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The map label for this gene is serS [H]

Identifier: 152973866

GI number: 152973866

Start: 20492

End: 21766

Strand: Direct

Name: serS [H]

Synonym: Bcer98_0012

Alternate gene names: 152973866

Gene position: 20492-21766 (Clockwise)

Preceding gene: 152973865

Following gene: 152973870

Centisome position: 0.5

GC content: 37.73

Gene sequence:

>1275_bases
GTGCTTGATATTAAATTTTTACGTGCCAATTTTGAAGAAGTAAAAGAAAAGTTGCAGCATAGAGGCGAAGACTTAGCTGA
TTTTGAGTGTTTTGAAGAATTAGATACAAAAAGAAGAGAGTTGCTTGTTCAAACAGAGGAACTAAAAAGTAAACGTAATG
AAGTATCTCAACAAATTTCTATGTTAAAGCGTGAAAAGAAAGATGCAGAAGCATTAATTTTAGAGATGCGTGAAGTAGGA
GAAAAAATAAAGGGTCTTGATAATGAGCTACGCGAAGTAGAAGAGGATTTAGAAAGATTAATGCTTTCTATTCCAAATAT
TCCACATGAATCTACACCTGTTGGTGAAACAGAAGATGATAACGTGGTAGTGCGTACTTGGGGAGAAGTAAAAGAATTTA
ACTTTGAGCCAAAACCACATTGGGATCTTGCGACTGATTTAGGTATTGTAGATTTTGAACGCGCAGGTAAAGTAACAGGA
AGTCGTTTCGTATTTTATAAGGGTGCAGGAGCTAGATTAGAACGTGCTTTAATTAGCTTCATGCTTGACCTTCACACAGA
AGAGCATGGGTATGAAGAGGTTTTACCTCCATACATGGTAAACCGTGCAAGTATGACAGGAACAGGTCAACTTCCGAAGT
TTGAAGAAGATGCATTCCTTATCGAAAGTGAAGATTACTTCTTAATCCCTACAGCTGAAGTTCCAGTAACAAATATGCAC
CGTGATGAAATCTTAAGTGCCGAGCAATTGCCAATTCGTTATGCTGCATTTAGCTCTTGTTTCCGTTCTGAGGCAGGTTC
AGCTGGACGTGATACACGCGGTTTAATTCGTCAACATCAATTTAATAAAGTAGAGCTTGTAAAGTTTGTTAAACCAGAAG
AGTCTTATGAGGAATTAGAAAAATTAACAAATGATGCGGAACGCGTGTTACAATTATTAGAGTTGCCATATCGTGTTATG
AGCATGTGTACAGGAGATTTAGGATTTACAGCAGCAAAGAAATATGATATCGAAGTATGGCTGCCAAGCTATGATACGTA
CCGTGAGATCTCTTCTTGCAGTAATTTCGAAGCATTCCAGGCAAGACGTGCAAATATTCGTTTCCGTCGTGAACCTAATG
CGAAACCAGAACCAGTTCATACATTGAATGGTTCAGGTCTTGCGATTGGCCGTACAGTTGCAGCGATTTTAGAAAATTAT
CAGCAAGAAGATGGTACAATTATAATTCCAGAAGTTCTTCGTCCTTATATGGGAGGAAAAACAGTTATTAAATAA

Upstream 100 bases:

>100_bases
AGAGTTGTTTTCAACTAGGGTGGCAACGCGGGTTAACTCCCGTCCCTTTTATAGGGACGGGAGTTTTTGTATTTTATAAA
ATAAAAGGAGGAGTTTACAG

Downstream 100 bases:

>100_bases
ATGAATACTTTCATCGGTATGAGTGATTGGTAATTTCAGTTGTTGTCAGTAATAACATGAAAGGAAAGGAAAATATAGAT
TATATTTTCCTTTCCTCATA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQISMLKREKKDAEALILEMREVG
EKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDDNVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMH
RDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Sequences:

>Translated_424_residues
MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQISMLKREKKDAEALILEMREVG
EKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDDNVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMH
RDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK
>Mature_424_residues
MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQISMLKREKKDAEALILEMREVG
EKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDDNVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTG
SRFVFYKGAGARLERALISFMLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMH
RDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELEKLTNDAERVLQLLELPYRVM
SMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENY
QQEDGTIIIPEVLRPYMGGKTVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=358, Percent_Identity=37.7094972067039, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI8923421, Length=433, Percent_Identity=29.7921478060046, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI225579074, Length=435, Percent_Identity=29.4252873563218, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=51.8779342723005, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=31.317494600432, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=355, Percent_Identity=29.8591549295775, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=390, Percent_Identity=36.1538461538462, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321799, Length=398, Percent_Identity=31.4070351758794, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=33.4047109207709, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17737985, Length=370, Percent_Identity=32.4324324324324, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48770; Mature: 48770

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKREKKDAEALILEMREVGEKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTGSRFVFYKGAGARLERALISF
CEEEEECCCHHHCCCCCCCCCCHHHHCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMH
HHHHHCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
RDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELE
HHHHCCHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCHHHHH
ARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC
>Mature Secondary Structure
MLDIKFLRANFEEVKEKLQHRGEDLADFECFEELDTKRRELLVQTEELKSKRNEVSQQIS
CCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKREKKDAEALILEMREVGEKIKGLDNELREVEEDLERLMLSIPNIPHESTPVGETEDD
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVVVRTWGEVKEFNFEPKPHWDLATDLGIVDFERAGKVTGSRFVFYKGAGARLERALISF
CEEEEECCCHHHCCCCCCCCCCHHHHCCCEEHHHCCCCCCCEEEEECCCCHHHHHHHHHH
MLDLHTEEHGYEEVLPPYMVNRASMTGTGQLPKFEEDAFLIESEDYFLIPTAEVPVTNMH
HHHHHCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCC
RDEILSAEQLPIRYAAFSSCFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEESYEELE
HHHHCCHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
KLTNDAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWLPSYDTYREISSCSNFEAFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCHHHHH
ARRANIRFRREPNAKPEPVHTLNGSGLAIGRTVAAILENYQQEDGTIIIPEVLRPYMGGK
HHHCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCC
TVIK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA