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The map label for this gene is prs [H]

Identifier: 152973898

GI number: 152973898

Start: 52916

End: 53869

Strand: Direct

Name: prs [H]

Synonym: Bcer98_0045

Alternate gene names: 152973898

Gene position: 52916-53869 (Clockwise)

Preceding gene: 152973897

Following gene: 152973899

Centisome position: 1.29

GC content: 36.48

Gene sequence:

>954_bases
ATGTCAACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAACAAGGAACTTGCTGAGCAAATTGCAAA
GCATATTGGAGTTGAGTTAGGGAAATGTTCTGTTGACCGTTTTAGCGATGGAGAAGTTCAAATTAACATTGAAGAAAGTA
TTCGTGGTTGTGATGTATTCATTATTCAATCTACAAGTTTTCCAGTAAACGAACATATCATGGAACTACTTATTATGATT
GATGCATTAAAACGTGCCTCTGCAAAAACAATTAATATTGTAATTCCTTACTATGGTTATGCACGTCAGGATCGTAAAGC
ACGTTCTCGTGAACCGATTACATCGAAACTTGTAGCAAACTTGCTTGAAACAGCAGGTGCAACTCGTGTAATTACTCTAG
ATTTACACGCTCCACAAATTCAAGGATTCTTTGATATCCCAATTGACCACTTAATGGGTGTACCAATTCTTTCTGATTAC
TTTGAGTCCAAAGGTCTTAAAGATATCGTAATTGTGTCTCCTGACCATGGTGGTGTAACACGTGCAAGAAAAATGGCTGA
TCGCTTAAAAGCGCCAATCGCTATTATTGATAAGCGTCGTCCTCGTCCGAACGTAGCTGAGGTAATGAACATTATCGGTA
ATATCGAAGGAAAAACAGCAATCTTAATTGATGACATTATTGATACAGCTGGTACAATTACATTAGCAGCAAACGCTCTT
GTTGAGAATGGTGCTTCTGAAGTATATGCTTGCTGTACACACCCAGTTTTATCTGGTCCAGCAATTGAGCGCATTGAAAA
TTCAAATATTAAAGAGTTGGTAGTAACGAACTCTATCGTATTACCAGAAGAGAAGAAAATTGACAAAGTACACGAACTTT
CTGTTGCTCCATTAATTGGAGAAGCAATCATTCGTGTGTACGAAGAAGAATCTGTAAGTGTATTATTCAATTAA

Upstream 100 bases:

>100_bases
AAAAGCATTATCAATTGCACGTGCGCGTCAAGTTAACAAAGAAGATTATGTTGATCAATTGCTGAATAAGAAAAAATCAT
AATGTGGAGGGTTAATCTAG

Downstream 100 bases:

>100_bases
TTGGATAGAATGAGACGTAACCAAATTTGGTTACGTCTTTTCGTATCGTAGAAAGAAAGTAGTGGTGGAAGAATGAAATT
AATAGTAGGACTTGGGAACC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVELGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDY
FESKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
VENGASEVYACCTHPVLSGPAIERIENSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN

Sequences:

>Translated_317_residues
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVELGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDY
FESKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
VENGASEVYACCTHPVLSGPAIERIENSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN
>Mature_316_residues
STQYLNSNLKVFSLNSNKELAEQIAKHIGVELGKCSVDRFSDGEVQINIEESIRGCDVFIIQSTSFPVNEHIMELLIMID
ALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVANLLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYF
ESKGLKDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIIGNIEGKTAILIDDIIDTAGTITLAANALV
ENGASEVYACCTHPVLSGPAIERIENSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIGEAIIRVYEEESVSVLFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=46.1783439490446, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=45.859872611465, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=45.2229299363057, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=45.4258675078864, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=39.1304347826087, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=36.8115942028986, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI310128524, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310115209, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310118259, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310119946, Length=136, Percent_Identity=34.5588235294118, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=51.1254019292604, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=47.7564102564103, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=47.7564102564103, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=47.7564102564103, Blast_Score=287, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=47.5728155339806, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=34.1176470588235, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=45.1923076923077, Blast_Score=265, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=43.4504792332268, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=45.859872611465, Blast_Score=257, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=40.8163265306122, Blast_Score=158, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=270, Percent_Identity=34.4444444444444, Blast_Score=149, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=47.1337579617834, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=44.213649851632, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.9295774647887, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.6898395721925, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.6898395721925, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.6898395721925, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34880; Mature: 34749

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQYLNSNLKVFSLNSNKELAEQIAKHIGVELGKCSVDRFSDGEVQINIEESIRGCDVF
CCCCEECCCEEEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCCEEEEEEHHCCCCCEEE
IIQSTSFPVNEHIMELLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVAN
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
LLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYFESKGLKDIVIVSPDHGGVT
HHHHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCHH
RARKMADRLKAPIAIIDKRRPRPNVAEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEHHHH
VENGASEVYACCTHPVLSGPAIERIENSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIG
HHCCCHHHHHHHCCCCCCCHHHHHHCCCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHH
EAIIRVYEEESVSVLFN
HHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
STQYLNSNLKVFSLNSNKELAEQIAKHIGVELGKCSVDRFSDGEVQINIEESIRGCDVF
CCCEECCCEEEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCCEEEEEEHHCCCCCEEE
IIQSTSFPVNEHIMELLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITSKLVAN
EEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
LLETAGATRVITLDLHAPQIQGFFDIPIDHLMGVPILSDYFESKGLKDIVIVSPDHGGVT
HHHHCCCCEEEEEEECCCCCCCEEECCHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCHH
RARKMADRLKAPIAIIDKRRPRPNVAEVMNIIGNIEGKTAILIDDIIDTAGTITLAANAL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCEEEEHHHH
VENGASEVYACCTHPVLSGPAIERIENSNIKELVVTNSIVLPEEKKIDKVHELSVAPLIG
HHCCCHHHHHHHCCCCCCCHHHHHHCCCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHH
EAIIRVYEEESVSVLFN
HHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]