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The map label for this gene is gcvT [H]

Identifier: 150397398

GI number: 150397398

Start: 2275109

End: 2277556

Strand: Reverse

Name: gcvT [H]

Synonym: Smed_2197

Alternate gene names: 150397398

Gene position: 2277556-2275109 (Counterclockwise)

Preceding gene: 150397399

Following gene: 150397397

Centisome position: 60.22

GC content: 62.7

Gene sequence:

>2448_bases
ATGACGAAGCCGATCCCTGAAAAGGCGCGCGTGGTCATCATCGGCGGTGGCGTTTCCGGTTGTTCGGTCGCCTATCACCT
GTCAAAGCTCGGCTGGACCGACGTCGTGCTGCTCGAGCGCAAGCAGCTCACCTGCGGCACCACCTGGCATGCGGCCGGGC
TGATCGGCCAGCTGCGCGCCTCGCAGAACATGACACGCCTCGCAAAATATTCGGCCGACCTTTACGTGAACCTCGAGGCG
GAGACCGGCATTGCTACCGGCATGCGCCAGAACGGCTCGATCACCGTGGCGCTGACGGAAGAGCGCAAGGAGGAGATCTA
CCGCCAGGCTTCGCTAGCGCGTGCCTTCGATGTGGATGTGCGCGAGATCTGTGCGAGCGAAGTGAAGGCGCTCTATCCGC
ACCTCAACGTCTCCGATGTTAAGGCGGCGGTGCACCTGCCGCTGGACGGTCAATGCGATCCGGCCAATATCGCCATGGCG
CTTGCCAAGGGTGCGCGGCAGAACGGCGCGACGATCATCGAGGGCGTGAAAGTCACCTCGGTGTTGAAGAAGGATGGCCG
TGTTGCCGGTGTCACCTGCAAGCAGAACGGCGAGAATTACACCATCGAGACCGAGAACGTCGTCAACTGCGCCGGCATGT
GGGGCAGGGAGCTTGCCCGGCAATCCGGTGTGACGGTGCCGCTGCACGCCTGCGAGCATTTCTACATCGTGACCGAGGCA
GTGCCGGGTCTGGGCCGCCTGCCGGTGCTGCGCGTACCCGACGAGTGCACCTACTACAAGGAAGACGCAGGCAAGATGCT
CGTGGGCGCCTTTGAGCTGAAAGCCAAGCCCTGGGGCATGGAAGGCATTCGCGAGGACTTCTGCTTCGACCAGCTGCCGG
AGGACTTCGACCATTTCGCGCCGATCCTCGAAATGGCGGTCAACCGCATGCCGATGCTGGAGACGGCCGGCATTCATACC
TTCTTCAACGGGCCGGAAAGCTTCACCCCCGACGACCGCTACTATCTTGGCGAGGCGCCCGAGGTTAAGGGATATTGGGT
TGCCGCCGGATATAATTCGATCGGCATCGTCTCTTCCGGGGGTGCCGGAATGGCGCTGGCGCAGTGGATGAACGACGGCG
AGCCGCCCTTCGACCTCTGGGAGGTCGACATCCGCCGCGCCCAGCCTTTTCAGAAAAACCGCTCCTACCTGAAGGAGCGC
GTGGGCGAGACGCTTGGACTGCTCTATGCAGATCATTTCCCCTATCGCCAGATGGCAACCGCGCGCGGTGTTCGCCGCTC
GCCCATCCATGAGCACCTGAAGGCGCGCGGTGCCGTGTTCGGCGAAGTGGCGGGATGGGAGCGGGCGAACTGGTTCGCGG
AACAGGGTCAGGAGCGCGAATATCGTTACTCCTGGAAGCGGCAGAACTGGTTTGAAAATCAGCGGCAGGAGCACCTTGCG
GTCCGCAGCAAGGTCGGCCTCTTCGACATGACGTCCTTCGGGAAGATTCGTGTCGAAGGTCGCGATGCGCTCGCCTTCCT
GCAACGGCTTTGCGCCAATGAGATGGATGTCGAGCCCGGCCGTGTCGTCTACACGCAGATGCTGAACGCTCGGGGCGGCA
TCGAGAGCGACCTTACCGTCACCCGGTTCTCGGAATCCGCATTTTTCCTCGTCGTGCCCGGTGCGACCCTGCAGCGGGAC
CTTTCCTGGTTGCGGAGGCACTTGCGTGACGAATTCGTGGTGGTCACTGACGTCACCGCCGCCGAAAGCGTACTCTGCGT
CATGGGACCGAAGGCTCGGGACCTTATGCAGAAGGTGAGCCCGAACGATTTCTCCAATGAAGCGCATCCTTTCGGCACCG
CGCGCGAGATCGAAGTCGGCATGGGTTTAGCCCGCGCTCACCGTGTCACGTATGTCGGCGAACTAGGCTGGGAGCTTTAT
GTATCGACCGACCAGGCGGCGCATGTGTTCGAGACGCTGGAGGCGGCGGGCGCCGACGCCGGCCTCCGGCTCTGCGGCCT
TCACACGCTGGACAGTTGCCGGATCGAGAAAGCGTTCCGGCATTTCGGCCATGACATAACCGATGAGGATCACGTGCTCG
AAGCCGGACTCGGCTTTGCAGTGAAGTCCGCCAAGGGCGAATTCATCGGCCGCGAAGCAGTGCTCGCGAAGCGCGACAAG
GGCCTTTCGCGCAGGCTGTTGCAGTTCCGGCTTTCCGATCCGGAGCCGTTGCTCTTCCACAACGAGGCGATCGTGCGCGA
TGGCGAGATCGTCGGAACGATCACGTCCGGCAATTACGGACATCACCTCGGTGGCGCGATCGGGCTCGGCTACGTGCCTT
GCCAGGGGGAGGGCGAGGCGGATGTGCTTGCATCGGGCTACGAGATCGAAATCGCCGGAACACGGGTCAAGGCCGTGGCT
TCATCGAAGCCGATGTACGATCCGAAGGCGGAGCGGGGGAAGGCCTGA

Upstream 100 bases:

>100_bases
CCGGGCGCGAGGTCGAGGTCGAGATTTTCGGCGACCGCTTCAAGGCCGTCGTGCAGCCGGACCAGCCGCTTTGGGATCCC
TCGAATGAAAGACTGAAAGC

Downstream 100 bases:

>100_bases
AGAAACCGCCCCTCATCCGCCTGCCGCCGCATTCTCCCGTTTTGACGGGGAGATGGGAACATACGGCGCCCTCTGAAACC
ATCCGGGGAGAGGGCAGGCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MTKPIPEKARVVIIGGGVSGCSVAYHLSKLGWTDVVLLERKQLTCGTTWHAAGLIGQLRASQNMTRLAKYSADLYVNLEA
ETGIATGMRQNGSITVALTEERKEEIYRQASLARAFDVDVREICASEVKALYPHLNVSDVKAAVHLPLDGQCDPANIAMA
LAKGARQNGATIIEGVKVTSVLKKDGRVAGVTCKQNGENYTIETENVVNCAGMWGRELARQSGVTVPLHACEHFYIVTEA
VPGLGRLPVLRVPDECTYYKEDAGKMLVGAFELKAKPWGMEGIREDFCFDQLPEDFDHFAPILEMAVNRMPMLETAGIHT
FFNGPESFTPDDRYYLGEAPEVKGYWVAAGYNSIGIVSSGGAGMALAQWMNDGEPPFDLWEVDIRRAQPFQKNRSYLKER
VGETLGLLYADHFPYRQMATARGVRRSPIHEHLKARGAVFGEVAGWERANWFAEQGQEREYRYSWKRQNWFENQRQEHLA
VRSKVGLFDMTSFGKIRVEGRDALAFLQRLCANEMDVEPGRVVYTQMLNARGGIESDLTVTRFSESAFFLVVPGATLQRD
LSWLRRHLRDEFVVVTDVTAAESVLCVMGPKARDLMQKVSPNDFSNEAHPFGTAREIEVGMGLARAHRVTYVGELGWELY
VSTDQAAHVFETLEAAGADAGLRLCGLHTLDSCRIEKAFRHFGHDITDEDHVLEAGLGFAVKSAKGEFIGREAVLAKRDK
GLSRRLLQFRLSDPEPLLFHNEAIVRDGEIVGTITSGNYGHHLGGAIGLGYVPCQGEGEADVLASGYEIEIAGTRVKAVA
SSKPMYDPKAERGKA

Sequences:

>Translated_815_residues
MTKPIPEKARVVIIGGGVSGCSVAYHLSKLGWTDVVLLERKQLTCGTTWHAAGLIGQLRASQNMTRLAKYSADLYVNLEA
ETGIATGMRQNGSITVALTEERKEEIYRQASLARAFDVDVREICASEVKALYPHLNVSDVKAAVHLPLDGQCDPANIAMA
LAKGARQNGATIIEGVKVTSVLKKDGRVAGVTCKQNGENYTIETENVVNCAGMWGRELARQSGVTVPLHACEHFYIVTEA
VPGLGRLPVLRVPDECTYYKEDAGKMLVGAFELKAKPWGMEGIREDFCFDQLPEDFDHFAPILEMAVNRMPMLETAGIHT
FFNGPESFTPDDRYYLGEAPEVKGYWVAAGYNSIGIVSSGGAGMALAQWMNDGEPPFDLWEVDIRRAQPFQKNRSYLKER
VGETLGLLYADHFPYRQMATARGVRRSPIHEHLKARGAVFGEVAGWERANWFAEQGQEREYRYSWKRQNWFENQRQEHLA
VRSKVGLFDMTSFGKIRVEGRDALAFLQRLCANEMDVEPGRVVYTQMLNARGGIESDLTVTRFSESAFFLVVPGATLQRD
LSWLRRHLRDEFVVVTDVTAAESVLCVMGPKARDLMQKVSPNDFSNEAHPFGTAREIEVGMGLARAHRVTYVGELGWELY
VSTDQAAHVFETLEAAGADAGLRLCGLHTLDSCRIEKAFRHFGHDITDEDHVLEAGLGFAVKSAKGEFIGREAVLAKRDK
GLSRRLLQFRLSDPEPLLFHNEAIVRDGEIVGTITSGNYGHHLGGAIGLGYVPCQGEGEADVLASGYEIEIAGTRVKAVA
SSKPMYDPKAERGKA
>Mature_814_residues
TKPIPEKARVVIIGGGVSGCSVAYHLSKLGWTDVVLLERKQLTCGTTWHAAGLIGQLRASQNMTRLAKYSADLYVNLEAE
TGIATGMRQNGSITVALTEERKEEIYRQASLARAFDVDVREICASEVKALYPHLNVSDVKAAVHLPLDGQCDPANIAMAL
AKGARQNGATIIEGVKVTSVLKKDGRVAGVTCKQNGENYTIETENVVNCAGMWGRELARQSGVTVPLHACEHFYIVTEAV
PGLGRLPVLRVPDECTYYKEDAGKMLVGAFELKAKPWGMEGIREDFCFDQLPEDFDHFAPILEMAVNRMPMLETAGIHTF
FNGPESFTPDDRYYLGEAPEVKGYWVAAGYNSIGIVSSGGAGMALAQWMNDGEPPFDLWEVDIRRAQPFQKNRSYLKERV
GETLGLLYADHFPYRQMATARGVRRSPIHEHLKARGAVFGEVAGWERANWFAEQGQEREYRYSWKRQNWFENQRQEHLAV
RSKVGLFDMTSFGKIRVEGRDALAFLQRLCANEMDVEPGRVVYTQMLNARGGIESDLTVTRFSESAFFLVVPGATLQRDL
SWLRRHLRDEFVVVTDVTAAESVLCVMGPKARDLMQKVSPNDFSNEAHPFGTAREIEVGMGLARAHRVTYVGELGWELYV
STDQAAHVFETLEAAGADAGLRLCGLHTLDSCRIEKAFRHFGHDITDEDHVLEAGLGFAVKSAKGEFIGREAVLAKRDKG
LSRRLLQFRLSDPEPLLFHNEAIVRDGEIVGTITSGNYGHHLGGAIGLGYVPCQGEGEADVLASGYEIEIAGTRVKAVAS
SKPMYDPKAERGKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI197927446, Length=863, Percent_Identity=36.8482039397451, Blast_Score=524, Evalue=1e-148,
Organism=Homo sapiens, GI21361378, Length=863, Percent_Identity=36.8482039397451, Blast_Score=524, Evalue=1e-148,
Organism=Homo sapiens, GI194306651, Length=825, Percent_Identity=37.2121212121212, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI24797151, Length=816, Percent_Identity=33.2107843137255, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI44662838, Length=398, Percent_Identity=24.8743718592965, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI257796258, Length=369, Percent_Identity=25.2032520325203, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI257796256, Length=321, Percent_Identity=25.2336448598131, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI257796254, Length=395, Percent_Identity=22.5316455696203, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789272, Length=334, Percent_Identity=30.8383233532934, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI32563613, Length=824, Percent_Identity=33.252427184466, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71994045, Length=826, Percent_Identity=29.1767554479419, Blast_Score=298, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI71994052, Length=833, Percent_Identity=28.9315726290516, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=25.2631578947368, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=246, Percent_Identity=24.7967479674797, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571104, Length=829, Percent_Identity=33.1724969843185, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI20130091, Length=857, Percent_Identity=31.9719953325554, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI20129441, Length=309, Percent_Identity=28.8025889967638, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 90070; Mature: 89939

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIPEKARVVIIGGGVSGCSVAYHLSKLGWTDVVLLERKQLTCGTTWHAAGLIGQLRA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
SQNMTRLAKYSADLYVNLEAETGIATGMRQNGSITVALTEERKEEIYRQASLARAFDVDV
HCCHHHHHHCCCEEEEEEECCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCH
REICASEVKALYPHLNVSDVKAAVHLPLDGQCDPANIAMALAKGARQNGATIIEGVKVTS
HHHHHHHHHHHCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHH
VLKKDGRVAGVTCKQNGENYTIETENVVNCAGMWGRELARQSGVTVPLHACEHFYIVTEA
HHHCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEC
VPGLGRLPVLRVPDECTYYKEDAGKMLVGAFELKAKPWGMEGIREDFCFDQLPEDFDHFA
CCCCCCCCEEECCCCCCEEHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHH
PILEMAVNRMPMLETAGIHTFFNGPESFTPDDRYYLGEAPEVKGYWVAAGYNSIGIVSSG
HHHHHHHCCCCCCHHCCCEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECC
GAGMALAQWMNDGEPPFDLWEVDIRRAQPFQKNRSYLKERVGETLGLLYADHFPYRQMAT
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARGVRRSPIHEHLKARGAVFGEVAGWERANWFAEQGQEREYRYSWKRQNWFENQRQEHLA
HCCCCCCHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VRSKVGLFDMTSFGKIRVEGRDALAFLQRLCANEMDVEPGRVVYTQMLNARGGIESDLTV
HHHHCCEEEECCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
TRFSESAFFLVVPGATLQRDLSWLRRHLRDEFVVVTDVTAAESVLCVMGPKARDLMQKVS
EEECCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHHCEEEEECCCHHHHHHHCC
PNDFSNEAHPFGTAREIEVGMGLARAHRVTYVGELGWELYVSTDQAAHVFETLEAAGADA
CCCCCCCCCCCCCCEEEHHCCCHHHHHHEEEEECCCEEEEEECCHHHHHHHHHHHCCCCC
GLRLCGLHTLDSCRIEKAFRHFGHDITDEDHVLEAGLGFAVKSAKGEFIGREAVLAKRDK
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHCC
GLSRRLLQFRLSDPEPLLFHNEAIVRDGEIVGTITSGNYGHHLGGAIGLGYVPCQGEGEA
CHHHHHHHHCCCCCCCEEEECCEEEECCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCC
DVLASGYEIEIAGTRVKAVASSKPMYDPKAERGKA
CEEECCEEEEEECCEEEEEECCCCCCCCCHHCCCC
>Mature Secondary Structure 
TKPIPEKARVVIIGGGVSGCSVAYHLSKLGWTDVVLLERKQLTCGTTWHAAGLIGQLRA
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
SQNMTRLAKYSADLYVNLEAETGIATGMRQNGSITVALTEERKEEIYRQASLARAFDVDV
HCCHHHHHHCCCEEEEEEECCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCH
REICASEVKALYPHLNVSDVKAAVHLPLDGQCDPANIAMALAKGARQNGATIIEGVKVTS
HHHHHHHHHHHCCCCCHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHH
VLKKDGRVAGVTCKQNGENYTIETENVVNCAGMWGRELARQSGVTVPLHACEHFYIVTEA
HHHCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEC
VPGLGRLPVLRVPDECTYYKEDAGKMLVGAFELKAKPWGMEGIREDFCFDQLPEDFDHFA
CCCCCCCCEEECCCCCCEEHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHH
PILEMAVNRMPMLETAGIHTFFNGPESFTPDDRYYLGEAPEVKGYWVAAGYNSIGIVSSG
HHHHHHHCCCCCCHHCCCEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECC
GAGMALAQWMNDGEPPFDLWEVDIRRAQPFQKNRSYLKERVGETLGLLYADHFPYRQMAT
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ARGVRRSPIHEHLKARGAVFGEVAGWERANWFAEQGQEREYRYSWKRQNWFENQRQEHLA
HCCCCCCHHHHHHHHCCCEEEHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VRSKVGLFDMTSFGKIRVEGRDALAFLQRLCANEMDVEPGRVVYTQMLNARGGIESDLTV
HHHHCCEEEECCCCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
TRFSESAFFLVVPGATLQRDLSWLRRHLRDEFVVVTDVTAAESVLCVMGPKARDLMQKVS
EEECCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECHHHHCEEEEECCCHHHHHHHCC
PNDFSNEAHPFGTAREIEVGMGLARAHRVTYVGELGWELYVSTDQAAHVFETLEAAGADA
CCCCCCCCCCCCCCEEEHHCCCHHHHHHEEEEECCCEEEEEECCHHHHHHHHHHHCCCCC
GLRLCGLHTLDSCRIEKAFRHFGHDITDEDHVLEAGLGFAVKSAKGEFIGREAVLAKRDK
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHCC
GLSRRLLQFRLSDPEPLLFHNEAIVRDGEIVGTITSGNYGHHLGGAIGLGYVPCQGEGEA
CHHHHHHHHCCCCCCCEEEECCEEEECCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCC
DVLASGYEIEIAGTRVKAVASSKPMYDPKAERGKA
CEEECCEEEEEECCEEEEEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA