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The map label for this gene is aroB

Identifier: 150397762

GI number: 150397762

Start: 2661507

End: 2662649

Strand: Reverse

Name: aroB

Synonym: Smed_2564

Alternate gene names: 150397762

Gene position: 2662649-2661507 (Counterclockwise)

Preceding gene: 150397763

Following gene: 150397761

Centisome position: 70.4

GC content: 63.78

Gene sequence:

>1143_bases
ATGAAACCCATGACCAGCGATGTGATGCCAGCCGCCGAGCGTAAGGTCCGCGTCGATCTTGCGGAGCGTTCCTACGATAT
CCTCATCGGCCCCGGCCTGATCGCCGCCGCGGGCGGGGAGATCGCCTCGCGGCTCAAGGGCCGGAAGATGGCGGTCATCA
CCGACGAGAATGTTGCGCCGCGCTATCTCGAACCGTTGATGGCGAGCCTTGCGGGAAGCGGCATGGATCCGGTCTCCCTG
ATTCTGCCGGCGGGTGAGAAGACCAAGAGCTTCGAGCACCTGATCCCGGTTTGCGAAGCGGTCCTGGGTGCCAGAATAGA
GCGTAACGACGCGGTGATCGCGCTCGGTGGCGGCGTGATCGGCGATCTCACCGGCTTCGCCGCTGGTATCGTCCGCCGCG
GCTCTCGCTTCATCCAGATCCCGACATCGCTGCTGGCGCAGGTCGATTCCTCCGTCGGCGGCAAGACCGGCATCAATTCG
CCGCACGGCAAAAACCTGATCGGCGTTTTCCACCAGCCGGACCTCGTTCTCGCCGACACCGCCGCGCTCGACACGCTCAG
CCCGCGCGAATTCCGTGCAGGCTATGCCGAGGTCGTGAAATACGGCCTGATCGACAAGCCGGATTTCTTCGAATGGCTTG
AGCAGAACTGGCAGGCCGTGTTTGCCGGCGGACCCGCCCGGATCGAGGCGATCGCCGTCAGCTGCCAGGCGAAAGCCGAC
GTCGTCGCCGCGGATGAGCGCGAAAACGGGCTGCGTGCGCTGCTCAATCTCGGCCACACCTTCGGTCATGCCCTGGAAGC
CGCCACCGGATACGACAGCAAACGGCTGGTGCACGGGGAGGGCGTTGCGATCGGTATGGTTCTGGCGCACGAGTTCTCGG
CCCGGATGAACATTGCGAGTCCCGACGATGCGCGGCGCGTGGAAATGCATCTGAAGACGGTCGGCCTCCCGACACGCATG
GCCGACATTCCCGGTATGTTGCCGCCCGCCGATCGACTGCTGGAGGCGATCGCCCAGGACAAGAAGGTAAAGGGAGGCAA
GTTCACCTTCATTCTCACCAGGGGCATCGGACAGTCCTTCATCGCGGATGACGTGCCCTCCTCGGAGGTCCTAAGCTTTC
TTGAGGAAAGGATCCCGCGATGA

Upstream 100 bases:

>100_bases
CGATCTATGCCGAGGCGGATCTGACGGTCCTTTCGCGCGATGTGAAAAAAGAAGCGATGGTCGAGGAGGTTCTCGCCGCC
ATCGCCGATCACCAGAAAGC

Downstream 100 bases:

>100_bases
CCGATGTTATCCTTGCCTTTCTGGCCGACTACTGGCTGTCGCTGCTTTCCGTTATCTGCCTTCTCGTCATTTCGGCGTTT
TTTTCCGGTTCGGAGACCGC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKPMTSDVMPAAERKVRVDLAERSYDILIGPGLIAAAGGEIASRLKGRKMAVITDENVAPRYLEPLMASLAGSGMDPVSL
ILPAGEKTKSFEHLIPVCEAVLGARIERNDAVIALGGGVIGDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINS
PHGKNLIGVFHQPDLVLADTAALDTLSPREFRAGYAEVVKYGLIDKPDFFEWLEQNWQAVFAGGPARIEAIAVSCQAKAD
VVAADERENGLRALLNLGHTFGHALEAATGYDSKRLVHGEGVAIGMVLAHEFSARMNIASPDDARRVEMHLKTVGLPTRM
ADIPGMLPPADRLLEAIAQDKKVKGGKFTFILTRGIGQSFIADDVPSSEVLSFLEERIPR

Sequences:

>Translated_380_residues
MKPMTSDVMPAAERKVRVDLAERSYDILIGPGLIAAAGGEIASRLKGRKMAVITDENVAPRYLEPLMASLAGSGMDPVSL
ILPAGEKTKSFEHLIPVCEAVLGARIERNDAVIALGGGVIGDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINS
PHGKNLIGVFHQPDLVLADTAALDTLSPREFRAGYAEVVKYGLIDKPDFFEWLEQNWQAVFAGGPARIEAIAVSCQAKAD
VVAADERENGLRALLNLGHTFGHALEAATGYDSKRLVHGEGVAIGMVLAHEFSARMNIASPDDARRVEMHLKTVGLPTRM
ADIPGMLPPADRLLEAIAQDKKVKGGKFTFILTRGIGQSFIADDVPSSEVLSFLEERIPR
>Mature_380_residues
MKPMTSDVMPAAERKVRVDLAERSYDILIGPGLIAAAGGEIASRLKGRKMAVITDENVAPRYLEPLMASLAGSGMDPVSL
ILPAGEKTKSFEHLIPVCEAVLGARIERNDAVIALGGGVIGDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINS
PHGKNLIGVFHQPDLVLADTAALDTLSPREFRAGYAEVVKYGLIDKPDFFEWLEQNWQAVFAGGPARIEAIAVSCQAKAD
VVAADERENGLRALLNLGHTFGHALEAATGYDSKRLVHGEGVAIGMVLAHEFSARMNIASPDDARRVEMHLKTVGLPTRM
ADIPGMLPPADRLLEAIAQDKKVKGGKFTFILTRGIGQSFIADDVPSSEVLSFLEERIPR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=369, Percent_Identity=46.6124661246612, Blast_Score=271, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6320332, Length=347, Percent_Identity=36.5994236311239, Blast_Score=185, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_SINMW (A6UCL4)

Other databases:

- EMBL:   CP000738
- RefSeq:   YP_001328229.1
- ProteinModelPortal:   A6UCL4
- SMR:   A6UCL4
- STRING:   A6UCL4
- GeneID:   5323432
- GenomeReviews:   CP000738_GR
- KEGG:   smd:Smed_2564
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   PRREWIN
- ProtClustDB:   PRK00002
- BioCyc:   SMED366394:SMED_2564-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40577; Mature: 40577

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPMTSDVMPAAERKVRVDLAERSYDILIGPGLIAAAGGEIASRLKGRKMAVITDENVAP
CCCCCCCCCCHHHHEEEEEECCCCEEEEECCCHHHHCCHHHHHHHCCCEEEEEECCCCCH
RYLEPLMASLAGSGMDPVSLILPAGEKTKSFEHLIPVCEAVLGARIERNDAVIALGGGVI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCEEEEECCCHH
GDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINSPHGKNLIGVFHQPDLVLADT
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEECC
AALDTLSPREFRAGYAEVVKYGLIDKPDFFEWLEQNWQAVFAGGPARIEAIAVSCQAKAD
HHHCCCCCHHHHCCHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCC
VVAADERENGLRALLNLGHTFGHALEAATGYDSKRLVHGEGVAIGMVLAHEFSARMNIAS
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCCCC
PDDARRVEMHLKTVGLPTRMADIPGMLPPADRLLEAIAQDKKVKGGKFTFILTRGIGQSF
CCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHH
IADDVPSSEVLSFLEERIPR
HHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPMTSDVMPAAERKVRVDLAERSYDILIGPGLIAAAGGEIASRLKGRKMAVITDENVAP
CCCCCCCCCCHHHHEEEEEECCCCEEEEECCCHHHHCCHHHHHHHCCCEEEEEECCCCCH
RYLEPLMASLAGSGMDPVSLILPAGEKTKSFEHLIPVCEAVLGARIERNDAVIALGGGVI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCEEEEECCCHH
GDLTGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINSPHGKNLIGVFHQPDLVLADT
HHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEECC
AALDTLSPREFRAGYAEVVKYGLIDKPDFFEWLEQNWQAVFAGGPARIEAIAVSCQAKAD
HHHCCCCCHHHHCCHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCEEEEEEEEECCCCC
VVAADERENGLRALLNLGHTFGHALEAATGYDSKRLVHGEGVAIGMVLAHEFSARMNIAS
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEHHHHHHHHHHCCCCCC
PDDARRVEMHLKTVGLPTRMADIPGMLPPADRLLEAIAQDKKVKGGKFTFILTRGIGQSF
CCCHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHH
IADDVPSSEVLSFLEERIPR
HHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA