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The map label for this gene is moaA [H]

Identifier: 150396791

GI number: 150396791

Start: 1678822

End: 1679871

Strand: Direct

Name: moaA [H]

Synonym: Smed_1582

Alternate gene names: 150396791

Gene position: 1678822-1679871 (Clockwise)

Preceding gene: 150396788

Following gene: 150396792

Centisome position: 44.39

GC content: 60.48

Gene sequence:

>1050_bases
TTGAACACTGCCGCCATAGACCAGACGAACGCCAGATCCCTCGACAGCACGACGGCTTCGATGGTCGATCCTTTCGGCCG
CGCAGTCACTTATCTGCGTGTCTCGGTCACGGATCGCTGCGACTTCCGCTGCACCTATTGCATGGCAGAGCATATGACCT
TCCTGCCGAAGAAGGATCTGCTGACGCTGGAAGAGCTCCACCGCCTCTGTTCGGCCTTCATCGCCAAGGGCGTGCGTAAG
CTGCGGCTGACCGGTGGCGAGCCGCTGGTGCGCAAGAATATCATGTTCCTCATTCGCGAACTCGGCAAAGAGATCGAAGC
TGGCCGGCTGGACGAACTGACACTCACCACCAACGGTTCGCAGCTGTCGAAATTCGCAGCCGAACTGGTCGATTGCGGCG
TGCGGCGGATCAATGTCTCGCTCGACACGCTTGATCCCGACAAGTTCCGCCAGATCACCCGCTGGGGCGAACTGACAAAG
GTGCTCGAAGGTATAGATGCGGCGCTGGCGGCGGGATTGAAGGTAAAGATCAACGCGGTCGCCCTCAAGGACTTCAACGA
TGCCGAGATACCGGAACTGATGCGGTGGGCGCACGGTCGAGGCATGGACCTGACGCTCATCGAGACCATGCCGATGGGCG
AAGTGGACGAGGACAGAACCGACCATTACCTGCCGCTCTCGGAAATGCGCAAACGGCTTGAAGCCGACTTCACGCTCAAG
GACATGTCTTACCGTACCGGCGGCCCTGCCCGCTATGTGGACGTTCTGGAGACCGGCGGCAGGCTTGGGCTCATCACGCC
GATGACGCACAACTTCTGCGAAAGCTGCAATCGGGTTCGCCTCACCTGCACCGGCACGCTTTACATGTGTCTCGGCCAGA
ACGACGCTGCCGATCTACGTTCGGCATTGCGCGCCACCGAAGACGACGCCTATCTCGCACAGGTTATCGACGACGCGATC
AGCCGCAAGCCGAAGGGCCATGATTTCATCATCGACCGCGAACACAACCGCCCCGCCGTCGCCCGCCACATGAGCGTCAC
CGGGGGTTAA

Upstream 100 bases:

>100_bases
TCAAAGGACATGTTTCCAGATATTTGAAACAGTTTGCGACAGTCTGCGCCTTGACGCGACCCTTTTTGGCCACGACATTA
AGAACGCAGGGAGACATGAC

Downstream 100 bases:

>100_bases
CGGCGGCAGTTTTTGCCCTCATCCGCCTCCCGGCATCATTTCCCCGCAGGCGGTGCGAGGAACGAGCGGCATGCTGCGCA
GCGCGGCATGCGTGTTAATT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDLLTLEELHRLCSAFIAKGVRK
LRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGSQLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTK
VLEGIDAALAAGLKVKINAVALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLK
DMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRSALRATEDDAYLAQVIDDAI
SRKPKGHDFIIDREHNRPAVARHMSVTGG

Sequences:

>Translated_349_residues
MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDLLTLEELHRLCSAFIAKGVRK
LRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGSQLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTK
VLEGIDAALAAGLKVKINAVALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLK
DMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRSALRATEDDAYLAQVIDDAI
SRKPKGHDFIIDREHNRPAVARHMSVTGG
>Mature_349_residues
MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDLLTLEELHRLCSAFIAKGVRK
LRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGSQLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTK
VLEGIDAALAAGLKVKINAVALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLK
DMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRSALRATEDDAYLAQVIDDAI
SRKPKGHDFIIDREHNRPAVARHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=328, Percent_Identity=34.7560975609756, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI22027536, Length=328, Percent_Identity=34.7560975609756, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=34.1317365269461, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=35.9281437125749, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17561210, Length=335, Percent_Identity=37.3134328358209, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=37.0607028753994, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI28574488, Length=329, Percent_Identity=36.7781155015198, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574490, Length=322, Percent_Identity=37.2670807453416, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39035; Mature: 39035

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
LTLEELHRLCSAFIAKGVRKLRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGS
CCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCH
QLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTKVLEGIDAALAAGLKVKINAV
HHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
ALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLK
EEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
DMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLR
CCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHH
SALRATEDDAYLAQVIDDAISRKPKGHDFIIDREHNRPAVARHMSVTGG
HHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHEECCCCC
>Mature Secondary Structure
MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
LTLEELHRLCSAFIAKGVRKLRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGS
CCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCH
QLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTKVLEGIDAALAAGLKVKINAV
HHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
ALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLK
EEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEE
DMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLR
CCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHH
SALRATEDDAYLAQVIDDAISRKPKGHDFIIDREHNRPAVARHMSVTGG
HHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]