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The map label for this gene is lrp [H]

Identifier: 150397772

GI number: 150397772

Start: 2671333

End: 2671797

Strand: Direct

Name: lrp [H]

Synonym: Smed_2574

Alternate gene names: 150397772

Gene position: 2671333-2671797 (Clockwise)

Preceding gene: 150397771

Following gene: 150397774

Centisome position: 70.63

GC content: 61.29

Gene sequence:

>465_bases
ATGCACCAGATCGACAAGACGGACCGGAGAATCCTCAATATCCTGCAGGCGGACGGGCGGATTACCAATCTGGAACTCGC
CGACCGGATCGGGCTTTCCCCGACCGCGACCAGCGAACGCCTGAGGCGGCTCCTGAAAGAGGGCTATGTTTCCGGCTTCG
GCGCACGCCTCGATCCGCACAAGCTCGGCTTCGGGCTGCTGGTCTTCATCGAGGTGATGCTCGACAAGACGACGCCGGAG
GTCTTCGACCAGTTCGCGGCCGCCATAAAGCAGGCGCCCGCGGTGCTCGAATGCCACATGGTGGCGGGAGGCTTCGATTA
TCTCGTCAAGACGCGCTTCGAGGACATGGCCGCCTATCGTAATTTTCTCGGCCAGGTGCTGTGGACACTCCCGGGCGTCA
AGGAGACGCGAACCTATGCGGTCATGGAGGAAATCAAGAATGACGGGCCGCTGCCGTTGCTTTGA

Upstream 100 bases:

>100_bases
ATGACTTCAACGACGAAGTCATCCCGCATGGAATCTCCTATTGGGTGAAACTCGCCGAGGCACGGCTCGCCGCCTGAATA
ACGGAAAGCGGGAGGGGGCC

Downstream 100 bases:

>100_bases
GACAACGGCAGCGGCCCTGCAAATCAGGCCTTGAGCGAGGCCATGTCGATGACGAAGCGGTAGCGTACGTCGCTTCTCAC
CACGCGTTCGTAAGCCTCGT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MHQIDKTDRRILNILQADGRITNLELADRIGLSPTATSERLRRLLKEGYVSGFGARLDPHKLGFGLLVFIEVMLDKTTPE
VFDQFAAAIKQAPAVLECHMVAGGFDYLVKTRFEDMAAYRNFLGQVLWTLPGVKETRTYAVMEEIKNDGPLPLL

Sequences:

>Translated_154_residues
MHQIDKTDRRILNILQADGRITNLELADRIGLSPTATSERLRRLLKEGYVSGFGARLDPHKLGFGLLVFIEVMLDKTTPE
VFDQFAAAIKQAPAVLECHMVAGGFDYLVKTRFEDMAAYRNFLGQVLWTLPGVKETRTYAVMEEIKNDGPLPLL
>Mature_154_residues
MHQIDKTDRRILNILQADGRITNLELADRIGLSPTATSERLRRLLKEGYVSGFGARLDPHKLGFGLLVFIEVMLDKTTPE
VFDQFAAAIKQAPAVLECHMVAGGFDYLVKTRFEDMAAYRNFLGQVLWTLPGVKETRTYAVMEEIKNDGPLPLL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=53.3783783783784, Blast_Score=177, Evalue=4e-46,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=32.6666666666667, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17321; Mature: 17321

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQIDKTDRRILNILQADGRITNLELADRIGLSPTATSERLRRLLKEGYVSGFGARLDPH
CCCCCHHHHHHHHHHHCCCCEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
KLGFGLLVFIEVMLDKTTPEVFDQFAAAIKQAPAVLECHMVAGGFDYLVKTRFEDMAAYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
NFLGQVLWTLPGVKETRTYAVMEEIKNDGPLPLL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHQIDKTDRRILNILQADGRITNLELADRIGLSPTATSERLRRLLKEGYVSGFGARLDPH
CCCCCHHHHHHHHHHHCCCCEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHH
KLGFGLLVFIEVMLDKTTPEVFDQFAAAIKQAPAVLECHMVAGGFDYLVKTRFEDMAAYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
NFLGQVLWTLPGVKETRTYAVMEEIKNDGPLPLL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]