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The map label for this gene is pyrD

Identifier: 154244014

GI number: 154244014

Start: 59274

End: 60347

Strand: Reverse

Name: pyrD

Synonym: Xaut_0056

Alternate gene names: 154244014

Gene position: 60347-59274 (Counterclockwise)

Preceding gene: 154244015

Following gene: 154244012

Centisome position: 1.14

GC content: 69.55

Gene sequence:

>1074_bases
ATGGACCTCTACGGCGTCCTCAAGCCCCTGTTCCGGTTCATGACGCCGGAGCAGGCGCATCACCTGTCCATCCGCGTGTT
GAAGAGCGGCCTGGTGCCGGACCTGTCGGGGGGACCCGACGATCCGGTGCTGGCGACGCGGGTGTGGGGGCTCGATTTCC
CCAATCCGGTGGGCCTTGCCGCCGGCTTCGACAAGCATTGCGAGGTGGCGGACGCCCTGTTCAGGTTCGGCTTCGGCTTT
GTGGAGGCCGGCACGGTGACGCCGCGCCCGCAGCCGGGCAATCCCCTGCCCCGCCTGTTCCGGCTGGATGAGGACGAGGC
GGTCATCAACCGCTTCGGCTTCAACAGCGAGGGCCTCGCCCCCTTCGTCTTCCGCCTTGGGCAGCGCCGGGCCAGCGGCA
AGCACGGCATCGTCGGCGCCAATGTGGGGAAGAACAAGGAGAGCGAGGACGCGCTGGAGGATTACGGCGCCGGCGTCTCG
GCCACCTGCCGCCTCGCCGACTATCTGGTGTGCAACATCTCCTCGCCCAACACGCCGGGCCTTCGGGCGCTGCAGGCGCG
GGCGGAGATGGAAACCCTGCTCGCCCACGTCATTAGCGTGCGCAATGCCTCCATGCCCGATCCCGCCGCGCGCACCCCCC
TGCTGGTAAAGGTGGCGCCGGACCTCGACGACGCGGCCCTGGCCGACGTGGCGGAGGCCTCCCTCGCCACCGGCGTGGAC
GGCATCATCATGGGAAACACCACCCTGTCGCGCCCGGCGAGCCTGCAAAGCAAGTTCAAGGACGAGACCGGCGGCCTCTC
CGGCAAGCCCCTGCTGGCCCTGTCCACCGAGCGCCTCGGGGCGCTTTATCGGCTTGTGGGCGGCCGGCTGCCCATCATCG
GCGTGGGCGGCATTGCTTCCGGAGCGGACGCCTATGCCAAGGTCCGCGCCGGGGCGAGCCTGGTGCAGATCTATTCCGCC
CTGGTGTTCCATGGCCCCGGCCTCGTGACCCGGATCAAGACGGATCTCGCCGCCCGCCTGAAGGCGGACGGCTTCGCCTC
CATTGCCGATGCGGTGGGCGTGGACGTGCGCTGA

Upstream 100 bases:

>100_bases
AATCCGCCCAGATCGCCGAGATCGAGTCCTTCCTCCACGATCCCCACTCCTGGTCGAAGGCCCACGGCGGCACCGCCGTC
ACCGGCGAGTGACCGCGCGG

Downstream 100 bases:

>100_bases
GGCGCCTAAGGTCGGGCGTGTCAGCTCGGGCGTTTGGCGAGCATGTCGCGGATCTCGGTGAGCAGCACCTCGGAGCGGGT
CGGCGCCGGCGCCGGCTTGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MDLYGVLKPLFRFMTPEQAHHLSIRVLKSGLVPDLSGGPDDPVLATRVWGLDFPNPVGLAAGFDKHCEVADALFRFGFGF
VEAGTVTPRPQPGNPLPRLFRLDEDEAVINRFGFNSEGLAPFVFRLGQRRASGKHGIVGANVGKNKESEDALEDYGAGVS
ATCRLADYLVCNISSPNTPGLRALQARAEMETLLAHVISVRNASMPDPAARTPLLVKVAPDLDDAALADVAEASLATGVD
GIIMGNTTLSRPASLQSKFKDETGGLSGKPLLALSTERLGALYRLVGGRLPIIGVGGIASGADAYAKVRAGASLVQIYSA
LVFHGPGLVTRIKTDLAARLKADGFASIADAVGVDVR

Sequences:

>Translated_357_residues
MDLYGVLKPLFRFMTPEQAHHLSIRVLKSGLVPDLSGGPDDPVLATRVWGLDFPNPVGLAAGFDKHCEVADALFRFGFGF
VEAGTVTPRPQPGNPLPRLFRLDEDEAVINRFGFNSEGLAPFVFRLGQRRASGKHGIVGANVGKNKESEDALEDYGAGVS
ATCRLADYLVCNISSPNTPGLRALQARAEMETLLAHVISVRNASMPDPAARTPLLVKVAPDLDDAALADVAEASLATGVD
GIIMGNTTLSRPASLQSKFKDETGGLSGKPLLALSTERLGALYRLVGGRLPIIGVGGIASGADAYAKVRAGASLVQIYSA
LVFHGPGLVTRIKTDLAARLKADGFASIADAVGVDVR
>Mature_357_residues
MDLYGVLKPLFRFMTPEQAHHLSIRVLKSGLVPDLSGGPDDPVLATRVWGLDFPNPVGLAAGFDKHCEVADALFRFGFGF
VEAGTVTPRPQPGNPLPRLFRLDEDEAVINRFGFNSEGLAPFVFRLGQRRASGKHGIVGANVGKNKESEDALEDYGAGVS
ATCRLADYLVCNISSPNTPGLRALQARAEMETLLAHVISVRNASMPDPAARTPLLVKVAPDLDDAALADVAEASLATGVD
GIIMGNTTLSRPASLQSKFKDETGGLSGKPLLALSTERLGALYRLVGGRLPIIGVGGIASGADAYAKVRAGASLVQIYSA
LVFHGPGLVTRIKTDLAARLKADGFASIADAVGVDVR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=350, Percent_Identity=52, Blast_Score=341, Evalue=6e-94,
Organism=Escherichia coli, GI1787177, Length=340, Percent_Identity=43.5294117647059, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17509475, Length=363, Percent_Identity=44.9035812672176, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI281361352, Length=352, Percent_Identity=45.7386363636364, Blast_Score=300, Evalue=9e-82,
Organism=Drosophila melanogaster, GI17137316, Length=352, Percent_Identity=45.7386363636364, Blast_Score=300, Evalue=9e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_XANP2 (A7IBC2)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001414972.1
- ProteinModelPortal:   A7IBC2
- SMR:   A7IBC2
- STRING:   A7IBC2
- GeneID:   5425363
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_0056
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- ProtClustDB:   PRK05286
- BioCyc:   XAUT78245:XAUT_0056-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37534; Mature: 37534

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLYGVLKPLFRFMTPEQAHHLSIRVLKSGLVPDLSGGPDDPVLATRVWGLDFPNPVGLA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
AGFDKHCEVADALFRFGFGFVEAGTVTPRPQPGNPLPRLFRLDEDEAVINRFGFNSEGLA
CCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHEECCCHHHHHHHCCCCCCCCH
PFVFRLGQRRASGKHGIVGANVGKNKESEDALEDYGAGVSATCRLADYLVCNISSPNTPG
HHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCC
LRALQARAEMETLLAHVISVRNASMPDPAARTPLLVKVAPDLDDAALADVAEASLATGVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GIIMGNTTLSRPASLQSKFKDETGGLSGKPLLALSTERLGALYRLVGGRLPIIGVGGIAS
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCCCCCEEEECCCCC
GADAYAKVRAGASLVQIYSALVFHGPGLVTRIKTDLAARLKADGFASIADAVGVDVR
CHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDLYGVLKPLFRFMTPEQAHHLSIRVLKSGLVPDLSGGPDDPVLATRVWGLDFPNPVGLA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHH
AGFDKHCEVADALFRFGFGFVEAGTVTPRPQPGNPLPRLFRLDEDEAVINRFGFNSEGLA
CCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHEECCCHHHHHHHCCCCCCCCH
PFVFRLGQRRASGKHGIVGANVGKNKESEDALEDYGAGVSATCRLADYLVCNISSPNTPG
HHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHHHEEEEEEEECCCCCCCC
LRALQARAEMETLLAHVISVRNASMPDPAARTPLLVKVAPDLDDAALADVAEASLATGVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GIIMGNTTLSRPASLQSKFKDETGGLSGKPLLALSTERLGALYRLVGGRLPIIGVGGIAS
EEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCCCCCEEEECCCCC
GADAYAKVRAGASLVQIYSALVFHGPGLVTRIKTDLAARLKADGFASIADAVGVDVR
CHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA