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The map label for this gene is etfA [H]

Identifier: 150397731

GI number: 150397731

Start: 2630914

End: 2631843

Strand: Direct

Name: etfA [H]

Synonym: Smed_2533

Alternate gene names: 150397731

Gene position: 2630914-2631843 (Clockwise)

Preceding gene: 150397730

Following gene: 150397732

Centisome position: 69.57

GC content: 64.84

Gene sequence:

>930_bases
ATGGCCATTCTGCTTCTGGCTGACCACGATAACAGCCACCTTTCCGACCAGACGGCGAAAGCGCTCACGGCGGCCGCCAA
GATCGGCTCCGACGTGCATGTGCTCGTTGCCGGCGCGGGCGTCAAAGGCATCGCCGAACAAGCCTCCAAGCTTTCGGGCG
TCGCCAAGGTGCTCGTCGCCGAGGACGCCTCGCTTGCCAACAATCTCGCCGAGCCGCTGGCCGCCCTGATCGTCTCACTC
GCGGGAGGTTACGACACGATCGTCGCCGCCGCCACCTCGGTCGGCAAGAACGTCATGCCGCGCGTGGCCGCCCTTCTCGA
TGTCGTTCAGGTCTCGGAGATCGTCGAGGTCGTGTCCGCCGATACCTTCAAGCGGCCGATCTATGCCGGCAACGCCATCC
AGACGGTGCAGACGAGCGAATCGAAGAAAGTGATCACCGTGCGCACGGCTTCCTTTGCCGCTGCCCCGGAAAGCGGCGCG
GCCCCGGTAGAGACGGTTGCCGCAGCGGCGAACCCGGGCCTTTCCTCCCATGTTTCCGATGCGCTGTCGTCCTCCGACCG
GCCGGAACTTACCTCGGCGAAGATCATCATCTCCGGCGGCCGGGCTCTTGGTTCTGCCGAAAAATTCCAGGAAGTGATCC
TGCCCGTGGCCGACAAGCTCGGTGCCGCCGTCGGCGCATCCCGCGCCGCCGTCGATGCCGGCTATGCGCCGAATGATTGG
CAGGTCGGTCAGACCGGCAAGGTGGTCGCCCCCGATCTCTACATCGCCTGCGGCATTTCCGGTGCGATCCAGCACCTCGC
CGGCATGAAGGATAGCAAGGTGATCGTCGCCATCAACAAGGACGAGGAGGCGCCGATCTTCCAGGTTGCCGACTACGGCC
TGGTCGCCGACCTGTTCGACGTCCTGCCGGAACTCGAAAAGGCGCTCTGA

Upstream 100 bases:

>100_bases
GCCGCAAGGCCGGCGTCAAGGTGAAGACGGTTGCCGAGCTCGTCGAGAAGCTCAAGAACGAAGCCGGCGTGCTCTGAGAA
CGGAAAGGGAGAACTAAACC

Downstream 100 bases:

>100_bases
GGAACTGGCCGCCGGCACGAAAAAGCTGGAAAAAGCGCCGGCATGGCATTAACAATCGTACCGGGCCGGCCCTGCCGGCC
CGGTATTTTTGCATCTACTG

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAILLLADHDNSHLSDQTAKALTAAAKIGSDVHVLVAGAGVKGIAEQASKLSGVAKVLVAEDASLANNLAEPLAALIVSL
AGGYDTIVAAATSVGKNVMPRVAALLDVVQVSEIVEVVSADTFKRPIYAGNAIQTVQTSESKKVITVRTASFAAAPESGA
APVETVAAAANPGLSSHVSDALSSSDRPELTSAKIIISGGRALGSAEKFQEVILPVADKLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDVLPELEKAL

Sequences:

>Translated_309_residues
MAILLLADHDNSHLSDQTAKALTAAAKIGSDVHVLVAGAGVKGIAEQASKLSGVAKVLVAEDASLANNLAEPLAALIVSL
AGGYDTIVAAATSVGKNVMPRVAALLDVVQVSEIVEVVSADTFKRPIYAGNAIQTVQTSESKKVITVRTASFAAAPESGA
APVETVAAAANPGLSSHVSDALSSSDRPELTSAKIIISGGRALGSAEKFQEVILPVADKLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDVLPELEKAL
>Mature_308_residues
AILLLADHDNSHLSDQTAKALTAAAKIGSDVHVLVAGAGVKGIAEQASKLSGVAKVLVAEDASLANNLAEPLAALIVSLA
GGYDTIVAAATSVGKNVMPRVAALLDVVQVSEIVEVVSADTFKRPIYAGNAIQTVQTSESKKVITVRTASFAAAPESGAA
PVETVAAAANPGLSSHVSDALSSSDRPELTSAKIIISGGRALGSAEKFQEVILPVADKLGAAVGASRAAVDAGYAPNDWQ
VGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFDVLPELEKAL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=309, Percent_Identity=53.7216828478964, Blast_Score=307, Evalue=9e-84,
Organism=Homo sapiens, GI189181759, Length=271, Percent_Identity=55.719557195572, Blast_Score=281, Evalue=4e-76,
Organism=Escherichia coli, GI1786226, Length=195, Percent_Identity=35.3846153846154, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787990, Length=259, Percent_Identity=32.4324324324324, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082157, Length=225, Percent_Identity=31.5555555555556, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=309, Percent_Identity=54.6925566343042, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6325261, Length=291, Percent_Identity=45.7044673539519, Blast_Score=248, Evalue=8e-67,
Organism=Drosophila melanogaster, GI17136898, Length=310, Percent_Identity=56.1290322580645, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24652801, Length=310, Percent_Identity=56.1290322580645, Blast_Score=313, Evalue=1e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31337; Mature: 31206

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILLLADHDNSHLSDQTAKALTAAAKIGSDVHVLVAGAGVKGIAEQASKLSGVAKVLVA
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EDASLANNLAEPLAALIVSLAGGYDTIVAAATSVGKNVMPRVAALLDVVQVSEIVEVVSA
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
DTFKRPIYAGNAIQTVQTSESKKVITVRTASFAAAPESGAAPVETVAAAANPGLSSHVSD
HHHCCCCCCCCCEEEEECCCCCEEEEEEECHHCCCCCCCCCHHHHHHHHCCCCCHHHHHH
ALSSSDRPELTSAKIIISGGRALGSAEKFQEVILPVADKLGAAVGASRAAVDAGYAPNDW
HHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFD
CCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHH
VLPELEKAL
HHHHHHHCC
>Mature Secondary Structure 
AILLLADHDNSHLSDQTAKALTAAAKIGSDVHVLVAGAGVKGIAEQASKLSGVAKVLVA
EEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
EDASLANNLAEPLAALIVSLAGGYDTIVAAATSVGKNVMPRVAALLDVVQVSEIVEVVSA
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
DTFKRPIYAGNAIQTVQTSESKKVITVRTASFAAAPESGAAPVETVAAAANPGLSSHVSD
HHHCCCCCCCCCEEEEECCCCCEEEEEEECHHCCCCCCCCCHHHHHHHHCCCCCHHHHHH
ALSSSDRPELTSAKIIISGGRALGSAEKFQEVILPVADKLGAAVGASRAAVDAGYAPNDW
HHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIACGISGAIQHLAGMKDSKVIVAINKDEEAPIFQVADYGLVADLFD
CCCCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHH
VLPELEKAL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]