Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 150398400

GI number: 150398400

Start: 3383576

End: 3384607

Strand: Reverse

Name: hemE

Synonym: Smed_3208

Alternate gene names: 150398400

Gene position: 3384607-3383576 (Counterclockwise)

Preceding gene: 150398406

Following gene: 150398399

Centisome position: 89.49

GC content: 63.57

Gene sequence:

>1032_bases
GTGAGCGGAACGCATCGCAAAGTGCTAGAGGTTTTGAACGGGAGATCGCTCACGCCTCCCCCCATCTGGCTGATGCGGCA
GGCTGGACGCTACCTCCCCGAATACAGGGCAACCCGGATAAAGGCCGGAAGCTTCCTCGACCTCTGCTACACACCCGAGC
TTGCAGTCGAAGTGACATTGCAGCCGATCCGCCGCTACGGCTTCGATGCCGCGATCCTCTTCTCCGATATTCTGGTCGTT
CCCGATGCACTCAATCGAAATGTTCGCTTCGAAGAGGGGCAGGGACCGCGGATGGATCCGATCGACGAGGACGGTATAGC
GCAGCTGAGCCAGACAGGCGTCATCGAGCACCTTGCCCCGGTCTTCGAGACGGTCTCTCGACTCAGGGGCGAATTGGCGG
CGGAAATCACGCTGCTCGGCTTTTGCGGGGCGCCCTGGACCGTGGCGACCTATATGATCGCCGGTCGCGGGACGCCAGAC
CAGGCGCCGGCGCGCCTCTTCGCCTATCGTCATCCCAAGGCCTTTGAACGGCTTCTGGCGCTGCTTGCCGATATTTCCGC
CGACTACCTGGTCGAACAGATCGATCGCGGTGCGGATGCGGTGCAAATCTTCGACTCCTGGGCCGGTGTGCTCGGCGAGG
AAGAATTCCAACGTTACGCGGTGGAGCCTGTCCGGCGCATCATCGCCTCGGTCCGGTCCCGCCGGCCTTCGGCGAAAATC
ATCGCCTTTGCGAAAGGCGCCGGCATCCTGTTGAAGAACTATCGGCAAGCGACCGGCGCGGACGCAATCGGCCTCGATTG
GTCGGTGCCGCTCTCCTTCGCAGCGGAGCTGCAGAAGGACGGGCCGGTTCAGGGCAATCTCGATCCGGTGCGGGTCGTGG
CCGGTGGCGCGGCGCTGGAGCATGGAATCGACCGTATCCTGGACGTCCTCGGGCAAGGGCCGCTGATCTTCAATCTGGGC
CACGGCATCACGCCGGACGCGGATCCGGAGCATGTCGCCGCGCTTGTGTCTCGCGTCCGAGGACGCCGATGA

Upstream 100 bases:

>100_bases
CTGGATGGAACGAGGATCGATTTTAATCCTTGATACTCACCGACTCTAAGAAATAGAAACCTTATAAATTCAGTTTTATT
TTTATATTAGGAAGCGGCAA

Downstream 100 bases:

>100_bases
GAGGCGAACGTCAAACCGACCGCGGCCCCGGCAGACGGGCGCGGTTTCGGGCTGCTATCGCGCTTTCCGCCTTTACGGCC
TTGCTGATCGGCCTCTTCGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSGTHRKVLEVLNGRSLTPPPIWLMRQAGRYLPEYRATRIKAGSFLDLCYTPELAVEVTLQPIRRYGFDAAILFSDILVV
PDALNRNVRFEEGQGPRMDPIDEDGIAQLSQTGVIEHLAPVFETVSRLRGELAAEITLLGFCGAPWTVATYMIAGRGTPD
QAPARLFAYRHPKAFERLLALLADISADYLVEQIDRGADAVQIFDSWAGVLGEEEFQRYAVEPVRRIIASVRSRRPSAKI
IAFAKGAGILLKNYRQATGADAIGLDWSVPLSFAAELQKDGPVQGNLDPVRVVAGGAALEHGIDRILDVLGQGPLIFNLG
HGITPDADPEHVAALVSRVRGRR

Sequences:

>Translated_343_residues
MSGTHRKVLEVLNGRSLTPPPIWLMRQAGRYLPEYRATRIKAGSFLDLCYTPELAVEVTLQPIRRYGFDAAILFSDILVV
PDALNRNVRFEEGQGPRMDPIDEDGIAQLSQTGVIEHLAPVFETVSRLRGELAAEITLLGFCGAPWTVATYMIAGRGTPD
QAPARLFAYRHPKAFERLLALLADISADYLVEQIDRGADAVQIFDSWAGVLGEEEFQRYAVEPVRRIIASVRSRRPSAKI
IAFAKGAGILLKNYRQATGADAIGLDWSVPLSFAAELQKDGPVQGNLDPVRVVAGGAALEHGIDRILDVLGQGPLIFNLG
HGITPDADPEHVAALVSRVRGRR
>Mature_342_residues
SGTHRKVLEVLNGRSLTPPPIWLMRQAGRYLPEYRATRIKAGSFLDLCYTPELAVEVTLQPIRRYGFDAAILFSDILVVP
DALNRNVRFEEGQGPRMDPIDEDGIAQLSQTGVIEHLAPVFETVSRLRGELAAEITLLGFCGAPWTVATYMIAGRGTPDQ
APARLFAYRHPKAFERLLALLADISADYLVEQIDRGADAVQIFDSWAGVLGEEEFQRYAVEPVRRIIASVRSRRPSAKII
AFAKGAGILLKNYRQATGADAIGLDWSVPLSFAAELQKDGPVQGNLDPVRVVAGGAALEHGIDRILDVLGQGPLIFNLGH
GITPDADPEHVAALVSRVRGRR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=329, Percent_Identity=42.2492401215805, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI2367337, Length=326, Percent_Identity=42.0245398773006, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=32.9512893982808, Blast_Score=195, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921920, Length=329, Percent_Identity=39.5136778115502, Blast_Score=215, Evalue=3e-56,
Organism=Drosophila melanogaster, GI221330099, Length=329, Percent_Identity=39.5136778115502, Blast_Score=215, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SINMW (A6UEF2)

Other databases:

- EMBL:   CP000738
- RefSeq:   YP_001328867.1
- ProteinModelPortal:   A6UEF2
- SMR:   A6UEF2
- STRING:   A6UEF2
- GeneID:   5324087
- GenomeReviews:   CP000738_GR
- KEGG:   smd:Smed_3208
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   SMED366394:SMED_3208-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37508; Mature: 37376

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 76-76 BINDING 151-151 BINDING 206-206 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTHRKVLEVLNGRSLTPPPIWLMRQAGRYLPEYRATRIKAGSFLDLCYTPELAVEVTL
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCEEEHHH
QPIRRYGFDAAILFSDILVVPDALNRNVRFEEGQGPRMDPIDEDGIAQLSQTGVIEHLAP
HHHHHCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VFETVSRLRGELAAEITLLGFCGAPWTVATYMIAGRGTPDQAPARLFAYRHPKAFERLLA
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
LLADISADYLVEQIDRGADAVQIFDSWAGVLGEEEFQRYAVEPVRRIIASVRSRRPSAKI
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IAFAKGAGILLKNYRQATGADAIGLDWSVPLSFAAELQKDGPVQGNLDPVRVVAGGAALE
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHH
HGIDRILDVLGQGPLIFNLGHGITPDADPEHVAALVSRVRGRR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGTHRKVLEVLNGRSLTPPPIWLMRQAGRYLPEYRATRIKAGSFLDLCYTPELAVEVTL
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCCEEEHHH
QPIRRYGFDAAILFSDILVVPDALNRNVRFEEGQGPRMDPIDEDGIAQLSQTGVIEHLAP
HHHHHCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VFETVSRLRGELAAEITLLGFCGAPWTVATYMIAGRGTPDQAPARLFAYRHPKAFERLLA
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
LLADISADYLVEQIDRGADAVQIFDSWAGVLGEEEFQRYAVEPVRRIIASVRSRRPSAKI
HHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IAFAKGAGILLKNYRQATGADAIGLDWSVPLSFAAELQKDGPVQGNLDPVRVVAGGAALE
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCHHHH
HGIDRILDVLGQGPLIFNLGHGITPDADPEHVAALVSRVRGRR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA