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The map label for this gene is pyrC [H]

Identifier: 152976249

GI number: 152976249

Start: 2637887

End: 2639173

Strand: Reverse

Name: pyrC [H]

Synonym: Bcer98_2537

Alternate gene names: 152976249

Gene position: 2639173-2637887 (Counterclockwise)

Preceding gene: 152976250

Following gene: 152976248

Centisome position: 64.57

GC content: 39.08

Gene sequence:

>1287_bases
ATGAATTATTTGTTTAAAAATGGACGTTACTTAAATGAAGAAGGAACAATCGTGGCAACAGATCTTCTTGTACAAGATGG
TAAAATTGCGAAAATAGCGAAAAATATTTCGGCTGAAAATGCTGAAGTAATCGATGTAAATGGAAAATTAATCGCACCTG
GATTAGTAGATGTACACGTTCATCTTCGCGAACCAGGTGGTGAACATAAAGAAACGATTGAAACTGGTACACTTGCAGCA
GCAAAAGGGGGCTTTACAACAATTTGTGCGATGCCAAATACACGCCCAGTGCCAGATAGTAAAGAGCATATGGAAGATTT
ACAAAAACGAATTCAGGAAAAAGCACATGTAAATGTACTGCCATATGGTGCAATTACAGTGCGTCAAGCAGGTTCTGAAA
TGACGGACTTTGAAACGTTAAAAGAACTTGGAGCATTCGCATTTACTGATGATGGAGTAGGCGTACAAGATGCAAGTATG
ATGTTAGCGGCTATGAAGCGTGCAGCTAAATTAAATATGGCAGTTGTTGCCCATTGCGAAGAAAATACGCTTATTAATAA
AGGTTGTGTACATGAAGGGAAATTTTCTGAGAAACATGGATTAAACGGTATCCCATCAGTATGTGAATCTGTACATATTG
CCAGGGACATTTTACTAGCGGAAGCGGCAGATTGTCACTATCATGTTTGTCACGTAAGTACAAAAGGGTCAGTGCGAGTA
ATTCGTGATGCAAAACGTGCAGGTATTAAAGTAACAGCAGAAGTAACACCACACCACTTAGTGCTATGTGAAGATGATAT
CCCATCTGTTGATCCCAACTTTAAAATGAACCCACCACTTCGAGGAAGAGAAGACCAAGAAGCACTCATTGAAGGTTTAT
TAGATGGAACAATCGACATCATTGCAACGGATCATGCACCGCATACAGCAGAAGAAAAAGCACAAGGCATTGAAAGAGCA
CCATTTGGAATTACTGGTTTTGAAACAGCGTTCCCATTACTATATACAAACCTTGTGAAAAAAGGAATTATCACATTAGA
ACAGCTTATCCAATTCTTAACAGAAAAGCCAGCAGATACATTTGGTTTAGAAACAGGACGTCTAAAAGAAGGAAGAGCAG
CTGATATTACCATTCTTGATTTAGAACAAGAAGAAAAAATTGACCCAACAACATTCTTATCAAAAGGAAAAAATACGCCA
TTTGCAGGCTGGAAGTGTCAAGGATGGCCAGTTATGACATTAGTGGGCGGGAAGATCGTATGGCAAAAGGAGAGTGCATT
AGTATGA

Upstream 100 bases:

>100_bases
TGTAAACGTTCTCGCATATTCAAACAGATGGAAAATGGAGTTTACGTAAGAATGGCTGTTTTAAAACGCGCATTACCAAA
TGTATTAGGAGGAATGAAAC

Downstream 100 bases:

>100_bases
AAAGACAGCTTATCTTAGAAGATGGAACAGTATTAATTGGAAAAGGATTCGGCGGAGAGATTGAAAAATCAGGTGAAGTT
GTATTTACAACTGGTATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNYLFKNGRYLNEEGTIVATDLLVQDGKIAKIAKNISAENAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDSKEHMEDLQKRIQEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSVDPNFKMNPPLRGREDQEALIEGLLDGTIDIIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLETGRLKEGRAADITILDLEQEEKIDPTTFLSKGKNTP
FAGWKCQGWPVMTLVGGKIVWQKESALV

Sequences:

>Translated_428_residues
MNYLFKNGRYLNEEGTIVATDLLVQDGKIAKIAKNISAENAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDSKEHMEDLQKRIQEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSVDPNFKMNPPLRGREDQEALIEGLLDGTIDIIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLETGRLKEGRAADITILDLEQEEKIDPTTFLSKGKNTP
FAGWKCQGWPVMTLVGGKIVWQKESALV
>Mature_428_residues
MNYLFKNGRYLNEEGTIVATDLLVQDGKIAKIAKNISAENAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDSKEHMEDLQKRIQEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSVDPNFKMNPPLRGREDQEALIEGLLDGTIDIIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLETGRLKEGRAADITILDLEQEEKIDPTTFLSKGKNTP
FAGWKCQGWPVMTLVGGKIVWQKESALV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=32.7319587628866, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=25.3897550111359, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4503051, Length=446, Percent_Identity=25.1121076233184, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI19923821, Length=444, Percent_Identity=25.2252252252252, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI62422571, Length=446, Percent_Identity=25.1121076233184, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503379, Length=450, Percent_Identity=23.5555555555556, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4503377, Length=454, Percent_Identity=24.4493392070485, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=29.438202247191, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87082175, Length=437, Percent_Identity=28.8329519450801, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=359, Percent_Identity=32.8690807799443, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71989490, Length=446, Percent_Identity=28.0269058295964, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17539558, Length=446, Percent_Identity=26.6816143497758, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=25.6756756756757, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=25.6880733944954, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=32.8125, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI18859883, Length=450, Percent_Identity=26.8888888888889, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46651; Mature: 46651

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLFKNGRYLNEEGTIVATDLLVQDGKIAKIAKNISAENAEVIDVNGKLIAPGLVDVHV
CCCEECCCEEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDSKEHMEDLQKRIQEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSVDPNFKMNPPLRGREDQEALIEGLLDGTIDI
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLETGRLKEGRAADITILDLEQEEKIDPTTFLSKGKNTPFAGWKCQGWPVMTLVGGKIV
HCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
EECCCCCC
>Mature Secondary Structure
MNYLFKNGRYLNEEGTIVATDLLVQDGKIAKIAKNISAENAEVIDVNGKLIAPGLVDVHV
CCCEECCCEEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDSKEHMEDLQKRIQEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSVDPNFKMNPPLRGREDQEALIEGLLDGTIDI
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLETGRLKEGRAADITILDLEQEEKIDPTTFLSKGKNTPFAGWKCQGWPVMTLVGGKIV
HCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA