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The map label for this gene is ppi [H]

Identifier: 150396484

GI number: 150396484

Start: 1360008

End: 1360517

Strand: Direct

Name: ppi [H]

Synonym: Smed_1266

Alternate gene names: 150396484

Gene position: 1360008-1360517 (Clockwise)

Preceding gene: 150396483

Following gene: 150396485

Centisome position: 35.96

GC content: 60.59

Gene sequence:

>510_bases
ATGGCCGAGATCAAGGATCCGGAAAACACGATCATAATGGAAACCACGAAGGGCAGGGTGGTGATCGAGCTGCTGCCGGA
CGTGGCTCCGGGCCATGTCGCCCGAATCAAGGAGCTGACACGCGAAGGCGCCTATGACGGTGTGGTCTTCCACCGCGTAA
TCGACGACTTCATGGCGCAGACCGGTGACGTGCAATACGGCAAGACCGGTGGCGAGCAGTTCAATCCGGCGCGCGCCGGC
ATGGGCGGTTCCTCCAAGCCGGACCTGAAGGCCGAATTCTCCGACGTTTCTCATGTACGCGGGACATGCTCGATGGCTCG
CAGCCAGATGCCGAATTCGGCCAATTCCCAGTTCTTCATCTGCTTCACCGACTCTCCCTGGCTCAACAAGCAGTATTCCG
TCTGGGGTCAGGTCGTCGAAGGAATGGAGAATATCGACGCCATCAAGCGCGGCGAACCGGTCCGCGATCCGGACTCCATC
GTCTCGATGCGGGTTGCCGCCGACGCCTGA

Upstream 100 bases:

>100_bases
CAAGCTCGGCGACGACGCCAATAATGGTGCGGTTGCCGATCCAGACCGCATAGTCAGCGTTAAGGTCGGCAGTTAGATCG
AAAACAGAAGGAGTAGAATC

Downstream 100 bases:

>100_bases
TTTGCGCTAATGCACTGACACGCCCGCCCCAGTCGCGCGAGCCGCCGGGGCGGGTTTGCTTTTGGCTGATATTCTAGATG
CGCGTAGACCTGTTTGATTT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MAEIKDPENTIIMETTKGRVVIELLPDVAPGHVARIKELTREGAYDGVVFHRVIDDFMAQTGDVQYGKTGGEQFNPARAG
MGGSSKPDLKAEFSDVSHVRGTCSMARSQMPNSANSQFFICFTDSPWLNKQYSVWGQVVEGMENIDAIKRGEPVRDPDSI
VSMRVAADA

Sequences:

>Translated_169_residues
MAEIKDPENTIIMETTKGRVVIELLPDVAPGHVARIKELTREGAYDGVVFHRVIDDFMAQTGDVQYGKTGGEQFNPARAG
MGGSSKPDLKAEFSDVSHVRGTCSMARSQMPNSANSQFFICFTDSPWLNKQYSVWGQVVEGMENIDAIKRGEPVRDPDSI
VSMRVAADA
>Mature_168_residues
AEIKDPENTIIMETTKGRVVIELLPDVAPGHVARIKELTREGAYDGVVFHRVIDDFMAQTGDVQYGKTGGEQFNPARAGM
GGSSKPDLKAEFSDVSHVRGTCSMARSQMPNSANSQFFICFTDSPWLNKQYSVWGQVVEGMENIDAIKRGEPVRDPDSIV
SMRVAADA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=36.1111111111111, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI5031987, Length=137, Percent_Identity=38.6861313868613, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7706339, Length=152, Percent_Identity=32.2368421052632, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI10863927, Length=142, Percent_Identity=33.0985915492958, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505991, Length=136, Percent_Identity=36.0294117647059, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI22547212, Length=149, Percent_Identity=36.9127516778523, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7657473, Length=149, Percent_Identity=36.9127516778523, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI22547215, Length=149, Percent_Identity=36.9127516778523, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786736, Length=148, Percent_Identity=35.1351351351351, Blast_Score=84, Evalue=4e-18,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=140, Percent_Identity=33.5714285714286, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=33.5714285714286, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565860, Length=150, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=155, Percent_Identity=32.9032258064516, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=153, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559074, Length=155, Percent_Identity=34.8387096774194, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=145, Percent_Identity=33.1034482758621, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=143, Percent_Identity=32.8671328671329, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=152, Percent_Identity=34.8684210526316, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=143, Percent_Identity=34.2657342657343, Blast_Score=71, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320510, Length=152, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=189, Percent_Identity=33.8624338624339, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45549139, Length=136, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664125, Length=152, Percent_Identity=34.8684210526316, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357783, Length=152, Percent_Identity=34.8684210526316, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17647301, Length=139, Percent_Identity=35.9712230215827, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=38.5185185185185, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650807, Length=150, Percent_Identity=35.3333333333333, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18525; Mature: 18394

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKDPENTIIMETTKGRVVIELLPDVAPGHVARIKELTREGAYDGVVFHRVIDDFMAQ
CCCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TGDVQYGKTGGEQFNPARAGMGGSSKPDLKAEFSDVSHVRGTCSMARSQMPNSANSQFFI
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CFTDSPWLNKQYSVWGQVVEGMENIDAIKRGEPVRDPDSIVSMRVAADA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AEIKDPENTIIMETTKGRVVIELLPDVAPGHVARIKELTREGAYDGVVFHRVIDDFMAQ
CCCCCCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TGDVQYGKTGGEQFNPARAGMGGSSKPDLKAEFSDVSHVRGTCSMARSQMPNSANSQFFI
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CFTDSPWLNKQYSVWGQVVEGMENIDAIKRGEPVRDPDSIVSMRVAADA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA