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The map label for this gene is lpxA [H]

Identifier: 150396360

GI number: 150396360

Start: 1210124

End: 1210936

Strand: Direct

Name: lpxA [H]

Synonym: Smed_1141

Alternate gene names: 150396360

Gene position: 1210124-1210936 (Clockwise)

Preceding gene: 150396359

Following gene: 150396361

Centisome position: 32.0

GC content: 59.66

Gene sequence:

>813_bases
ATGATAGCATCAAGTGCGAAGATCCATCCGTCCTCGGCGATCGAGGGCGGGGCGGTAATCGGCGAAAACGTTAAGATCGG
CCCGTTCTGCCATATCGGGCCGAATGTCGTTCTTGCCGATGAAGTCGAAATTCTGAGCCACGTCACAGTCATCGGCCGTA
CCACCGTCGGCAAGGGGACGAAGATCTTTCCGGGAGCGGTTATCGGCGGCGATTCGCAGAGCATGCACCATAGCGCATTG
AATACCACGCTGGTGATCGGCGAGAACTGTACCATCCGCGAAGGCGTGACCATGAATACGGGCACGGTGGAGCATGGCGG
TGCAACGATTGTCGGCGATAACAATCTTTTCCTTGCCTACTCGCACGTAGCGCATGATTGCCGCCTCGGAAACAATATCA
TCCTCTCCAACAATGTCATGCTTGCGGGGCACGTCACCGTTGCGGACCGCGCCATCCTCGGCGGCGGTTCGGCAGTTCAC
CAGTTCACCCGTATCGGCCGGCAGGCCTTCATCGGCGGGCTGTCCGCGGTGAGCTATGACGTTATTCCCTACGGGATGCT
CAACGGCAATCCCGGGCTCTTGAGCGGCCTCAACGTCGTCGGGATGACTCGCGCAGGGTTCGATCGTTCGACGATTCATC
GGGTTCGGCGGTGCTACAAGCAGATTTTCGAGGGGGATGGCTCGATCCGTGCAAACGCAGCCGCAATCCGCGACGAGTAT
CTCGATTGCGCACCGGCTCTAGAGATCCTGGACTTTATCGCCGCCGAGAGCGACCGCGCGCTGTCGTCGCCGAATCGCGG
CGCCAAAGGCTGA

Upstream 100 bases:

>100_bases
GCAATATCTGGAAGTTTCACTGTGATGCAAAAGTTGACGGGCAACTCGTCGCCGAAGCTGATATCGGCGCGATGATTGTC
AGCAAGGAAGACGTCTGAGA

Downstream 100 bases:

>100_bases
TGTCGGTGGCGATTCATCGCCTGCCGCAGTCAAAAGGCAGGCTCGCCATCATTGCCGGTGCCGGTGCACTTCCCCATCAT
GTCGCCGAGGCGGCACGCCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGTKIFPGAVIGGDSQSMHHSAL
NTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAYSHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVH
QFTRIGRQAFIGGLSAVSYDVIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEY
LDCAPALEILDFIAAESDRALSSPNRGAKG

Sequences:

>Translated_270_residues
MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGTKIFPGAVIGGDSQSMHHSAL
NTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAYSHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVH
QFTRIGRQAFIGGLSAVSYDVIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEY
LDCAPALEILDFIAAESDRALSSPNRGAKG
>Mature_270_residues
MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGTKIFPGAVIGGDSQSMHHSAL
NTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAYSHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVH
QFTRIGRQAFIGGLSAVSYDVIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEY
LDCAPALEILDFIAAESDRALSSPNRGAKG

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=261, Percent_Identity=41.3793103448276, Blast_Score=194, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28198; Mature: 28198

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGT
CCCCCCCCCCCCCCCCCEEECCCEEECCEEECCCCEEEEHHHHHHHHEEEEEEEECCCCC
KIFPGAVIGGDSQSMHHSALNTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAY
EECCCEEECCCCCHHHHHHCCEEEEECCCCEEECCEEECCCEEECCCEEEEECCCEEEEE
SHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVHQFTRIGRQAFIGGLSAVSYD
HHHHHHHHCCCEEEEECCEEEEEEEEEECEEEECCCHHHHHHHHHHHHHHHCCHHHEEEE
VIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEY
CEEEEEECCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
LDCAPALEILDFIAAESDRALSSPNRGAKG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGT
CCCCCCCCCCCCCCCCCEEECCCEEECCEEECCCCEEEEHHHHHHHHEEEEEEEECCCCC
KIFPGAVIGGDSQSMHHSALNTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAY
EECCCEEECCCCCHHHHHHCCEEEEECCCCEEECCEEECCCEEECCCEEEEECCCEEEEE
SHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVHQFTRIGRQAFIGGLSAVSYD
HHHHHHHHCCCEEEEECCEEEEEEEEEECEEEECCCHHHHHHHHHHHHHHHCCHHHEEEE
VIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEY
CEEEEEECCCCCHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
LDCAPALEILDFIAAESDRALSSPNRGAKG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]