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The map label for this gene is dmsA [H]

Identifier: 152969213

GI number: 152969213

Start: 729446

End: 731755

Strand: Direct

Name: dmsA [H]

Synonym: KPN_00642

Alternate gene names: 152969213

Gene position: 729446-731755 (Clockwise)

Preceding gene: 152969207

Following gene: 152969216

Centisome position: 13.72

GC content: 64.29

Gene sequence:

>2310_bases
ATGAAGAAACAGCATAATTATACGGTGATGCACTGGGGAACCTGGCAGGTGGAGAGCCGTGAGGGCGAGATCGTGGCGGT
TAAGCCGGTGCCCTGGGATAAAAATCCCTCACGCATCGGCCAGTCGCTCCCCGACGCGGTGACCAGCCAAACGCGCATTC
GCCGTCCGGCGGTGCGCGCCGGCTATCTCCAGCACGGGCCGGCGTCACGAGAAGGGCGAGGTAAAGAGCCCTTTGTCGAA
GTCAGCTGGGAGGTGGCCCTGGACCTGCTGGCGCGCGAGCTGCGCTCGGTCAAGGCGCGCTGCGGCAATGAGGCGATCTA
CGGCGGCTCCTACGGCTGGGCCAGCGCTGGACGCTTTCACCATGCGCAGAGCCAGCTGCACCGGTTTCTCAAGGGCTTTG
GCGGGTACACCGCCAGCACCAATACCTATAGCAGCGCCGCGGGCGAGCGTATTCTGCCGCATATTCTCGGGCCGCTGAGC
CCGCTGCACCGGCAGCATACCCATTTTTCCGAGCTGGCTCGGGAGTGTCAGCTGTTTGTCGCCATCGGCGGACTGCCGCT
GCGCAATGCCCAGGTCAACGGCGGCGGCGCCAATGACCATATGCTCCAGTACTGGCTGGATAAGATGCAGGCCAACGGCA
CGCGGTTTATCAATATCAGTCCGGTGCGCAATGACCTCAGCGCGGTGCCCGACGCCGAGTGGCTGGCCATTCGGCCGGGT
ACCGATATCGCACTGCTGCTGGCCCTGAGCTATGTGCTGATCGCTGAGTCTCTCTACGACCAGGCGTTTGTTGCCAGCCA
TACCGTCGGGTTTGCCCCCTATCGCGCTTATCTGTTGGGCGAGCACGATGGCGTAGCGAAAACCCCGGCGTGGGCGGCGG
CGATTACCGGCCTGGACGCCCAGCGCATCGCCGACCTGGCGCGGGAGATGGCCCGCCACCGGACGATGGTGAATATCTCC
TGGTCTATCCAGCGCGCCCGTCAAGGGGAGCAGGCCTACTGGGCGACGGTGGCCCTGACCGCGCTGCTGGGACAGCTCGG
CACCCCGGGCGGCGGCCTCGGGTTTGGCTACGCCTGCACCAACCTGGCGGGCGCGGTGCGAAAAGCGTTTTCCGGCCCGC
GCTTACCCGCCGGGGAGAATGCGGTGGACAGCGTTATCCCGGTGGCGCGGCTGTCCGATATGCTGCTGCACCCGGGAGAA
ACCTATGAGTTCGACGGTCAGCAGCGGCGCTATCCCGATATCCGTTTAGTCTACTGGGCGGGAGGCAATGCGTTTCATCA
TCATCAGGACATCAACCGACTGTGCGAGGCCTGGCGCCGCCCGGAGACGGTGGTGGTGCATGAGCAGTACTGGACCGCGC
AGGCCAAATTCTCCGATATCGTTCTGCCGGCCACCACCTCGCTGGAGCGAGAGGATATCGGCAGCGGCGGTCACGACGGG
TTTATGATCGCCATGAGCGCGCAGATCCCGCCGGTGGGCGAAGCGCGTGACGATTACGCCATTTTCTGCGATCTGGCCGG
GCGGCTGGGCTTCGGGGAAGCGTTCAGCGAAGGGCGTGACGCCGGGCAGTGGCTACGTCATCTCTATGAGGAGTCAAGAC
CGCGGGCGCAGGAGGAGGGTATTGCGCTGCCCTCGTTCGATGACTTCTGGCAGCAAGGGGTGCTGGAATACAGCGCGCCG
GAGCGGCCGCAAATTTTTCTCGCCGATTTTCGCGCCGATCCGCAGCGCTATCCGCTCTCCACCCCCTCCGGCAAAATTGA
ACTCTTTTCCGCCACCGTCGCCGGGTTTGGCTATCGCGAATGCCCTGGCCATCCGTGGTGGGATGAACAGGAGGCCGCCC
GCCAGCGGCAGGAGGCGGCGCGCTGGCCGCTTCATCTGCTCTCCAGCCAGCCGCGCGCCCGCCTGCACAGTCAGTACGAC
CACGGCAGCGTCAGCCGGGCGACGAAAGTTCAGGGACGCGAGCCGCTGTGGATGCATCCGAGCGATGCGCAGGCAAGGGA
TATCCGCGAAGGCAGCGTGGTGAAAGTCTATAACGACCGCGGGGCAATTCTGGCGGGGGTGCACCTGAGCGAGCAGATTT
TGCCCGGCGTGGTACAGATGTCCACCGGCGCCTGGTATGACCCGCTGGATCCGAAGGAAGAACGGTCGCTCGATAAGCAC
GGTAATCCCAACGTATTAACCGAGGATCGCGGCAGTTCGCGCCTGGGGCAGGGCTGTAGCGCCCAGAGCTGTTGGGTGGA
GATCGCCCCGTGGCGAGAGGAGCTGCCGCCGATCACTGCCTTTGATCCGCCGAAATTTATTGAAGTTTAG

Upstream 100 bases:

>100_bases
AAGCTTTTTTTAGCAGAGCAATGTCTGGCCGGGTAAGGATTATTACCCTATTTCCCCGCTTTATTGTAATGAACCTTAAG
CTGAGAAGAACGCGGGCGCT

Downstream 100 bases:

>100_bases
GCGTTGGCGCTCGCCGGCGGCGGGGCGGGTAGCCCGGAGAAGGCGCGGTATGCGCCGCCTCCGGCAAAGCCCGCGCCTGG
CGGTTTTAGACTGACGACAG

Product: biotin sulfoxide reductase

Products: Biotin [C]

Alternate protein names: DMSO reductase; DMSOR [H]

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MKKQHNYTVMHWGTWQVESREGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGFGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDIALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLAGRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPQRYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPKEERSLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV

Sequences:

>Translated_769_residues
MKKQHNYTVMHWGTWQVESREGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGFGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDIALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLAGRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPQRYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPKEERSLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
>Mature_769_residues
MKKQHNYTVMHWGTWQVESREGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRAGYLQHGPASREGRGKEPFVE
VSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFHHAQSQLHRFLKGFGGYTASTNTYSSAAGERILPHILGPLS
PLHRQHTHFSELARECQLFVAIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
TDIALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDAQRIADLAREMARHRTMVNIS
WSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACTNLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGE
TYEFDGQQRRYPDIRLVYWAGGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
FMIAMSAQIPPVGEARDDYAIFCDLAGRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEGIALPSFDDFWQQGVLEYSAP
ERPQIFLADFRADPQRYPLSTPSGKIELFSATVAGFGYRECPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYD
HGSVSRATKVQGREPLWMHPSDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPKEERSLDKH
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=778, Percent_Identity=37.2750642673522, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI145693196, Length=771, Percent_Identity=39.1699092088197, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1787231, Length=788, Percent_Identity=38.8324873096447, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=31.9148936170213, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1787870, Length=748, Percent_Identity=30.6149732620321, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI171474008, Length=751, Percent_Identity=30.3595206391478, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI3868721, Length=496, Percent_Identity=24.1935483870968, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.7.2.3 [C]

Molecular weight: Translated: 85391; Mature: 85391

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQHNYTVMHWGTWQVESREGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRA
CCCCCCEEEEEECEEEEECCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHCCHHHH
GYLQHGPASREGRGKEPFVEVSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFH
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
HAQSQLHRFLKGFGGYTASTNTYSSAAGERILPHILGPLSPLHRQHTHFSELARECQLFV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
AIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
EECCCEECCCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEECCC
TDIALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCH
QRIADLAREMARHRTMVNISWSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACT
HHHHHHHHHHHHCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
NLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGETYEFDGQQRRYPDIRLVYWA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
GGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
CCCCCHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEECCCCCCCHHHCCCCCCCC
FMIAMSAQIPPVGEARDDYAIFCDLAGRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEG
EEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHCC
IALPSFDDFWQQGVLEYSAPERPQIFLADFRADPQRYPLSTPSGKIELFSATVAGFGYRE
CCCCCHHHHHHHCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCC
CPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYDHGSVSRATKVQGREPLWMHP
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEECC
SDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPKEERSLDKH
CCCCHHHCCCCCEEEEECCCCCEEEECCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHC
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
CCCCEEECCCCCHHHCCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKQHNYTVMHWGTWQVESREGEIVAVKPVPWDKNPSRIGQSLPDAVTSQTRIRRPAVRA
CCCCCCEEEEEECEEEEECCCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHCCHHHH
GYLQHGPASREGRGKEPFVEVSWEVALDLLARELRSVKARCGNEAIYGGSYGWASAGRFH
CCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
HAQSQLHRFLKGFGGYTASTNTYSSAAGERILPHILGPLSPLHRQHTHFSELARECQLFV
HHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEE
AIGGLPLRNAQVNGGGANDHMLQYWLDKMQANGTRFINISPVRNDLSAVPDAEWLAIRPG
EECCCEECCCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCEEEECCC
TDIALLLALSYVLIAESLYDQAFVASHTVGFAPYRAYLLGEHDGVAKTPAWAAAITGLDA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCH
QRIADLAREMARHRTMVNISWSIQRARQGEQAYWATVALTALLGQLGTPGGGLGFGYACT
HHHHHHHHHHHHCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
NLAGAVRKAFSGPRLPAGENAVDSVIPVARLSDMLLHPGETYEFDGQQRRYPDIRLVYWA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEE
GGNAFHHHQDINRLCEAWRRPETVVVHEQYWTAQAKFSDIVLPATTSLEREDIGSGGHDG
CCCCCHHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCEEECCCCCCCHHHCCCCCCCC
FMIAMSAQIPPVGEARDDYAIFCDLAGRLGFGEAFSEGRDAGQWLRHLYEESRPRAQEEG
EEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCHHHCC
IALPSFDDFWQQGVLEYSAPERPQIFLADFRADPQRYPLSTPSGKIELFSATVAGFGYRE
CCCCCHHHHHHHCCEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCCCCCC
CPGHPWWDEQEAARQRQEAARWPLHLLSSQPRARLHSQYDHGSVSRATKVQGREPLWMHP
CCCCCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCCCCHHHHCCCCCCCEECC
SDAQARDIREGSVVKVYNDRGAILAGVHLSEQILPGVVQMSTGAWYDPLDPKEERSLDKH
CCCCHHHCCCCCEEEEECCCCCEEEECCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHC
GNPNVLTEDRGSSRLGQGCSAQSCWVEIAPWREELPPITAFDPPKFIEV
CCCCEEECCCCCHHHCCCCCCCCCEEEECCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds) [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8645727; 8534974; 7625833; 8658134 [H]