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The map label for this gene is lpxB [H]

Identifier: 150396362

GI number: 150396362

Start: 1211820

End: 1213019

Strand: Direct

Name: lpxB [H]

Synonym: Smed_1143

Alternate gene names: 150396362

Gene position: 1211820-1213019 (Clockwise)

Preceding gene: 150396361

Following gene: 150396364

Centisome position: 32.04

GC content: 63.5

Gene sequence:

>1200_bases
ATGACCGATAGAGCCTACAGGCTGGCGGTCATCGCCGGCGAAGTTTCCGGCGACCTGCTCGGCGCCGACCTCGTGCGGGC
CCTGCGCGATCGGGCGGACGGTACCGTCGAACTCGTTGGTATCGGCGGCGAGGCACTCGAGGCCGAAGGGCTTCGGCCGT
TGTTCGACTATTCCGAACTCTCGATCATGGGCTTCTCGCAGGTCCTGGCAAATCTTCCCAAGCTCCTGGCGCGGATTCGA
CAGACCGCGAGCGCGATCACCGCTGCGCGGCCGGATGCTCTGGTTATAATCGACAGCCCCGATTTCACTCACCGAGTGGC
GCAGCGCGTCCGCGCCGCACTGCCGGACTTGCCGGTGATCGATTATGTCTGCCCGAGCGTCTGGGCATGGAAGCCGGAAC
GGGCGCCGCGCATGCGGGCTTATGTGGATCACGTGCTGGCGGTTCTGCCGTTCGAACCGGACGTGATGGTGAAACTCGGC
GGCCCGCCGACCACCTATGTCGGTCACAGGCTGGCATTGGACAGCAACGTGCTTGCCGTACGGCAGCGCCAGCGGCTGAA
GCAACAGGCGCAGGAACCGGGCGGGGCGAACGCCTGTCTCCTGTTACCCGGCTCACGCGGAAGCGAGATCAGCCGCCTGC
TGCCTGTCTTTCGCGACACAGTCGAAGAACTCGCTGATCGGAACGAAGGCATCCGCTTCCTTCTGCCAACTGTGCCTCGG
CAGGAAGAACGGGTGAGGGCGATGACGGCCTCCTGGAGGGTGCAACCCGCGATCAGTGTAACTTCGGAAAGGAAATGGGA
GGCTTTCGCCGAAGCCGACGCGGCCATAGCCGCATCGGGTACGGTTATCCTCGAGCTGGCGCTCGCCGGCGTTCCCGTCG
TCTCCACCTATTCTGCCGACTGGCTCGTAAGCCTCCTGCATTCCCGCATCCGGATCTGGACCGCAGCGCTTCCGAACCTG
ATCGCGGATTTTCCGGTCGTTCCGGAATATTTCAACAAGATGATACGGCCGGCCTCCCTGACGCGCTGGTTCGAGCGGCT
TTCCTGTGACACGCCTCAACGACGCGCGATGCTCGACGGGTTCGCGCTCGTGCAGCAGCGAATGGAGACGGATCGTCCGC
CAGGCGAAAAGGCGGCGGACATCGTTTTGACCTATATTCAAGCGGGGCGGAAGGGATCCTCGGGTCAAGCCAAAGGATGA

Upstream 100 bases:

>100_bases
GGCGCGCGCTGGTTCTGGAGCGGACACGCCTTGTGGAGGCGGCCGACAGGAGCGGTATGTTTGTACTGGGTATCGAGCGC
AATCTCCGCAGGGAGCGGGA

Downstream 100 bases:

>100_bases
CGAGTGGTGGGGTAGCGCACGAGAACGGCACGGGGCGGTCCGTGCAGCCATCGGCTGGTGGTCCGCACTGCGAACGGCCG
AGGCAATCATAGGTTTTGCG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTDRAYRLAVIAGEVSGDLLGADLVRALRDRADGTVELVGIGGEALEAEGLRPLFDYSELSIMGFSQVLANLPKLLARIR
QTASAITAARPDALVIIDSPDFTHRVAQRVRAALPDLPVIDYVCPSVWAWKPERAPRMRAYVDHVLAVLPFEPDVMVKLG
GPPTTYVGHRLALDSNVLAVRQRQRLKQQAQEPGGANACLLLPGSRGSEISRLLPVFRDTVEELADRNEGIRFLLPTVPR
QEERVRAMTASWRVQPAISVTSERKWEAFAEADAAIAASGTVILELALAGVPVVSTYSADWLVSLLHSRIRIWTAALPNL
IADFPVVPEYFNKMIRPASLTRWFERLSCDTPQRRAMLDGFALVQQRMETDRPPGEKAADIVLTYIQAGRKGSSGQAKG

Sequences:

>Translated_399_residues
MTDRAYRLAVIAGEVSGDLLGADLVRALRDRADGTVELVGIGGEALEAEGLRPLFDYSELSIMGFSQVLANLPKLLARIR
QTASAITAARPDALVIIDSPDFTHRVAQRVRAALPDLPVIDYVCPSVWAWKPERAPRMRAYVDHVLAVLPFEPDVMVKLG
GPPTTYVGHRLALDSNVLAVRQRQRLKQQAQEPGGANACLLLPGSRGSEISRLLPVFRDTVEELADRNEGIRFLLPTVPR
QEERVRAMTASWRVQPAISVTSERKWEAFAEADAAIAASGTVILELALAGVPVVSTYSADWLVSLLHSRIRIWTAALPNL
IADFPVVPEYFNKMIRPASLTRWFERLSCDTPQRRAMLDGFALVQQRMETDRPPGEKAADIVLTYIQAGRKGSSGQAKG
>Mature_398_residues
TDRAYRLAVIAGEVSGDLLGADLVRALRDRADGTVELVGIGGEALEAEGLRPLFDYSELSIMGFSQVLANLPKLLARIRQ
TASAITAARPDALVIIDSPDFTHRVAQRVRAALPDLPVIDYVCPSVWAWKPERAPRMRAYVDHVLAVLPFEPDVMVKLGG
PPTTYVGHRLALDSNVLAVRQRQRLKQQAQEPGGANACLLLPGSRGSEISRLLPVFRDTVEELADRNEGIRFLLPTVPRQ
EERVRAMTASWRVQPAISVTSERKWEAFAEADAAIAASGTVILELALAGVPVVSTYSADWLVSLLHSRIRIWTAALPNLI
ADFPVVPEYFNKMIRPASLTRWFERLSCDTPQRRAMLDGFALVQQRMETDRPPGEKAADIVLTYIQAGRKGSSGQAKG

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=399, Percent_Identity=32.5814536340852, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43830; Mature: 43699

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRAYRLAVIAGEVSGDLLGADLVRALRDRADGTVELVGIGGEALEAEGLRPLFDYSEL
CCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCHHCCCHH
SIMGFSQVLANLPKLLARIRQTASAITAARPDALVIIDSPDFTHRVAQRVRAALPDLPVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHH
DYVCPSVWAWKPERAPRMRAYVDHVLAVLPFEPDVMVKLGGPPTTYVGHRLALDSNVLAV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCEEEECCCHHHH
RQRQRLKQQAQEPGGANACLLLPGSRGSEISRLLPVFRDTVEELADRNEGIRFLLPTVPR
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
QEERVRAMTASWRVQPAISVTSERKWEAFAEADAAIAASGTVILELALAGVPVVSTYSAD
HHHHHHHHHHHCEECCCEECCCCHHHHHHHHHCHHHHCCCHHHHHHHHCCCCEEECCCHH
WLVSLLHSRIRIWTAALPNLIADFPVVPEYFNKMIRPASLTRWFERLSCDTPQRRAMLDG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
FALVQQRMETDRPPGEKAADIVLTYIQAGRKGSSGQAKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDRAYRLAVIAGEVSGDLLGADLVRALRDRADGTVELVGIGGEALEAEGLRPLFDYSEL
CCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCHHCCCHH
SIMGFSQVLANLPKLLARIRQTASAITAARPDALVIIDSPDFTHRVAQRVRAALPDLPVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHH
DYVCPSVWAWKPERAPRMRAYVDHVLAVLPFEPDVMVKLGGPPTTYVGHRLALDSNVLAV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCEEEECCCHHHH
RQRQRLKQQAQEPGGANACLLLPGSRGSEISRLLPVFRDTVEELADRNEGIRFLLPTVPR
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
QEERVRAMTASWRVQPAISVTSERKWEAFAEADAAIAASGTVILELALAGVPVVSTYSAD
HHHHHHHHHHHCEECCCEECCCCHHHHHHHHHCHHHHCCCHHHHHHHHCCCCEEECCCHH
WLVSLLHSRIRIWTAALPNLIADFPVVPEYFNKMIRPASLTRWFERLSCDTPQRRAMLDG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
FALVQQRMETDRPPGEKAADIVLTYIQAGRKGSSGQAKG
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA