Click here to switch to the map view.

The map label for this gene is hisA [H]

Identifier: 152971019

GI number: 152971019

Start: 2704694

End: 2705431

Strand: Direct

Name: hisA [H]

Synonym: KPN_02480

Alternate gene names: 152971019

Gene position: 2704694-2705431 (Clockwise)

Preceding gene: 152971018

Following gene: 152971020

Centisome position: 50.89

GC content: 64.09

Gene sequence:

>738_bases
ATGATTATTCCTGCTTTAGATTTAATCGACGGCACCGTCGTTCGTCTCCATCAGGGCGATTACGGCCAGCAGCGCGACTA
TGGCAGCGATCCGCTGCCGCGCCTGCAGGCCTATGCCGCTCAGGGGGCAAAAGTCCTGCACCTGGTCGACCTGACCGGGG
CGAAGGATCCGGCGAAGCGCCAGATCCCGCTGCTGAAATCGCTGGTCGCCGGGGTTGACGTCCCGGTGCAGGTCGGCGGC
GGCGTGCGGACCGAAGCGGATGTCGCGGCCCTGCTTGAGGCCGGCGTCGCCCGCGTGGTGGTCGGCTCCACCGCGGTGAA
ATCCCCGGAGGAAGTGAAAGGCTGGTTCAAACGCTTTGGCCCAGAACGGCTGGTGCTCGCCCTCGACGTGCGTATCGACG
CCGACGGCAATAAGCAGGTGGCGGTCAGCGGCTGGCAGGAAAACTCCGGCGTGACGCTGGAGGAGCTGGTGGAAAGTTAT
CTGCCGGTCGGCCTGCAGCACGTGCTGTGCACCGATATCTCCCGCGACGGCACGCTGGCAGGCTCTAACGTCTCGCTGTA
CGAGGAAGTCTGCGCCCGCTACCCGCAGGTGGCGTTTCAGTCATCCGGCGGCATCGGCGATCTCAAAGATATTGCCGCGC
TGCGCGGCACCGGGGTGCGCGGCGTGATTGTTGGCCGCGCGCTGCTGGAAGGTAAATTCAACGTAACGGAGGCCATTCAA
TGCTGGCAAAACGGATAA

Upstream 100 bases:

>100_bases
CCGCCGCGGTGCAGAAAGATAACTTCTTTGGCGTGCAGTTTCACCCGGAGCGCTCCGGGAGCGCCGGGGCGCAGCTGCTG
AAAAACTTCCTGGAGATGTG

Downstream 100 bases:

>100_bases
TCCCCTGCCTCGACGTCCGCGACGGCCAGGTAGTGAAAGGCGTGCAGTTCCGTAATCACGAGATCATTGGCGACATCGTC
CCGCTGGCCAAGCGCTATGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPALDLIDGTVVRLHQGDYGQQRDYGSDPLPRLQAYAAQGAKVLHLVDLTGAKDPAKRQIPLLKSLVAGVDVPVQVGG
GVRTEADVAALLEAGVARVVVGSTAVKSPEEVKGWFKRFGPERLVLALDVRIDADGNKQVAVSGWQENSGVTLEELVESY
LPVGLQHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDLKDIAALRGTGVRGVIVGRALLEGKFNVTEAIQ
CWQNG

Sequences:

>Translated_245_residues
MIIPALDLIDGTVVRLHQGDYGQQRDYGSDPLPRLQAYAAQGAKVLHLVDLTGAKDPAKRQIPLLKSLVAGVDVPVQVGG
GVRTEADVAALLEAGVARVVVGSTAVKSPEEVKGWFKRFGPERLVLALDVRIDADGNKQVAVSGWQENSGVTLEELVESY
LPVGLQHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDLKDIAALRGTGVRGVIVGRALLEGKFNVTEAIQ
CWQNG
>Mature_245_residues
MIIPALDLIDGTVVRLHQGDYGQQRDYGSDPLPRLQAYAAQGAKVLHLVDLTGAKDPAKRQIPLLKSLVAGVDVPVQVGG
GVRTEADVAALLEAGVARVVVGSTAVKSPEEVKGWFKRFGPERLVLALDVRIDADGNKQVAVSGWQENSGVTLEELVESY
LPVGLQHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDLKDIAALRGTGVRGVIVGRALLEGKFNVTEAIQ
CWQNG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=88.5245901639344, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1788336, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25995; Mature: 25995

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPALDLIDGTVVRLHQGDYGQQRDYGSDPLPRLQAYAAQGAKVLHLVDLTGAKDPAKR
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHH
QIPLLKSLVAGVDVPVQVGGGVRTEADVAALLEAGVARVVVGSTAVKSPEEVKGWFKRFG
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHEEECCHHCCCHHHHHHHHHHCC
PERLVLALDVRIDADGNKQVAVSGWQENSGVTLEELVESYLPVGLQHVLCTDISRDGTLA
CCEEEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCC
GSNVSLYEEVCARYPQVAFQSSGGIGDLKDIAALRGTGVRGVIVGRALLEGKFNVTEAIQ
CCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHH
CWQNG
HHCCC
>Mature Secondary Structure
MIIPALDLIDGTVVRLHQGDYGQQRDYGSDPLPRLQAYAAQGAKVLHLVDLTGAKDPAKR
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHH
QIPLLKSLVAGVDVPVQVGGGVRTEADVAALLEAGVARVVVGSTAVKSPEEVKGWFKRFG
HHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHEEECCHHCCCHHHHHHHHHHCC
PERLVLALDVRIDADGNKQVAVSGWQENSGVTLEELVESYLPVGLQHVLCTDISRDGTLA
CCEEEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCC
GSNVSLYEEVCARYPQVAFQSSGGIGDLKDIAALRGTGVRGVIVGRALLEGKFNVTEAIQ
CCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHH
CWQNG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA