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The map label for this gene is serA [H]

Identifier: 150397359

GI number: 150397359

Start: 2227149

End: 2228186

Strand: Reverse

Name: serA [H]

Synonym: Smed_2158

Alternate gene names: 150397359

Gene position: 2228186-2227149 (Counterclockwise)

Preceding gene: 150397360

Following gene: 150397358

Centisome position: 58.92

GC content: 62.91

Gene sequence:

>1038_bases
ATGAAGAAGATAGCCATTATCGGCGACCGGTTCATGCTGCCGGATGTTTTTCGCGACAAGATCGTCGAGGCATGCGGCGA
CGGGCACGAGATAAGCATGCTCGAACTGCCCTGGCCGGACGTGCCGATGGAGCACGGCTACGCAGTCGAAGGCATGGACG
GGCTCAAGGAATATCTAGGCAAGCCCGGCGAAATCGTCGATTTCATCGGCGATGCCGAAATTCTGGTGACGCAGCTTGCT
CCTTTATCGCGAACGATGCTTCAGGACCTGCCGGGTTTGAAACTCGTCGCCGTGTCACGCGGCGGCCCGGTCAATATCGA
TATCAAGGCGGCCCGCGATGCAGGGGTCCGCGTCGTCAATGCGCCCGGCCGGAATGCGAGCGCCGTCGCCGAGTTCACGA
TCGGCGCCATCCTCGCGGAGACGCGCCTCATTCGCGTGGGGCACGAGGCGCTGAGGCGGAGCGAATGGCGCGGCGATCTC
TATCGCGCCGACCGCACCGGGCGGGAGCTGTCCGAAATGACCGTGGGCGTCATCGGCTACGGCAATATCGGCACCAGGGT
GGTTCGGCTGCTTCGCGCCTTCGGCACCAAAGTGCTCGTCCATGACCCCTATGTTCAGCTCAGCGCCGAGGACCGGAATG
CCGGCGTCGAGCATGTTTCCCTCGATGATCTGCTCGCCCGTGCGGACCTCGTGACGCTGCATCCGCGCGTGAGCGAAGAG
ACGAGGAATATGATGAATGCGGAGACCTTCGCGAAGATGAAGCCGGGTGCGATCTTCGTGAACACGGCGCGCGGCCCGCT
CTGCGATTATGACGCGCTCTACGAAAACCTCGTCAGCGGTCATCTTGCAAGCGCCATGCTGGAGACTTTTGCCGTCGAGC
CCGTGCCGGAAGGCTGGCCGCTCCTGAAACTCCCCAACGTGACGCTGACGCCGCACATAGCGGGAGCGTCGGTGCGTACC
GTGACCTATGCGGCTGAAATGGCCGCAGAGGAAGTGCGCCGCTATATCGCCGGTCTGCCGCCGGTCAATCCGTGCTGA

Upstream 100 bases:

>100_bases
CAATTTTCCCCGCCTACAAGCAGTCGCGCCTCGCGCTCGAACCCGTCTGGCATGCGCTCTCCCACGCAACCGGAACGGGA
AACCAACAGGAAAGACCGCA

Downstream 100 bases:

>100_bases
GGTGGGACGATGAACGAACTTCAACTGCGCCAGTCGATCATCGATCATTGCCGCCACATGAATGCGATCGGTCTGAACCA
GGGCACGTCGGGTAATATCA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKKIAIIGDRFMLPDVFRDKIVEACGDGHEISMLELPWPDVPMEHGYAVEGMDGLKEYLGKPGEIVDFIGDAEILVTQLA
PLSRTMLQDLPGLKLVAVSRGGPVNIDIKAARDAGVRVVNAPGRNASAVAEFTIGAILAETRLIRVGHEALRRSEWRGDL
YRADRTGRELSEMTVGVIGYGNIGTRVVRLLRAFGTKVLVHDPYVQLSAEDRNAGVEHVSLDDLLARADLVTLHPRVSEE
TRNMMNAETFAKMKPGAIFVNTARGPLCDYDALYENLVSGHLASAMLETFAVEPVPEGWPLLKLPNVTLTPHIAGASVRT
VTYAAEMAAEEVRRYIAGLPPVNPC

Sequences:

>Translated_345_residues
MKKIAIIGDRFMLPDVFRDKIVEACGDGHEISMLELPWPDVPMEHGYAVEGMDGLKEYLGKPGEIVDFIGDAEILVTQLA
PLSRTMLQDLPGLKLVAVSRGGPVNIDIKAARDAGVRVVNAPGRNASAVAEFTIGAILAETRLIRVGHEALRRSEWRGDL
YRADRTGRELSEMTVGVIGYGNIGTRVVRLLRAFGTKVLVHDPYVQLSAEDRNAGVEHVSLDDLLARADLVTLHPRVSEE
TRNMMNAETFAKMKPGAIFVNTARGPLCDYDALYENLVSGHLASAMLETFAVEPVPEGWPLLKLPNVTLTPHIAGASVRT
VTYAAEMAAEEVRRYIAGLPPVNPC
>Mature_345_residues
MKKIAIIGDRFMLPDVFRDKIVEACGDGHEISMLELPWPDVPMEHGYAVEGMDGLKEYLGKPGEIVDFIGDAEILVTQLA
PLSRTMLQDLPGLKLVAVSRGGPVNIDIKAARDAGVRVVNAPGRNASAVAEFTIGAILAETRLIRVGHEALRRSEWRGDL
YRADRTGRELSEMTVGVIGYGNIGTRVVRLLRAFGTKVLVHDPYVQLSAEDRNAGVEHVSLDDLLARADLVTLHPRVSEE
TRNMMNAETFAKMKPGAIFVNTARGPLCDYDALYENLVSGHLASAMLETFAVEPVPEGWPLLKLPNVTLTPHIAGASVRT
VTYAAEMAAEEVRRYIAGLPPVNPC

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=35.8490566037736, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=35.8490566037736, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=34.1726618705036, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=34.1726618705036, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=34.1818181818182, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI23308577, Length=267, Percent_Identity=31.8352059925094, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=29.2, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1789279, Length=230, Percent_Identity=35.6521739130435, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787645, Length=213, Percent_Identity=34.7417840375587, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082289, Length=254, Percent_Identity=29.5275590551181, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788660, Length=297, Percent_Identity=28.2828282828283, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=174, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=247, Percent_Identity=34.0080971659919, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=30.0724637681159, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=286, Percent_Identity=31.1188811188811, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=30.718954248366, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=281, Percent_Identity=30.2491103202847, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=30.2521008403361, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=188, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=31.25, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=34.1818181818182, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=34.1818181818182, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=34.1818181818182, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=34.1818181818182, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=34.1818181818182, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=26.5993265993266, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19921140, Length=276, Percent_Identity=31.8840579710145, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585514, Length=256, Percent_Identity=28.90625, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574282, Length=256, Percent_Identity=28.90625, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574284, Length=256, Percent_Identity=28.90625, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45552429, Length=256, Percent_Identity=28.90625, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45551003, Length=256, Percent_Identity=28.90625, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=31.4516129032258, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37599; Mature: 37599

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAIIGDRFMLPDVFRDKIVEACGDGHEISMLELPWPDVPMEHGYAVEGMDGLKEYLG
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHC
KPGEIVDFIGDAEILVTQLAPLSRTMLQDLPGLKLVAVSRGGPVNIDIKAARDAGVRVVN
CCCCEEHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEEEEE
APGRNASAVAEFTIGAILAETRLIRVGHEALRRSEWRGDLYRADRTGRELSEMTVGVIGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHCEEEEEEE
GNIGTRVVRLLRAFGTKVLVHDPYVQLSAEDRNAGVEHVSLDDLLARADLVTLHPRVSEE
CCHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCEECHHHHHHHCCEEEECCCCCHH
TRNMMNAETFAKMKPGAIFVNTARGPLCDYDALYENLVSGHLASAMLETFAVEPVPEGWP
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LLKLPNVTLTPHIAGASVRTVTYAAEMAAEEVRRYIAGLPPVNPC
EEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKIAIIGDRFMLPDVFRDKIVEACGDGHEISMLELPWPDVPMEHGYAVEGMDGLKEYLG
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHC
KPGEIVDFIGDAEILVTQLAPLSRTMLQDLPGLKLVAVSRGGPVNIDIKAARDAGVRVVN
CCCCEEHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCEEEEE
APGRNASAVAEFTIGAILAETRLIRVGHEALRRSEWRGDLYRADRTGRELSEMTVGVIGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHCEEEEEEE
GNIGTRVVRLLRAFGTKVLVHDPYVQLSAEDRNAGVEHVSLDDLLARADLVTLHPRVSEE
CCHHHHHHHHHHHHCCEEEEECCEEEEECCCCCCCCCEECHHHHHHHCCEEEECCCCCHH
TRNMMNAETFAKMKPGAIFVNTARGPLCDYDALYENLVSGHLASAMLETFAVEPVPEGWP
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LLKLPNVTLTPHIAGASVRTVTYAAEMAAEEVRRYIAGLPPVNPC
EEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]