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The map label for this gene is paaH [H]

Identifier: 152970029

GI number: 152970029

Start: 1638586

End: 1640010

Strand: Direct

Name: paaH [H]

Synonym: KPN_01476

Alternate gene names: 152970029

Gene position: 1638586-1640010 (Clockwise)

Preceding gene: 152970028

Following gene: 152970030

Centisome position: 30.83

GC content: 62.32

Gene sequence:

>1425_bases
ATGATGACGACATCCTTAGCCACCGTGGCGGTGATCGGCAGCGGCACCATGGGGGCCGGCATCGCCGAAGTGGCTGCCGC
CGCCGGACATCCGGTGCGTATTTTCGATATTAATCAAACCGCGATTGCCCAGGCGATCGACGGCATTGCTATGCGTCTGG
CGTCACGGGTCGAGCGCGGCAAACTGGCGTCAGAGCAGGCCGACGCGCTGCTGGCGCGCCTGCATCCGGCTCACGATTTA
GCCGCGCTTGCCGACGCGGATTTAGTAATTGAAGCGGCCTCTGAACGGTTGGAGGTGAAAACGGCGCTGTTCGCGCAGCT
GGCGGCGATCTGCGCGCCGTCAACGCTGTTGACCAGTAACACCTCGTCTATTTCGATTACCGCTATCGCCGCCGGGGTCA
AAAACCCGGAGCGGGTGGCCGGACTGCACTTTTTTAATCCGGCGCCGGTGATGAAGCTGGTCGAGGTGGTGAGTGGTCTT
GCGACCTCCACAGAAGTGGTGGAGCAGCTGTGCCAGTGCGTAAGCGGCTGGGGGAAACAGCCGGTACGCTGCCGCTCAAC
GCCGGGATTTATCGTTAACCGCGTAGCGCGTCCGTTCTACGCTGAGGCCTGGCGCGCGCTGGAAGAACAGGTTGCCGCCC
CGGAGGTTATCGATGCCGCTTTGCGTGACGGCGGCGGTTTTCCGATGGGACCGTTGGCGCTGACTGACCTGATTGGCCAG
GACGTCAACTTCGCCGTGACCTGTTCGGTGTTTAACGCCTTCTGGCAGGACCGCCGCTACCTGCCATCGCTCCTCCAGCA
AGAGCTGGCGCTGGCCGGGAGGCTGGGTAAAAAGAGCGGTCACGGCGTCTATCGCTGGCCCGCGGAGACGCAGCCGGACG
CGGCGCTGCCGCCGGTAATGATGGGTGCTGAATCCGTTACCGTCAGAAGTGACAACGTCACTGAATTAGACGATGTCTTG
CTGCTGGAGACTGAAGGCGAGACCGCCCTGGCGCTGAGTATTAAGCATCACCGCCCGGTGGTGGTGTATGACCTGTGCGC
CAGCGATACGGTGGTGCTGGCCGCAGCGGCAACCAACGTGCCTGCGGCCACTGAAAAGGCCGTGCATTACTTCCAGCAGC
AGGGCAAGAAAGTGCTGCGTATTGCCGATTATCCCGGCCTGCTGGTGTGGCGCACGGTGGCGATGCTGATTAACGAAGCG
CTGGATGCGGTGCAAAAAGGCGTCGCCAGCCCGCAGGATGTCGATACCGCGATGCGCCTTGGCGTGAACTATCCGCATGG
CCCGCTGGCATGGGGAGAACGCCTTGGCTGGCGGCGGGTGCTGCAACTGCTGGAGAACCTGCAACACCATTATGGCGAGG
AGCGCTATCGCCCCAGTTCCCTGCTGCGCCAGAAGGCGCTGATGGAGAAGCACCATGAGCAATGA

Upstream 100 bases:

>100_bases
GGAGCGCGATTATCAGCGTCTGGCCGGGCGCAGCGATGATTACCGCGAAGGGGTCAGCGCGTTTCTGGCCAAACGGCCAC
CACAGTTCAGCGGGAAATAG

Downstream 100 bases:

>100_bases
TCCGTGGCGCAACGCGCGCGTGATGTACGAAAAAGATACCTGCGCCAGAAAGATGGGGATCGAACTTATCGAAATGGACG
ACGGTTTTGCGCAGATGAGT

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MMTTSLATVAVIGSGTMGAGIAEVAAAAGHPVRIFDINQTAIAQAIDGIAMRLASRVERGKLASEQADALLARLHPAHDL
AALADADLVIEAASERLEVKTALFAQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGL
ATSTEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQ
DVNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAETQPDAALPPVMMGAESVTVRSDNVTELDDVL
LLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNVPAATEKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEA
LDAVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ

Sequences:

>Translated_474_residues
MMTTSLATVAVIGSGTMGAGIAEVAAAAGHPVRIFDINQTAIAQAIDGIAMRLASRVERGKLASEQADALLARLHPAHDL
AALADADLVIEAASERLEVKTALFAQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGL
ATSTEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQ
DVNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAETQPDAALPPVMMGAESVTVRSDNVTELDDVL
LLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNVPAATEKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEA
LDAVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
>Mature_474_residues
MMTTSLATVAVIGSGTMGAGIAEVAAAAGHPVRIFDINQTAIAQAIDGIAMRLASRVERGKLASEQADALLARLHPAHDL
AALADADLVIEAASERLEVKTALFAQLAAICAPSTLLTSNTSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGL
ATSTEVVEQLCQCVSGWGKQPVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQ
DVNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAETQPDAALPPVMMGAESVTVRSDNVTELDDVL
LLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNVPAATEKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEA
LDAVQKGVASPQDVDTAMRLGVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=284, Percent_Identity=40.4929577464789, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI296179427, Length=301, Percent_Identity=38.2059800664452, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI20127408, Length=461, Percent_Identity=27.114967462039, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=32.1917808219178, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=32.1917808219178, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI115430219, Length=245, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787661, Length=474, Percent_Identity=72.9957805907173, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1788682, Length=281, Percent_Identity=36.2989323843416, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790281, Length=269, Percent_Identity=32.3420074349442, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=295, Percent_Identity=39.6610169491525, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=37.9790940766551, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=38.0622837370242, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=278, Percent_Identity=33.8129496402878, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17508951, Length=278, Percent_Identity=33.8129496402878, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508953, Length=278, Percent_Identity=33.8129496402878, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71985923, Length=346, Percent_Identity=27.4566473988439, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=441, Percent_Identity=23.5827664399093, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17558304, Length=278, Percent_Identity=32.7338129496403, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=26.6331658291457, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=26.6331658291457, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583077, Length=288, Percent_Identity=32.9861111111111, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24583079, Length=288, Percent_Identity=32.9861111111111, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI19921000, Length=288, Percent_Identity=32.9861111111111, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=30.4166666666667, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI20129993, Length=225, Percent_Identity=27.1111111111111, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 51016; Mature: 51016

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01186 EGF_2 ; PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTTSLATVAVIGSGTMGAGIAEVAAAAGHPVRIFDINQTAIAQAIDGIAMRLASRVERG
CCCCHHHHEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHC
KLASEQADALLARLHPAHDLAALADADLVIEAASERLEVKTALFAQLAAICAPSTLLTSN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECC
TSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLATSTEVVEQLCQCVSGWGKQ
CCCEEEEEEECCCCCHHHHHCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQ
CEEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHCC
DVNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAETQPDAALPPVM
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHH
MGAESVTVRSDNVTELDDVLLLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNV
CCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCC
PAATEKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEALDAVQKGVASPQDVDTAMRL
CCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMTTSLATVAVIGSGTMGAGIAEVAAAAGHPVRIFDINQTAIAQAIDGIAMRLASRVERG
CCCCHHHHEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHC
KLASEQADALLARLHPAHDLAALADADLVIEAASERLEVKTALFAQLAAICAPSTLLTSN
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECC
TSSISITAIAAGVKNPERVAGLHFFNPAPVMKLVEVVSGLATSTEVVEQLCQCVSGWGKQ
CCCEEEEEEECCCCCHHHHHCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PVRCRSTPGFIVNRVARPFYAEAWRALEEQVAAPEVIDAALRDGGGFPMGPLALTDLIGQ
CEEECCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHCC
DVNFAVTCSVFNAFWQDRRYLPSLLQQELALAGRLGKKSGHGVYRWPAETQPDAALPPVM
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHH
MGAESVTVRSDNVTELDDVLLLETEGETALALSIKHHRPVVVYDLCASDTVVLAAAATNV
CCCCEEEEECCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCCCEEEEEECCCC
PAATEKAVHYFQQQGKKVLRIADYPGLLVWRTVAMLINEALDAVQKGVASPQDVDTAMRL
CCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GVNYPHGPLAWGERLGWRRVLQLLENLQHHYGEERYRPSSLLRQKALMEKHHEQ
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]