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The map label for this gene is ppi [H]

Identifier: 150396483

GI number: 150396483

Start: 1359393

End: 1359983

Strand: Direct

Name: ppi [H]

Synonym: Smed_1265

Alternate gene names: 150396483

Gene position: 1359393-1359983 (Clockwise)

Preceding gene: 150396482

Following gene: 150396484

Centisome position: 35.94

GC content: 60.91

Gene sequence:

>591_bases
ATGAAGATCCTCCAATTCGCTGTTGCCGGAGCCTTGGCGCTCGCCACCTTCACGGGAGGCGCCTTCTTTGCGGGAGGTGC
CGTGGCGCAGTCTGGCGAAAACATTCTCACCGTTCAGCTCAAGGACGGCCCCGTCGTCATCGAGCTGCGTCCGGATATCG
CTCCGAAGCACGTGCAGCAGATCAAGGAACTGGCCGCCGCCGGCGAATATGACAATGTCGCGTTTCATCGCGTCATCAAG
GGCTTCATGGCCCAGACCGGCGACGTCGAGTTCGGCGACATGAAGGACGGTTACCAGGCTGATCGCGCCGGGACCGGTGG
TTCGTCCAAGCCCGACCTCCCGGCCGAGTTCTCCGACGTTCCTTTTGAGCGCGGTACGGTCGGAATGGCCCGAGCGCAGG
ACCCGAACAGCGCGAATTCCCAATTCTTCATCATGCTCGCACCCGGCGACTTCCTCAATGGCCAGTACACGGTCGTCGGC
AAGGTGGTGGAAGGCATGGAGAATGTCGACAAGATCAAGCTCGGCGACGACGCCAATAATGGTGCGGTTGCCGATCCAGA
CCGCATAGTCAGCGTTAAGGTCGGCAGTTAG

Upstream 100 bases:

>100_bases
CGCGGCCATGGGCGGTGACGTCAGCGCTTTCGTCCCCGGCGCGGTTCATCAGGCGCTTCAGGCCAAGCGCAAGTAAGCTT
ACATCACGCAAGGAGTTCCA

Downstream 100 bases:

>100_bases
ATCGAAAACAGAAGGAGTAGAATCATGGCCGAGATCAAGGATCCGGAAAACACGATCATAATGGAAACCACGAAGGGCAG
GGTGGTGATCGAGCTGCTGC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKILQFAVAGALALATFTGGAFFAGGAVAQSGENILTVQLKDGPVVIELRPDIAPKHVQQIKELAAAGEYDNVAFHRVIK
GFMAQTGDVEFGDMKDGYQADRAGTGGSSKPDLPAEFSDVPFERGTVGMARAQDPNSANSQFFIMLAPGDFLNGQYTVVG
KVVEGMENVDKIKLGDDANNGAVADPDRIVSVKVGS

Sequences:

>Translated_196_residues
MKILQFAVAGALALATFTGGAFFAGGAVAQSGENILTVQLKDGPVVIELRPDIAPKHVQQIKELAAAGEYDNVAFHRVIK
GFMAQTGDVEFGDMKDGYQADRAGTGGSSKPDLPAEFSDVPFERGTVGMARAQDPNSANSQFFIMLAPGDFLNGQYTVVG
KVVEGMENVDKIKLGDDANNGAVADPDRIVSVKVGS
>Mature_196_residues
MKILQFAVAGALALATFTGGAFFAGGAVAQSGENILTVQLKDGPVVIELRPDIAPKHVQQIKELAAAGEYDNVAFHRVIK
GFMAQTGDVEFGDMKDGYQADRAGTGGSSKPDLPAEFSDVPFERGTVGMARAQDPNSANSQFFIMLAPGDFLNGQYTVVG
KVVEGMENVDKIKLGDDANNGAVADPDRIVSVKVGS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI5031987, Length=139, Percent_Identity=37.410071942446, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI19557636, Length=144, Percent_Identity=34.0277777777778, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7706339, Length=142, Percent_Identity=34.5070422535211, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4505991, Length=138, Percent_Identity=39.1304347826087, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI24308049, Length=137, Percent_Identity=35.7664233576642, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4758950, Length=138, Percent_Identity=39.8550724637681, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=148, Percent_Identity=37.8378378378378, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789763, Length=174, Percent_Identity=35.0574712643678, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=154, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=35.9154929577465, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=35.9154929577465, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=139, Percent_Identity=37.410071942446, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=34.0277777777778, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=169, Percent_Identity=36.094674556213, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=139, Percent_Identity=37.410071942446, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=153, Percent_Identity=32.0261437908497, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=162, Percent_Identity=35.8024691358025, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322492, Length=158, Percent_Identity=32.9113924050633, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=141, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=167, Percent_Identity=33.5329341317365, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664125, Length=141, Percent_Identity=36.1702127659575, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357783, Length=141, Percent_Identity=36.1702127659575, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45549139, Length=139, Percent_Identity=35.2517985611511, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24661775, Length=139, Percent_Identity=33.0935251798561, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355237, Length=139, Percent_Identity=33.0935251798561, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24661771, Length=139, Percent_Identity=33.0935251798561, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20550; Mature: 20550

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILQFAVAGALALATFTGGAFFAGGAVAQSGENILTVQLKDGPVVIELRPDIAPKHVQQ
CCHHHHHHHHHHHHHHHCCCCCEECCHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHH
IKELAAAGEYDNVAFHRVIKGFMAQTGDVEFGDMKDGYQADRAGTGGSSKPDLPAEFSDV
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PFERGTVGMARAQDPNSANSQFFIMLAPGDFLNGQYTVVGKVVEGMENVDKIKLGDDANN
CCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHCCCEEEECCCCCC
GAVADPDRIVSVKVGS
CCCCCCCEEEEEEECC
>Mature Secondary Structure
MKILQFAVAGALALATFTGGAFFAGGAVAQSGENILTVQLKDGPVVIELRPDIAPKHVQQ
CCHHHHHHHHHHHHHHHCCCCCEECCHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHH
IKELAAAGEYDNVAFHRVIKGFMAQTGDVEFGDMKDGYQADRAGTGGSSKPDLPAEFSDV
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PFERGTVGMARAQDPNSANSQFFIMLAPGDFLNGQYTVVGKVVEGMENVDKIKLGDDANN
CCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHCCCEEEECCCCCC
GAVADPDRIVSVKVGS
CCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA