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The map label for this gene is gcvT [H]

Identifier: 150398506

GI number: 150398506

Start: 3510085

End: 3512454

Strand: Reverse

Name: gcvT [H]

Synonym: Smed_3316

Alternate gene names: 150398506

Gene position: 3512454-3510085 (Counterclockwise)

Preceding gene: 150398508

Following gene: 150398498

Centisome position: 92.88

GC content: 62.15

Gene sequence:

>2370_bases
ATGGAAGATCGCCATCCCGGAATGCTTGGAGGGAGGCCCGTTTCGGCGAGCATCATCCGCTATCCGGGCATTCCTGCGCT
TCCAAAGGACAGGGAACGGTATCGATGCAAGGGTGGCGGCTCGCTGGTCGTTCGCGTCGAAGCGGGAGACCACGTGACGG
TCACCGATATCGAAGGTTGCCAGGCATGCGAGCTTTCCTTCCTCGACGAAGACGGCCGCTTCCAGTCGGCAGGACTTGGC
ACCGCTTTCACCAATGACGCGGAGGGACTGAAGACCATTCTGTCCCTCGAAGAGGAGAGCTCGCTTCGCACTCGAAACGC
CCTCCGGCGTCGCGGCGCGGATCTCTCCACGGCCGGCGCTCTGCGTGTCTTCGGGGAGCGGTCCACGCCGGGCAGCAAGG
CGGAATTCACGACCACGATGAAGGGACTGCTGATCGTTGCCGCTCCCGGAAAGGCGATGGCGCCAGAGGCACAGGACACG
GCAACGCCCATCGAGACCATGATCCGCCGCAGCAGGCCGATCCGCGACTATACCTCCGCCCTGCCGGAACCGCTGGCCGA
TCCGATCCACGACATCCGCATCAAGGCCGCCACTGCGTCAGCATATTTCGTACGGGCCGGAGAATTCATACAAATCATCG
ACGTATACGGCCGCCAGTGCACGGACTTCCAGGCCTTTGCCGCCCGCAAGGTCGACAAGGGCCTCGACCGGGCGCTCGAT
TCGACCGTCACGCGTACCCTGCTGGGACGCAGCTACCCGGCGCCGGGCCTGCCGTCCAAGGCTTTCGATCGCGATTTCGA
GCCGCTTGTGGAGATCGTACAGGACACGGTCGGCCGCCATGACGCCTTCGCCACCGCCTGCAATGCGCGGTACTACGACG
ATATGGGCTATCCCGGCCACGTCAATTGTACGGACAATTTCAATGCGGCGCTTGCTCCTTACGGAATTTCCGGCCGGAAG
GGCTGGGAAGCGCTCAATTATTTCTACAACACCAGTATCGATCACAACAACCAGCTCTATCTCGATGAGCCCTGGTCTCG
TCCGGGCGACTATGTGCTGATGCGAGCCGTGACGGACCTGATCTGCGTCTCGTCCTCCTGCCCAGACGACATCGATGCGG
CAAACGGCTGGGATCCGACCGACATTCACGTCCGGACCTTTTCCGGAAACGAGCAATTCTCACGAGCGGTAGCCTATCGC
ATGACACCCGATGCCGATCCCGAAATGACGCGCGAAACAGCCTTCCATCCCCGCTTCTCGGCGCTCACGCGGGACTACGC
CGAGTATCGCGGCTATTGGCTGCCGAACCGGTTTTCGTCGGAAGGACCGATCGAGGAATACTGGGCCTGCCGCGAGAGAG
CCGCAGTCATCGACCTCTCGCCGCTGCGGAAGTTCGAGGTCACGGGCCCGGATGCCGAGGAATTGCTGCAATATTGCCTG
ACGCGCGACGTACGCAAGCTTTCCACGGGCCAGGTCGTCTATTCCGCAATGTGCTACGAGCATGGCGGCATGATCGACGA
CGGAACCCTCTTCCGCCTCGGTGATAAGAACTTCCGCTGGATCGGCGGCGACGATTACAGCGGCATCTGGCTGCGAGAGC
AGGCGGAGAAGAAGGGCTTCAGGGCCTGGGTGCGCTCATCGACCGACCAGATGCATAATATTGCCGTTCAGGGGCCGAAG
AGCCGCGATATCCTCAGGGAGATCATCTGGACAGCACCCCGTCAGTCCACGATCAGCGAGCTCGAATGGTTCCGCTTTGC
GGTCGGTCGCATCGGGGGGTTCGAAGGCGCACCTGTCGTCGTCTCCCGCACCGGGTATACCGGCGAACTCGGCTACGAAA
TATTCTGTCATCCGAAAGATGCACTGACCGTATTCGACGCGGTCTGGCAGGCTGGAGAGCCGCATGGGATGAAGCCGATG
GGGTTGGAAGCGCTCGACATGGTTCGCATCGAGGCGGGCCTGATCTTCGCCCATTACGACTTCGACGATCAGACCGACCC
GTTCGAGGCCGGTATCGGCTTCACGGTGCCGCTGAAATCAAAGCCGGACGATTTCATAGGCCGCGAAGCGCTGATGCGCC
GCAAGGAAAGCCCACGCCAGCTGATGGTCGGGCTCGACGTTCTGGCGAACGAGGCGATCGGCCATGGCGATTGCGTGCAT
GTCGGACGCGCGCAGATCGGCGTTGTCACCAGTGCAACCCGTTCGCCGGTCCTCGGCAAGACGATCGCACTCGCCCGGAT
CGACGTCACGCATGCGACGGTCGGTACGCAGGTCGAGATCGGCAAACTCGACGGCCAGCAAAAACGCCTGCCGGCGGCTG
TCGTGCCGCTGTCGCATTACGATCCCCAGAAGAAGCGGCCGCGCTCGTAG

Upstream 100 bases:

>100_bases
ATAGTGAAGAAAGTTTCTTCTTAGTCAATATCCCCTTTACTTCCGCCTGGTACTTTGCCAGCATGATCGGGCCAGGGGAC
ATTCCTACGCGAGGGTTGTT

Downstream 100 bases:

>100_bases
ACCGCGACGTTTTCACGTGGGATCGATCTAAAAACATGAACGTGATCTAAACAATTTCGCCCTTCATCCGGCATACGGAT
GAAGGGCGAAGCGATTTCGC

Product: glycine cleavage T protein (aminomethyl transferase)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MEDRHPGMLGGRPVSASIIRYPGIPALPKDRERYRCKGGGSLVVRVEAGDHVTVTDIEGCQACELSFLDEDGRFQSAGLG
TAFTNDAEGLKTILSLEEESSLRTRNALRRRGADLSTAGALRVFGERSTPGSKAEFTTTMKGLLIVAAPGKAMAPEAQDT
ATPIETMIRRSRPIRDYTSALPEPLADPIHDIRIKAATASAYFVRAGEFIQIIDVYGRQCTDFQAFAARKVDKGLDRALD
STVTRTLLGRSYPAPGLPSKAFDRDFEPLVEIVQDTVGRHDAFATACNARYYDDMGYPGHVNCTDNFNAALAPYGISGRK
GWEALNYFYNTSIDHNNQLYLDEPWSRPGDYVLMRAVTDLICVSSSCPDDIDAANGWDPTDIHVRTFSGNEQFSRAVAYR
MTPDADPEMTRETAFHPRFSALTRDYAEYRGYWLPNRFSSEGPIEEYWACRERAAVIDLSPLRKFEVTGPDAEELLQYCL
TRDVRKLSTGQVVYSAMCYEHGGMIDDGTLFRLGDKNFRWIGGDDYSGIWLREQAEKKGFRAWVRSSTDQMHNIAVQGPK
SRDILREIIWTAPRQSTISELEWFRFAVGRIGGFEGAPVVVSRTGYTGELGYEIFCHPKDALTVFDAVWQAGEPHGMKPM
GLEALDMVRIEAGLIFAHYDFDDQTDPFEAGIGFTVPLKSKPDDFIGREALMRRKESPRQLMVGLDVLANEAIGHGDCVH
VGRAQIGVVTSATRSPVLGKTIALARIDVTHATVGTQVEIGKLDGQQKRLPAAVVPLSHYDPQKKRPRS

Sequences:

>Translated_789_residues
MEDRHPGMLGGRPVSASIIRYPGIPALPKDRERYRCKGGGSLVVRVEAGDHVTVTDIEGCQACELSFLDEDGRFQSAGLG
TAFTNDAEGLKTILSLEEESSLRTRNALRRRGADLSTAGALRVFGERSTPGSKAEFTTTMKGLLIVAAPGKAMAPEAQDT
ATPIETMIRRSRPIRDYTSALPEPLADPIHDIRIKAATASAYFVRAGEFIQIIDVYGRQCTDFQAFAARKVDKGLDRALD
STVTRTLLGRSYPAPGLPSKAFDRDFEPLVEIVQDTVGRHDAFATACNARYYDDMGYPGHVNCTDNFNAALAPYGISGRK
GWEALNYFYNTSIDHNNQLYLDEPWSRPGDYVLMRAVTDLICVSSSCPDDIDAANGWDPTDIHVRTFSGNEQFSRAVAYR
MTPDADPEMTRETAFHPRFSALTRDYAEYRGYWLPNRFSSEGPIEEYWACRERAAVIDLSPLRKFEVTGPDAEELLQYCL
TRDVRKLSTGQVVYSAMCYEHGGMIDDGTLFRLGDKNFRWIGGDDYSGIWLREQAEKKGFRAWVRSSTDQMHNIAVQGPK
SRDILREIIWTAPRQSTISELEWFRFAVGRIGGFEGAPVVVSRTGYTGELGYEIFCHPKDALTVFDAVWQAGEPHGMKPM
GLEALDMVRIEAGLIFAHYDFDDQTDPFEAGIGFTVPLKSKPDDFIGREALMRRKESPRQLMVGLDVLANEAIGHGDCVH
VGRAQIGVVTSATRSPVLGKTIALARIDVTHATVGTQVEIGKLDGQQKRLPAAVVPLSHYDPQKKRPRS
>Mature_789_residues
MEDRHPGMLGGRPVSASIIRYPGIPALPKDRERYRCKGGGSLVVRVEAGDHVTVTDIEGCQACELSFLDEDGRFQSAGLG
TAFTNDAEGLKTILSLEEESSLRTRNALRRRGADLSTAGALRVFGERSTPGSKAEFTTTMKGLLIVAAPGKAMAPEAQDT
ATPIETMIRRSRPIRDYTSALPEPLADPIHDIRIKAATASAYFVRAGEFIQIIDVYGRQCTDFQAFAARKVDKGLDRALD
STVTRTLLGRSYPAPGLPSKAFDRDFEPLVEIVQDTVGRHDAFATACNARYYDDMGYPGHVNCTDNFNAALAPYGISGRK
GWEALNYFYNTSIDHNNQLYLDEPWSRPGDYVLMRAVTDLICVSSSCPDDIDAANGWDPTDIHVRTFSGNEQFSRAVAYR
MTPDADPEMTRETAFHPRFSALTRDYAEYRGYWLPNRFSSEGPIEEYWACRERAAVIDLSPLRKFEVTGPDAEELLQYCL
TRDVRKLSTGQVVYSAMCYEHGGMIDDGTLFRLGDKNFRWIGGDDYSGIWLREQAEKKGFRAWVRSSTDQMHNIAVQGPK
SRDILREIIWTAPRQSTISELEWFRFAVGRIGGFEGAPVVVSRTGYTGELGYEIFCHPKDALTVFDAVWQAGEPHGMKPM
GLEALDMVRIEAGLIFAHYDFDDQTDPFEAGIGFTVPLKSKPDDFIGREALMRRKESPRQLMVGLDVLANEAIGHGDCVH
VGRAQIGVVTSATRSPVLGKTIALARIDVTHATVGTQVEIGKLDGQQKRLPAAVVPLSHYDPQKKRPRS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=354, Percent_Identity=28.8135593220339, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI197927446, Length=364, Percent_Identity=29.9450549450549, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI21361378, Length=364, Percent_Identity=29.9450549450549, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI194306651, Length=254, Percent_Identity=30.7086614173228, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI44662838, Length=387, Percent_Identity=24.031007751938, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI257796258, Length=365, Percent_Identity=24.1095890410959, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI257796256, Length=329, Percent_Identity=25.2279635258359, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI257796254, Length=231, Percent_Identity=28.1385281385281, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789272, Length=351, Percent_Identity=32.1937321937322, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560118, Length=364, Percent_Identity=29.6703296703297, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71994052, Length=325, Percent_Identity=31.3846153846154, Blast_Score=118, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71994045, Length=325, Percent_Identity=31.3846153846154, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563613, Length=312, Percent_Identity=27.5641025641026, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320222, Length=394, Percent_Identity=24.6192893401015, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571104, Length=273, Percent_Identity=30.4029304029304, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI20129441, Length=349, Percent_Identity=25.7879656160458, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI20130091, Length=314, Percent_Identity=25.4777070063694, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 87489; Mature: 87489

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDRHPGMLGGRPVSASIIRYPGIPALPKDRERYRCKGGGSLVVRVEAGDHVTVTDIEGC
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHEEECCCCEEEEEEECCCEEEEEECCCC
QACELSFLDEDGRFQSAGLGTAFTNDAEGLKTILSLEEESSLRTRNALRRRGADLSTAGA
CEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LRVFGERSTPGSKAEFTTTMKGLLIVAAPGKAMAPEAQDTATPIETMIRRSRPIRDYTSA
EEEEECCCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHH
LPEPLADPIHDIRIKAATASAYFVRAGEFIQIIDVYGRQCTDFQAFAARKVDKGLDRALD
CCHHHHCCHHHEEEEEEECCEEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
STVTRTLLGRSYPAPGLPSKAFDRDFEPLVEIVQDTVGRHDAFATACNARYYDDMGYPGH
HHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCE
VNCTDNFNAALAPYGISGRKGWEALNYFYNTSIDHNNQLYLDEPWSRPGDYVLMRAVTDL
EECCCCCCCEECCCCCCCCCHHHHHHHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHH
ICVSSSCPDDIDAANGWDPTDIHVRTFSGNEQFSRAVAYRMTPDADPEMTRETAFHPRFS
HHHCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHEEEECCCCCCHHHHHHHCCCCHHH
ALTRDYAEYRGYWLPNRFSSEGPIEEYWACRERAAVIDLSPLRKFEVTGPDAEELLQYCL
HHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCHHHHHHHHH
TRDVRKLSTGQVVYSAMCYEHGGMIDDGTLFRLGDKNFRWIGGDDYSGIWLREQAEKKGF
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCCEEEHHHHHHHHH
RAWVRSSTDQMHNIAVQGPKSRDILREIIWTAPRQSTISELEWFRFAVGRIGGFEGAPVV
HHHHHCCHHHHHEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
VSRTGYTGELGYEIFCHPKDALTVFDAVWQAGEPHGMKPMGLEALDMVRIEAGLIFAHYD
EEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEEEEEEEEC
FDDQTDPFEAGIGFTVPLKSKPDDFIGREALMRRKESPRQLMVGLDVLANEAIGHGDCVH
CCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEE
VGRAQIGVVTSATRSPVLGKTIALARIDVTHATVGTQVEIGKLDGQQKRLPAAVVPLSHY
ECCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCCHHHCCCEEEEECCCC
DPQKKRPRS
CCCCCCCCC
>Mature Secondary Structure
MEDRHPGMLGGRPVSASIIRYPGIPALPKDRERYRCKGGGSLVVRVEAGDHVTVTDIEGC
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHEEECCCCEEEEEEECCCEEEEEECCCC
QACELSFLDEDGRFQSAGLGTAFTNDAEGLKTILSLEEESSLRTRNALRRRGADLSTAGA
CEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LRVFGERSTPGSKAEFTTTMKGLLIVAAPGKAMAPEAQDTATPIETMIRRSRPIRDYTSA
EEEEECCCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHH
LPEPLADPIHDIRIKAATASAYFVRAGEFIQIIDVYGRQCTDFQAFAARKVDKGLDRALD
CCHHHHCCHHHEEEEEEECCEEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
STVTRTLLGRSYPAPGLPSKAFDRDFEPLVEIVQDTVGRHDAFATACNARYYDDMGYPGH
HHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCE
VNCTDNFNAALAPYGISGRKGWEALNYFYNTSIDHNNQLYLDEPWSRPGDYVLMRAVTDL
EECCCCCCCEECCCCCCCCCHHHHHHHHEECCCCCCCEEEEECCCCCCCCHHHHHHHHHH
ICVSSSCPDDIDAANGWDPTDIHVRTFSGNEQFSRAVAYRMTPDADPEMTRETAFHPRFS
HHHCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHEEEECCCCCCHHHHHHHCCCCHHH
ALTRDYAEYRGYWLPNRFSSEGPIEEYWACRERAAVIDLSPLRKFEVTGPDAEELLQYCL
HHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEECCCCHHHHHHHHH
TRDVRKLSTGQVVYSAMCYEHGGMIDDGTLFRLGDKNFRWIGGDDYSGIWLREQAEKKGF
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCCEEEHHHHHHHHH
RAWVRSSTDQMHNIAVQGPKSRDILREIIWTAPRQSTISELEWFRFAVGRIGGFEGAPVV
HHHHHCCHHHHHEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
VSRTGYTGELGYEIFCHPKDALTVFDAVWQAGEPHGMKPMGLEALDMVRIEAGLIFAHYD
EEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEEEEEEEEC
FDDQTDPFEAGIGFTVPLKSKPDDFIGREALMRRKESPRQLMVGLDVLANEAIGHGDCVH
CCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEE
VGRAQIGVVTSATRSPVLGKTIALARIDVTHATVGTQVEIGKLDGQQKRLPAAVVPLSHY
ECCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCEEEEECCCCHHHCCCEEEEECCCC
DPQKKRPRS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA