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The map label for this gene is hflK [H]

Identifier: 150397219

GI number: 150397219

Start: 2067873

End: 2068961

Strand: Reverse

Name: hflK [H]

Synonym: Smed_2018

Alternate gene names: 150397219

Gene position: 2068961-2067873 (Counterclockwise)

Preceding gene: 150397220

Following gene: 150397218

Centisome position: 54.71

GC content: 61.43

Gene sequence:

>1089_bases
ATGCCCTGGAGCAATCAGAATGGCGGCGGCGGTGGCCCTTGGGGCGGCGGCGGCGGCAATCAAGGGCCATGGGGCCAGGG
GCCCAACCGGCCACGCGGCGGAAGAGGTGGTCCGCCGGATCTGGAGGAGATCATCCGGCGTGGCCAGGATCAGCTGAAAA
GCGTGGTTCCCGGGGGCTTCAACGGCGGGATCTTCGTCATTGTCGGCCTGCTGGTTCTCGGTTTCATCCTGCTGAACTCC
ATCTATACCGTTCAGCCGGACGAACGCGGCGTTGAGATGCGCTTCGGCAAGCCGAAGGAAGAAATCTCCATGCCGGGCTT
GCACTATCACTTCTGGCCGCTTGAAACGGTAGAGATCGTCAAGGTGACCGAGCAGCAGCAGAATATCGGCGGTCGCACGG
GCCAAACAAATTCCGGCCTGATGCTGAGCGGCGATCAGAACATCGTCAACGTGCAGTTCTCGGTGCTGTTTTCGGTTACC
GATCCGAAGGCGTATCTCTTCAATGTCGAAAACCCGGCCGACACGCTGCAGCAGGTGGCCGAAAGCGCAATGCGCGAGGT
CGTCGGACGCCGTCCTGCGCAGGACATTTTCCGCGACAACCGTCAGGCGATCGCCGCGGATGTGAAGAACACGATCCAGG
CGACCATGGACAGCTATGGCGCCGGCATATCGGTGAATACCGTGGCGATCGAGGATGCCGCCCCGCCACGCGAAGTGGCC
GATGCCTTCGACGAAGTGCAGCGTGCCGAGCAGGACGAGGATCGCTTCGTCGAAGAGGCCAACCAGTATGCCAACCAGGT
GCTCGGCAAGGCGCGCGGCCAAGGCGCGCAGATCCGGGAAGAGGCGGCCGCATACAAGGATCGGGTGGTCAAGGAGGCTC
AGGGTGAGGCTCAGCGCTTCATCTCAGTCTATGACGAGTATTCCAAGGCTCCGGAAGTCACGCGCAAGCGGCTCTATCTC
GAAACGATGCAAGGCGTTCTCGGCAAGTCCAAGAAGTTCATCCTCGACGAGAAGAACGGCCAGGGTGTGCTGCCCTATCT
GCCGCTCAATGAAATCGGCAGGCCCGTGCAGTCGGGAGGAAACCAATGA

Upstream 100 bases:

>100_bases
TGAAAGCAATGCACATGATACCTATAACGGGTTCACATCGTGACCGGCCGCAATGCCTGCGGGGCGTTCAGCGAAATATT
TTCTTGGAAGTGAGGTTTTG

Downstream 100 bases:

>100_bases
TCAACAATCGCAGCTCCATTATCCTGATCGTCCTCGCCGCTGTCCTGTTCGTCGTCTACTCCTCGGTCTTCGTGGTGAAC
GAGCGTCAGCAGGCGATCGT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MPWSNQNGGGGGPWGGGGGNQGPWGQGPNRPRGGRGGPPDLEEIIRRGQDQLKSVVPGGFNGGIFVIVGLLVLGFILLNS
IYTVQPDERGVEMRFGKPKEEISMPGLHYHFWPLETVEIVKVTEQQQNIGGRTGQTNSGLMLSGDQNIVNVQFSVLFSVT
DPKAYLFNVENPADTLQQVAESAMREVVGRRPAQDIFRDNRQAIAADVKNTIQATMDSYGAGISVNTVAIEDAAPPREVA
DAFDEVQRAEQDEDRFVEEANQYANQVLGKARGQGAQIREEAAAYKDRVVKEAQGEAQRFISVYDEYSKAPEVTRKRLYL
ETMQGVLGKSKKFILDEKNGQGVLPYLPLNEIGRPVQSGGNQ

Sequences:

>Translated_362_residues
MPWSNQNGGGGGPWGGGGGNQGPWGQGPNRPRGGRGGPPDLEEIIRRGQDQLKSVVPGGFNGGIFVIVGLLVLGFILLNS
IYTVQPDERGVEMRFGKPKEEISMPGLHYHFWPLETVEIVKVTEQQQNIGGRTGQTNSGLMLSGDQNIVNVQFSVLFSVT
DPKAYLFNVENPADTLQQVAESAMREVVGRRPAQDIFRDNRQAIAADVKNTIQATMDSYGAGISVNTVAIEDAAPPREVA
DAFDEVQRAEQDEDRFVEEANQYANQVLGKARGQGAQIREEAAAYKDRVVKEAQGEAQRFISVYDEYSKAPEVTRKRLYL
ETMQGVLGKSKKFILDEKNGQGVLPYLPLNEIGRPVQSGGNQ
>Mature_361_residues
PWSNQNGGGGGPWGGGGGNQGPWGQGPNRPRGGRGGPPDLEEIIRRGQDQLKSVVPGGFNGGIFVIVGLLVLGFILLNSI
YTVQPDERGVEMRFGKPKEEISMPGLHYHFWPLETVEIVKVTEQQQNIGGRTGQTNSGLMLSGDQNIVNVQFSVLFSVTD
PKAYLFNVENPADTLQQVAESAMREVVGRRPAQDIFRDNRQAIAADVKNTIQATMDSYGAGISVNTVAIEDAAPPREVAD
AFDEVQRAEQDEDRFVEEANQYANQVLGKARGQGAQIREEAAAYKDRVVKEAQGEAQRFISVYDEYSKAPEVTRKRLYLE
TMQGVLGKSKKFILDEKNGQGVLPYLPLNEIGRPVQSGGNQ

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=374, Percent_Identity=34.4919786096257, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 39544; Mature: 39413

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWSNQNGGGGGPWGGGGGNQGPWGQGPNRPRGGRGGPPDLEEIIRRGQDQLKSVVPGGF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHCCCCC
NGGIFVIVGLLVLGFILLNSIYTVQPDERGVEMRFGKPKEEISMPGLHYHFWPLETVEIV
CCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHH
KVTEQQQNIGGRTGQTNSGLMLSGDQNIVNVQFSVLFSVTDPKAYLFNVENPADTLQQVA
HHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCEEEEECCCHHHHHHHHH
ESAMREVVGRRPAQDIFRDNRQAIAADVKNTIQATMDSYGAGISVNTVAIEDAAPPREVA
HHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
DAFDEVQRAEQDEDRFVEEANQYANQVLGKARGQGAQIREEAAAYKDRVVKEAQGEAQRF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISVYDEYSKAPEVTRKRLYLETMQGVLGKSKKFILDEKNGQGVLPYLPLNEIGRPVQSGG
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHCCHHHCCC
NQ
CC
>Mature Secondary Structure 
PWSNQNGGGGGPWGGGGGNQGPWGQGPNRPRGGRGGPPDLEEIIRRGQDQLKSVVPGGF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHCCCCC
NGGIFVIVGLLVLGFILLNSIYTVQPDERGVEMRFGKPKEEISMPGLHYHFWPLETVEIV
CCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHH
KVTEQQQNIGGRTGQTNSGLMLSGDQNIVNVQFSVLFSVTDPKAYLFNVENPADTLQQVA
HHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCEEEEECCCHHHHHHHHH
ESAMREVVGRRPAQDIFRDNRQAIAADVKNTIQATMDSYGAGISVNTVAIEDAAPPREVA
HHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
DAFDEVQRAEQDEDRFVEEANQYANQVLGKARGQGAQIREEAAAYKDRVVKEAQGEAQRF
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISVYDEYSKAPEVTRKRLYLETMQGVLGKSKKFILDEKNGQGVLPYLPLNEIGRPVQSGG
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCCHHHHCCHHHCCC
NQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]