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The map label for this gene is argH1 [H]

Identifier: 150397734

GI number: 150397734

Start: 2633597

End: 2635000

Strand: Direct

Name: argH1 [H]

Synonym: Smed_2536

Alternate gene names: 150397734

Gene position: 2633597-2635000 (Clockwise)

Preceding gene: 150397732

Following gene: 150397735

Centisome position: 69.64

GC content: 63.96

Gene sequence:

>1404_bases
ATGGCTGACGGCAGTTCCGAGACGAAATCCTCCAACCAGATGTGGGGCGGTCGCTTCGCCTCGGGGCCCGCTTCCATCAT
GGAGGAGATAAATGCCTCGATCGGCTTCGACAAGAAGCTCTATGCCCAGGACATCCGCGGCTCAATAGCGCATGCGACGA
TGCTGGCGCAGCAAGGCATCATTTCCGCCGAGGACAAAGACAAGATCGTTCACGGCCTCAACACGATATTGTCAGAGATC
GAAGCCGGCGCATTCGAGTTCTCGCGTCGCCTCGAGGACATTCACATGAACATCGAAGCGCGGCTGGCGGCGCTGATCGG
CCCTGCCGCCGGGCGCCTCCATACGGCGCGGTCGCGCAACGACCAGGTTGCGCTCGATTTTCGCCTGTGGGTCAAGGAAG
AGCTTCAGAAAGCCGATGCGGCACTCACGGCTCTGATCGCCGCCTTTCTCGACCGCGCCGAGGAGCATGCCGAAACCGTG
ATGCCCGGCTTCACCCATCTGCAGACGGCGCAGCCGGTCACCTTCGGGCATCACTGCATGGCCTATGTGGAAATGTTCGG
CCGCGACCGGGCGCGTGTTCGTCACGCGATCGAGCACATGGACGAGAGCCCGATCGGCGCTGCAGCCCTCGCCGGCACGG
GCTTTCCGATCGACCGGCACATGACCGCCAGGGCGCTCGGCTTCCGCGAGCCGACGCGCAACTCGATCGATACGGTTTCC
GACCGCGACTTCGCGCTGGAGTTTCTCGCGATCGCAGCGATCGCGGCGACGCACCTGTCGCGGCTTGCAGAAGAAATCGT
CATCTGGTCTACGCCGCAATTCGGCTTCATCCGGCTCTCGGACGCCTTTTCGACCGGATCCTCGATCATGCCGCAGAAGA
AGAATCCGGATGCGGCGGAGCTCGTACGTGCCAAGACGGGCCGCGTCAACGGCTCGCTGATCGCACTGCTGACGGTGATG
AAGGGCCTCCCGCTCGCCTATTCCAAGGATATGCAGGAAGACAAGGAACAGGTCTTCGATGCGGCCGAGAGCCTCGAGCT
CGCGATCGCGGCAATGACCGGCATGGTCCGCGACCTGACCGTGCGGGCCGACCGGATGAAATCCGCAGCCGGTTCCGGCT
ATTCGACAGCGACCGATCTCGCCGACTGGCTGGTGCGCGAGGCAGGCCTTCCTTTCCGTGACGCCCACCATGTGACCGGT
CGCGTGGTCGCGCTTGCCGAAGAGAAGGAATGCGATCTCGCCGACCTGCCGCTGGGCGAACTTCAGGCGATCCATTCCGC
GATCACGGACAAGGTCTTCGGCGTCCTGACGGTCGAGGCCTCCGTGGCGAGCCGCACCAGTTTCGGCGGTACCGCGCCCT
CCGAGGTCCGCAAGCAGATCGCCTGGTGGCGGGCGCGCGATTGA

Upstream 100 bases:

>100_bases
ACCGGCGATCACCCCAAGAAGGGCAGCGATCGCGAACAATTTCCGGGCTGGAGGGCGTTTCTTCTGGTCTGGCATTTCAT
TCTCCAAGGCGGGCATCCTG

Downstream 100 bases:

>100_bases
TCCTGCCGCTGGGTCCGTCGCAGGTGGCCCGTCCATCGCCGGCCGGCCGTCTCCTTCCGCAGGCGGGGCGAAGCCGGCAC
CCTGTTCCTTCGGAGCAAGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MADGSSETKSSNQMWGGRFASGPASIMEEINASIGFDKKLYAQDIRGSIAHATMLAQQGIISAEDKDKIVHGLNTILSEI
EAGAFEFSRRLEDIHMNIEARLAALIGPAAGRLHTARSRNDQVALDFRLWVKEELQKADAALTALIAAFLDRAEEHAETV
MPGFTHLQTAQPVTFGHHCMAYVEMFGRDRARVRHAIEHMDESPIGAAALAGTGFPIDRHMTARALGFREPTRNSIDTVS
DRDFALEFLAIAAIAATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRVNGSLIALLTVM
KGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDLTVRADRMKSAAGSGYSTATDLADWLVREAGLPFRDAHHVTG
RVVALAEEKECDLADLPLGELQAIHSAITDKVFGVLTVEASVASRTSFGGTAPSEVRKQIAWWRARD

Sequences:

>Translated_467_residues
MADGSSETKSSNQMWGGRFASGPASIMEEINASIGFDKKLYAQDIRGSIAHATMLAQQGIISAEDKDKIVHGLNTILSEI
EAGAFEFSRRLEDIHMNIEARLAALIGPAAGRLHTARSRNDQVALDFRLWVKEELQKADAALTALIAAFLDRAEEHAETV
MPGFTHLQTAQPVTFGHHCMAYVEMFGRDRARVRHAIEHMDESPIGAAALAGTGFPIDRHMTARALGFREPTRNSIDTVS
DRDFALEFLAIAAIAATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRVNGSLIALLTVM
KGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDLTVRADRMKSAAGSGYSTATDLADWLVREAGLPFRDAHHVTG
RVVALAEEKECDLADLPLGELQAIHSAITDKVFGVLTVEASVASRTSFGGTAPSEVRKQIAWWRARD
>Mature_466_residues
ADGSSETKSSNQMWGGRFASGPASIMEEINASIGFDKKLYAQDIRGSIAHATMLAQQGIISAEDKDKIVHGLNTILSEIE
AGAFEFSRRLEDIHMNIEARLAALIGPAAGRLHTARSRNDQVALDFRLWVKEELQKADAALTALIAAFLDRAEEHAETVM
PGFTHLQTAQPVTFGHHCMAYVEMFGRDRARVRHAIEHMDESPIGAAALAGTGFPIDRHMTARALGFREPTRNSIDTVSD
RDFALEFLAIAAIAATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAELVRAKTGRVNGSLIALLTVMK
GLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDLTVRADRMKSAAGSGYSTATDLADWLVREAGLPFRDAHHVTGR
VVALAEEKECDLADLPLGELQAIHSAITDKVFGVLTVEASVASRTSFGGTAPSEVRKQIAWWRARD

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=450, Percent_Identity=42.4444444444444, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=450, Percent_Identity=42.4444444444444, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303549, Length=450, Percent_Identity=41.3333333333333, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI68303547, Length=450, Percent_Identity=40.2222222222222, Blast_Score=340, Evalue=2e-93,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=45.0549450549451, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=41.9006479481641, Blast_Score=352, Evalue=5e-98,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=37.6106194690265, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=37.6106194690265, Blast_Score=333, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50783; Mature: 50652

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGSSETKSSNQMWGGRFASGPASIMEEINASIGFDKKLYAQDIRGSIAHATMLAQQGI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ISAEDKDKIVHGLNTILSEIEAGAFEFSRRLEDIHMNIEARLAALIGPAAGRLHTARSRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
DQVALDFRLWVKEELQKADAALTALIAAFLDRAEEHAETVMPGFTHLQTAQPVTFGHHCM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHH
AYVEMFGRDRARVRHAIEHMDESPIGAAALAGTGFPIDRHMTARALGFREPTRNSIDTVS
HHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
DRDFALEFLAIAAIAATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAE
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHH
LVRAKTGRVNGSLIALLTVMKGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDLT
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRADRMKSAAGSGYSTATDLADWLVREAGLPFRDAHHVTGRVVALAEEKECDLADLPLGE
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCCCCCCCCCHHH
LQAIHSAITDKVFGVLTVEASVASRTSFGGTAPSEVRKQIAWWRARD
HHHHHHHHHHHHHEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADGSSETKSSNQMWGGRFASGPASIMEEINASIGFDKKLYAQDIRGSIAHATMLAQQGI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
ISAEDKDKIVHGLNTILSEIEAGAFEFSRRLEDIHMNIEARLAALIGPAAGRLHTARSRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
DQVALDFRLWVKEELQKADAALTALIAAFLDRAEEHAETVMPGFTHLQTAQPVTFGHHCM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHH
AYVEMFGRDRARVRHAIEHMDESPIGAAALAGTGFPIDRHMTARALGFREPTRNSIDTVS
HHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
DRDFALEFLAIAAIAATHLSRLAEEIVIWSTPQFGFIRLSDAFSTGSSIMPQKKNPDAAE
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHH
LVRAKTGRVNGSLIALLTVMKGLPLAYSKDMQEDKEQVFDAAESLELAIAAMTGMVRDLT
HHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRADRMKSAAGSGYSTATDLADWLVREAGLPFRDAHHVTGRVVALAEEKECDLADLPLGE
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCCCCCCCCCHHH
LQAIHSAITDKVFGVLTVEASVASRTSFGGTAPSEVRKQIAWWRARD
HHHHHHHHHHHHHEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]