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The map label for this gene is cirA [C]

Identifier: 150397496

GI number: 150397496

Start: 2372143

End: 2374347

Strand: Reverse

Name: cirA [C]

Synonym: Smed_2296

Alternate gene names: 150397496

Gene position: 2374347-2372143 (Counterclockwise)

Preceding gene: 229577668

Following gene: 150397495

Centisome position: 62.78

GC content: 61.22

Gene sequence:

>2205_bases
ATGCTCAACCGGCATCATCGCCTGGCGCTTTTGGCTTGCACGGCATTCGTTACCCTCGTCGAAACGACACTTTCTCACGC
GCAATCCACCGAGGAGGCGGCAGGTGCCGCCGAAAAGCAGGGGCGCGTAACAGTGCTGAAGAAACTTTCCATCCAAGGCG
GCGAGAAGGAGGGTGTGGCCGACACGCCGCTCGCAGAACAAGTGACCGAGGAAGAACTCGACCGCAATCAGATCACGAGC
TTCGAAGACCTGGGCAGAAGCCTCGAACCTGGCGTGAACTTCAACCGGACGAGCGGCAGCGTAAATATACGCGGCCTCGA
AGGGCCGCGCGTGCTGACGACGATCGACGGCATTCCCATCCCCTTCATCGACGATGGCGCGCGCGATGCCGATGGCGGCA
TAGACAGCTTCGATTTCTCGGCGCTCTCGACCATCGACATCGTTCGCGGCGCGGATTCCAGCCGCGCGGGCGGCGGTGCT
CTCGGAGGAGCCGTGGTGCTGCGCACGCTCGAACCGGAGGACCTGATCGGCGAGGGCAAGACGTGGGGCGGCATCTTCAA
ATTCGCCTATGACGGCGAGGACGACAGCCTCGGGGGCTCCGCTGCCGTTGCTGCGCGCTATGACAACACGGCGGCCCTGT
TCCAGGGGGGGTACAGGAGGGGGCATGAACGGGAGAGCAACGGCGACGTCGGCGGCTATTCCACGACGCGCACCGAGGCC
GACCCGGCTGACTACGACCAGAACAATCTCCTGTTCAAGGTGCGGCAATATACCGAAAGCGGCCATACTTTCGGCTTCAC
GGCCGAGCGCTTCGACCGCGACAAGGATATCGACTTCATGTCCGGCCAGAGCCTCTTCGGCAATTATCGGCCGGGCGATT
ACGACAAGCTTGATGACACCCGGCGCGAGCGTCTTTCGCTCGATTACGAATTCGAAGCCACCGACGACAACGCTTGGTTC
GACAGCGCTTCGGCGACGGTCTACTGGCAGCGGCTGTTGCGCGAAAACGGCGTCGACGCCTACCGCAGCACGTCGGTGAT
CGGCGACTATTCGCGTCTCAACGAAGCGGAAGAAGAGGGCTTCGGCGCCAGCGGTTATGTCGAGAAATTCTTTGAAACCG
GTAACCTGCAGCACCAGGTGACGCTCGGCGGCGACTTTGCCATCGGCAAGCTGCATCAATATTCCTCGGGCGAGGATAGC
TGCGACACGGCGCCGAGCCCATCATGCAATTTCCTGCATACCAACCAGTCTGACAGCCCCGACGTCGACAGCAGGAAAAT
CGGCGTCTACTTGCAGGACCGCATCTCGATCGGCGACGGACCCTTCGCGCTGACGCCGGGGCTTCGCCTCGACTGGTACG
ACTACGCGCCTGAGAACACGGCCGCCTACATGCGCAACCCCAACTATGACGGTTTGCCGCCGGGACAGAGCGACCTCGCG
CTGTCGCCGAAGCTGCTTGCAACCTATCAGGCAGCGGAGGAGGTCGAACTCTTCGCGCAATGGGCAATGGCTTTCCGGCC
TCCGACCGCCGAGGAGCTCTATCTGAATTACGGCGCACCGGGCAGCTATCTTCAAATAGGCAATCCCGACCTGAAGCCGG
AAACGAGCCAGGGTTTCGAGATCGGAGCCAATCTCGGCGATGAGGAATTCGGCGGTCGCATCGCTGCCTTCTACAACAGA
TACAGAAATTTCATCGATGAGCGCTGGAGTTTCGATCCGACCGGCACCTACCCGATCGGCATCACCGAAGCCATCAACCG
CGCCAATGTCTCCATCCATGGCGTCGAGGTCTCGGGGCACAAGGTTTTCGCCAATGGTGTCCACGTGCGTACCGCGCTCG
CCTACGCTCACGGCCGCGATCTCGATACCGACGAAGTCCTTGGTTCTGTTGCCCCGTTGAAAGGCGTCCTCAATGTCGGC
TACGCCGCAGAGACCTGGGGAACCGATCTCATCGTGACAGCCGCGATGGACGTGTCCGACAAATCGACGAACAGTTTCAA
GGCGCCGGGCTATGGCATCGTCGATGTCACCGGCTGGTGGGAGCCGGAGCAAATGCCGGGTCTCAGAGTAAATGCCGGCG
TCTACAACATCTTCGACAAGACCTATTGGGACGCGGTGAACACGCAGAACGCGTTCACGCAGCCCGCCGACTTCTATTCG
GAGCCGGGGCGCACTTTCAAGGTCTCGCTGACACAGCGGTTCTGA

Upstream 100 bases:

>100_bases
GAGATTGGCCGCCTGTTCGATTCCTGCACATGCCCAGCCAGCCCTTGAGTTCGCCGCTCAACAGCAAGCCCGGCCTCACA
TTTTTTAAAAGGACTGGTCC

Downstream 100 bases:

>100_bases
GCTTGGAAGGCATGCATCAAGGGGCGGCCCCGATGGCCGCCTTTCTTTTGACAGGACCGGATCAGCAGCCCACTTTTCCC
GCTTGCGCGCCACCGCAAGC

Product: TonB-dependent hemoglobin/transferrin/lactoferrin family receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MLNRHHRLALLACTAFVTLVETTLSHAQSTEEAAGAAEKQGRVTVLKKLSIQGGEKEGVADTPLAEQVTEEELDRNQITS
FEDLGRSLEPGVNFNRTSGSVNIRGLEGPRVLTTIDGIPIPFIDDGARDADGGIDSFDFSALSTIDIVRGADSSRAGGGA
LGGAVVLRTLEPEDLIGEGKTWGGIFKFAYDGEDDSLGGSAAVAARYDNTAALFQGGYRRGHERESNGDVGGYSTTRTEA
DPADYDQNNLLFKVRQYTESGHTFGFTAERFDRDKDIDFMSGQSLFGNYRPGDYDKLDDTRRERLSLDYEFEATDDNAWF
DSASATVYWQRLLRENGVDAYRSTSVIGDYSRLNEAEEEGFGASGYVEKFFETGNLQHQVTLGGDFAIGKLHQYSSGEDS
CDTAPSPSCNFLHTNQSDSPDVDSRKIGVYLQDRISIGDGPFALTPGLRLDWYDYAPENTAAYMRNPNYDGLPPGQSDLA
LSPKLLATYQAAEEVELFAQWAMAFRPPTAEELYLNYGAPGSYLQIGNPDLKPETSQGFEIGANLGDEEFGGRIAAFYNR
YRNFIDERWSFDPTGTYPIGITEAINRANVSIHGVEVSGHKVFANGVHVRTALAYAHGRDLDTDEVLGSVAPLKGVLNVG
YAAETWGTDLIVTAAMDVSDKSTNSFKAPGYGIVDVTGWWEPEQMPGLRVNAGVYNIFDKTYWDAVNTQNAFTQPADFYS
EPGRTFKVSLTQRF

Sequences:

>Translated_734_residues
MLNRHHRLALLACTAFVTLVETTLSHAQSTEEAAGAAEKQGRVTVLKKLSIQGGEKEGVADTPLAEQVTEEELDRNQITS
FEDLGRSLEPGVNFNRTSGSVNIRGLEGPRVLTTIDGIPIPFIDDGARDADGGIDSFDFSALSTIDIVRGADSSRAGGGA
LGGAVVLRTLEPEDLIGEGKTWGGIFKFAYDGEDDSLGGSAAVAARYDNTAALFQGGYRRGHERESNGDVGGYSTTRTEA
DPADYDQNNLLFKVRQYTESGHTFGFTAERFDRDKDIDFMSGQSLFGNYRPGDYDKLDDTRRERLSLDYEFEATDDNAWF
DSASATVYWQRLLRENGVDAYRSTSVIGDYSRLNEAEEEGFGASGYVEKFFETGNLQHQVTLGGDFAIGKLHQYSSGEDS
CDTAPSPSCNFLHTNQSDSPDVDSRKIGVYLQDRISIGDGPFALTPGLRLDWYDYAPENTAAYMRNPNYDGLPPGQSDLA
LSPKLLATYQAAEEVELFAQWAMAFRPPTAEELYLNYGAPGSYLQIGNPDLKPETSQGFEIGANLGDEEFGGRIAAFYNR
YRNFIDERWSFDPTGTYPIGITEAINRANVSIHGVEVSGHKVFANGVHVRTALAYAHGRDLDTDEVLGSVAPLKGVLNVG
YAAETWGTDLIVTAAMDVSDKSTNSFKAPGYGIVDVTGWWEPEQMPGLRVNAGVYNIFDKTYWDAVNTQNAFTQPADFYS
EPGRTFKVSLTQRF
>Mature_734_residues
MLNRHHRLALLACTAFVTLVETTLSHAQSTEEAAGAAEKQGRVTVLKKLSIQGGEKEGVADTPLAEQVTEEELDRNQITS
FEDLGRSLEPGVNFNRTSGSVNIRGLEGPRVLTTIDGIPIPFIDDGARDADGGIDSFDFSALSTIDIVRGADSSRAGGGA
LGGAVVLRTLEPEDLIGEGKTWGGIFKFAYDGEDDSLGGSAAVAARYDNTAALFQGGYRRGHERESNGDVGGYSTTRTEA
DPADYDQNNLLFKVRQYTESGHTFGFTAERFDRDKDIDFMSGQSLFGNYRPGDYDKLDDTRRERLSLDYEFEATDDNAWF
DSASATVYWQRLLRENGVDAYRSTSVIGDYSRLNEAEEEGFGASGYVEKFFETGNLQHQVTLGGDFAIGKLHQYSSGEDS
CDTAPSPSCNFLHTNQSDSPDVDSRKIGVYLQDRISIGDGPFALTPGLRLDWYDYAPENTAAYMRNPNYDGLPPGQSDLA
LSPKLLATYQAAEEVELFAQWAMAFRPPTAEELYLNYGAPGSYLQIGNPDLKPETSQGFEIGANLGDEEFGGRIAAFYNR
YRNFIDERWSFDPTGTYPIGITEAINRANVSIHGVEVSGHKVFANGVHVRTALAYAHGRDLDTDEVLGSVAPLKGVLNVG
YAAETWGTDLIVTAAMDVSDKSTNSFKAPGYGIVDVTGWWEPEQMPGLRVNAGVYNIFDKTYWDAVNTQNAFTQPADFYS
EPGRTFKVSLTQRF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 80341; Mature: 80341

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRHHRLALLACTAFVTLVETTLSHAQSTEEAAGAAEKQGRVTVLKKLSIQGGEKEGVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCC
DTPLAEQVTEEELDRNQITSFEDLGRSLEPGVNFNRTSGSVNIRGLEGPRVLTTIDGIPI
CCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCCEEEEEECCCCEEEEEECCCCC
PFIDDGARDADGGIDSFDFSALSTIDIVRGADSSRAGGGALGGAVVLRTLEPEDLIGEGK
CCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCHHHHCCCC
TWGGIFKFAYDGEDDSLGGSAAVAARYDNTAALFQGGYRRGHERESNGDVGGYSTTRTEA
CCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHCHHHCCCCCCCCCCCCCCCCCCCCC
DPADYDQNNLLFKVRQYTESGHTFGFTAERFDRDKDIDFMSGQSLFGNYRPGDYDKLDDT
CCCCCCCCCEEEEEEEHHCCCCEECEEHHHCCCCCCCCEECCHHHCCCCCCCCCCCCHHH
RRERLSLDYEFEATDDNAWFDSASATVYWQRLLRENGVDAYRSTSVIGDYSRLNEAEEEG
HHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHCCHHHHHHHHHHC
FGASGYVEKFFETGNLQHQVTLGGDFAIGKLHQYSSGEDSCDTAPSPSCNFLHTNQSDSP
CCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCC
DVDSRKIGVYLQDRISIGDGPFALTPGLRLDWYDYAPENTAAYMRNPNYDGLPPGQSDLA
CCCCEEEEEEEEEEEECCCCCEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCC
LSPKLLATYQAAEEVELFAQWAMAFRPPTAEELYLNYGAPGSYLQIGNPDLKPETSQGFE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCEEECCCCCCCCCCCCCEE
IGANLGDEEFGGRIAAFYNRYRNFIDERWSFDPTGTYPIGITEAINRANVSIHGVEVSGH
ECCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCC
KVFANGVHVRTALAYAHGRDLDTDEVLGSVAPLKGVLNVGYAAETWGTDLIVTAAMDVSD
EEEECCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCEEHHHCCCCEEEEEEECCCC
KSTNSFKAPGYGIVDVTGWWEPEQMPGLRVNAGVYNIFDKTYWDAVNTQNAFTQPADFYS
CCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEHHHHHHHHCCCCCCCCCCCHHHHC
EPGRTFKVSLTQRF
CCCCEEEEEEEECC
>Mature Secondary Structure
MLNRHHRLALLACTAFVTLVETTLSHAQSTEEAAGAAEKQGRVTVLKKLSIQGGEKEGVA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCC
DTPLAEQVTEEELDRNQITSFEDLGRSLEPGVNFNRTSGSVNIRGLEGPRVLTTIDGIPI
CCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEECCCCEEEEEECCCCEEEEEECCCCC
PFIDDGARDADGGIDSFDFSALSTIDIVRGADSSRAGGGALGGAVVLRTLEPEDLIGEGK
CCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCHHHHCCCC
TWGGIFKFAYDGEDDSLGGSAAVAARYDNTAALFQGGYRRGHERESNGDVGGYSTTRTEA
CCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHCHHHCCCCCCCCCCCCCCCCCCCCC
DPADYDQNNLLFKVRQYTESGHTFGFTAERFDRDKDIDFMSGQSLFGNYRPGDYDKLDDT
CCCCCCCCCEEEEEEEHHCCCCEECEEHHHCCCCCCCCEECCHHHCCCCCCCCCCCCHHH
RRERLSLDYEFEATDDNAWFDSASATVYWQRLLRENGVDAYRSTSVIGDYSRLNEAEEEG
HHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHCCHHHHHHHHHHC
FGASGYVEKFFETGNLQHQVTLGGDFAIGKLHQYSSGEDSCDTAPSPSCNFLHTNQSDSP
CCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCC
DVDSRKIGVYLQDRISIGDGPFALTPGLRLDWYDYAPENTAAYMRNPNYDGLPPGQSDLA
CCCCEEEEEEEEEEEECCCCCEEECCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCC
LSPKLLATYQAAEEVELFAQWAMAFRPPTAEELYLNYGAPGSYLQIGNPDLKPETSQGFE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCEEECCCCCCCCCCCCCEE
IGANLGDEEFGGRIAAFYNRYRNFIDERWSFDPTGTYPIGITEAINRANVSIHGVEVSGH
ECCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCC
KVFANGVHVRTALAYAHGRDLDTDEVLGSVAPLKGVLNVGYAAETWGTDLIVTAAMDVSD
EEEECCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHCCEEHHHCCCCEEEEEEECCCC
KSTNSFKAPGYGIVDVTGWWEPEQMPGLRVNAGVYNIFDKTYWDAVNTQNAFTQPADFYS
CCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEHHHHHHHHCCCCCCCCCCCHHHHC
EPGRTFKVSLTQRF
CCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]