGGGGAAGGCCAGCCGCAGACCCAGTCCGCCATCTTCAGCCGCCACGTGCTGTTCGACGTGCCGCTGG
GAGAGGCCATCGCCCGGCCGCGCTGGCTGCTGGGCCGCACCTGGGGCGATGTGGAGACCCGGCTGCGACTGGAGCCGCGC
TTCGACGACGAGGTGGTGGAGCGCCTGAAGCTGGTGGGGCACGACCTGGCGCTGGTTCCGGAAGCCTACAGCGACACCAT
GGGGCACGCGGGGGCGGTGGTGCTGCATCCTGGCGGACGCATGGAGGGCGCGCACGACCCGCGCTCGGACGGCGGCGCGG
CGGGGGTGTAG

Upstream 100 bases:

>100_bases
CTCATGCCGAAGGCCTTGGTCCTGAACGGGTCGGGAAACTGCGACGCGCGCGCCGCCGGGTCAAGTCCGACCCGCCGGAA
CGCCGAGAAGGAGACCTTGC

Downstream 100 bases:

>100_bases
GGCGCCGCAAGGCGCCCGCGACCACCCGGGAGGCCAAAATAAAACCGGCTGCCCCCCGGGGAGAGGGCAGCCGGCGGCTT
CGGCTCTGTCTTCGGGCATA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MLPAEAHESLHAMGGMVAAPHQLAAEAGREVLAEGGNAIEAMVAAAAAIAVVYPHMNHVGGDGFWLIREPSGRVRYIEAC
GFAGARATIPFYHEVGLGAVPTRGPLAAVTVPGAVDGWRLALEAAAVHGGRMTLKRLLEPAVRHAREGVAVSRSQAALTA
QKKAELEDAPGFAAAFLTADRAVPQAGTLQRQQRLADTLDHLARAGLADFYRGDVGREIGTDLERIGSPVTREDLKRYAA
VERPPLSVDIGVGRLFNAPPPTQGLASLLILALFDRLKVKRGDSFEHVHGLIEATKRAFMVRDKVVCDYDHLTHDLAALL
TPEAIAKRADGIEMGRALPWPQAKAGGDTVWLGATDKSGLVVSYIQSIFFEFGSGCVLPSTGVLMQNRGASFSLEPGALN
PLKPGRRPFHTLNPALAVLADGRVMAYGTMGGEGQPQTQSAIFSRHVLFDVPLGEAIARPRWLLGRTWGDVETRLRLEPR
FDDEVVERLKLVGHDLALVPEAYSDTMGHAGAVVLHPGGRMEGAHDPRSDGGAAGV

Sequences:

>Translated_536_residues
MLPAEAHESLHAMGGMVAAPHQLAAEAGREVLAEGGNAIEAMVAAAAAIAVVYPHMNHVGGDGFWLIREPSGRVRYIEAC
GFAGARATIPFYHEVGLGAVPTRGPLAAVTVPGAVDGWRLALEAAAVHGGRMTLKRLLEPAVRHAREGVAVSRSQAALTA
QKKAELEDAPGFAAAFLTADRAVPQAGTLQRQQRLADTLDHLARAGLADFYRGDVGREIGTDLERIGSPVTREDLKRYAA
VERPPLSVDIGVGRLFNAPPPTQGLASLLILALFDRLKVKRGDSFEHVHGLIEATKRAFMVRDKVVCDYDHLTHDLAALL
TPEAIAKRADGIEMGRALPWPQAKAGGDTVWLGATDKSGLVVSYIQSIFFEFGSGCVLPSTGVLMQNRGASFSLEPGALN
PLKPGRRPFHTLNPALAVLADGRVMAYGTMGGEGQPQTQSAIFSRHVLFDVPLGEAIARPRWLLGRTWGDVETRLRLEPR
FDDEVVERLKLVGHDLALVPEAYSDTMGHAGAVVLHPGGRMEGAHDPRSDGGAAGV
>Mature_536_residues
MLPAEAHESLHAMGGMVAAPHQLAAEAGREVLAEGGNAIEAMVAAAAAIAVVYPHMNHVGGDGFWLIREPSGRVRYIEAC
GFAGARATIPFYHEVGLGAVPTRGPLAAVTVPGAVDGWRLALEAAAVHGGRMTLKRLLEPAVRHAREGVAVSRSQAALTA
QKKAELEDAPGFAAAFLTADRAVPQAGTLQRQQRLADTLDHLARAGLADFYRGDVGREIGTDLERIGSPVTREDLKRYAA
VERPPLSVDIGVGRLFNAPPPTQGLASLLILALFDRLKVKRGDSFEHVHGLIEATKRAFMVRDKVVCDYDHLTHDLAALL
TPEAIAKRADGIEMGRALPWPQAKAGGDTVWLGATDKSGLVVSYIQSIFFEFGSGCVLPSTGVLMQNRGASFSLEPGALN
PLKPGRRPFHTLNPALAVLADGRVMAYGTMGGEGQPQTQSAIFSRHVLFDVPLGEAIARPRWLLGRTWGDVETRLRLEPR
FDDEVVERLKLVGHDLALVPEAYSDTMGHAGAVVLHPGGRMEGAHDPRSDGGAAGV

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=547, Percent_Identity=26.508226691042, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI73915090, Length=547, Percent_Identity=26.508226691042, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI73915096, Length=547, Percent_Identity=26.508226691042, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI73915094, Length=547, Percent_Identity=26.508226691042, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI113429324, Length=546, Percent_Identity=26.3736263736264, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI113429326, Length=552, Percent_Identity=25.7246376811594, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI109148539, Length=502, Percent_Identity=27.2908366533865, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI153266885, Length=559, Percent_Identity=25.9391771019678, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI153266901, Length=560, Percent_Identity=25.8928571428571, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=547, Percent_Identity=29.981718464351, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=448, Percent_Identity=24.7767857142857, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI72000294, Length=550, Percent_Identity=24, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI212646519, Length=550, Percent_Identity=24, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193208245, Length=492, Percent_Identity=24.5934959349593, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI193208247, Length=492, Percent_Identity=24.5934959349593, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859893, Length=530, Percent_Identity=26.2264150943396, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI161077496, Length=518, Percent_Identity=23.5521235521236, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161077878, Length=555, Percent_Identity=23.963963963964, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642670, Length=555, Percent_Identity=23.963963963964, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642666, Length=555, Percent_Identity=23.963963963964, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45551474, Length=555, Percent_Identity=23.963963963964, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161077880, Length=555, Percent_Identity=23.963963963964, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859741, Length=382, Percent_Identity=24.869109947644, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57050; Mature: 57050

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPAEAHESLHAMGGMVAAPHQLAAEAGREVLAEGGNAIEAMVAAAAAIAVVYPHMNHVG
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCC
GDGFWLIREPSGRVRYIEACGFAGARATIPFYHEVGLGAVPTRGPLAAVTVPGAVDGWRL
CCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHH
ALEAAAVHGGRMTLKRLLEPAVRHAREGVAVSRSQAALTAQKKAELEDAPGFAAAFLTAD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
RAVPQAGTLQRQQRLADTLDHLARAGLADFYRGDVGREIGTDLERIGSPVTREDLKRYAA
HCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHCCHHHHCCCCCHHHHHHHHH
VERPPLSVDIGVGRLFNAPPPTQGLASLLILALFDRLKVKRGDSFEHVHGLIEATKRAFM
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VRDKVVCDYDHLTHDLAALLTPEAIAKRADGIEMGRALPWPQAKAGGDTVWLGATDKSGL
HHCCEEECHHHHHHHHHHHHCHHHHHHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCH
VVSYIQSIFFEFGSGCVLPSTGVLMQNRGASFSLEPGALNPLKPGRRPFHTLNPALAVLA
HHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHCCHHHHEEE
DGRVMAYGTMGGEGQPQTQSAIFSRHVLFDVPLGEAIARPRWLLGRTWGDVETRLRLEPR
CCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCHHHHCCCCHHHCCCCCCCCEEEEECCC
FDDEVVERLKLVGHDLALVPEAYSDTMGHAGAVVLHPGGRMEGAHDPRSDGGAAGV
CCHHHHHHHHHHCCCCEECCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLPAEAHESLHAMGGMVAAPHQLAAEAGREVLAEGGNAIEAMVAAAAAIAVVYPHMNHVG
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCC
GDGFWLIREPSGRVRYIEACGFAGARATIPFYHEVGLGAVPTRGPLAAVTVPGAVDGWRL
CCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHH
ALEAAAVHGGRMTLKRLLEPAVRHAREGVAVSRSQAALTAQKKAELEDAPGFAAAFLTAD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
RAVPQAGTLQRQQRLADTLDHLARAGLADFYRGDVGREIGTDLERIGSPVTREDLKRYAA
HCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHCCHHHHCCCCCHHHHHHHHH
VERPPLSVDIGVGRLFNAPPPTQGLASLLILALFDRLKVKRGDSFEHVHGLIEATKRAFM
CCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VRDKVVCDYDHLTHDLAALLTPEAIAKRADGIEMGRALPWPQAKAGGDTVWLGATDKSGL
HHCCEEECHHHHHHHHHHHHCHHHHHHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCH
VVSYIQSIFFEFGSGCVLPSTGVLMQNRGASFSLEPGALNPLKPGRRPFHTLNPALAVLA
HHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCHHCCHHHHEEE
DGRVMAYGTMGGEGQPQTQSAIFSRHVLFDVPLGEAIARPRWLLGRTWGDVETRLRLEPR
CCEEEEEECCCCCCCCHHHHHHHHHHEEEECCCHHHHCCCCHHHCCCCCCCCEEEEECCC
FDDEVVERLKLVGHDLALVPEAYSDTMGHAGAVVLHPGGRMEGAHDPRSDGGAAGV
CCHHHHHHHHHHCCCCEECCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]