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The map label for this gene is uppS [H]

Identifier: 152968768

GI number: 152968768

Start: 220654

End: 221430

Strand: Direct

Name: uppS [H]

Synonym: KPN_00187

Alternate gene names: 152968768

Gene position: 220654-221430 (Clockwise)

Preceding gene: 152968767

Following gene: 152968769

Centisome position: 4.15

GC content: 53.93

Gene sequence:

>777_bases
ATGGACTTAAAACGCGTGATGTTGTCTGCTAATCAAACTGTCAGCGAAATATCGCCCACCCATGGCTGCCGTCATGTCGC
CATTATTATGGATGGCAACGGCCGTTGGGCGAAACGGCAAGGTAAAATTCGCGCTTTCGGGCATAAGGCCGGTGCGAAAT
CCGTGCGTCGCGCGGTCTCCTTCGCGGCGAATAATGGGATTGAGGCGTTAACGTTATACGCGTTCAGCAGCGAAAACTGG
AACCGTCCGGCTCAGGAAGTCAGTGCGCTGATGGAACTGTTCGTCTGGGCGCTGGATAGCGAAGTCAAAAGCCTGCACCG
ACACAATGTGCGTCTGCGGATTATTGGCGACACCACGCGCTTCAATGCGCGCCTGCAGGAGCGGATCCGCAAAGCGGAAG
CGCTAACCGCAAACAATACCGGCTTAACGCTGAATATTGCAGCCAATTACGGCGGTCGCTGGGATATTACCCAGGGCGTT
CGTTTGCTGGCGAAACAGGTACAGGACGGGACGCTGCTGCCTGAGCAGATCACGGAAGACATGCTGAGTCAGCAGGTCTG
CATGCATGAACTGGCTCCCGTTGATTTAGTTATTAGGACCGGGGGAGAGCACCGAATAAGTAACTTTCTGATTTGGCAAA
TTGCCTATGCCGAACTTTACTTTACGGATGTTCTTTGGCCCGATTTTGCTGAACAGGACTTTGAAGGTGCACTCCATGCC
TTTGTTAATCGAGAGCGTCGTTTCGGCGGCACTGAGCCGGGTGGCAGTCATGCCTGA

Upstream 100 bases:

>100_bases
TTGGTTGTTCTCTGCGATTGGCTGCAGCCCCGGCACCGGATAAAAATGCGTATCCAGCGCGGCCCGGTGGCCTCTGTTTG
GTGGCTAGTTAATCCTTATT

Downstream 100 bases:

>100_bases
TGGGGGTCACTTTTGCTGAAGTATCGCCTGATATCTGCTTTCGTCTTAATCCCCATCGTCATTGCGGCATTGTTTTTATT
GCCGCCGATGGGCTTTGCTA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MDLKRVMLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENW
NRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGV
RLLAKQVQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHA
FVNRERRFGGTEPGGSHA

Sequences:

>Translated_258_residues
MDLKRVMLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENW
NRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGV
RLLAKQVQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHA
FVNRERRFGGTEPGGSHA
>Mature_258_residues
MDLKRVMLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVSFAANNGIEALTLYAFSSENW
NRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTRFNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGV
RLLAKQVQDGTLLPEQITEDMLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHA
FVNRERRFGGTEPGGSHA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=209, Percent_Identity=37.3205741626794, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI45580742, Length=209, Percent_Identity=37.3205741626794, Blast_Score=137, Evalue=8e-33,
Organism=Escherichia coli, GI1786371, Length=253, Percent_Identity=87.7470355731225, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71993029, Length=216, Percent_Identity=36.1111111111111, Blast_Score=130, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=236, Percent_Identity=33.4745762711864, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=31.3084112149533, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18857969, Length=222, Percent_Identity=35.1351351351351, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28953; Mature: 28953

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKRVMLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVS
CCHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHH
FAANNGIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTR
HHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
FNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQVQDGTLLPEQITED
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
MLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FVNRERRFGGTEPGGSHA
HHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDLKRVMLSANQTVSEISPTHGCRHVAIIMDGNGRWAKRQGKIRAFGHKAGAKSVRRAVS
CCHHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHHH
FAANNGIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTTR
HHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
FNARLQERIRKAEALTANNTGLTLNIAANYGGRWDITQGVRLLAKQVQDGTLLPEQITED
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
MLSQQVCMHELAPVDLVIRTGGEHRISNFLIWQIAYAELYFTDVLWPDFAEQDFEGALHA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FVNRERRFGGTEPGGSHA
HHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]