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The map label for this gene is fhs [H]

Identifier: 229577668

GI number: 229577668

Start: 2375519

End: 2377198

Strand: Reverse

Name: fhs [H]

Synonym: Smed_2298

Alternate gene names: 229577668

Gene position: 2377198-2375519 (Counterclockwise)

Preceding gene: 150397499

Following gene: 150397496

Centisome position: 62.86

GC content: 61.31

Gene sequence:

>1680_bases
GTGGGAGAGGTAAAGACCGACATCGAGATCGCGCGCGCGGCGCGCAAGCAACCAATCATGGAGGTCGGCGCGAGACTCGG
TATCCCGCCGGAGCATCTGCTTCCCTACGGCCATGACAAGGCCAAGGTGAGCGCCGAGTTCATCGCGGCGCAAAGGGAGA
AGAAGAACGGGCGGCTCATCCTGGTCACAGCGATCAACCCGACGCCGGCGGGCGAGGGCAAGACGACGACGACCGTCGGT
CTCGTCGATGGCTTGAACCGTATCGGCAAGAAGGCGATCGTCTGTATTCGCGAGGCCTCGCTCGGTCCTTGCTTCGGTAT
CAAGGGCGGGGCGGCCGGTGGCGGTTATGCGCAGGTCGTGCCGATGGAGGACATCAATCTCCACTTCACCGGCGATTTCC
ACGCGATCACTTCGGCCCACAACCTTCTCTCCGCCTTGATAGACAACCACATCTATTGGGGGAACGAGCAGGCGATTGAC
ATCCGCCGAATTGCCTGGCGGCGGGTCATGGACATGAACGACCGGGCGCTGCGCCATATCGTCGGCTCGCTCGGCGGGGT
CGCCAACGGCTATCCACGAGAGACCGGCTTCGACATTACCGTCGCCTCGGAAGTCATGGCGATCCTCTGTCTCGCGATGG
ACATCAGGGACCTCGAAAGGCGGCTCGGCAACATCATCATCGGCTATCGGCGCGACAAGAGCCCGGTCTATGCGCGCGAT
ATCAAGGCCGACGGAGCCATGGCGGTGCTGCTCAAGGACGCGATGCAGCCGAACCTGGTGCAGACGCTCGAGAACAATCC
GGCATTCGTGCACGGCGGTCCGTTCGCCAATATCGCGCATGGCTGCAATTCGGTCGTTGCCACCACGACGGCGCTGAAGC
TTGCCGATTACGTCGTGACCGAAGCGGGTTTCGGTGCGGATCTCGGTGCCGAGAAGTTCTTCGACATAAAGTGCCGCAAG
GCAGGCCTCATGCCGGATGCTGCGGTGATCGTTGCGACGGTCCGGGCAATCAAGATGAACGGCGGCGTGAAGAAGGAGGA
TCTCGCGAAAGAAAATGTCGAAGCGCTCAGGAAGGGGTGCCCGAACCTCGGGCGCCACATCCAGAACGTCAAGAAGTTCG
GCGTACCGGTGCTCGTCGCAATCAACCACTTCACTTCCGATACCGAGGCCGAAATCCAGGCGATCAAGGACTATGTCCGC
ACGCTCGGTTCCGAAGCGGTCTTATGCAAGCATTGGGCAGAGGGCTCAGCCGGCATCGAGGAACTTGCCGATAAGGTTGC
CGATCTCGCCGACGCCGGCCATTCGCAGTTTTCGCCGCTCTATCCCGACGAGATGCCGCTTTTTCAGAAGATCGAGGCGA
TCGCCAAGGATATTTATCACGCGAGCGAGGTGATCGCCGACAAGCTGGTGCGCGACCAGCTTCGAATCTGGGAAGACCAG
GGTTACGGTCATCTGCCGATCTGCATGGCCAAGACGCAATATTCCTTCTCCACCGACCCGAATCTCCGCGGCGCGCCCAC
CGGCCACACCGTACCGATACGCGAGGTTCGCCTGGCCGCCGGCGCTGGGTTCATCGTCGTCATCACCGGCGAGATCATGA
CGATGCCGGGCCTGCCGAAAGTACCCTCTTCGGAGCGGATACGGCTCGACGAGGAGGGATACATCGAGGGTTTGTTCTGA

Upstream 100 bases:

>100_bases
TATTCTTGCCCGTTGACGGGCTTCGTGCGAGCGTAGGCAAAGGAAACGGACTTGCGGATGCCGCGGAGGAGGCGGGATGC
GCAAGCAACTGGGGGAAGCC

Downstream 100 bases:

>100_bases
AGGGGATTCAGAGGCTGGGCTGGCGCCGCGGGCCATCATGCGCGCCGTCAACGGCAATACCGATACCCGTTCCTTCTTTC
GATGACATCGAGATGCAGAT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MGEVKTDIEIARAARKQPIMEVGARLGIPPEHLLPYGHDKAKVSAEFIAAQREKKNGRLILVTAINPTPAGEGKTTTTVG
LVDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVVPMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAID
IRRIAWRRVMDMNDRALRHIVGSLGGVANGYPRETGFDITVASEVMAILCLAMDIRDLERRLGNIIIGYRRDKSPVYARD
IKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRK
AGLMPDAAVIVATVRAIKMNGGVKKEDLAKENVEALRKGCPNLGRHIQNVKKFGVPVLVAINHFTSDTEAEIQAIKDYVR
TLGSEAVLCKHWAEGSAGIEELADKVADLADAGHSQFSPLYPDEMPLFQKIEAIAKDIYHASEVIADKLVRDQLRIWEDQ
GYGHLPICMAKTQYSFSTDPNLRGAPTGHTVPIREVRLAAGAGFIVVITGEIMTMPGLPKVPSSERIRLDEEGYIEGLF

Sequences:

>Translated_559_residues
MGEVKTDIEIARAARKQPIMEVGARLGIPPEHLLPYGHDKAKVSAEFIAAQREKKNGRLILVTAINPTPAGEGKTTTTVG
LVDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVVPMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAID
IRRIAWRRVMDMNDRALRHIVGSLGGVANGYPRETGFDITVASEVMAILCLAMDIRDLERRLGNIIIGYRRDKSPVYARD
IKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRK
AGLMPDAAVIVATVRAIKMNGGVKKEDLAKENVEALRKGCPNLGRHIQNVKKFGVPVLVAINHFTSDTEAEIQAIKDYVR
TLGSEAVLCKHWAEGSAGIEELADKVADLADAGHSQFSPLYPDEMPLFQKIEAIAKDIYHASEVIADKLVRDQLRIWEDQ
GYGHLPICMAKTQYSFSTDPNLRGAPTGHTVPIREVRLAAGAGFIVVITGEIMTMPGLPKVPSSERIRLDEEGYIEGLF
>Mature_558_residues
GEVKTDIEIARAARKQPIMEVGARLGIPPEHLLPYGHDKAKVSAEFIAAQREKKNGRLILVTAINPTPAGEGKTTTTVGL
VDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVVPMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAIDI
RRIAWRRVMDMNDRALRHIVGSLGGVANGYPRETGFDITVASEVMAILCLAMDIRDLERRLGNIIIGYRRDKSPVYARDI
KADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVTEAGFGADLGAEKFFDIKCRKA
GLMPDAAVIVATVRAIKMNGGVKKEDLAKENVEALRKGCPNLGRHIQNVKKFGVPVLVAINHFTSDTEAEIQAIKDYVRT
LGSEAVLCKHWAEGSAGIEELADKVADLADAGHSQFSPLYPDEMPLFQKIEAIAKDIYHASEVIADKLVRDQLRIWEDQG
YGHLPICMAKTQYSFSTDPNLRGAPTGHTVPIREVRLAAGAGFIVVITGEIMTMPGLPKVPSSERIRLDEEGYIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=42.1900161030596, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI36796743, Length=625, Percent_Identity=41.92, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=38.3720930232558, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=44.8, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=44.8, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.1800947867299, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.1725239616613, Blast_Score=448, Evalue=1e-127,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=42.0289855072464, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=42.0289855072464, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=42.0289855072464, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=42.0289855072464, Blast_Score=457, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60580; Mature: 60448

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVKTDIEIARAARKQPIMEVGARLGIPPEHLLPYGHDKAKVSAEFIAAQREKKNGRLI
CCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
LVTAINPTPAGEGKTTTTVGLVDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVV
EEEEECCCCCCCCCCEEEHHHHHHHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAIDIRRIAWRRVMDMNDRALRHI
EECCCEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHH
VGSLGGVANGYPRETGFDITVASEVMAILCLAMDIRDLERRLGNIIIGYRRDKSPVYARD
HHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
IKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKAGLMPDAAVIVATVRAIKMNGGVKKEDLAKENVEALRKGC
CCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PNLGRHIQNVKKFGVPVLVAINHFTSDTEAEIQAIKDYVRTLGSEAVLCKHWAEGSAGIE
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHH
ELADKVADLADAGHSQFSPLYPDEMPLFQKIEAIAKDIYHASEVIADKLVRDQLRIWEDQ
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYGHLPICMAKTQYSFSTDPNLRGAPTGHTVPIREVRLAAGAGFIVVITGEIMTMPGLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCEEECCCCCC
VPSSERIRLDEEGYIEGLF
CCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
GEVKTDIEIARAARKQPIMEVGARLGIPPEHLLPYGHDKAKVSAEFIAAQREKKNGRLI
CCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEE
LVTAINPTPAGEGKTTTTVGLVDGLNRIGKKAIVCIREASLGPCFGIKGGAAGGGYAQVV
EEEEECCCCCCCCCCEEEHHHHHHHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAITSAHNLLSALIDNHIYWGNEQAIDIRRIAWRRVMDMNDRALRHI
EECCCEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHH
VGSLGGVANGYPRETGFDITVASEVMAILCLAMDIRDLERRLGNIIIGYRRDKSPVYARD
HHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEE
IKADGAMAVLLKDAMQPNLVQTLENNPAFVHGGPFANIAHGCNSVVATTTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKAGLMPDAAVIVATVRAIKMNGGVKKEDLAKENVEALRKGC
CCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PNLGRHIQNVKKFGVPVLVAINHFTSDTEAEIQAIKDYVRTLGSEAVLCKHWAEGSAGIE
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHH
ELADKVADLADAGHSQFSPLYPDEMPLFQKIEAIAKDIYHASEVIADKLVRDQLRIWEDQ
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYGHLPICMAKTQYSFSTDPNLRGAPTGHTVPIREVRLAAGAGFIVVITGEIMTMPGLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCEEECCCCCC
VPSSERIRLDEEGYIEGLF
CCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA