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The map label for this gene is fumC [H]

Identifier: 150396785

GI number: 150396785

Start: 1674597

End: 1676045

Strand: Direct

Name: fumC [H]

Synonym: Smed_1576

Alternate gene names: 150396785

Gene position: 1674597-1676045 (Clockwise)

Preceding gene: 150396783

Following gene: 150396788

Centisome position: 44.28

GC content: 61.28

Gene sequence:

>1449_bases
ATGGAACCGGCTCCCCGCCTCGGCTTCATGAACCGCATGATGAAAGCAGGTATCACGATGACATCGACCCGCACGGAAAC
TGATACGTTCGGCCCCATCGAGGTGGCGAGCGATCGTTATTGGGGCGCCCAGGCTCAGCGATCCCTTGGCAATTTCAAAA
TCGGCTGGGAGAAACAGCCCCTGGCAGTCGTGCGTGCCCTCGGCATCGTCAAACAGGCGGCTGCTCGCGCCAATATGGCG
CTCGGTCGCCTCGATCCAACGATCGGCGACGCTATCGTCAAGGCCGCACAGGAAGTCATCGACGGCAAACTCGACGACCA
TTTCCCCCTCGTCGTCTGGCAGACGGGCTCCGGCACCCAATCGAACATGAATGCGAACGAGGTCATCTCCAATCGGGCCA
TTGAGCTGCTCGGCGGGGTCATGGGCTCGAAAAAGCCGGTTCATCCGAACGACCACGTCAATATGAGCCAGTCCTCGAAC
GACACCTATCCGACGGCTATGCACATCGCCTGCGCGGAGCGCGTGATTCACGATCTGCTGCCCGCCCTCAAGCATCTGCA
TAAGGCGCTCGAAGAAAAGGTGAAGGCCTTCCAGTCCATCATCAAAATCGGACGTACCCACACGCAGGACGCGACGCCTC
TAACGCTCGGGCAGGAGTTTTCCGGCTATGCGGCACAGGTCGCCTCCTCGATCAAGCGGATCGAGATGACGCTTCCCGGC
CTTTGCGAACTCGCCCAAGGCGGCACGGCCGTCGGCACAGGGCTTAACGCACCCGTCGGCTTTGCAGAGAAGGTTGCGGA
GCAAATCGCCAGCATCACCGGCATCGGCTTCACCTCCGCACCGAACAAGTTCGAAGCGCTGGCCGCTCACGACTCGATGG
TCTTCAGCCACGGCGCCATCAATGCCACTGCCGCCGCGCTCTTCAAAATAGCCAACGACATCCGCTTTCTCGGCTCCGGC
CCCCGCTCCGGTCTCGGCGAGCTCTCGCTTCCGGAAAACGAGCCGGGTTCGTCGATCATGCCGGGCAAAGTGAACCCCAC
GCAATGCGAGGCGTTGACGCAGGTCTGCGTCCAGGTCTTCGGTAACCACGCGTCCCTCACCTTCGCCGGCAGCCAGGGCC
ATTTCGAACTCAACGTCTATAATCCTCTGATGGCCTACAATTATCTGCAATCGGTGCAGCTGCTCGCGGATGCGGCCGTG
TCCTTCACCGACAATTGCGTCGTCGGGATCGAGGCGCGCGAAGACAACATCAAGGCGGCACTCGACCGTTCGCTCATGCT
GGTGACTGCGCTCGCACCGAAGATCGGCTACGACAACGCGGCCAAGATCGCCAAGACCGCGCACAAGAACGGCACGACAT
TGCGCCAGGAGGCAGTCGGCGGTGGGTACGTCACGGACGAGGAATTCGATGCCGTGGTGCGTCCGGAAACCATGATCGGA
CCGGCCTGA

Upstream 100 bases:

>100_bases
AATTCAAACGATTGTAGAGGCATCCAAGCGCCCGCGGCCTCTTTACAAGGCGTCATGGCCGGGGCAGAGAAATTCCCGGC
AGCGGGGAGGAAAACCGGCC

Downstream 100 bases:

>100_bases
CAGACCACAGGCGGCCGCGGCTGGGCATATGGCCGCCGCGGCCGCCTACCACATCGTCTTCACCGCGCGGCCGGCCCACT
CCCGATCGTAGCTTTCCTTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MEPAPRLGFMNRMMKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQPLAVVRALGIVKQAAARANMA
LGRLDPTIGDAIVKAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSN
DTYPTAMHIACAERVIHDLLPALKHLHKALEEKVKAFQSIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPG
LCELAQGGTAVGTGLNAPVGFAEKVAEQIASITGIGFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSG
PRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNHASLTFAGSQGHFELNVYNPLMAYNYLQSVQLLADAAV
SFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLRQEAVGGGYVTDEEFDAVVRPETMIG
PA

Sequences:

>Translated_482_residues
MEPAPRLGFMNRMMKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQPLAVVRALGIVKQAAARANMA
LGRLDPTIGDAIVKAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSN
DTYPTAMHIACAERVIHDLLPALKHLHKALEEKVKAFQSIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPG
LCELAQGGTAVGTGLNAPVGFAEKVAEQIASITGIGFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSG
PRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNHASLTFAGSQGHFELNVYNPLMAYNYLQSVQLLADAAV
SFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLRQEAVGGGYVTDEEFDAVVRPETMIG
PA
>Mature_482_residues
MEPAPRLGFMNRMMKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQPLAVVRALGIVKQAAARANMA
LGRLDPTIGDAIVKAAQEVIDGKLDDHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSN
DTYPTAMHIACAERVIHDLLPALKHLHKALEEKVKAFQSIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPG
LCELAQGGTAVGTGLNAPVGFAEKVAEQIASITGIGFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSG
PRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNHASLTFAGSQGHFELNVYNPLMAYNYLQSVQLLADAAV
SFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLRQEAVGGGYVTDEEFDAVVRPETMIG
PA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=465, Percent_Identity=65.8064516129032, Blast_Score=610, Evalue=1e-175,
Organism=Homo sapiens, GI266458395, Length=62, Percent_Identity=51.6129032258064, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=57.2668112798265, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=38.3620689655172, Blast_Score=324, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=469, Percent_Identity=66.3113006396588, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=67.5840978593272, Blast_Score=450, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=64.3628509719222, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=64.4251626898048, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=64.4251626898048, Blast_Score=604, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=60.1293103448276, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=59.5238095238095, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=470, Percent_Identity=50.8510638297872, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51278; Mature: 51278

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPAPRLGFMNRMMKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQP
CCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEECCCCCCCHHHHHCCCCEECCCCCCH
LAVVRALGIVKQAAARANMALGRLDPTIGDAIVKAAQEVIDGKLDDHFPLVVWQTGSGTQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCC
SNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERVIHDLL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PALKHLHKALEEKVKAFQSIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
LCELAQGGTAVGTGLNAPVGFAEKVAEQIASITGIGFTSAPNKFEALAAHDSMVFSHGAI
HHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHEECCCC
NATAAALFKIANDIRFLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GNHASLTFAGSQGHFELNVYNPLMAYNYLQSVQLLADAAVSFTDNCVVGIEAREDNIKAA
CCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
LDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLRQEAVGGGYVTDEEFDAVVRPETMIG
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCHHCCCEECCCCCCC
PA
CC
>Mature Secondary Structure
MEPAPRLGFMNRMMKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQP
CCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEECCCCCCCHHHHHCCCCEECCCCCCH
LAVVRALGIVKQAAARANMALGRLDPTIGDAIVKAAQEVIDGKLDDHFPLVVWQTGSGTQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCC
SNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERVIHDLL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PALKHLHKALEEKVKAFQSIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
LCELAQGGTAVGTGLNAPVGFAEKVAEQIASITGIGFTSAPNKFEALAAHDSMVFSHGAI
HHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHEECCCC
NATAAALFKIANDIRFLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GNHASLTFAGSQGHFELNVYNPLMAYNYLQSVQLLADAAVSFTDNCVVGIEAREDNIKAA
CCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
LDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLRQEAVGGGYVTDEEFDAVVRPETMIG
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCHHCCCEECCCCCCC
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]