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The map label for this gene is hisC1 [H]

Identifier: 150397748

GI number: 150397748

Start: 2648242

End: 2649348

Strand: Reverse

Name: hisC1 [H]

Synonym: Smed_2550

Alternate gene names: 150397748

Gene position: 2649348-2648242 (Counterclockwise)

Preceding gene: 150397749

Following gene: 150397747

Centisome position: 70.05

GC content: 61.61

Gene sequence:

>1107_bases
ATGAATCTTGCCCTGAAAAGCCCTGAGCCGCGTTCCGGCATTCTGGACATCGCCGCCTACGTGCCCGGCAAGGAAATAGC
GCCCGGTCTTGCCAAGGTGCACAAGCTTTCGTCGAACGAAACGCCTCTCGGCGCGAGCCCGCGCGCGATCGAGGCTTTCC
AGAAGGCAGCTTTCAATCTCGAACGCTACCCGGACGGTCAGGCGAATGCGTTGAAGGAAGCGATCGCTGCCGTTCATGGG
CTGAATGCCGCCAATATCCTGTGCGGAAACGGGTCGGACGAACTGCTCGGTCTTCTCTGCCAGACCTATCTCGGCCCTGG
CGACGAGGGGATCGTCACCCAGCATGGTTTTCTGGTCTACAGGATCCAGATCGCTGCCTCCGGCGGGACGCCCGTCACGG
TCAGCGAAAGGGACGAGCGCGTCGATGTCGATGCGATCATCGCGGCCGTCACCGAACGGACGAGGATCGTGTTCATAGCC
AACCCGGGCAATCCGACCGGCACCTATGTCCCGGTGGACGAAGTCCGGCGCCTGCATGCGGCTTTGCCGGCCGGCGCTCT
GCTGGTGCTCGATGCCGCCTATGCGGAATATGTCAGGCGCAACGACTATGAAGCCGGGCTTGAGCTCGTATCCTCCAACC
GCAATGTCGTGATGACGCGAACCTTCTCGAAAATCTACGGCCTCGCGGGTTTGCGCATCGGCTGGATGTATGCGCCGCGC
GACGTGGTGGAGGCGTTGGACCGCGTGCGCGGCCCCTTCAACCTGAATGCTCCGGCGATCGCCGCCGGCGCCGCGGCAAT
CCGCGATCAGGCCTTTATTGCCGAGGCGGGCGACCACAATCAAAAATGGCTGGCAATCGTCAGTCAGGCGCTGACGAAAA
TCGGCCTCCGCGTTACGCCGTCGGTGACGAACTTCGTGCTGATCCATTTTCCGGCAGAAGCCGGCATGTCTGCCGGCGAT
GCGGATTCCTATCTGACAAGCCGCGGTTTCATCTTGCGTGCCGTCGGCGCCTACGGTTTTCCCAATGCGCTGAGAATGAC
GATAGGCACGAAAGAAGCGAACGAGGGCGTCGTTGCGGCGCTGACTGAATTCATGGGACGGAAATGA

Upstream 100 bases:

>100_bases
CCGACACAGCGGAGGCCGCCAGCATGCCACGGCCGCACTCGACAAACTCCACCGTCCCCGGTATTGGCTGGACCGCATTC
TCCCCGTGAAAGCTGGTCCG

Downstream 100 bases:

>100_bases
TGGCTCAGCAGTTCGAAACCATCGCTCTGATCGGCGTCGGTTTGATCGGATCGTCGATTGCGCGGGATATCCGTGAGAAG
CAGCTTGCCGGTCGGGTAGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNLALKSPEPRSGILDIAAYVPGKEIAPGLAKVHKLSSNETPLGASPRAIEAFQKAAFNLERYPDGQANALKEAIAAVHG
LNAANILCGNGSDELLGLLCQTYLGPGDEGIVTQHGFLVYRIQIAASGGTPVTVSERDERVDVDAIIAAVTERTRIVFIA
NPGNPTGTYVPVDEVRRLHAALPAGALLVLDAAYAEYVRRNDYEAGLELVSSNRNVVMTRTFSKIYGLAGLRIGWMYAPR
DVVEALDRVRGPFNLNAPAIAAGAAAIRDQAFIAEAGDHNQKWLAIVSQALTKIGLRVTPSVTNFVLIHFPAEAGMSAGD
ADSYLTSRGFILRAVGAYGFPNALRMTIGTKEANEGVVAALTEFMGRK

Sequences:

>Translated_368_residues
MNLALKSPEPRSGILDIAAYVPGKEIAPGLAKVHKLSSNETPLGASPRAIEAFQKAAFNLERYPDGQANALKEAIAAVHG
LNAANILCGNGSDELLGLLCQTYLGPGDEGIVTQHGFLVYRIQIAASGGTPVTVSERDERVDVDAIIAAVTERTRIVFIA
NPGNPTGTYVPVDEVRRLHAALPAGALLVLDAAYAEYVRRNDYEAGLELVSSNRNVVMTRTFSKIYGLAGLRIGWMYAPR
DVVEALDRVRGPFNLNAPAIAAGAAAIRDQAFIAEAGDHNQKWLAIVSQALTKIGLRVTPSVTNFVLIHFPAEAGMSAGD
ADSYLTSRGFILRAVGAYGFPNALRMTIGTKEANEGVVAALTEFMGRK
>Mature_368_residues
MNLALKSPEPRSGILDIAAYVPGKEIAPGLAKVHKLSSNETPLGASPRAIEAFQKAAFNLERYPDGQANALKEAIAAVHG
LNAANILCGNGSDELLGLLCQTYLGPGDEGIVTQHGFLVYRIQIAASGGTPVTVSERDERVDVDAIIAAVTERTRIVFIA
NPGNPTGTYVPVDEVRRLHAALPAGALLVLDAAYAEYVRRNDYEAGLELVSSNRNVVMTRTFSKIYGLAGLRIGWMYAPR
DVVEALDRVRGPFNLNAPAIAAGAAAIRDQAFIAEAGDHNQKWLAIVSQALTKIGLRVTPSVTNFVLIHFPAEAGMSAGD
ADSYLTSRGFILRAVGAYGFPNALRMTIGTKEANEGVVAALTEFMGRK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=326, Percent_Identity=27.9141104294479, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786816, Length=307, Percent_Identity=25.0814332247557, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=369, Percent_Identity=24.9322493224932, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39138; Mature: 39138

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLALKSPEPRSGILDIAAYVPGKEIAPGLAKVHKLSSNETPLGASPRAIEAFQKAAFNL
CCCCCCCCCCCCCCEEHEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
ERYPDGQANALKEAIAAVHGLNAANILCGNGSDELLGLLCQTYLGPGDEGIVTQHGFLVY
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEE
RIQIAASGGTPVTVSERDERVDVDAIIAAVTERTRIVFIANPGNPTGTYVPVDEVRRLHA
EEEEEECCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHH
ALPAGALLVLDAAYAEYVRRNDYEAGLELVSSNRNVVMTRTFSKIYGLAGLRIGWMYAPR
HCCCCHHEEHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEHHHHHCCCCCEEEEEECCH
DVVEALDRVRGPFNLNAPAIAAGAAAIRDQAFIAEAGDHNQKWLAIVSQALTKIGLRVTP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCEECC
SVTNFVLIHFPAEAGMSAGDADSYLTSRGFILRAVGAYGFPNALRMTIGTKEANEGVVAA
CCCEEEEEEECHHCCCCCCCCHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHH
LTEFMGRK
HHHHHCCC
>Mature Secondary Structure
MNLALKSPEPRSGILDIAAYVPGKEIAPGLAKVHKLSSNETPLGASPRAIEAFQKAAFNL
CCCCCCCCCCCCCCEEHEEECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCC
ERYPDGQANALKEAIAAVHGLNAANILCGNGSDELLGLLCQTYLGPGDEGIVTQHGFLVY
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCEEEE
RIQIAASGGTPVTVSERDERVDVDAIIAAVTERTRIVFIANPGNPTGTYVPVDEVRRLHA
EEEEEECCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHHHHHHH
ALPAGALLVLDAAYAEYVRRNDYEAGLELVSSNRNVVMTRTFSKIYGLAGLRIGWMYAPR
HCCCCHHEEHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEHHHHHCCCCCEEEEEECCH
DVVEALDRVRGPFNLNAPAIAAGAAAIRDQAFIAEAGDHNQKWLAIVSQALTKIGLRVTP
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCEECC
SVTNFVLIHFPAEAGMSAGDADSYLTSRGFILRAVGAYGFPNALRMTIGTKEANEGVVAA
CCCEEEEEEECHHCCCCCCCCHHHHHHCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHH
LTEFMGRK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]