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The map label for this gene is trpC [H]

Identifier: 150396623

GI number: 150396623

Start: 1490892

End: 1491707

Strand: Direct

Name: trpC [H]

Synonym: Smed_1409

Alternate gene names: 150396623

Gene position: 1490892-1491707 (Clockwise)

Preceding gene: 150396622

Following gene: 150396624

Centisome position: 39.42

GC content: 61.15

Gene sequence:

>816_bases
ATGACGGACATCCTGCGTCGGATCGAAGCCTATAAGCGCGGCGAGATCGCGGCCGCGAAAGTACGTATTCCGCTGGCCGA
ATTGAAGGCGCGGATTGCCGAACAGTCGCCGCCGCGCGGATTCCGTGCTGCACTCGGGGCGCACCGGGAAAAAGGCGACT
TCGGCTTGATCGCCGAAATCAAGAAGGCGAGCCCGTCGAAAGGATTGATCCGGCCGGATTTCGATCCTCCGGAACTGGCG
AAGGCCTATGCCGCTGGCGGCGCTGCCTGTTTGTCCGTCCTTACCGACGCGCCGAGCTTCCAGGGTGCACCGGAGTTCCT
GACGAAGGCACGCGAGGCCTGCCCGCTCCCGGCGCTGCGCAAGGACTTCATGTTCGACACCTATCAGGTTTTCGAAGCGC
GGGCCTGGGGTGCCGATTGCATTCTGCTTATCATGGCGTCGCTTGCCGACGATGATGCTCGCCGGCTGGAAGAAGCTGCA
TTCGCACTCGGCATGGACGTCCTTGTCGAAGTACACGACGCGGAGGAAATGGATAGAGCACTTCGCTTGTCATCTCCGCT
CGTCGGTATCAATAACCGTAATCTCAGGACGTTCGAGGTTGACCTTGCCGTCTCCGAAAGGCTCGCGACGATGGTCTCCT
CCGACCATCTCCTGGTCGGCGAGAGCGGCGTTTTCACTCACGAAGACTGCCGACGCCTTGAGAAGAGCGGGATTACCACC
TTCCTGGTCGGTGAAAGCCTGATGAGGAAGGACGACGTCGAGGCGGCAACGCGTGCGCTGCTGACCGGCTCCGCAAACAT
TCTGGCGGCAGAGTGA

Upstream 100 bases:

>100_bases
GGAGGGCATGGACTTGGCCCGGAAATCGCTTTCGAGCGGCGCCGCAAAGGTCGCCTTGCAGCGATTGATCACCGTTTCGA
ACGCGGCATGAGGAAAAGAC

Downstream 100 bases:

>100_bases
TGAGCGGGCCTGCCCTCACCCATATCGACAGCGCCGGCGAAGCGAGCATGGTCGATGTCGGCGACAAGACCGAGACGGTC
CGCGTCGCCGTCGCGGAGGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTDILRRIEAYKRGEIAAAKVRIPLAELKARIAEQSPPRGFRAALGAHREKGDFGLIAEIKKASPSKGLIRPDFDPPELA
KAYAAGGAACLSVLTDAPSFQGAPEFLTKAREACPLPALRKDFMFDTYQVFEARAWGADCILLIMASLADDDARRLEEAA
FALGMDVLVEVHDAEEMDRALRLSSPLVGINNRNLRTFEVDLAVSERLATMVSSDHLLVGESGVFTHEDCRRLEKSGITT
FLVGESLMRKDDVEAATRALLTGSANILAAE

Sequences:

>Translated_271_residues
MTDILRRIEAYKRGEIAAAKVRIPLAELKARIAEQSPPRGFRAALGAHREKGDFGLIAEIKKASPSKGLIRPDFDPPELA
KAYAAGGAACLSVLTDAPSFQGAPEFLTKAREACPLPALRKDFMFDTYQVFEARAWGADCILLIMASLADDDARRLEEAA
FALGMDVLVEVHDAEEMDRALRLSSPLVGINNRNLRTFEVDLAVSERLATMVSSDHLLVGESGVFTHEDCRRLEKSGITT
FLVGESLMRKDDVEAATRALLTGSANILAAE
>Mature_270_residues
TDILRRIEAYKRGEIAAAKVRIPLAELKARIAEQSPPRGFRAALGAHREKGDFGLIAEIKKASPSKGLIRPDFDPPELAK
AYAAGGAACLSVLTDAPSFQGAPEFLTKAREACPLPALRKDFMFDTYQVFEARAWGADCILLIMASLADDDARRLEEAAF
ALGMDVLVEVHDAEEMDRALRLSSPLVGINNRNLRTFEVDLAVSERLATMVSSDHLLVGESGVFTHEDCRRLEKSGITTF
LVGESLMRKDDVEAATRALLTGSANILAAE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=40.0749063670412, Blast_Score=174, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6322638, Length=232, Percent_Identity=37.5, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29486; Mature: 29355

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILRRIEAYKRGEIAAAKVRIPLAELKARIAEQSPPRGFRAALGAHREKGDFGLIAEI
CHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHH
KKASPSKGLIRPDFDPPELAKAYAAGGAACLSVLTDAPSFQGAPEFLTKAREACPLPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
KDFMFDTYQVFEARAWGADCILLIMASLADDDARRLEEAAFALGMDVLVEVHDAEEMDRA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHH
LRLSSPLVGINNRNLRTFEVDLAVSERLATMVSSDHLLVGESGVFTHEDCRRLEKSGITT
HHHCCCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCEE
FLVGESLMRKDDVEAATRALLTGSANILAAE
EEHHHHHHHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
TDILRRIEAYKRGEIAAAKVRIPLAELKARIAEQSPPRGFRAALGAHREKGDFGLIAEI
HHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHH
KKASPSKGLIRPDFDPPELAKAYAAGGAACLSVLTDAPSFQGAPEFLTKAREACPLPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHH
KDFMFDTYQVFEARAWGADCILLIMASLADDDARRLEEAAFALGMDVLVEVHDAEEMDRA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHH
LRLSSPLVGINNRNLRTFEVDLAVSERLATMVSSDHLLVGESGVFTHEDCRRLEKSGITT
HHHCCCEEECCCCCEEEEEEHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCEE
FLVGESLMRKDDVEAATRALLTGSANILAAE
EEHHHHHHHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]