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The map label for this gene is pyrH [H]

Identifier: 150396352

GI number: 150396352

Start: 1201772

End: 1202494

Strand: Direct

Name: pyrH [H]

Synonym: Smed_1133

Alternate gene names: 150396352

Gene position: 1201772-1202494 (Clockwise)

Preceding gene: 150396351

Following gene: 150396353

Centisome position: 31.78

GC content: 60.86

Gene sequence:

>723_bases
ATGTCGGCACAACCAATCTACAAGCGCGTTCTTCTCAAAGCCTCCGGCGAAGCGCTGATGGGAAGCCAGGGATTTGGCAT
CGATGTTGCCGTTGCCGATCGAATCGCTTCCGACATCGCGCAAGCCAGGGCCATGGGGGTCGAAGTCGGCGTCGTCGTCG
GCGGTGGCAACATATTTCGCGGCGTCGCTGTCGCTTCCAAGGGCGGCGATCGCGTGACGGGCGACCACATGGGGATGCTG
GCGACGGTCATCAACGCGCTTGCTCTGGCGACGTCGCTGCGCAAGCTCGACATCGACACCGTCGTCCTGTCGGCAATCGC
GATGCCGGAGATCTGCGAGAGTTTTTCGCAGCGCGCGACGCTCTACCATCTTTCGCTCGGTCGCGTTGTGATTTTCGCTG
GTGGCACAGGCAATCCGTTCTTCACGACGGATTCGGCAGCCGCGCTCCGCGCGGCGGAAATGGGCGCCGAGGCGATTTTC
AAGGGGACACAGGTCGACGGCATCTATTCCGCCGATCCGAAGAAGGATCCTTCCGCCACCCGCTTCGATCGCCTGACGCA
CAGCGAAGTTCTCGAGAAAGGCCTCGCGGTAATGGATGTTGCCGCTGTGGCACTTGCGCGGGAAAATGCCATTCCGATCG
TCGTCTTCTCGATCCATGAGAAAGACGGCTTCACGGAGATATTGACGGGTGGCGGTCGTGCCACCATCGTGACCGATAGT
TGA

Upstream 100 bases:

>100_bases
GGACCCGCCGGAGCGGTTGATACCACGCAGCGGAGTTTTTCCTTTACGCCGCTGTGCGCCACATGCTGCGCAGGCGAGCC
GGTCTACTTCAGGAGTGACG

Downstream 100 bases:

>100_bases
CTAGCTGCTGGGGGCCCGCAAGGCCGCTGAAAATTACGGGAGTCTCGAACCATGAGTGAAGGTGTGGATCTGAAGGAACT
CAAGCGTCGCATGGACGGCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGML
ATVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRATLYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIF
KGTQVDGIYSADPKKDPSATRFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS

Sequences:

>Translated_240_residues
MSAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGML
ATVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRATLYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIF
KGTQVDGIYSADPKKDPSATRFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS
>Mature_239_residues
SAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFRGVAVASKGGDRVTGDHMGMLA
TVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRATLYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFK
GTQVDGIYSADPKKDPSATRFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=238, Percent_Identity=49.5798319327731, Blast_Score=256, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 24912; Mature: 24781

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFR
CCCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GVAVASKGGDRVTGDHMGMLATVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRAT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCE
LYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPSAT
EEEEEECEEEEEECCCCCCCEECCHHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCCCH
RFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SAQPIYKRVLLKASGEALMGSQGFGIDVAVADRIASDIAQARAMGVEVGVVVGGGNIFR
CCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEE
GVAVASKGGDRVTGDHMGMLATVINALALATSLRKLDIDTVVLSAIAMPEICESFSQRAT
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCE
LYHLSLGRVVIFAGGTGNPFFTTDSAAALRAAEMGAEAIFKGTQVDGIYSADPKKDPSAT
EEEEEECEEEEEECCCCCCCEECCHHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCCCH
RFDRLTHSEVLEKGLAVMDVAAVALARENAIPIVVFSIHEKDGFTEILTGGGRATIVTDS
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]