Click here to switch to the map view.

The map label for this gene is glmU [H]

Identifier: 152973897

GI number: 152973897

Start: 51518

End: 52897

Strand: Direct

Name: glmU [H]

Synonym: Bcer98_0044

Alternate gene names: 152973897

Gene position: 51518-52897 (Clockwise)

Preceding gene: 152973896

Following gene: 152973898

Centisome position: 1.26

GC content: 38.33

Gene sequence:

>1380_bases
ATGTCAAACAGATTTGCAGTGATTCTGGCTGCAGGTAAGGGCACGCGTATGAAGTCCAAGCTATACAAAGTGCTTCATCC
TGTATGCGGAAAACCAATGGTACAGCATGTAGTGGATCAAGTATCTCAATTAGGATTGCAGAAACTTGTGACGGTAGTGG
GACATGGTGCTGAAAAAGTACAAGAACAACTAGGAAACGTAAGTGAATTTGCATTACAAGCAGAACAACTTGGTACAGCA
CACGCTGTCGATCGGGCTGCTGATATCCTTGCAAATGAAGAAGGAACAACTTTGGTTATTTGTGGTGATACGCCGCTTAT
AACTGCAGAAACAATGGAAGCATTGTTAAAACATCATGAGGAAGCAGGAGCTAAAGCTACAGTGCTAACGGCATACATAG
AAGAGCCTGCTGGATATGGTCGTATTGTTCGTAATGAAAATGGTCATGTTGAAAAAATTGTTGAGCACAAAGATGCAAAT
GAAGTAGAGCTAACTATTAAAGAGATTAATACAGGTACGTATTGTTTTGATAATAAAGCGCTATTTGCGTCACTTTCTAA
AGTTTCAAATGATAATGCACAAGGTGAATACTACCTTCCAGATGTTATTGAAATTTTGAAAGGTGAAGGGCATATTGTAT
CGGCTTATCAAACGGAGCATTTTGATGAAACGTTAGGTGTAAACGACAGAGTCGCTCTATCGCAAGCGGAAGTCATTATG
AAGAATCGTATCAATCATAAGAACATGGTAAATGGTGTTACAATTATAGATCCAAGTAACACATATATTTCTGCAGATGC
AATTATTGGTAGTGATACAGTTATTCATCCAGGCACAATTATTGAGGGCAAGACTGTAATTGGGTCTGATTGTGAAATTG
GACCACATACGGTTATTCGTGATAGTGAAATTGGAGACGGTACAACAATTCGTCAATCTACTGTGCATGACAGCAAGATT
GGTACAGAAGTATCAGTTGGTCCATTTGCACATATTCGTCCAGATTCCGTTATTGGTAATGAAGTACGCGTTGGAAATTT
CGTAGAAATCAAGAAAACTGTTTTTGGTAATGGAAGTAAAGCTTCACACTTAAGTTATATCGGGGATGCACAAATTGGAG
AAAACGTGAATCTTGGTTGTGGTTCAATTACAGTGAATTATGATGGCAAGAATAAATTCAAAACAGTTATTGGAGATGGC
GTATTTATTGGTTGTAACTCAAACCTTGTTGCTCCTGTAACAGTTGAAGATGGTGCGTATGTGGCAGCAGGCTCTACAAT
TACAGAGAATGTTCCATCAAAAGCATTATCAATTGCACGTGCGCGTCAAGTTAACAAAGAAGATTATGTTGATCAATTGC
TGAATAAGAAAAAATCATAA

Upstream 100 bases:

>100_bases
AATTATGGTAAAATTTAATAGTTATGCTGTGTTTCTTGAAATATATAATGATTTAGGATAATATCTTTAATGGATAAATA
GGTTGCGATGGAGGGTCTAT

Downstream 100 bases:

>100_bases
TGTGGAGGGTTAATCTAGATGTCAACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAACAAGGAACT
TGCTGAGCAAATTGCAAAGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEKVQEQLGNVSEFALQAEQLGTA
HAVDRAADILANEEGTTLVICGDTPLITAETMEALLKHHEEAGAKATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EVELTIKEINTGTYCFDNKALFASLSKVSNDNAQGEYYLPDVIEILKGEGHIVSAYQTEHFDETLGVNDRVALSQAEVIM
KNRINHKNMVNGVTIIDPSNTYISADAIIGSDTVIHPGTIIEGKTVIGSDCEIGPHTVIRDSEIGDGTTIRQSTVHDSKI
GTEVSVGPFAHIRPDSVIGNEVRVGNFVEIKKTVFGNGSKASHLSYIGDAQIGENVNLGCGSITVNYDGKNKFKTVIGDG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSIARARQVNKEDYVDQLLNKKKS

Sequences:

>Translated_459_residues
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEKVQEQLGNVSEFALQAEQLGTA
HAVDRAADILANEEGTTLVICGDTPLITAETMEALLKHHEEAGAKATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDAN
EVELTIKEINTGTYCFDNKALFASLSKVSNDNAQGEYYLPDVIEILKGEGHIVSAYQTEHFDETLGVNDRVALSQAEVIM
KNRINHKNMVNGVTIIDPSNTYISADAIIGSDTVIHPGTIIEGKTVIGSDCEIGPHTVIRDSEIGDGTTIRQSTVHDSKI
GTEVSVGPFAHIRPDSVIGNEVRVGNFVEIKKTVFGNGSKASHLSYIGDAQIGENVNLGCGSITVNYDGKNKFKTVIGDG
VFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSIARARQVNKEDYVDQLLNKKKS
>Mature_458_residues
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEKVQEQLGNVSEFALQAEQLGTAH
AVDRAADILANEEGTTLVICGDTPLITAETMEALLKHHEEAGAKATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANE
VELTIKEINTGTYCFDNKALFASLSKVSNDNAQGEYYLPDVIEILKGEGHIVSAYQTEHFDETLGVNDRVALSQAEVIMK
NRINHKNMVNGVTIIDPSNTYISADAIIGSDTVIHPGTIIEGKTVIGSDCEIGPHTVIRDSEIGDGTTIRQSTVHDSKIG
TEVSVGPFAHIRPDSVIGNEVRVGNFVEIKKTVFGNGSKASHLSYIGDAQIGENVNLGCGSITVNYDGKNKFKTVIGDGV
FIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSIARARQVNKEDYVDQLLNKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=389, Percent_Identity=23.9074550128535, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI11761619, Length=363, Percent_Identity=23.4159779614325, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=45.3932584269663, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931050, Length=366, Percent_Identity=25.4098360655738, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=381, Percent_Identity=24.9343832020997, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=380, Percent_Identity=23.9473684210526, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644084, Length=380, Percent_Identity=23.9473684210526, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49253; Mature: 49122

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEKV
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDRAADILANEEGTTLVICGDTPLITAETMEALLKHHE
HHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAKATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEVELTIKEINTGTYCFDNKA
HCCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCEEEEEEEEECCCEEEECCHH
LFASLSKVSNDNAQGEYYLPDVIEILKGEGHIVSAYQTEHFDETLGVNDRVALSQAEVIM
HHHHHHHHCCCCCCCCEECHHHHHHHCCCCCEEEEEEHHCHHHHCCCCCCCHHHHHHHHH
KNRINHKNMVNGVTIIDPSNTYISADAIIGSDTVIHPGTIIEGKTVIGSDCEIGPHTVIR
HHCCCCCHHHCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDGTTIRQSTVHDSKIGTEVSVGPFAHIRPDSVIGNEVRVGNFVEIKKTVFGNGSK
CCCCCCCCEEECCCCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEEHHHCCCCCC
ASHLSYIGDAQIGENVNLGCGSITVNYDGKNKFKTVIGDGVFIGCNSNLVAPVTVEDGAY
CCCEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCEEEECCCCEEEEEEECCCCE
VAAGSTITENVPSKALSIARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEKV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QEQLGNVSEFALQAEQLGTAHAVDRAADILANEEGTTLVICGDTPLITAETMEALLKHHE
HHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEHHHHHHHHHHHH
EAGAKATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEVELTIKEINTGTYCFDNKA
HCCCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCEEEEEEEEECCCEEEECCHH
LFASLSKVSNDNAQGEYYLPDVIEILKGEGHIVSAYQTEHFDETLGVNDRVALSQAEVIM
HHHHHHHHCCCCCCCCEECHHHHHHHCCCCCEEEEEEHHCHHHHCCCCCCCHHHHHHHHH
KNRINHKNMVNGVTIIDPSNTYISADAIIGSDTVIHPGTIIEGKTVIGSDCEIGPHTVIR
HHCCCCCHHHCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCCCCEEEE
DSEIGDGTTIRQSTVHDSKIGTEVSVGPFAHIRPDSVIGNEVRVGNFVEIKKTVFGNGSK
CCCCCCCCEEECCCCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEEHHHCCCCCC
ASHLSYIGDAQIGENVNLGCGSITVNYDGKNKFKTVIGDGVFIGCNSNLVAPVTVEDGAY
CCCEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCEEEECCCCEEEEEEECCCCE
VAAGSTITENVPSKALSIARARQVNKEDYVDQLLNKKKS
EEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA