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The map label for this gene is hbdA [H]

Identifier: 150397732

GI number: 150397732

Start: 2631987

End: 2632859

Strand: Direct

Name: hbdA [H]

Synonym: Smed_2534

Alternate gene names: 150397732

Gene position: 2631987-2632859 (Clockwise)

Preceding gene: 150397731

Following gene: 150397734

Centisome position: 69.59

GC content: 60.25

Gene sequence:

>873_bases
ATGATCAAGACGGTGGGAATTATCGGCGCAGGACAGATGGGCTGCGGAATTGCCCATGTTTCGGCTGCCGCCGGATATAA
GGTTCAGCTCTACGACATCGCTGCAGACCGCATCGAGGCAGGGCTTGCCACCATCAATGGCAACCTTGCCCGGCAGGTTT
CGTCCGGCAAGATGACGGACGAAGACCGCAAGCGCGCTCTTTCCCTGATCAAGGGCTCAGGCGATATCAACGATCTCGCC
CAGGCCGATCTCGTCATCGAAGCGGTGACGGAAGACGAAACCGTCAAGCGGAAGATCTACGGCCAGGTTTGTCCGGTCAT
GAGACCCGATGCCATTCTGGCAACCAACACCTCGTCTCTGTCCATCACCCGGCTTGCCTCCGCGACCGACCGCCCCGAGC
GCTTCATGGGCATCCACTTCATGAACCCGGTCCCGGTCATGAAGCTGGTGGAGCTCGTACGGGGTATCGCTACGGAGGAA
GGGACCTTCAAGGCGGCAAAGGAATTCGTCGCGCATCTCGACAAGACCGTCACTGTCGCAGAAGATTTTCCCGCCTTTAT
CGTCAACCGCATCCTGCTGCCGATGATCAACGAGGCGATCTACACCCTGTATGAGGGCGTTGGAAGCGTCGATGCCATCG
ACACCGCCATGAAGCTCGGCGCCAACCATCCGATGGGCCCGCTGCAGCTTGCCGACTTCATCGGTCTCGACACCTGCCTT
TCGATCATGCAGGTGCTCCATGACGGCCTGGCGGATTCGAAGTATCGCCCCTGTCCGCTGCTCGTGAAATATGTCGAGGC
CGGCTGGCTCGGCCGCAAGTCCGGCCGCGGCTTCTACGACTATCGGGGCGAGGCTCCCGTACCGACACGCTGA

Upstream 100 bases:

>100_bases
TGGCATTAACAATCGTACCGGGCCGGCCCTGCCGGCCCGGTATTTTTGCATCTACTGCAGCATCGCTGCCGTAACCTGTT
GAACATGGGTGTTCGCTTCA

Downstream 100 bases:

>100_bases
ACCTTTCTTCAGCAACGGCGAAAACCCGCCTGCGTCTTCAACTCGCCGCGGGCGGAGCCATCGCCGCCTCGATCAGCTTC
TTTGCATCGTCGCTGTCCCA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMTDEDRKRALSLIKGSGDINDLA
QADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEE
GTFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMKLGANHPMGPLQLADFIGLDTCL
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEAPVPTR

Sequences:

>Translated_290_residues
MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMTDEDRKRALSLIKGSGDINDLA
QADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEE
GTFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMKLGANHPMGPLQLADFIGLDTCL
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEAPVPTR
>Mature_290_residues
MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMTDEDRKRALSLIKGSGDINDLA
QADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEE
GTFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMKLGANHPMGPLQLADFIGLDTCL
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEAPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=41.3793103448276, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=39.9350649350649, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=33.8028169014084, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=30.4794520547945, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=30.4794520547945, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=29.3617021276596, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=41.1971830985916, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=36.4661654135338, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790281, Length=270, Percent_Identity=31.8518518518519, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=40.7534246575342, Blast_Score=208, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.9722222222222, Blast_Score=207, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=38.8888888888889, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=34.1637010676157, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=32.7402135231317, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=28.3687943262411, Blast_Score=123, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=27.1428571428571, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=34.3859649122807, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=34.3859649122807, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=34.3859649122807, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=27.5, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI20129993, Length=221, Percent_Identity=25.3393665158371, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31330; Mature: 31330

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMTD
CCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHCCCCCH
EDRKRALSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSL
HHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCE
SITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEGTFKAAKEFVAHLDKTVTVA
EHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEH
EDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMKLGANHPMGPLQLADFIGLDTCL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEAPVPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMTD
CCEEEEEEECCCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHCCCCCH
EDRKRALSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSL
HHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCE
SITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEGTFKAAKEFVAHLDKTVTVA
EHHHHHCCCCCHHHHEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEH
EDFPAFIVNRILLPMINEAIYTLYEGVGSVDAIDTAMKLGANHPMGPLQLADFIGLDTCL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SIMQVLHDGLADSKYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEAPVPTR
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]