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The map label for this gene is pyrB [H]

Identifier: 152976250

GI number: 152976250

Start: 2639157

End: 2640071

Strand: Reverse

Name: pyrB [H]

Synonym: Bcer98_2538

Alternate gene names: 152976250

Gene position: 2640071-2639157 (Counterclockwise)

Preceding gene: 152976251

Following gene: 152976249

Centisome position: 64.6

GC content: 37.38

Gene sequence:

>915_bases
ATGAGCCAATTGTTAACGATGAGTGAATTATCGAAGGAAGAAATTTCAGAAATCCTAAAAGATGCAGAAGATTTCGCGAA
TGGAAAAGAAAGAAAAGCGACAGAGCAAACATTTGTAGCAAACTTGTTTTTTGAGAATAGTACGAGAACAAGATTTAGCT
TCGAGGTTGCTGAGAAGAGATTGGGATTAGAAGTATTAAACTTCTCAGCAGATTCTTCTAGCGTACAAAAAGGAGAAACG
TTATACGATACGATAAGAACACTAGAATCGATTGGAGCCAAAGCAGTAGTCATCCGCCATCAGCAAGATCGCTACTTTGA
TGAGCTAAAAGACAAAGTAAATATCCCTATTTTAAATGCAGGTGATGGATGTGGAAATCACCCGACGCAATGTTTGTTAG
ATCTTCTAACAATTAAACAAGAGTTTGGGAGATTTGAAGGATTAAAGATTGCGATTGTAGGAGACATTCGTCACAGCCGA
GTGGCACGCTCGAATGCAGAAGCATTAACGAAATTAGGTGCAACAATTTACTTTGCTAGTCCTGAAGAGTGGAAAGATGA
AACAAATACATTCGGAACATATAGAAGCTTAGATGAACTTATTCCAGAAGTTGATGTGATGATGTTACTTCGTGTACAGC
ATGAGCGTCATGATCATTATGAAACAGACATCATGAAAGAGTATCATGAAAACCATGGGTTAACAATGGAACGAGAAGAA
CGCATGAAAGAAGGAAGCATTATTATGCATCCGGCTCCAGTAAATCGTGATGTAGAAATTGCAAGTGAACTTGTTGAGTG
TAAACGTTCTCGCATATTCAAACAGATGGAAAATGGAGTTTACGTAAGAATGGCTGTTTTAAAACGCGCATTACCAAATG
TATTAGGAGGAATGAAACATGAATTATTTGTTTAA

Upstream 100 bases:

>100_bases
CTTGCACCCTAGTCTCGCATGACTAGGGTGTTTTTATGCGATTGTTAGTATATAAATGCAAAAGGTGTTATCATAAAAAT
CAGAAAGATGAGGGATGACA

Downstream 100 bases:

>100_bases
AAATGGACGTTACTTAAATGAAGAAGGAACAATCGTGGCAACAGATCTTCTTGTACAAGATGGTAAAATTGCGAAAATAG
CGAAAAATATTTCGGCTGAA

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSQLLTMSELSKEEISEILKDAEDFANGKERKATEQTFVANLFFENSTRTRFSFEVAEKRLGLEVLNFSADSSSVQKGET
LYDTIRTLESIGAKAVVIRHQQDRYFDELKDKVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDIRHSR
VARSNAEALTKLGATIYFASPEEWKDETNTFGTYRSLDELIPEVDVMMLLRVQHERHDHYETDIMKEYHENHGLTMEREE
RMKEGSIIMHPAPVNRDVEIASELVECKRSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV

Sequences:

>Translated_304_residues
MSQLLTMSELSKEEISEILKDAEDFANGKERKATEQTFVANLFFENSTRTRFSFEVAEKRLGLEVLNFSADSSSVQKGET
LYDTIRTLESIGAKAVVIRHQQDRYFDELKDKVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDIRHSR
VARSNAEALTKLGATIYFASPEEWKDETNTFGTYRSLDELIPEVDVMMLLRVQHERHDHYETDIMKEYHENHGLTMEREE
RMKEGSIIMHPAPVNRDVEIASELVECKRSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV
>Mature_303_residues
SQLLTMSELSKEEISEILKDAEDFANGKERKATEQTFVANLFFENSTRTRFSFEVAEKRLGLEVLNFSADSSSVQKGETL
YDTIRTLESIGAKAVVIRHQQDRYFDELKDKVNIPILNAGDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDIRHSRV
ARSNAEALTKLGATIYFASPEEWKDETNTFGTYRSLDELIPEVDVMMLLRVQHERHDHYETDIMKEYHENHGLTMEREER
MKEGSIIMHPAPVNRDVEIASELVECKRSRIFKQMENGVYVRMAVLKRALPNVLGGMKHELFV

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=306, Percent_Identity=35.6209150326797, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI38788445, Length=305, Percent_Identity=24.2622950819672, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367364, Length=305, Percent_Identity=34.7540983606557, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193204318, Length=318, Percent_Identity=35.2201257861635, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322331, Length=262, Percent_Identity=35.1145038167939, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24642586, Length=313, Percent_Identity=35.1437699680511, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 34831; Mature: 34700

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLLTMSELSKEEISEILKDAEDFANGKERKATEQTFVANLFFENSTRTRFSFEVAEKR
CCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
LGLEVLNFSADSSSVQKGETLYDTIRTLESIGAKAVVIRHQQDRYFDELKDKVNIPILNA
HCHHHEECCCCCCHHHCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCEEEC
GDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDIRHSRVARSNAEALTKLGATIYFAS
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEECC
PEEWKDETNTFGTYRSLDELIPEVDVMMLLRVQHERHDHYETDIMKEYHENHGLTMEREE
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
RMKEGSIIMHPAPVNRDVEIASELVECKRSRIFKQMENGVYVRMAVLKRALPNVLGGMKH
HHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHH
ELFV
HHCC
>Mature Secondary Structure 
SQLLTMSELSKEEISEILKDAEDFANGKERKATEQTFVANLFFENSTRTRFSFEVAEKR
CCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHH
LGLEVLNFSADSSSVQKGETLYDTIRTLESIGAKAVVIRHQQDRYFDELKDKVNIPILNA
HCHHHEECCCCCCHHHCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCEEEC
GDGCGNHPTQCLLDLLTIKQEFGRFEGLKIAIVGDIRHSRVARSNAEALTKLGATIYFAS
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEECC
PEEWKDETNTFGTYRSLDELIPEVDVMMLLRVQHERHDHYETDIMKEYHENHGLTMEREE
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
RMKEGSIIMHPAPVNRDVEIASELVECKRSRIFKQMENGVYVRMAVLKRALPNVLGGMKH
HHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHH
ELFV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA