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The map label for this gene is vanR [H]

Identifier: 152974099

GI number: 152974099

Start: 274680

End: 275420

Strand: Direct

Name: vanR [H]

Synonym: Bcer98_0255

Alternate gene names: 152974099

Gene position: 274680-275420 (Clockwise)

Preceding gene: 152974098

Following gene: 152974100

Centisome position: 6.72

GC content: 33.2

Gene sequence:

>741_bases
ATGGAAAGTAGGGAGTTTAAGAATTTTGGGGGAGATATTGTGAGACAAGAAACAATACTTGTTGTAGATGATGAAAAAGA
AATTAGAGATTTAATTACAATTTATTTAAAGAATGAAGGATATAACATACTGCAAGCAGGAGATGGAGCAGAAGGGTTAG
AGATATTAGAAAACAATGAAGTCCATTTAGTTGTACTAGATATTATGATGCCAAAAATTGATGGGATTCATATGTGCATG
AAAGTAAGAGAACAAAAAGAAATGCCGATTATTATGTTATCGGCTAAAACACAAGATATGGATAAAATTTTAGGATTAAC
AACAGGTGCAGATGATTATGTGACAAAACCATTTAATCCGTTAGAACTTGTAGCAAGAGTGAAATCACAACTTCGTCGAT
ATATGAAAATGAGCGGATTTATGATTGAAAACGAAAATGAAATAGAGATTGGGGATATAAAAATAAATGTTTCTACACAT
GAGGTAGTTGTAGCGGATCGAGAGGTGAAATTAACACCAAGGGAATTTTCAATTTTAGAGTTACTAGTGCGCAATTCAGG
GATGGTATTTAGTACAGAACAAATTTATGAAAAGGTGTGGAATGAAAGGTCTTTTCAGTCAGACAATACTGTAATGGTAC
ATATTCGAAAAATTCGCGAGAAGGTTGAAGAAAATGCAAGAAAGCCGAGATACATAAAAACAGTATGGGGAGTGGGGTAT
AAGGTTGAGAAGGATAATTAA

Upstream 100 bases:

>100_bases
GTTTTTAAAGGTCTAGACTAAGAGGGGGTCTAGACCTTTTTTTACGTCTTCAGAAAATCTTAAGGATTTCGCACCGTTTT
TCTTTAGAAGTTTTTTTATA

Downstream 100 bases:

>100_bases
AAATATATTTAGACCAATTGGTTGGATAAGTGGGATTTTAAAAAAAATAATATATAAAGGAATATGTGGGGTACAAAAGA
GTTTGCGTGTACAACTGATA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MESREFKNFGGDIVRQETILVVDDEKEIRDLITIYLKNEGYNILQAGDGAEGLEILENNEVHLVVLDIMMPKIDGIHMCM
KVREQKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELVARVKSQLRRYMKMSGFMIENENEIEIGDIKINVSTH
EVVVADREVKLTPREFSILELLVRNSGMVFSTEQIYEKVWNERSFQSDNTVMVHIRKIREKVEENARKPRYIKTVWGVGY
KVEKDN

Sequences:

>Translated_246_residues
MESREFKNFGGDIVRQETILVVDDEKEIRDLITIYLKNEGYNILQAGDGAEGLEILENNEVHLVVLDIMMPKIDGIHMCM
KVREQKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELVARVKSQLRRYMKMSGFMIENENEIEIGDIKINVSTH
EVVVADREVKLTPREFSILELLVRNSGMVFSTEQIYEKVWNERSFQSDNTVMVHIRKIREKVEENARKPRYIKTVWGVGY
KVEKDN
>Mature_246_residues
MESREFKNFGGDIVRQETILVVDDEKEIRDLITIYLKNEGYNILQAGDGAEGLEILENNEVHLVVLDIMMPKIDGIHMCM
KVREQKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNPLELVARVKSQLRRYMKMSGFMIENENEIEIGDIKINVSTH
EVVVADREVKLTPREFSILELLVRNSGMVFSTEQIYEKVWNERSFQSDNTVMVHIRKIREKVEENARKPRYIKTVWGVGY
KVEKDN

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=37.9464285714286, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=34.070796460177, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=33.7719298245614, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=30.4932735426009, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=33.7662337662338, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.4821428571429, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.4801762114537, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=31.7391304347826, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=36, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=31.1111111111111, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.3144104803493, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=29.0748898678414, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28543; Mature: 28543

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESREFKNFGGDIVRQETILVVDDEKEIRDLITIYLKNEGYNILQAGDGAEGLEILENNE
CCCCCCCCCCCCEEECEEEEEEECHHHHHHHEEEEECCCCCEEEECCCCCCCHHEECCCC
VHLVVLDIMMPKIDGIHMCMKVREQKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNP
EEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCH
LELVARVKSQLRRYMKMSGFMIENENEIEIGDIKINVSTHEVVVADREVKLTPREFSILE
HHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCEEEEEECCEEEECCCHHHHHH
LLVRNSGMVFSTEQIYEKVWNERSFQSDNTVMVHIRKIREKVEENARKPRYIKTVWGVGY
HHHHCCCCEEEHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCE
KVEKDN
EEECCC
>Mature Secondary Structure
MESREFKNFGGDIVRQETILVVDDEKEIRDLITIYLKNEGYNILQAGDGAEGLEILENNE
CCCCCCCCCCCCEEECEEEEEEECHHHHHHHEEEEECCCCCEEEECCCCCCCHHEECCCC
VHLVVLDIMMPKIDGIHMCMKVREQKEMPIIMLSAKTQDMDKILGLTTGADDYVTKPFNP
EEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCH
LELVARVKSQLRRYMKMSGFMIENENEIEIGDIKINVSTHEVVVADREVKLTPREFSILE
HHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCEEEEEECCEEEECCCHHHHHH
LLVRNSGMVFSTEQIYEKVWNERSFQSDNTVMVHIRKIREKVEENARKPRYIKTVWGVGY
HHHHCCCCEEEHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCE
KVEKDN
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]