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The map label for this gene is gcvT [H]

Identifier: 150397399

GI number: 150397399

Start: 2277553

End: 2280000

Strand: Reverse

Name: gcvT [H]

Synonym: Smed_2198

Alternate gene names: 150397399

Gene position: 2280000-2277553 (Counterclockwise)

Preceding gene: 150397401

Following gene: 150397398

Centisome position: 60.29

GC content: 62.05

Gene sequence:

>2448_bases
ATGTCGAATTTGCCGTCTCACGCACGCGTCGTGATCATTGGTGGGGGCGCCGTCGGCGCCTCCTCGATCTACCATCTCGC
CAAGGCCGGCTGGACAGACTGCGTGCTTCTCGAAAAGAACGAGCTCACGGCCGGCTCCACCTGGCATGCTGCTGGTAACG
TGCCGACCTTCTCCTCGTCCTGGTCGATCATGAACATGCAGCGCTATTCGGCGTCGCTTTACCGCGACCTGGGTGTGCAA
GTCGATTATCCGATGAACTACCACGTGACGGGCTCCCTCCGTCTCGGCCATACGAAGGAGCGCCTGCAGGAATTCAAGCG
CGTCGTGGGCATGGGCCGCTACCAGGGCATGGAACTCGACATTCTGGCGCCCGACGAAATGCGCAGCCGCTATCCCTTCC
TCGAGACGCATGAGCTCACGGGCGCGCTCTACGACCCCTATGACGGCGACATCGATCCGGCGCAGCTCACGCAGGCGCTG
GCCAAGGGCGCACGCGACATGGGTGCGAAGATCATCCGCTTCTGTCCCGTGACCGGTGCCCGGCGCGAAAAGGACGAATG
GGTGATCGAGACGCCGCAAGGCGAAATCCGCTGCGAATACGTTGTGAATGCGGCCGGCTATTACGCCCGTGAGGTCGGCA
GGATGTTCGGCCGCGACGTGCCGATGATGGTGATGAGCCATCAATATGTCCTCTTCGACGAGATTCCGGAACTTGCCGCC
TGGTCCAAGGAGGCGGGTCACAAGCTGCCGCTGCTGCGCGACGTCGACAGCTCCTATTATCTCCGGCAGGAGAAATACGG
CATGAATCTCGGCCCGTACGAGAAGAACTGTCGTGCTCACTGGACGACGACGGACGATCCGATGCCGGAGGACTTTTCCT
TCCAGCTCTTTCCGGACGACCTCGAAAGGCTCGAATGGTATCTGAACGACGCGGTCGAACGCGTTCCGATCCTCGGTACC
GCCGGACTCTCCCGCGTCATCAACGGGCCGATCCCCTACGCTCCGGATGGAAATCCGCTGATAGGGCCGATGCCGGGCGT
GCCGAACGCCTTCGAGGCCTGCGTCTTCACCTTCGGCATTTGCCAGGCTGGCGGTGCGGGCAAGGTCCTTGCGGAATGGG
TGACCGAAGGTCAGACGGAATGGGACATGTGGTCCTGCGATCCGCGCCGTTACACGGACTACACCGATCAGGACTATTGC
ATCGCCAAGGGCATGCAGATCTACGGCAACGAATATGCGATGCATTTCCCCAAGCACTACTGGCCGGCGGGGCGCAATAG
AAAGCTTTCGCAGATCCATGACCGCATTGCCGCACTCGGCGCTCAGTTCAAGCCATATAATGGCTGGGAACGCGCCATGT
GGTACGCCAAGCCGGGCGACGACACGTCGGAGGAGGCGACGCAGACCTGGGGCAGGGAAGGCCCCTGGGCGAAGCGGATC
GAGGAGGAGTGCCTGGCCGTGCGCGACGCCGCGGGTATTCTCGACCTGCCTGGCTTCTCGCGCTTTCGCTTGAAAGGCGA
GGGCGCGCGCGAATGGCTTTCCGGTCTCATTACCGGCCGCGTGCCGAAGCCGGGCCGAATCGGCCTTGCCTATTTCGCCG
ATAGCAAAGGCCGCATCCTCACCGAAATGTCGGTCATGGCAATCGAGGAGGATTTCTTCTTCCTGATAACCGCGGCGACG
GCGCAGTGGCATGACTTCGAGTGGCTCCGGAAGCACCGCCCTGTTGATGCGGCTTTTACATTGGACGACGTGACGGCGAA
TTTTTCATGCCAGATCCTGACAGGCCCGAAATCACGCGCGATCCTGGCCGAGGTCTGCGATGCCGATCTTGCAAAGGGCT
GGCTGACGCACCAGACGGCTCAGATCGCGGGGCGCTATTGCCAGCTCGTGCGGGTGTCTTTCGCCGGCGAGCTCGGTTGG
GAAATCCATACCAAGATCGACGATACCCCGGCGATCTTCGACGCCGTGTGGGAAGCGGGCCAGAAGCACGGCCTCAGGCC
ATTCGGCATGGAAGCGCTCGACAGCCTGCGCATAGAGAAGGGTTACCGCGCCTGGAAGGGCGATCTTTCGACAGATTATA
CCGTGCTTCAGGGCGGCCTTGAACGCTTTGTCGACTGGTCGAAGCCCGACTTCAAGGGCAAGGCGGCACTGGAGCGCGAG
AAGCAACAGGGGGTTACCAGGCGTTTCGTGACGTTGACGGTGGAGGCCGAGGCCTGCGACGCGCCCTACATGTCGACGCT
GTGGTCCGGGGGCGAGGTGGTCGGCGAGACGACTTCCGGAAACTGGGGCTATCGGACAGGAAGATCGATCGCGCTCGGCA
TGTTACGCGCCGATCTCGCCGTTCCCGGGCGCGAGGTCGAGGTCGAGATTTTCGGCGACCGCTTCAAGGCCGTCGTGCAG
CCGGACCAGCCGCTTTGGGATCCCTCGAATGAAAGACTGAAAGCATGA

Upstream 100 bases:

>100_bases
CTCGGCAATCTAATCGAATTCATCGATTAATAAAGCCGCCTCGCGGCGCTTGATGGACTTCAGCTTCCTCGTCAAAAATC
GCCGTAACAGAGGAGCCAGC

Downstream 100 bases:

>100_bases
CGAAGCCGATCCCTGAAAAGGCGCGCGTGGTCATCATCGGCGGTGGCGTTTCCGGTTGTTCGGTCGCCTATCACCTGTCA
AAGCTCGGCTGGACCGACGT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MSNLPSHARVVIIGGGAVGASSIYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSSWSIMNMQRYSASLYRDLGVQ
VDYPMNYHVTGSLRLGHTKERLQEFKRVVGMGRYQGMELDILAPDEMRSRYPFLETHELTGALYDPYDGDIDPAQLTQAL
AKGARDMGAKIIRFCPVTGARREKDEWVIETPQGEIRCEYVVNAAGYYAREVGRMFGRDVPMMVMSHQYVLFDEIPELAA
WSKEAGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWTTTDDPMPEDFSFQLFPDDLERLEWYLNDAVERVPILGT
AGLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGICQAGGAGKVLAEWVTEGQTEWDMWSCDPRRYTDYTDQDYC
IAKGMQIYGNEYAMHFPKHYWPAGRNRKLSQIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEEATQTWGREGPWAKRI
EEECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGLITGRVPKPGRIGLAYFADSKGRILTEMSVMAIEEDFFFLITAAT
AQWHDFEWLRKHRPVDAAFTLDDVTANFSCQILTGPKSRAILAEVCDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGW
EIHTKIDDTPAIFDAVWEAGQKHGLRPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWSKPDFKGKAALERE
KQQGVTRRFVTLTVEAEACDAPYMSTLWSGGEVVGETTSGNWGYRTGRSIALGMLRADLAVPGREVEVEIFGDRFKAVVQ
PDQPLWDPSNERLKA

Sequences:

>Translated_815_residues
MSNLPSHARVVIIGGGAVGASSIYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSSWSIMNMQRYSASLYRDLGVQ
VDYPMNYHVTGSLRLGHTKERLQEFKRVVGMGRYQGMELDILAPDEMRSRYPFLETHELTGALYDPYDGDIDPAQLTQAL
AKGARDMGAKIIRFCPVTGARREKDEWVIETPQGEIRCEYVVNAAGYYAREVGRMFGRDVPMMVMSHQYVLFDEIPELAA
WSKEAGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWTTTDDPMPEDFSFQLFPDDLERLEWYLNDAVERVPILGT
AGLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGICQAGGAGKVLAEWVTEGQTEWDMWSCDPRRYTDYTDQDYC
IAKGMQIYGNEYAMHFPKHYWPAGRNRKLSQIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEEATQTWGREGPWAKRI
EEECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGLITGRVPKPGRIGLAYFADSKGRILTEMSVMAIEEDFFFLITAAT
AQWHDFEWLRKHRPVDAAFTLDDVTANFSCQILTGPKSRAILAEVCDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGW
EIHTKIDDTPAIFDAVWEAGQKHGLRPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWSKPDFKGKAALERE
KQQGVTRRFVTLTVEAEACDAPYMSTLWSGGEVVGETTSGNWGYRTGRSIALGMLRADLAVPGREVEVEIFGDRFKAVVQ
PDQPLWDPSNERLKA
>Mature_814_residues
SNLPSHARVVIIGGGAVGASSIYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSSWSIMNMQRYSASLYRDLGVQV
DYPMNYHVTGSLRLGHTKERLQEFKRVVGMGRYQGMELDILAPDEMRSRYPFLETHELTGALYDPYDGDIDPAQLTQALA
KGARDMGAKIIRFCPVTGARREKDEWVIETPQGEIRCEYVVNAAGYYAREVGRMFGRDVPMMVMSHQYVLFDEIPELAAW
SKEAGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWTTTDDPMPEDFSFQLFPDDLERLEWYLNDAVERVPILGTA
GLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGICQAGGAGKVLAEWVTEGQTEWDMWSCDPRRYTDYTDQDYCI
AKGMQIYGNEYAMHFPKHYWPAGRNRKLSQIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEEATQTWGREGPWAKRIE
EECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGLITGRVPKPGRIGLAYFADSKGRILTEMSVMAIEEDFFFLITAATA
QWHDFEWLRKHRPVDAAFTLDDVTANFSCQILTGPKSRAILAEVCDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGWE
IHTKIDDTPAIFDAVWEAGQKHGLRPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWSKPDFKGKAALEREK
QQGVTRRFVTLTVEAEACDAPYMSTLWSGGEVVGETTSGNWGYRTGRSIALGMLRADLAVPGREVEVEIFGDRFKAVVQP
DQPLWDPSNERLKA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=820, Percent_Identity=36.5853658536585, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI197927446, Length=873, Percent_Identity=32.4169530355097, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI21361378, Length=873, Percent_Identity=32.4169530355097, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI194306651, Length=825, Percent_Identity=29.4545454545455, Blast_Score=322, Evalue=1e-87,
Organism=Escherichia coli, GI1789272, Length=327, Percent_Identity=25.3822629969419, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=844, Percent_Identity=27.0142180094787, Blast_Score=270, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71994052, Length=851, Percent_Identity=26.6745005875441, Blast_Score=266, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI32563613, Length=842, Percent_Identity=27.1971496437055, Blast_Score=264, Evalue=2e-70,
Organism=Drosophila melanogaster, GI20130091, Length=873, Percent_Identity=28.7514318442153, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571104, Length=858, Percent_Identity=27.8554778554779, Blast_Score=297, Evalue=2e-80,
Organism=Drosophila melanogaster, GI20129441, Length=330, Percent_Identity=23.6363636363636, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 91606; Mature: 91474

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLPSHARVVIIGGGAVGASSIYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSS
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WSIMNMQRYSASLYRDLGVQVDYPMNYHVTGSLRLGHTKERLQEFKRVVGMGRYQGMELD
CCEEHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
ILAPDEMRSRYPFLETHELTGALYDPYDGDIDPAQLTQALAKGARDMGAKIIRFCPVTGA
EECCHHHHHCCCCEEEHHCCCCEECCCCCCCCHHHHHHHHHHCHHHHHHHHEEECCCCCC
RREKDEWVIETPQGEIRCEYVVNAAGYYAREVGRMFGRDVPMMVMSHQYVLFDEIPELAA
CCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCHHHCCCEEEHHHCHHHHH
WSKEAGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWTTTDDPMPEDFSFQLFPDD
HHHHCCCCCCEEEECCCHHEEEHHHCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECHHH
LERLEWYLNDAVERVPILGTAGLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGI
HHHHHHHHHHHHHHCCCEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
CQAGGAGKVLAEWVTEGQTEWDMWSCDPRRYTDYTDQDYCIAKGMQIYGNEYAMHFPKHY
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHEECCCEEEECCHHH
WPAGRNRKLSQIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEEATQTWGREGPWAKRI
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHH
EEECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGLITGRVPKPGRIGLAYFADSKGRIL
HHHHHHHHHCCCEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEE
TEMSVMAIEEDFFFLITAATAQWHDFEWLRKHRPVDAAFTLDDVTANFSCQILTGPKSRA
EHEEEEEEECCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCH
ILAEVCDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGWEIHTKIDDTPAIFDAVWEAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCHHHHHHHHHHH
QKHGLRPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWSKPDFKGKAALERE
HHCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
KQQGVTRRFVTLTVEAEACDAPYMSTLWSGGEVVGETTSGNWGYRTGRSIALGMLRADLA
HHCCCEEEEEEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
VPGREVEVEIFGDRFKAVVQPDQPLWDPSNERLKA
CCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNLPSHARVVIIGGGAVGASSIYHLAKAGWTDCVLLEKNELTAGSTWHAAGNVPTFSSS
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WSIMNMQRYSASLYRDLGVQVDYPMNYHVTGSLRLGHTKERLQEFKRVVGMGRYQGMELD
CCEEHHHHHHHHHHHHCCCEECCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCEEE
ILAPDEMRSRYPFLETHELTGALYDPYDGDIDPAQLTQALAKGARDMGAKIIRFCPVTGA
EECCHHHHHCCCCEEEHHCCCCEECCCCCCCCHHHHHHHHHHCHHHHHHHHEEECCCCCC
RREKDEWVIETPQGEIRCEYVVNAAGYYAREVGRMFGRDVPMMVMSHQYVLFDEIPELAA
CCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCHHHCCCEEEHHHCHHHHH
WSKEAGHKLPLLRDVDSSYYLRQEKYGMNLGPYEKNCRAHWTTTDDPMPEDFSFQLFPDD
HHHHCCCCCCEEEECCCHHEEEHHHCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECHHH
LERLEWYLNDAVERVPILGTAGLSRVINGPIPYAPDGNPLIGPMPGVPNAFEACVFTFGI
HHHHHHHHHHHHHHCCCEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
CQAGGAGKVLAEWVTEGQTEWDMWSCDPRRYTDYTDQDYCIAKGMQIYGNEYAMHFPKHY
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHEECCCEEEECCHHH
WPAGRNRKLSQIHDRIAALGAQFKPYNGWERAMWYAKPGDDTSEEATQTWGREGPWAKRI
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHH
EEECLAVRDAAGILDLPGFSRFRLKGEGAREWLSGLITGRVPKPGRIGLAYFADSKGRIL
HHHHHHHHHCCCEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEE
TEMSVMAIEEDFFFLITAATAQWHDFEWLRKHRPVDAAFTLDDVTANFSCQILTGPKSRA
EHEEEEEEECCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCH
ILAEVCDADLAKGWLTHQTAQIAGRYCQLVRVSFAGELGWEIHTKIDDTPAIFDAVWEAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCHHHHHHHHHHH
QKHGLRPFGMEALDSLRIEKGYRAWKGDLSTDYTVLQGGLERFVDWSKPDFKGKAALERE
HHCCCCCCCHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
KQQGVTRRFVTLTVEAEACDAPYMSTLWSGGEVVGETTSGNWGYRTGRSIALGMLRADLA
HHCCCEEEEEEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
VPGREVEVEIFGDRFKAVVQPDQPLWDPSNERLKA
CCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]