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The map label for this gene is gyrA [H]

Identifier: 152973860

GI number: 152973860

Start: 6711

End: 9176

Strand: Direct

Name: gyrA [H]

Synonym: Bcer98_0006

Alternate gene names: 152973860

Gene position: 6711-9176 (Clockwise)

Preceding gene: 152973859

Following gene: 152973862

Centisome position: 0.16

GC content: 37.59

Gene sequence:

>2466_bases
ATGTCAGATAATCAACAACAAGCACGAATTCGAGAGGTTAATATTAGTCAGGAAATGCGTACCTCGTTTTTAGATTACGC
AATGAGTGTTATCGTATCTCGTGCATTACCAGATGTGCGAGATGGATTAAAGCCTGTACATCGCAGGGTTTTATATGCAA
TGAATGATTTAGGTATTACTGCTGATAAAGCGTATAAAAAATCAGCACGTATTGTTGGGGAAGTAATCGGTAAGTATCAT
CCACACGGTGATTCAGCTGTTTATGAAACTATGGTACGTATGGCACAAGATTTTAGCCAGCGCTATATGCTCGTTGATGG
ACATGGAAACTTTGGTTCTATTGATGGTGACTCTGCAGCAGCGATGCGTTATACAGAAGCAAAAATGTCTAAAATCTCTA
TGGAACTATTGCGCGATATTACAAAAAATACAATAGACTATCAAGATAACTATGATGGTTCTGAGAGAGAGCCGGTTGTA
CTACCTGCTCGTTTCCCTAATTTATTAGTAAATGGTGCGACTGGTATCGCTGTTGGTATGGCGACAAATATTCCACCTCA
TCAACTTGGAGAAGTAATTGATGGGGTCTTAGCTTTAAGCCGTAATCCTGAGATTACAATCGCGGAGTTAATGGAGTATA
TTCCAGGGCCAGATTTCCCTACAGCAGGTCTTATTTTAGGGAGAAGTGGAATTCGCAGAGCCTATGAAACTGGGCGCGGT
TCTATTACACTACGGGCAAAGGTTGAAATTGAAGAAAAAGCGAATGGACGACAATCCATTATTGTCACAGAAATACCTTA
TCAAGTAAATAAGGCTCGCCTTATTGAAAAAATTGCAGAATTAGTTCGCGATAAAAAAATTGATGGTATTACAGATTTGC
GTGATGAATCTGATAGAAGAGGTTTACGAATTGTCATGGAAGTTCGTCGTGATGCAAATGCTAACGTGCTTCTAAACAAT
TTATATAAACATACGGCCCTTCAAACAAGTTTTGGCATTAATATGCTTTCACTTGTAGATGGAGAACCAAAAGTATTAAA
TTTAAAACAAACGCTATATTATTACTTGGAACATCAAAAAGTAGTTATTCGTAGACGCACAGCTTACGAATTAGAAAAGG
CAGAGGCTCGTGCTCATATTTTAGAAGGTTTACGAATTGCTTTAGATCACCTTGATGAAGTAATTACGTTAATACGTAGT
TCGAAAACAGCAGATATTGCAAAACAAGGATTGATAGAGCGATTTGCTTTAAGTGAAAAACAAGCACAGGCAATATTAGA
TATGCGCTTGCAACGCTTAACAGGATTAGAACGAGAGAAAATCGAGCAAGAATATCAAGAACTATTGAAATTGATTGCTG
AGTTAAAAGCAATCTTAGCCGATGAAGAAAAGGTTCTAGAAATTATTCGTGAAGAATTAACAGAAGTAAAAGAACGATTT
AACGATGAGAGAAGAACTGAAATTACAATTGGTGGTATTGAATCTATTGAGGATGAAGATTTAATACCAGAGCAAAATAT
TGCGATTACGTTGACTCATAACGGATACATTAAACGATTACCAGCTTCTACATATAAAACGCAGAATCGTGGAGGTCGTG
GTGTACAAGGAATGGGTACAAATGATGATGATTTTGTTGAACACTTATTAACGACATCAACACATGATCATATTTTATAC
TTTACCAATAAAGGTAAAGTATACCGTACAAAGGGATATGAAATCCCAGAGTATAGCCGTACAGCGAAAGGAATACCGAT
TATTAATTTATTAGAAGTAGATAAGGATGAGTGGGTCAACGCTATTATTCCAATTCGTGAATTTGGTGATGATCAATTCT
TATTCTTTACAACAAAACAAGGGATCTCTAAGAGAACGCCGCTTTCATCATTCTCAAATATTCGTACAAACGGCTTGATA
GCCATCTCTCTTCGTGAAGAAGACGAGGTGATTTCTGTACGTTTAACATCTGGTGACAAAGATATTATTGTTGGTACAAG
TAACGGTATGTTAATTCGATTTAATGAACAAGATGTGCGCTCTATGGGACGTAATGCAGCTGGGGTAAAAGCTATAACAT
TAGATGAAGATGATCATGTTGTAGGTATGGAAATTGTCGAAGAGAATATGAATGTGTTAATTGTAACGAAGAATGGATAC
GGAAAGCGTACACCGATTGAGGAGTATCGCATCCAAAGTCGTGGCGGGAAAGGTTTGAAAACGTGTAATATTACAGAGAA
AAACGGCAAGTTAGTAGCAGTTAAGTCTGTAACAGGCGAAGAAGATATCATGCTGATTACGGCAGCAGGTGTTATTATTC
GAATGCCAGTTGAACAAATCTCGCAAATGGGGCGTAATACACAGGGTGTACGTTTGATTCGTCTGGAAGATGATCAAGAA
GTAGCAACAGTAGCAAAAGCCCAAAAAGAAGATGAGGAAGAAAGCGAAGAAGCTTCTGAAGAATAA

Upstream 100 bases:

>100_bases
TGATATTTAAGATAAATAACGACAGGAATCTCAATGTTCCTGTCGTCTATATATAAATCAATGTAATTTGTAACGGAAAT
GTAAGAGGAGGTGCTGGTTG

Downstream 100 bases:

>100_bases
GAGAGGGGGAATAATCCCTTTCTCTTATTTTTTTAGATTCATGCTTGCAAAGTAAAAGAAAAGCCTATATAATAGGCAAA
GTCAGCAAATAAAGAAGTAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 821; Mature: 820

Protein sequence:

>821_residues
MSDNQQQARIREVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYH
PHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSIDGDSAAAMRYTEAKMSKISMELLRDITKNTIDYQDNYDGSEREPVV
LPARFPNLLVNGATGIAVGMATNIPPHQLGEVIDGVLALSRNPEITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRG
SITLRAKVEIEEKANGRQSIIVTEIPYQVNKARLIEKIAELVRDKKIDGITDLRDESDRRGLRIVMEVRRDANANVLLNN
LYKHTALQTSFGINMLSLVDGEPKVLNLKQTLYYYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRS
SKTADIAKQGLIERFALSEKQAQAILDMRLQRLTGLEREKIEQEYQELLKLIAELKAILADEEKVLEIIREELTEVKERF
NDERRTEITIGGIESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILY
FTNKGKVYRTKGYEIPEYSRTAKGIPIINLLEVDKDEWVNAIIPIREFGDDQFLFFTTKQGISKRTPLSSFSNIRTNGLI
AISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLDEDDHVVGMEIVEENMNVLIVTKNGY
GKRTPIEEYRIQSRGGKGLKTCNITEKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVEQISQMGRNTQGVRLIRLEDDQE
VATVAKAQKEDEEESEEASEE

Sequences:

>Translated_821_residues
MSDNQQQARIREVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYH
PHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSIDGDSAAAMRYTEAKMSKISMELLRDITKNTIDYQDNYDGSEREPVV
LPARFPNLLVNGATGIAVGMATNIPPHQLGEVIDGVLALSRNPEITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRG
SITLRAKVEIEEKANGRQSIIVTEIPYQVNKARLIEKIAELVRDKKIDGITDLRDESDRRGLRIVMEVRRDANANVLLNN
LYKHTALQTSFGINMLSLVDGEPKVLNLKQTLYYYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRS
SKTADIAKQGLIERFALSEKQAQAILDMRLQRLTGLEREKIEQEYQELLKLIAELKAILADEEKVLEIIREELTEVKERF
NDERRTEITIGGIESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILY
FTNKGKVYRTKGYEIPEYSRTAKGIPIINLLEVDKDEWVNAIIPIREFGDDQFLFFTTKQGISKRTPLSSFSNIRTNGLI
AISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLDEDDHVVGMEIVEENMNVLIVTKNGY
GKRTPIEEYRIQSRGGKGLKTCNITEKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVEQISQMGRNTQGVRLIRLEDDQE
VATVAKAQKEDEEESEEASEE
>Mature_820_residues
SDNQQQARIREVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGITADKAYKKSARIVGEVIGKYHP
HGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSIDGDSAAAMRYTEAKMSKISMELLRDITKNTIDYQDNYDGSEREPVVL
PARFPNLLVNGATGIAVGMATNIPPHQLGEVIDGVLALSRNPEITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRGS
ITLRAKVEIEEKANGRQSIIVTEIPYQVNKARLIEKIAELVRDKKIDGITDLRDESDRRGLRIVMEVRRDANANVLLNNL
YKHTALQTSFGINMLSLVDGEPKVLNLKQTLYYYLEHQKVVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRSS
KTADIAKQGLIERFALSEKQAQAILDMRLQRLTGLEREKIEQEYQELLKLIAELKAILADEEKVLEIIREELTEVKERFN
DERRTEITIGGIESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGTNDDDFVEHLLTTSTHDHILYF
TNKGKVYRTKGYEIPEYSRTAKGIPIINLLEVDKDEWVNAIIPIREFGDDQFLFFTTKQGISKRTPLSSFSNIRTNGLIA
ISLREEDEVISVRLTSGDKDIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLDEDDHVVGMEIVEENMNVLIVTKNGYG
KRTPIEEYRIQSRGGKGLKTCNITEKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVEQISQMGRNTQGVRLIRLEDDQEV
ATVAKAQKEDEEESEEASEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=25.8566978193146, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1788562, Length=850, Percent_Identity=52.8235294117647, Blast_Score=878, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=755, Percent_Identity=35.8940397350993, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17535065, Length=230, Percent_Identity=30, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=225, Percent_Identity=29.3333333333333, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=508, Percent_Identity=22.6377952755905, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=200, Percent_Identity=29, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=31.9277108433735, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92407; Mature: 92276

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNQQQARIREVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGIT
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSIDGDSAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
AMRYTEAKMSKISMELLRDITKNTIDYQDNYDGSEREPVVLPARFPNLLVNGATGIAVGM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEEE
ATNIPPHQLGEVIDGVLALSRNPEITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRG
ECCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCC
SITLRAKVEIEEKANGRQSIIVTEIPYQVNKARLIEKIAELVRDKKIDGITDLRDESDRR
CEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GLRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVDGEPKVLNLKQTLYYYLEHQK
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
VVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRSSKTADIAKQGLIERFALSEK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHH
QAQAILDMRLQRLTGLEREKIEQEYQELLKLIAELKAILADEEKVLEIIREELTEVKERF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NDERRTEITIGGIESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGT
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCC
NDDDFVEHLLTTSTHDHILYFTNKGKVYRTKGYEIPEYSRTAKGIPIINLLEVDKDEWVN
CHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHCCCCCEEEEEECCHHHHHH
AIIPIREFGDDQFLFFTTKQGISKRTPLSSFSNIRTNGLIAISLREEDEVISVRLTSGDK
EEEEHHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCC
DIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLDEDDHVVGMEIVEENMNVLIVTKNGY
EEEEECCCCEEEEECHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHCCCCEEEEEECCC
GKRTPIEEYRIQSRGGKGLKTCNITEKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVEQI
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEECCHHHH
SQMGRNTQGVRLIRLEDDQEVATVAKAQKEDEEESEEASEE
HHHCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure 
SDNQQQARIREVNISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMNDLGIT
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
ADKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQDFSQRYMLVDGHGNFGSIDGDSAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
AMRYTEAKMSKISMELLRDITKNTIDYQDNYDGSEREPVVLPARFPNLLVNGATGIAVGM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEEE
ATNIPPHQLGEVIDGVLALSRNPEITIAELMEYIPGPDFPTAGLILGRSGIRRAYETGRG
ECCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCCC
SITLRAKVEIEEKANGRQSIIVTEIPYQVNKARLIEKIAELVRDKKIDGITDLRDESDRR
CEEEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GLRIVMEVRRDANANVLLNNLYKHTALQTSFGINMLSLVDGEPKVLNLKQTLYYYLEHQK
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
VVIRRRTAYELEKAEARAHILEGLRIALDHLDEVITLIRSSKTADIAKQGLIERFALSEK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHH
QAQAILDMRLQRLTGLEREKIEQEYQELLKLIAELKAILADEEKVLEIIREELTEVKERF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NDERRTEITIGGIESIEDEDLIPEQNIAITLTHNGYIKRLPASTYKTQNRGGRGVQGMGT
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHCCCCCCCCCCCCCCC
NDDDFVEHLLTTSTHDHILYFTNKGKVYRTKGYEIPEYSRTAKGIPIINLLEVDKDEWVN
CHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCHHCCCCCEEEEEECCHHHHHH
AIIPIREFGDDQFLFFTTKQGISKRTPLSSFSNIRTNGLIAISLREEDEVISVRLTSGDK
EEEEHHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCC
DIIVGTSNGMLIRFNEQDVRSMGRNAAGVKAITLDEDDHVVGMEIVEENMNVLIVTKNGY
EEEEECCCCEEEEECHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHCCCCEEEEEECCC
GKRTPIEEYRIQSRGGKGLKTCNITEKNGKLVAVKSVTGEEDIMLITAAGVIIRMPVEQI
CCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEECCHHHH
SQMGRNTQGVRLIRLEDDQEVATVAKAQKEDEEESEEASEE
HHHCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]