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The map label for this gene is gcvPB [H]

Identifier: 152976622

GI number: 152976622

Start: 2974841

End: 2976316

Strand: Reverse

Name: gcvPB [H]

Synonym: Bcer98_2913

Alternate gene names: 152976622

Gene position: 2976316-2974841 (Counterclockwise)

Preceding gene: 152976623

Following gene: 152976621

Centisome position: 72.82

GC content: 39.3

Gene sequence:

>1476_bases
ATGAAGAACCAAGACCAAGCACTTATTTTTGAAATGAGTAAAGAAGGGCGCGTAGGATATAGCTTACCCCAATTGGATGT
AGAGGAAGTAAAATTAGAAGATGTGTTTGAGAGCAATTATATTCGAGCAGAAGATGCAGAACTTCCAGAAGTATCTGAAC
TGGATATTATGCGTCATTACACAGCGCTTTCAAACCGTAACCACGGCGTTGACTCTGGATTTTATCCGCTTGGGTCTTGT
ACGATGAAATACAATCCAAAAATCAATGAAAACGTGGCACGTTTCCCAGGCTTTGCAAATATTCATCCGCTTCAAGATGA
AAAGACCGTGCAAGGGGCAATGGAATTAATGTACGATTTACAAGAGCATTTAGTTGAAATTACTGGTATGGATGCTGTAA
CACTTCAACCAGCAGCTGGTGCACATGGAGAATGGACAGGATTAATGTTAATTCGTGCATACCATGAAGCAAATGGTGAC
CATAATCGTACAAAAGTTATTGTCCCAGACTCAGCGCATGGAACAAATCCAGCATCTGCAACAGTAGCAGGCTTTGAAAC
AATTACCGTAAAATCAAATGAACATGGACTTGTTGACTTAGAAGATTTAAAACGCGTTGTGAATGAAGAAACAGCGGCGC
TTATGTTAACAAATCCAAATACACTTGGTTTATTTGAAGAAAACATTTTAGAAATGGCAGAGATCGTTCATAATGCAGGT
GGTAAATTATATTATGATGGTGCGAACTTAAATGCGGTATTAAGTCAAGCACGTCCGGGAGATATGGGATTTGATGTGGT
GCATTTAAACCTTCATAAAACATTTACAGGTCCTCACGGAGGAGGTGGGCCAGGTTCTGGTCCAGTAGGTGTAAAAGAAG
ATTTAATTCCATTTCTACCAAAACCAATTTTAGAGAAAACAGAGAATGGATATCACTTCAATTATGATCGTCCGCAAGCA
ATTGGCCGCGTGAAGCCATTCTATGGAAACTTTGGTATTAACGTTCGTGCGTATACGTATATCCGTTCTATGGGGCCAGA
TGGATTGCGTGCAGTAACGGAAAACGCAGTATTAAATGCAAACTATATGATGAGAAGATTAGCACCATACTACGATCTTC
CATTTGATAGACATTGCAAACATGAATTTGTATTGTCAGGACGTTGTCAAAAGAAACTTGGTGTACGTACACTTGATATC
GCAAAACGTTTGCTTGATTTTGGTTACCATCCACCAACAATTTACTTCCCGTTAAATGTGGAAGAATGTATTATGATTGA
GCCAACTGAAACTGAATCAAAAGAAACGTTAGATGGTTTCATTGATAAAATGATTCAAATTGCCAAAGAAGCAAAAGAGA
ATCCAGAGATTGTACAAGAAGCACCGCATACAACAGTGATTACACGTTTGGACGAAACGATGGCTGCTCGTAAGCCGATA
TTACGCTATCAAAAGCCAACTCCTGTACAAGTTTGA

Upstream 100 bases:

>100_bases
GCGATGATGAAAAATTAGTAAATCATATGCTTGTAGCAGTAACAGAGCTTCGGACAAAAGCAGAAATTGACACACTTGTA
AACGAAATGGGGGCTATCCA

Downstream 100 bases:

>100_bases
TGATATGAAGAGAACTCGTTATATGCGAGTTCTTTTTTTTTAGAGTAATGATCTAGATTATATAAAAAGAATGTTGAAAA
TGTATCTTTTTTGTATTGCG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKNQDQALIFEMSKEGRVGYSLPQLDVEEVKLEDVFESNYIRAEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINENVARFPGFANIHPLQDEKTVQGAMELMYDLQEHLVEITGMDAVTLQPAAGAHGEWTGLMLIRAYHEANGD
HNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKEDLIPFLPKPILEKTENGYHFNYDRPQA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTENAVLNANYMMRRLAPYYDLPFDRHCKHEFVLSGRCQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEAKENPEIVQEAPHTTVITRLDETMAARKPI
LRYQKPTPVQV

Sequences:

>Translated_491_residues
MKNQDQALIFEMSKEGRVGYSLPQLDVEEVKLEDVFESNYIRAEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINENVARFPGFANIHPLQDEKTVQGAMELMYDLQEHLVEITGMDAVTLQPAAGAHGEWTGLMLIRAYHEANGD
HNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKEDLIPFLPKPILEKTENGYHFNYDRPQA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTENAVLNANYMMRRLAPYYDLPFDRHCKHEFVLSGRCQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEAKENPEIVQEAPHTTVITRLDETMAARKPI
LRYQKPTPVQV
>Mature_491_residues
MKNQDQALIFEMSKEGRVGYSLPQLDVEEVKLEDVFESNYIRAEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSC
TMKYNPKINENVARFPGFANIHPLQDEKTVQGAMELMYDLQEHLVEITGMDAVTLQPAAGAHGEWTGLMLIRAYHEANGD
HNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKEDLIPFLPKPILEKTENGYHFNYDRPQA
IGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTENAVLNANYMMRRLAPYYDLPFDRHCKHEFVLSGRCQKKLGVRTLDI
AKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEAKENPEIVQEAPHTTVITRLDETMAARKPI
LRYQKPTPVQV

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=43.8725490196078, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1789269, Length=406, Percent_Identity=42.1182266009852, Blast_Score=288, Evalue=8e-79,
Organism=Caenorhabditis elegans, GI17535605, Length=453, Percent_Identity=39.514348785872, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI32564013, Length=410, Percent_Identity=40.2439024390244, Blast_Score=266, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6323843, Length=469, Percent_Identity=42.6439232409382, Blast_Score=330, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24645648, Length=460, Percent_Identity=39.1304347826087, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54868; Mature: 54868

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQDQALIFEMSKEGRVGYSLPQLDVEEVKLEDVFESNYIRAEDAELPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHH
TALSNRNHGVDSGFYPLGSCTMKYNPKINENVARFPGFANIHPLQDEKTVQGAMELMYDL
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QEHLVEITGMDAVTLQPAAGAHGEWTGLMLIRAYHEANGDHNRTKVIVPDSAHGTNPASA
HHHHHHHCCCCEEEECCCCCCCCCCHHEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKEDLIPFLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPILEKTENGYHFNYDRPQAIGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTENAVLNA
CHHHHHCCCCEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRRLAPYYDLPFDRHCKHEFVLSGRCQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDGFIDKMIQIAKEAKENPEIVQEAPHTTVITRLDETMAARKPI
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEHHHHHHHHHHHHH
LRYQKPTPVQV
HHCCCCCCCCC
>Mature Secondary Structure
MKNQDQALIFEMSKEGRVGYSLPQLDVEEVKLEDVFESNYIRAEDAELPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHH
TALSNRNHGVDSGFYPLGSCTMKYNPKINENVARFPGFANIHPLQDEKTVQGAMELMYDL
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QEHLVEITGMDAVTLQPAAGAHGEWTGLMLIRAYHEANGDHNRTKVIVPDSAHGTNPASA
HHHHHHHCCCCEEEECCCCCCCCCCHHEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKEDLIPFLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCC
KPILEKTENGYHFNYDRPQAIGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTENAVLNA
CHHHHHCCCCEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRRLAPYYDLPFDRHCKHEFVLSGRCQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNV
HHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCC
EECIMIEPTETESKETLDGFIDKMIQIAKEAKENPEIVQEAPHTTVITRLDETMAARKPI
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEHHHHHHHHHHHHH
LRYQKPTPVQV
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]