Click here to switch to the map view.

The map label for this gene is hflC [H]

Identifier: 150397218

GI number: 150397218

Start: 2066944

End: 2067876

Strand: Reverse

Name: hflC [H]

Synonym: Smed_2017

Alternate gene names: 150397218

Gene position: 2067876-2066944 (Counterclockwise)

Preceding gene: 150397219

Following gene: 150397217

Centisome position: 54.68

GC content: 60.45

Gene sequence:

>933_bases
ATGATCAACAATCGCAGCTCCATTATCCTGATCGTCCTCGCCGCTGTCCTGTTCGTCGTCTACTCCTCGGTCTTCGTGGT
GAACGAGCGTCAGCAGGCGATCGTCGTGCGCTTCGGTCAGATCCGTGAGGTGAAGAGCGAACCGGGCCTTTATTTCAAGC
TTCCGTTCGGCTTCATGGATGCCGACCGTGTTCAGTACGTCGAAGACCAGGCACTCCGTTTCGATCTCGACAATATCCGA
GTGCAGGTTTCCGGAGGCAAGTTCTATGAGGTGGACGCATTCGTCGTCTACAAGATCTCCGATCCTCGCCGCTTCCGCCA
GACGGTTTCCGGCGACCGGGAATCCGCGGAGTCGCGGCTCAGGACTCGCCTGGATGCGTCCCTGCGCCGGGTTTATGGTC
TCAGGGGCTTCGAGGCAGCGCTTTCGGACGAACGCGCGTCGATGATGCGGGAGGTCCGGACCGACCTCAGCGCCGATGCG
GAATCGCTTGGCCTCAACATCGAGGACGTGCGCATCCGCCGTACGGATCTGACCCAGGAAGTCTCGCAACAGACCTTTGA
TCGGATGAAGGCGGAGCGTCTGGCCGAAGCCGAACTGATCCGTGCCCGCGGTAACGAGGAAGGCCAGAGACGCCGTGCAA
TTGCCGACCGCCAGGTGGTCGAAATCGTCGCCGAAGCACAACGTGATTCGGAAATTCTGCGCGGTGAGGGCGAAGCGGAG
CGGACGCAGATCTTTGCCGACGCATTCCAGCGTGATCCCGGCTTTTTCGAGTTCTACCGGTCGATGGCGGCTTATTCGCA
ATCGATCGGCAGCCCGGATACAACCATCGTGCTTTCGCCGCACTCGGAATTCTTCCGTTATTTCAACAGTGCCGACGGTG
CGGACCAGCCGCTGCCGACCCCGGGACCGGCGGCACCGACCACCACAGATTAA

Upstream 100 bases:

>100_bases
AGTCCAAGAAGTTCATCCTCGACGAGAAGAACGGCCAGGGTGTGCTGCCCTATCTGCCGCTCAATGAAATCGGCAGGCCC
GTGCAGTCGGGAGGAAACCA

Downstream 100 bases:

>100_bases
GCGAACGATGTCAGACTTTCTGACCGGGTTTGCTTTTTTCCTGATCATCGAGGGGCTGGTGTACGCACTGGCCCCTTTGG
TTTTGGTGGAACTGGCGAAG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MINNRSSIILIVLAAVLFVVYSSVFVVNERQQAIVVRFGQIREVKSEPGLYFKLPFGFMDADRVQYVEDQALRFDLDNIR
VQVSGGKFYEVDAFVVYKISDPRRFRQTVSGDRESAESRLRTRLDASLRRVYGLRGFEAALSDERASMMREVRTDLSADA
ESLGLNIEDVRIRRTDLTQEVSQQTFDRMKAERLAEAELIRARGNEEGQRRRAIADRQVVEIVAEAQRDSEILRGEGEAE
RTQIFADAFQRDPGFFEFYRSMAAYSQSIGSPDTTIVLSPHSEFFRYFNSADGADQPLPTPGPAAPTTTD

Sequences:

>Translated_310_residues
MINNRSSIILIVLAAVLFVVYSSVFVVNERQQAIVVRFGQIREVKSEPGLYFKLPFGFMDADRVQYVEDQALRFDLDNIR
VQVSGGKFYEVDAFVVYKISDPRRFRQTVSGDRESAESRLRTRLDASLRRVYGLRGFEAALSDERASMMREVRTDLSADA
ESLGLNIEDVRIRRTDLTQEVSQQTFDRMKAERLAEAELIRARGNEEGQRRRAIADRQVVEIVAEAQRDSEILRGEGEAE
RTQIFADAFQRDPGFFEFYRSMAAYSQSIGSPDTTIVLSPHSEFFRYFNSADGADQPLPTPGPAAPTTTD
>Mature_310_residues
MINNRSSIILIVLAAVLFVVYSSVFVVNERQQAIVVRFGQIREVKSEPGLYFKLPFGFMDADRVQYVEDQALRFDLDNIR
VQVSGGKFYEVDAFVVYKISDPRRFRQTVSGDRESAESRLRTRLDASLRRVYGLRGFEAALSDERASMMREVRTDLSADA
ESLGLNIEDVRIRRTDLTQEVSQQTFDRMKAERLAEAELIRARGNEEGQRRRAIADRQVVEIVAEAQRDSEILRGEGEAE
RTQIFADAFQRDPGFFEFYRSMAAYSQSIGSPDTTIVLSPHSEFFRYFNSADGADQPLPTPGPAAPTTTD

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=324, Percent_Identity=34.2592592592593, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 35208; Mature: 35208

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNRSSIILIVLAAVLFVVYSSVFVVNERQQAIVVRFGQIREVKSEPGLYFKLPFGFMD
CCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCC
ADRVQYVEDQALRFDLDNIRVQVSGGKFYEVDAFVVYKISDPRRFRQTVSGDRESAESRL
HHHHHHHHHHHHEEECCCEEEEECCCEEEEEEEEEEEEECCHHHHHHHHCCCHHHHHHHH
RTRLDASLRRVYGLRGFEAALSDERASMMREVRTDLSADAESLGLNIEDVRIRRTDLTQE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHEEEEHHHHHHH
VSQQTFDRMKAERLAEAELIRARGNEEGQRRRAIADRQVVEIVAEAQRDSEILRGEGEAE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RTQIFADAFQRDPGFFEFYRSMAAYSQSIGSPDTTIVLSPHSEFFRYFNSADGADQPLPT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCC
PGPAAPTTTD
CCCCCCCCCC
>Mature Secondary Structure
MINNRSSIILIVLAAVLFVVYSSVFVVNERQQAIVVRFGQIREVKSEPGLYFKLPFGFMD
CCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCEEEEECCCCCC
ADRVQYVEDQALRFDLDNIRVQVSGGKFYEVDAFVVYKISDPRRFRQTVSGDRESAESRL
HHHHHHHHHHHHEEECCCEEEEECCCEEEEEEEEEEEEECCHHHHHHHHCCCHHHHHHHH
RTRLDASLRRVYGLRGFEAALSDERASMMREVRTDLSADAESLGLNIEDVRIRRTDLTQE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHEEEEHHHHHHH
VSQQTFDRMKAERLAEAELIRARGNEEGQRRRAIADRQVVEIVAEAQRDSEILRGEGEAE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RTQIFADAFQRDPGFFEFYRSMAAYSQSIGSPDTTIVLSPHSEFFRYFNSADGADQPLPT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCC
PGPAAPTTTD
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]