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The map label for this gene is guaB [H]

Identifier: 152973862

GI number: 152973862

Start: 15620

End: 17083

Strand: Direct

Name: guaB [H]

Synonym: Bcer98_0008

Alternate gene names: 152973862

Gene position: 15620-17083 (Clockwise)

Preceding gene: 152973860

Following gene: 152973863

Centisome position: 0.38

GC content: 38.32

Gene sequence:

>1464_bases
ATGTGGGAATCTAAATTTGTTAAAGAAGGTTTGACATTTGATGATGTATTACTTATACCAGCAAAATCAGATGTATTACC
AAGAGAAGTAAATGTTAAAACGGTTCTATCTGAAAGTTTGCAGTTAAATATTCCTTTAATTAGCGCAGGGATGGACACAG
TAACAGAAGCTGATATGGCTATTGCAATGGCACGTCAAGGTGGATTAGGAATTATTCATAAGAATATGTCAATTGAGCAA
CAAGCTGAACAAGTTGATAAAGTAAAACGTTCTGAAAGTGGCGTTATTTCAGATCCTTTCTTTTTAACTCCAGAGCATCA
AGTGTACGATGCAGAACATTTAATGGGAAAATATCGCATCTCAGGTGTACCAATTGTAAATAATTTAGATGAGCAAAAAC
TAGTTGGTATTATTACAAACCGTGATATGCGTTTTATTCAAGATTACTCTATCAAAATTTCCGACGTGATGACAAAAGAA
CAACTCATTACTGCTCCGGTCGGTACTACGCTAAAAGAAGCTGAAAAGATCCTACAGAAATATAAAATTGAAAAGCTCCC
TCTTGTTGATCAAAACGGTGTGTTAAAAGGTCTTATTACCATTAAAGATATTGAAAAAGTCATTGAGTTTCCAAACTCAG
CAAAGGATAAACAGGGGCGTTTATTAGTTGGGGCAGCAGTTGGTGTAACTGCAGATGCAATGCTTCGTATTGACGCATTA
GTAAAAGCAAACGTAGACGTTATTGTAATTGATACAGCTCATGGACATTCACAAGGTGTTCTTGAAAAAGTAAAAGAGGT
TCGTACTAAATATCCAGAATTAAATATTATTGCAGGGAACGTTGCTACAGCTGAAGCAACACGTGCATTAATTGAAGCTG
GTGCAAATATTATCAAAGTTGGTATTGGACCAGGCTCAATTTGTACAACACGCGTTGTAGCTGGCGTAGGTGTTCCACAA
TTAACAGCAGTATATGATTGTGCAACTGAAGCGCGTAAACATGGTATCCCGGTTATTGCTGATGGCGGTATTAAATACTC
TGGTGATATGGTGAAGGCTTTAGCGGCAGGTGCTCACGTTGTAATGCTTGGTAGCATGTTCGCTGGTGTAGCTGAAAGCC
CAGGGGAAACTGAAATTTACCAAGGTCGTCAATTTAAAGTGTACCGTGGTATGGGTTCTGTTGGAGCGATGGAAAAAGGA
AGTAAGGATCGTTACTTCCAAGAAGGAAATAAAAAACTTGTTCCAGAGGGTATTGAAGGCCGTGTACCATATAAAGGACC
TTTAGCTGATACAGTTCATCAATTAGTTGGTGGATTACGTGCAGGAATGGGATATTGCGGAGCACATGATTTAGAGTTCT
TACGTGAAAATGCACAATTTATTCGTATGACAGGTGCTGGACTACGCGAAAGTCATCCACACCATGTACAAATTACAAAA
GAAGCGCCAAATTACTCTCTATAA

Upstream 100 bases:

>100_bases
TATTATCTAAAAATTCCAACATATAATCACTTTCTTGACAGTATTTTAACCAATTGTTAAGCTACTAATAATAATTTCTG
GTATCATAGGGGGAACAATT

Downstream 100 bases:

>100_bases
TGTCTTATATATAAATAGACAGAGGTTTGATACCTCTGTCTATTTTTTTTTGATTATGTTAGAATAACGGTTATGTGAGT
ACAATGAGATATTGGGGGTA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MWESKFVKEGLTFDDVLLIPAKSDVLPREVNVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPIVNNLDEQKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLKEAEKILQKYKIEKLPLVDQNGVLKGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMLRIDAL
VKANVDVIVIDTAHGHSQGVLEKVKEVRTKYPELNIIAGNVATAEATRALIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAHDLEFLRENAQFIRMTGAGLRESHPHHVQITK
EAPNYSL

Sequences:

>Translated_487_residues
MWESKFVKEGLTFDDVLLIPAKSDVLPREVNVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPIVNNLDEQKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLKEAEKILQKYKIEKLPLVDQNGVLKGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMLRIDAL
VKANVDVIVIDTAHGHSQGVLEKVKEVRTKYPELNIIAGNVATAEATRALIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAHDLEFLRENAQFIRMTGAGLRESHPHHVQITK
EAPNYSL
>Mature_487_residues
MWESKFVKEGLTFDDVLLIPAKSDVLPREVNVKTVLSESLQLNIPLISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQ
QAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRISGVPIVNNLDEQKLVGIITNRDMRFIQDYSIKISDVMTKE
QLITAPVGTTLKEAEKILQKYKIEKLPLVDQNGVLKGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMLRIDAL
VKANVDVIVIDTAHGHSQGVLEKVKEVRTKYPELNIIAGNVATAEATRALIEAGANIIKVGIGPGSICTTRVVAGVGVPQ
LTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKG
SKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYCGAHDLEFLRENAQFIRMTGAGLRESHPHHVQITK
EAPNYSL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=45.374449339207, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=45.4746136865342, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=45.4746136865342, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=45.4746136865342, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=45.413870246085, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=44.4933920704846, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=42.6048565121413, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=42.511013215859, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI156104880, Length=224, Percent_Identity=46.875, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=41.869918699187, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=41.869918699187, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=41.869918699187, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.869918699187, Blast_Score=175, Evalue=1e-43,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=55.761316872428, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=219, Percent_Identity=41.0958904109589, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=473, Percent_Identity=35.7293868921776, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=37.2037914691943, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=44.2922374429224, Blast_Score=176, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=467, Percent_Identity=40.2569593147752, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=40.8296943231441, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=467, Percent_Identity=40.6852248394004, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=39.8826979472141, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=41.3793103448276, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=41.7536534446764, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=41.7536534446764, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571163, Length=437, Percent_Identity=41.8764302059497, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52733; Mature: 52733

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWESKFVKEGLTFDDVLLIPAKSDVLPREVNVKTVLSESLQLNIPLISAGMDTVTEADMA
CCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCEEEECEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHEE
SGVPIVNNLDEQKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLKEAEKILQK
CCCCEECCCCCCCEEEEEECCCEEEHHHCCEEHHHHHHHHHHEECCCCCHHHHHHHHHHH
YKIEKLPLVDQNGVLKGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMLRIDAL
HCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VKANVDVIVIDTAHGHSQGVLEKVKEVRTKYPELNIIAGNVATAEATRALIEAGANIIKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHH
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
HHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEECCCCCCC
RVPYKGPLADTVHQLVGGLRAGMGYCGAHDLEFLRENAQFIRMTGAGLRESHPHHVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEE
EAPNYSL
CCCCCCC
>Mature Secondary Structure
MWESKFVKEGLTFDDVLLIPAKSDVLPREVNVKTVLSESLQLNIPLISAGMDTVTEADMA
CCCHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCEEEECEEEECCCHHHHHHHHH
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHEE
SGVPIVNNLDEQKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLKEAEKILQK
CCCCEECCCCCCCEEEEEECCCEEEHHHCCEEHHHHHHHHHHEECCCCCHHHHHHHHHHH
YKIEKLPLVDQNGVLKGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMLRIDAL
HCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VKANVDVIVIDTAHGHSQGVLEKVKEVRTKYPELNIIAGNVATAEATRALIEAGANIIKV
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEE
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHH
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
HHHHHHHHHHCCCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEECCCCCCC
RVPYKGPLADTVHQLVGGLRAGMGYCGAHDLEFLRENAQFIRMTGAGLRESHPHHVQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEE
EAPNYSL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]