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The map label for this gene is gcvPA [H]

Identifier: 152976623

GI number: 152976623

Start: 2976313

End: 2977656

Strand: Reverse

Name: gcvPA [H]

Synonym: Bcer98_2914

Alternate gene names: 152976623

Gene position: 2977656-2976313 (Counterclockwise)

Preceding gene: 152976624

Following gene: 152976622

Centisome position: 72.86

GC content: 37.72

Gene sequence:

>1344_bases
ATGTTGCATCGTTATCTTCCAATGACAGAAGAAGACAAAAAAGAAATGTTAGAAACGATCGGTGTTCAAACCATTGATGA
ATTATTTTCTGATATTCCAGAAAGTGTTCGTTTTAAAGGGGATTTAAAAATTAAACAAGCAAAGTCAGAACCAGAGCTTT
TAAAAGAGCTATCTGGACTTGCTCGTAAAAATGCTAACTTAAAAGAATACGCTTCTTTCCTAGGAGCAGGTGTATATGAC
CATTATGCACCCGTAATTGTGGATCATGTTCTTTCCCGTTCAGAATTTTATACAGCGTATACACCATATCAACCAGAGAT
TTCACAAGGGGAATTACAGGCAATTTTTGAATTCCAAACAATGATTTGTGAATTAACGGGAATGGATGTAGCAAACTCCT
CTATGTATGACGGAGGTACAGCGTTAGCAGAAGCTGCCATGTTAGCAGCAGGCCATACTCGTAAAAAGAAAATTCTTGTT
TCTAAAGCAGTTCATCCAGAATCAAGAGCAGTACTAGAAACATATGCAAAAGGACAACATCTTGAAGTAGTTGAAATTGA
TCATAAAGATGGTGTAACAAATTTAGACGGATTACAAAGTGAAATGGATGATACTGTGGCTTGTGTAATCGTTCAATATC
CAAACTTCTTTGGACAAATTGAAAAGTTAGCTGATATTGAAAAGATTGTCCATGAGCAAAAAGCATTATTTATTGTATCT
TCAAACCCACTATCATTAGGGGTATTAACACCTCCAGGGAAATTTGGAGCTGATATTGTAATCGGTGATGCACAGCCATT
TGGCATTCCAACACAATTTGGTGGACCGCATTGCGGTTACTTCGCAACAACGAAAGCATTTATGCGTAAAATTCCAGGAC
GTCTTGTCGGACAAACTGTAGATACAGAGGGTAAACGTGGTTTTGTATTAACATTGCAAGCTCGTGAACAGCATATCCGT
CGTGATAAAGCGACATCTAATATTTGCTCTAACCAAGCGTTAAATGCATTAGCTGCATCAGTGGCAATGACTGCACTTGG
AAAACGAGGTGTAAAGGAAATGGCACGTCAAAACATTTCTAAAGCACAATATGCTAAACGCCAATTTGAAGAAAAAGGTT
TCAAAGTAGTATTTACTGGGCCGTTCTTCAATGAATTTGTTGTGGATTGCAAGCGCCCGGTAAAAGAAATAAACGACACT
TTATTGCAAAAGGGTATAATCGGTGGTTATGATTTAGGTCGCGATGATGAAAAATTAGTAAATCATATGCTTGTAGCAGT
AACAGAGCTTCGGACAAAAGCAGAAATTGACACACTTGTAAACGAAATGGGGGCTATCCAATGA

Upstream 100 bases:

>100_bases
CAGAAGTAGAAATTGAAATTCGAAAAAAACGCGTGAAAGCAGTAGTTGTTCCAACACCATTTTATAAACGTTCAAAGTAA
CCTGGAGAGGGGTAGATTTC

Downstream 100 bases:

>100_bases
AGAACCAAGACCAAGCACTTATTTTTGAAATGAGTAAAGAAGGGCGCGTAGGATATAGCTTACCCCAATTGGATGTAGAG
GAAGTAAAATTAGAAGATGT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLHRYLPMTEEDKKEMLETIGVQTIDELFSDIPESVRFKGDLKIKQAKSEPELLKELSGLARKNANLKEYASFLGAGVYD
HYAPVIVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SKAVHPESRAVLETYAKGQHLEVVEIDHKDGVTNLDGLQSEMDDTVACVIVQYPNFFGQIEKLADIEKIVHEQKALFIVS
SNPLSLGVLTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDTEGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKRGVKEMARQNISKAQYAKRQFEEKGFKVVFTGPFFNEFVVDCKRPVKEINDT
LLQKGIIGGYDLGRDDEKLVNHMLVAVTELRTKAEIDTLVNEMGAIQ

Sequences:

>Translated_447_residues
MLHRYLPMTEEDKKEMLETIGVQTIDELFSDIPESVRFKGDLKIKQAKSEPELLKELSGLARKNANLKEYASFLGAGVYD
HYAPVIVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SKAVHPESRAVLETYAKGQHLEVVEIDHKDGVTNLDGLQSEMDDTVACVIVQYPNFFGQIEKLADIEKIVHEQKALFIVS
SNPLSLGVLTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDTEGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKRGVKEMARQNISKAQYAKRQFEEKGFKVVFTGPFFNEFVVDCKRPVKEINDT
LLQKGIIGGYDLGRDDEKLVNHMLVAVTELRTKAEIDTLVNEMGAIQ
>Mature_447_residues
MLHRYLPMTEEDKKEMLETIGVQTIDELFSDIPESVRFKGDLKIKQAKSEPELLKELSGLARKNANLKEYASFLGAGVYD
HYAPVIVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SKAVHPESRAVLETYAKGQHLEVVEIDHKDGVTNLDGLQSEMDDTVACVIVQYPNFFGQIEKLADIEKIVHEQKALFIVS
SNPLSLGVLTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDTEGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKRGVKEMARQNISKAQYAKRQFEEKGFKVVFTGPFFNEFVVDCKRPVKEINDT
LLQKGIIGGYDLGRDDEKLVNHMLVAVTELRTKAEIDTLVNEMGAIQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=419, Percent_Identity=37.2315035799523, Blast_Score=281, Evalue=6e-76,
Organism=Escherichia coli, GI1789269, Length=381, Percent_Identity=33.8582677165354, Blast_Score=204, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=378, Percent_Identity=38.6243386243386, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=367, Percent_Identity=40.0544959128065, Blast_Score=263, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24645648, Length=360, Percent_Identity=38.6111111111111, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49456; Mature: 49456

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRYLPMTEEDKKEMLETIGVQTIDELFSDIPESVRFKGDLKIKQAKSEPELLKELSGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ARKNANLKEYASFLGAGVYDHYAPVIVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSKAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC
LEVVEIDHKDGVTNLDGLQSEMDDTVACVIVQYPNFFGQIEKLADIEKIVHEQKALFIVS
EEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEEE
SNPLSLGVLTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DTEGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKRGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEEKGFKVVFTGPFFNEFVVDCKRPVKEINDTLLQKGIIGGYDLGRDDEKLV
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
NHMLVAVTELRTKAEIDTLVNEMGAIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHRYLPMTEEDKKEMLETIGVQTIDELFSDIPESVRFKGDLKIKQAKSEPELLKELSGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ARKNANLKEYASFLGAGVYDHYAPVIVDHVLSRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSKAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC
LEVVEIDHKDGVTNLDGLQSEMDDTVACVIVQYPNFFGQIEKLADIEKIVHEQKALFIVS
EEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEEE
SNPLSLGVLTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DTEGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKRGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEEKGFKVVFTGPFFNEFVVDCKRPVKEINDTLLQKGIIGGYDLGRDDEKLV
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
NHMLVAVTELRTKAEIDTLVNEMGAIQ
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA