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The map label for this gene is hemC [H]

Identifier: 150398163

GI number: 150398163

Start: 3112412

End: 3113404

Strand: Direct

Name: hemC [H]

Synonym: Smed_2966

Alternate gene names: 150398163

Gene position: 3112412-3113404 (Clockwise)

Preceding gene: 150398157

Following gene: 150398164

Centisome position: 82.3

GC content: 64.95

Gene sequence:

>993_bases
ATGGTTTCGTCCTTAAATCGATTCCGATTTAAGCAACCACGCAGTAACAACGGATGGCAGAGGATGCAAACAAAACCTTT
CCGCATAGGCACCCGCGGCAGTCCGCTGGCGCTGGCCCAGACGCATGAAACGCGCGATCGTCTCGCCGCCGCTCATGGTC
TGCCCGTGGAGATGTTCGAGATCGTCACACTCTCCACCAAGGGCGACCGGATCACCGACCGGTCCCTTGCAGAGATCGGC
GGCAAGGGTCTGTTCACCGAAGAGCTCGAACAGCAGCTTCTGTCGGGAGACCTCGATTTTGCCGTGCATTCGTCGAAGGA
CATGACGACGAAGCTGCCCGACGGTCTGTTTCTTTCTGCTTTTCTGCCGCGCGAGGACGTCCGCGACGCCTTTGTCGGCC
GTTCCGCCACAAGGCTTGCCGAGCTCCCGCAAGGGGCCACCGTGGGGTCGTCGTCCCTGCGGCGTCAGGCGCTGATCCGG
CGGTTGCGACCGGACGTCAACGTGATCACCTATCGTGGTCAGGTCGAGACGCGCCTGCGCAAGCTCGCCGAGGGGCAGGT
CGACGGCACGCTTCTGGCCTATGCCGGCCTGAGGCGGCTGGGCATGGCCCATGTTCCAACGGAGCTGCTCGACCCCGAGT
CGTTCCCGCCGGCGCCCGCCCAAGGTGCGATCTGTATCGAAGCGCGCCTCGGCGACGACCGCATCAACGCGCTGCTTTCT
GCTGTCGACGACCCCCGCACCCATGAGGCAGTCTCCTGCGAGCGTGGCTTCCTGGCGACGCTCGACGGCTCCTGCCGCAC
GCCGATAGCCGGTTACGCGCAGTCGGATGGGGCGCGTATCCGCTTTTCCGGCATGATCCTGACGCCGGACGGCACGACCT
GCCATCGCATCGAAACCGATGGCAGAACGGCGGACGCGGCGGCGCTCGGGCGGGAAGCGGGCGAGCGGATCCGCGCCAAG
GCCGGACCGGAATTCTTCTTGAGCTGGAGCTAG

Upstream 100 bases:

>100_bases
TCAACGATTGCGGTCGCAGTGAAAGGTGGCTACACGGAACTCACACAGCGGCGTGCGTCTGTCTGAGCATGAAGGACGCT
TTAAAGCTTTGAAGTGCTGC

Downstream 100 bases:

>100_bases
AGCGGGATGAAGAAGAACATGCGCGATTTACCCCCCGCGTTCCGCTTTGATTTTGCCGGAGGCGCGTGCGGAGATTTCAA
TCCGATCCTCCCTGAAATCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MVSSLNRFRFKQPRSNNGWQRMQTKPFRIGTRGSPLALAQTHETRDRLAAAHGLPVEMFEIVTLSTKGDRITDRSLAEIG
GKGLFTEELEQQLLSGDLDFAVHSSKDMTTKLPDGLFLSAFLPREDVRDAFVGRSATRLAELPQGATVGSSSLRRQALIR
RLRPDVNVITYRGQVETRLRKLAEGQVDGTLLAYAGLRRLGMAHVPTELLDPESFPPAPAQGAICIEARLGDDRINALLS
AVDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGARIRFSGMILTPDGTTCHRIETDGRTADAAALGREAGERIRAK
AGPEFFLSWS

Sequences:

>Translated_330_residues
MVSSLNRFRFKQPRSNNGWQRMQTKPFRIGTRGSPLALAQTHETRDRLAAAHGLPVEMFEIVTLSTKGDRITDRSLAEIG
GKGLFTEELEQQLLSGDLDFAVHSSKDMTTKLPDGLFLSAFLPREDVRDAFVGRSATRLAELPQGATVGSSSLRRQALIR
RLRPDVNVITYRGQVETRLRKLAEGQVDGTLLAYAGLRRLGMAHVPTELLDPESFPPAPAQGAICIEARLGDDRINALLS
AVDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGARIRFSGMILTPDGTTCHRIETDGRTADAAALGREAGERIRAK
AGPEFFLSWS
>Mature_330_residues
MVSSLNRFRFKQPRSNNGWQRMQTKPFRIGTRGSPLALAQTHETRDRLAAAHGLPVEMFEIVTLSTKGDRITDRSLAEIG
GKGLFTEELEQQLLSGDLDFAVHSSKDMTTKLPDGLFLSAFLPREDVRDAFVGRSATRLAELPQGATVGSSSLRRQALIR
RLRPDVNVITYRGQVETRLRKLAEGQVDGTLLAYAGLRRLGMAHVPTELLDPESFPPAPAQGAICIEARLGDDRINALLS
AVDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGARIRFSGMILTPDGTTCHRIETDGRTADAAALGREAGERIRAK
AGPEFFLSWS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=273, Percent_Identity=39.1941391941392, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI66933009, Length=273, Percent_Identity=39.1941391941392, Blast_Score=171, Evalue=8e-43,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=42.2950819672131, Blast_Score=217, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6319996, Length=320, Percent_Identity=31.5625, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20130425, Length=260, Percent_Identity=43.0769230769231, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 36070; Mature: 36070

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSLNRFRFKQPRSNNGWQRMQTKPFRIGTRGSPLALAQTHETRDRLAAAHGLPVEMFE
CCCCCCHHHCCCCCCCCCHHHHCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
IVTLSTKGDRITDRSLAEIGGKGLFTEELEQQLLSGDLDFAVHSSKDMTTKLPDGLFLSA
EEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEE
FLPREDVRDAFVGRSATRLAELPQGATVGSSSLRRQALIRRLRPDVNVITYRGQVETRLR
CCCHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
KLAEGQVDGTLLAYAGLRRLGMAHVPTELLDPESFPPAPAQGAICIEARLGDDRINALLS
HHHCCCCCCHHHHHHHHHHHCHHHCCHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHH
AVDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGARIRFSGMILTPDGTTCHRIETD
HHCCCCCCCHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEECC
GRTADAAALGREAGERIRAKAGPEFFLSWS
CCCHHHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MVSSLNRFRFKQPRSNNGWQRMQTKPFRIGTRGSPLALAQTHETRDRLAAAHGLPVEMFE
CCCCCCHHHCCCCCCCCCHHHHCCCCEEECCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
IVTLSTKGDRITDRSLAEIGGKGLFTEELEQQLLSGDLDFAVHSSKDMTTKLPDGLFLSA
EEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEE
FLPREDVRDAFVGRSATRLAELPQGATVGSSSLRRQALIRRLRPDVNVITYRGQVETRLR
CCCHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
KLAEGQVDGTLLAYAGLRRLGMAHVPTELLDPESFPPAPAQGAICIEARLGDDRINALLS
HHHCCCCCCHHHHHHHHHHHCHHHCCHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHH
AVDDPRTHEAVSCERGFLATLDGSCRTPIAGYAQSDGARIRFSGMILTPDGTTCHRIETD
HHCCCCCCCHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEEEECC
GRTADAAALGREAGERIRAKAGPEFFLSWS
CCCHHHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]